Patents Assigned to The University of Arizona
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Patent number: 12281988Abstract: An optical microtoroid resonator including one or more nanoparticles attached to a surface of the resonator and capable of receiving an input signal from afar-field source (via free-space transmission) and outputting light propagating within the optical apparatus. A method for coupling light into and out of an optical resonator using a nanoparticle or nanoparticles to interface with spatially separated far-field optical elements.Type: GrantFiled: December 17, 2021Date of Patent: April 22, 2025Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Tsu-Te Judith Su, Euan McLeod
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Patent number: 12239134Abstract: Compositions and methods that utilize a combination of essential oils or other plant-derived extracts or compounds and an emulsifier as an antimicrobial are provided. In some embodiments the compositions further include ozone. In some embodiments, the composition includes one or more plant essential oils, plant extracts, or plant-derived compounds, or combinations thereof, and an emulsifier (such as a saponin). The antimicrobial composition may also include water, peracetic acid, acetic acid, lactic acid, citric acid, and/or hydrogen peroxide. Methods of killing a microorganism, including contacting the microorganism with the disclosed antimicrobial compositions are also provided. The microorganism may be present on a food item or a food contact of non-food contact surface and may be in the form of a biofilm. In some examples, the antimicrobial composition is used one or more times (such as 1 to 5 times).Type: GrantFiled: November 22, 2021Date of Patent: March 4, 2025Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Sadhana Ravishankar, Govindaraj Dev Kumar, Libin Zhu, Bibiana Law
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Patent number: 12173087Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imagable contrast agent and/or anti-cancer agent) selectively to the tumor cell.Type: GrantFiled: January 24, 2022Date of Patent: December 24, 2024Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Intezyne Technologies Inc., Arizona Board of Regents on Behalf of The University of Arizona, Board of Regents, The University of Texas SystemInventors: Robert J. Gillies, David L. Morse, Natalie M. Barkey, Kevin N. Sill, Josef Vagner, Narges K. Tafreshi, Jonathan L. Sessler, Christian Preihs, Victor J. Hruby
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Patent number: 11955676Abstract: A unit configured as constituent part of a fuel cell for use in novel electrochemical hydrogen compressor material technology system includes a combination of a hydrocarbon auto-thermal reformer, a water-gas shift reactor, and at least two countercurrent flow heat recuperators at least one of which is downstream from both the reformer and reactor. Optionally, two of the at least two recuperators are separated by the reactor to generate H2 in addition to that already contained in reformate formed at the reformer. The unit may include a proton conducting membrane that includes an inorganic polymer with pores filled with an organic polymer, each of which is configured to operate individually within a wide range of temperatures with no added solvent.Type: GrantFiled: April 2, 2021Date of Patent: April 9, 2024Assignee: Arizona Board of Regents on behalf of The University of ArizonaInventors: Peiwen Li, Xinhai Xu, Shuyang Zhang, Xiaoxin Wang
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Patent number: 11867713Abstract: An optomechanical inertial reference mirror combines an optomechanical resonator with a reflector that serves as an inertial reference for an atom interferometer. The optomechanical resonator is optically monitored to obtain a first inertial measurement of the reflector that features high bandwidth and high dynamic range. The atom interferometer generates a second inertial measurement of the reflector that features high accuracy and stability. The second inertial measurement corrects for drift of the first inertial measurement, thereby resulting in a single inertial measurement of the reflector having high bandwidth, high dynamic range, excellent long-term stability, and high accuracy. The reflector may be bonded to the resonator, or formed directly onto a test mass of the resonator. With a volume of less than one cubic centimeter, the optomechanical inertial reference mirror is particularly advantageous for portable atomic-based sensors and systems.Type: GrantFiled: February 15, 2020Date of Patent: January 9, 2024Assignees: Arizona Board of Regents on Behalf of The University of Arizona, Leibniz Universität HannoverInventors: Felipe Guzmán, Ernst Maria Rasel, Dennis Schlippert
