Patents Assigned to The University of British Columbia
  • Patent number: 11367001
    Abstract: A computer-implemented method of facilitating neural network image analysis involves receiving signals representing a set of images, causing at least one neural network function to be applied to the set of images to determine at least one property confidence distribution parameter, and causing a cumulative distribution function defined at least in part by the at least one property confidence distribution parameter to be applied to a plurality of ranges, each range associated with a respective property that may be associated with the set of images, to determine a plurality of property confidences, each of the property confidences representing a confidence that the set of images should be associated with a respective one of the properties. Other methods, systems, and computer-readable media are disclosed.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: June 21, 2022
    Assignee: The University of British Columbia
    Inventors: Purang Abolmaesumi, Zhibin Liao, Teresa Tsang, Delaram Behnami
  • Patent number: 11345670
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: May 31, 2022
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Kunzhong Jian, Marianne Dorothy Sadar, Nasrin R. Mawji, Carmen Adriana Banuelos
  • Patent number: 11340188
    Abstract: A method of exposing a sample to an electrical effect for electrochemical analysis of the sample in an electrolyte solution is disclosed. The method comprises causing an external electrical conductor of an electrode head to apply the electrical effect, the external electrical conductor of the electrode head being external to the electrode head and on an external side of the sample exposed to the electrolyte solution. Apparatuses are also disclosed.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: May 24, 2022
    Assignee: The University of British Columbia
    Inventors: David Wilkinson, Arman Bonakdarpour, Jason Kwan, Louis Greg Afonso
  • Patent number: 11342828
    Abstract: Aspects of the invention provide methods and systems for moving a plurality of moveable stages relative to a stator. The stator comprises a plurality of coils shaped to provide pluralities of coil trace groups where each coil trace group comprises a corresponding plurality of generally linearly elongated coil traces which extend across a stator tile. Each moveable stage comprises a plurality of magnet arrays. Methods and apparatus are provided for moving the moveable stages relative to the stator, where a magnet array from a first moveable stage and a magnet array from a second moveable stage both overlap a shared group of coil traces. For at least a portion of the time that the magnet arrays from the first and second moveable stages overlap the shared group of coil traces, currents are controllably driven in the shared coil trace group based on the positions of both the first and second moveable stages. The positions of the first and second moveable stages may be ascertained by feedback.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: May 24, 2022
    Assignee: The University of British Columbia
    Inventor: Xiaodong Lu
  • Publication number: 20220148784
    Abstract: There is a solenoid including a stator having a first stator tooth and a second stator tooth, and an armature having a first armature tooth and a second armature tooth. The armature is moveable with respect to the stator over a predetermined stroke. A coil is associated with one of the stator and the armature for conducting an electric current and generating magnetic flux that is guided by the stator and the armature. The stator or the armature acts as a ferromagnetic core for the coil. There is a first air-gap between the first stator tooth and the first armature tooth that has a first length, and a second air-gap between the second stator tooth and the second armature tooth that has a second length. The first and second lengths are constant to within a predetermined margin over the predetermined stroke when the first and second armature teeth overlap the first and second stator teeth respectively.
    Type: Application
    Filed: March 20, 2020
    Publication date: May 12, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Rudolf Seethaler, Bradley Reinholz, Gordon McTaggart-Cowan, Ashish Singh, Devin Reinholz
  • Patent number: 11320260
    Abstract: A device for determining a height of soil above a structure buried below a soil bed includes a sensor assembly comprising a total stress pressure sensor for transmitting a first signal indicating a total pressure, a pore water pressure sensor located proximate to the total stress pressure sensor, the pore water pressure sensor for transmitting a second signal indicating a fluid pressure, a sensor module configured to receive the first and the second signals, determine a difference between the first signal and the second signal, based on the difference between the first signal and the second signal, determine a height of soil above the sensor assembly, and transmit a third signal indicating the height of soil to an external device.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: May 3, 2022
    Assignee: The University of British Columbia
    Inventors: Kaluarachchige Dharmapriya Wijewickreme, Michael Isaacson, Ruslan Shanth Amarasinghe, Noboru Yonemitsu
  • Publication number: 20220118112
    Abstract: Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.