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Patent number: 11860256Abstract: A method for producing a streak-suppressed MR image of a subject includes (i) generating an interference correlation matrix from M coil images, (ii) producing eigenvectors of the interference correlation matrix, and (iii) determining, from the subspace-eigenvectors, a projection matrix of the interference null space. The subspace-eigenvectors include a plurality of subspace-eigenvectors that span an interference subspace and a plurality of null-space-eigenvectors that span an interference null space.Type: GrantFiled: April 19, 2022Date of Patent: January 2, 2024Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Zhiyang Fu, Maria I. Altbach, Ali Bilgin
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Patent number: 11846828Abstract: A stabilizing locking clamp for a kinematic optical mount includes a clamp plate configured for optical access and a plurality of clamp actuators affixed to the clamp plate. The clamp actuators are positioned such that each clamp actuator exerts a force on a front plate of the kinematic optical mount in a push-push configuration. A stabilizing kinematic optical mount includes a kinematic optical mount and a plurality of clamp arms, each clamp arm including a clamp actuator positioned to exert a force on a front plate of the kinematic optical mount in a push-push configuration. The stabilizing locking clamp and stabilizing kinematic optical mount reduce temperature-dependent and vibration-induced changes in pitch and yaw, thereby improving pointing stability for optical setups that rely on critical beam alignment.Type: GrantFiled: February 8, 2019Date of Patent: December 19, 2023Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Laird M. Close, Maggie Y. Kautz
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Patent number: 11727828Abstract: A training system uses a physical model of a head and neck with a first tracker, a second tracker on a physical laryngoscope model, a third tracker on a physical endotracheal tube model, and a fourth tracker on a VR goggle; the system uses the trackers to determine positions of the physical models. A simulation system has corresponding digital 3D models of a laryngoscope, an endotracheal tube, and an airway, the airway including 3D models of surfaces of tongue, epiglottis, larynx, pharynx, and trachea. The physical model locations are registered to the digital models. In embodiments, the physical laryngoscope model has sensors measure strain or pressure along its blade and the simulation system has instructions to distort the digital 3D model of the airway according to readings of the sensors. The system can render the digital 3D model viewed from the VR goggle or a camera of the laryngoscope.Type: GrantFiled: February 19, 2021Date of Patent: August 15, 2023Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Jarrod Mosier, Young-Jun Son, David E. Biffar, Vignesh Subbain, Saurabh Jain, Bijoy Dripta Barua Chowdhury, Thomas Cahir, Eze Ahanonu
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Patent number: 11622535Abstract: Features are described for a pellet dispenser. The pellet dispenser be implemented as a complex molded unit to fit within the home cage of laboratory animals (e.g., hanging from a wall of the cage or inside a food hopper of the cage). The pellet dispenser may be contained within the cage or otherwise attached to the cage so as not to take up additional floor space in the cage which should be allocated for the small laboratory animal. The pellets may be gravity or screw drive fed towards an ejector port. At prescribed times during the day, a prescribed number of pellets may be ejected into the animal cage. Additional components of the pellet dispenser include an ejector (e.g., a linear actuator) and pellet hopper.Type: GrantFiled: March 13, 2020Date of Patent: April 11, 2023Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Jonathan Lifshitz, Bret Tallent, Addison Wessel, Loren Matthew Law
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Patent number: 11617788Abstract: Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof.Type: GrantFiled: July 9, 2019Date of Patent: April 4, 2023Assignees: Arizona Board of Regents on Behalf of The University of Arizona, The University of North Carolina at Chapel Hill, The Board of Supervisors of Louisiana State University and Agricultura and Mechanical ColleaeInventors: Felicia Goodrum, Nathaniel Moorman, Jeremy Kamil
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Patent number: 11611194Abstract: A collinear T-cavity VECSEL system generating intracavity Hermite-Gaussian modes at multiple wavelengths, configured to vary each of these wavelengths individually and independently. A mode converter element and/or an astigmatic mode converter is/are aligned intracavity to reversibly convert the Gaussian modes to HG modes to Laguerre-Gaussian modes, the latter forming the system output having any of the wavelengths provided by the spectrum resulting from nonlinear frequency-mixing intracavity (including generation of UV, visible, mid-IR light). The laser system delivers Watt-level output power in tunable high-order transverse mode distribution.Type: GrantFiled: March 23, 2021Date of Patent: March 21, 2023Assignee: Arizona Board of Regents on behalf of The University of ArizonaInventors: Mahmoud Fallahi, Ewan Wright, Chris Hessenius
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Publication number: 20220350109Abstract: A heliostat includes a reflecting surface; an elastically deformable frame on which the reflecting surface is mounted; a truss structure behind the elastically deformable frame that includes at least four bracing struts with first ends attached to the elastically deformable frame and second ends attached to at least one node located centrally behind the frame; at least one actuator connected to at least one of the at least four struts at the at least one node; an electronic control system configured to communicate with the least one actuator; and a dual-axis mount to support and orient the above assembly. The actuation of the at least one actuator in response to the electronic control system causes compression or tension of at least one of the at least four bracing struts to thereby control a shape of the reflecting surface and the elastically deformable frame in at least low order bending modes.Type: ApplicationFiled: September 28, 2020Publication date: November 3, 2022Applicant: Arizona Board Of Regents On Behalf Of The University Of ArizonaInventors: James Roger P. Angel, Nicholas J. Didato, Ryker Eads, Mathew Rademacher, Nicholas Emerson
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Patent number: 11399713Abstract: Systems and methods for assessing multi-layer structures in which a spectrum array is generated from low coherence interferometry and input into a statistical estimator, which determines the thickness and layer number based on the inputted spectrum and other information, including information about a source intensity noise, Poisson noise, and dark noise associated with the low coherence interferometry.Type: GrantFiled: April 30, 2019Date of Patent: August 2, 2022Assignees: University of Rochester, The University of ArizonaInventors: Jinxin Huang, Jannick P. Rolland, Eric Clarkson, Matthew Kupinski
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System, apparatus, and process for leaching metal and storing thermal energy during metal extraction
Patent number: 11390933Abstract: An environmentally friendly (e.g. no acid, base, or cyanide) system and process for large scale extraction of metal ion into aerobic molten salt (or ionic liquid) and the electrodeposition of metal (e.g. copper, gold, silver, etc.) from the metal ion dissolved in the molten salt. The non-volatile low vapor pressure liquid salt is reusable, and heat from the molten slag can heat the molten salts or ionic liquids. Another embodiment comprises a one-pot apparatus for the extraction of metal (e.g. copper) from metal earths and electrodepositing the metal using a low melting (209° C.) aerated Na—K—Zn chloride salt in which copper metal oxidizes and is converted to soluble copper chloride. When an electrical power supply is connected to the graphite vessel (cathode) and to copper rods in the melt (anodes), then the copper chloride is deposited as copper metal by electroreduction on the bottom of the graphite reaction vessel.Type: GrantFiled: September 16, 2020Date of Patent: July 19, 2022Assignees: CLEAN RESOURCES PTE. LTD, The Arizona Board of Regent on Behalf of The University of ArizonaInventors: Abraham Fouad Jalbout, Andres Godinez, Dominic Francis Gervasio, Hassan H. Elsentriecy -
Patent number: 11333893Abstract: A light-combining optical imager includes a spatially-curved waveguide-body complemented with at least two and preferably at least three holographic layers disposed on the surface(s) of the waveguide-body to couple light into the waveguide-body, optionally redirect its propagation inside the waveguide-body, and outcouple light from the waveguide body to form an optical image with reduced aberrations and—when desired—while expanding the pupil size of the imager upon propagation of light through the waveguide-body to achieve a one-to-one optical conjugation between an object and an image. At least one of the holographic layers includes potions having different diffraction efficiencies. At least one of the holographic layers is optionally configured to operate as a non-zero optical power lens element. Spatial separations between the holographic layers judiciously relate to dimensions of the portions of the holographic layers to achieve the desired result.Type: GrantFiled: May 13, 2020Date of Patent: May 17, 2022Assignee: Arizona Board of Regents on behalf of The University of ArizonaInventors: Craig Thomas Draper, Pierre Alexandre Blanche