    Type: Application
    Filed: October 9, 2019
    Publication date: April 21, 2022
    Applicant: The University of British Columbia
    Inventors: Blair Leavitt, Pieter Cullis, Terri Petkau, Austin Hill, Pamela Wagner, Jayesh Kulkami
  • Patent number: 11266596
    Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: March 8, 2022
    Assignees: The University of British Columbia, The General Hospital Corporation
    Inventors: Christian Kastrup, Ju Hun Yeon, James Baylis, Thomas Frederick Burke
  • Patent number: 11266780
    Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: March 8, 2022
    Assignee: University of British Columbia
    Inventors: Guy Dumont, Mark Ansermino, Sara Khosravi, Nicholas West
  • Publication number: 20220062446
    Abstract: A compound or molecular complex. The compound or molecular complex comprises: a metal chelator configured for chelation with a radioactive isotope or a non-radioactive isotope; and a trifluoroborate (BF3)-containing moiety configured for 19F/18F exchange or a precursor thereof; and optionally a cell-targeting domain.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 3, 2022
    Applicants: Provincial Health Services Authority, The University of British Columbia
    Inventors: David Perrin, Aron Roxin, Mathieu Lepage, Sungjoon Huh, Zhibo Liu, Rajaguru Kandasamy, Francois Benard, Kuo-Shyan Lin, Hsiou-Ting Kuo, Chengcheng Zhang
  • Patent number: 11245415
    Abstract: Methods, systems, and techniques for data compression. A cluster fingerprint of an uncompressed data block is determined to correspond to a cluster fingerprint of a base block stored in a base array. This determining involves looking up the cluster fingerprint of the first base block from the base array using the cluster fingerprint of the first uncompressed data block. The difference between the uncompressed data block and the base block is determined, and a compressed data block is encoded using this difference. The compressed data block is then stored in a data array.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: February 8, 2022
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA UNIVERSITY-INDUSTRY LIAISON OFFICE
    Inventors: Amin Ghasemazar, Prashant Jayaprakash Nair, Mieszko Lis
  • Publication number: 20220031820
    Abstract: Methods for treating inflammatory skin conditions, such as atopic dermatitis and psoriasis, and for promoting skin wound healing and for treating skin wounds, such as thermal and pressure injury, by reducing the activity of Granzyme K.
    Type: Application
    Filed: September 24, 2019
    Publication date: February 3, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: David J. GRANVILLE, Christopher TURNER, Matthew ZEGLINSKI, Katlyn RICHARDSON, Sho HIROYASU
  • Publication number: 20220031945
    Abstract: The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 3, 2022
    Applicant: The University of British Columbia
    Inventors: Guy Dumont, Klaske Van Heusden, Mark Ansermino
  • Patent number: 11235154
    Abstract: A device and algorithm for controlling an autonomic function in an individual. In particular, a controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. In particular, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: February 1, 2022
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aaron Phillips, Andrei Krassioukov, Jordan Squair
  • Patent number: 11228232
    Abstract: Displacement devices comprise a stator and a moveable stage. The stator comprises a plurality of coils shaped to provide pluralities of generally linearly elongated coil traces in one or more layers. Layers of coils may overlap in the Z-direction. The moveable stage comprises a plurality of magnet arrays. Each magnet array may comprise a plurality of magnetization segments generally linearly elongated in a corresponding direction. Each magnetization segment has a magnetization direction generally orthogonal to the direction in which it is elongated and at least two of the magnetization directions are different from one another. One or more amplifiers may be connected to selectively drive current in the coil traces and to thereby effect relative movement between the stator and the moveable stage.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 18, 2022
    Assignee: The University of British Columbia
    Inventors: Xiaodong Lu, Irfan-Ur-Rab Usman
  • Publication number: 20220002744
    Abstract: The invention is directed to BAHD acyltransferase enzymes, nucleic acids encoding BAHD acyltransferase enzymes, and inhibitory nucleic acids adapted to inhibit the expression and/or translation of BAHD acyltransferase RNA; expression cassettes, plant cells, and plants that have or encode such nucleic acids and enzymes; and methods of making and using such nucleic acids, enzymes, expression cassettes, cells, and plants.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Steven D. Karlen, Rebecca Anne Smith, John Ralph, Emily Beebe, Craig Bingman, Brian Fox, Shawn Mansfield, Heather Mackay, Hoon Kim, Yaseen Mottiar, Faride Unda
  • Patent number: 11214613
    Abstract: The disclosure pertains to conformational epitopes in TDP-43, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: January 4, 2022
    Assignee: The University of British Columbia
    Inventors: Steven S. Plotkin, Neil R. Cashman, Xubiao Peng
  • Patent number: 11208697
    Abstract: The present invention relates to methods, systems and kits for the diagnosis, prognosis, and treatment of bladder cancer in a subject. The invention also provides biomarkers that define subgroups of bladder cancer, clinically useful classifiers for distinguishing bladder cancer subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of subtyping bladder cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in subtyping bladder cancer in a subject. Classifiers for subtyping a bladder cancer are provided. Methods of treating bladder cancer based on molecular subtyping are also provided.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: December 28, 2021
    Assignees: Decipher Biosciences, Inc., The University of British Columbia
    Inventors: Elai Davicioni, Hussam Al-Deen Ashab, Nicholas Erho, Peter Black
  • Patent number: 11207432
    Abstract: Fluoridated organofluoroborates comprising at least one 18F atom and precursors thereto, for use in PET scanning.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: December 28, 2021
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: David Perrin, Zhibo Liu
  • Patent number: 11195117
    Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: December 7, 2021
    Assignees: University of Maryland, Duke University, University of British Columbia
    Inventors: Christopher Monroe, Jungsang Kim, Robert Raussendorf