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Patent number: 11303036Abstract: A hollow light-weight, low-cost, and high-performance 3D Luneburg lens structure using partially-metalized thin film, string, threads, fiber or wire base metamaterial to implement the continuously varying relative permittivity profile, characteristic of Luneburg lens structures, is disclosed. The hollow light-weight lens structure is based on the effective medium approach and may be implemented by a number of means. Further, most of the volume of the lens structure is free-space, thus the weight of the lens is significantly less than conventional 3D Luneburg lens structures of the same dimensions.Type: GrantFiled: June 15, 2018Date of Patent: April 12, 2022Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Hao Xin, Min Liang
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Patent number: 11221966Abstract: Provided herein are biological information pattern (BIP) arrays and related methods for reading out information stored in a biological medium. In this manner, encoded digital information in biomolecular medium can be used as a high data density storage medium that may be read-out and accessed in a label-free manner.Type: GrantFiled: June 4, 2019Date of Patent: January 11, 2022Assignees: Arizona Board of Regents on Behalf of The University of Arizona, Whitespace Enterprise CorporationInventors: Frederic Zenhausern, Cedric Hurth
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Patent number: 11191275Abstract: Compositions and methods that utilize a combination of essential oils or other plant-derived extracts or compounds and an emulsifier as an antimicrobial are provided. In some embodiments the compositions further include ozone. In some embodiments, the composition includes one or more plant essential oils, plant extracts, or plant-derived compounds, or combinations thereof, and an emulsifier (such as a saponin). The antimicrobial composition may also include water, peracetic acid, acetic acid, lactic acid, citric acid, and/or hydrogen peroxide. Methods of killing a microorganism, including contacting the microorganism with the disclosed antimicrobial compositions are also provided. The microorganism may be present on a food item or a food contact of non-food contact surface and may be in the form of a biofilm. In some examples, the antimicrobial composition is used one or more times (such as 1 to 5 times).Type: GrantFiled: December 5, 2019Date of Patent: December 7, 2021Assignee: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Sadhana Ravishankar, Govindaraj Dev Kumar, Libin Zhu, Bibiana Law
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Publication number: 20210244474Abstract: An apparatus has a device representing an endoscope, the device being either an endoscope or a dummy endoscope having shape and feel resembling an endoscope, and includes a tracker adapted to operate with a three-dimensional tracking system to track location and orientation of the device in three dimensions in a simulated operating-room environment. The apparatus also has a physical head model comprising hard and soft components, the device representing an endoscope configured to be inserted into the physical head model to provide a haptic feedback of endoscopic surgery.Type: ApplicationFiled: April 18, 2019Publication date: August 12, 2021Applicant: Arizona Board of Regents on Behalf of The University of ArizonaInventors: Samuel BARBER, Saurabh JAIN, Young-Jun SON, Eugene CHANG
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Patent number: 11033665Abstract: A needle assembly includes an outer cannula having a distal end portion, the distal end portion comprising a sharp bevel facilitating insertion of the needle assembly into a subject. The needle assembly further includes an inner cannula slidably disposed coaxially in the lumen of the outer cannula and movable between an extended position and a retracted position, the inner cannula having a blunt distal end portion extending beyond the sharp bevel of the outer cannula whenever the inner cannula is in the extended position. The needle assembly further includes a bias coupled to the inner cannula in a manner favoring automatic positioning of the inner cannula at the extended position. The needle assembly includes a valve located in fluid communication with the lumen of the inner cannula to allow fluid to exit the subject through the inner cannula, and to prevent ingress of fluid into the subject.Type: GrantFiled: November 3, 2017Date of Patent: June 15, 2021Assignee: The Arizona Board of Regents on Behalf of The University of ArizonaInventors: Peter Rhee, Andrew Tang, Kevin Okarski