Patents Assigned to The University of British Columbia
  • Patent number: 10493437
    Abstract: A method of preparing a metal/metal oxide material can make use of a nanostructure that includes a first metal to form the metal oxide, and a reaction surface with a reducing agent on the reaction surface. A second metal is deposited onto the reaction surface to form a bimetallic product. The bimetallic product is calcined to form the metal/metal oxide material.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: December 3, 2019
    Assignee: The University of British Columbia
    Inventors: Mark Maclachlan, Michael Wolf, Gomathi Anandhanatarajan
  • Patent number: 10475525
    Abstract: A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein; the free energy of unfolding of each set is determined; and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes identified by the epitope prediction methods, and related antibodies, to diagnose and treat disease and to screen samples for the presence of such epitopes.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: November 12, 2019
    Assignee: The University of British Columbia
    Inventors: Neil R. Cashman, Steven S. Plotkin, William C. Guest
  • Publication number: 20190338342
    Abstract: Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 7, 2019
    Applicant: The University of British Columbia
    Inventors: Andrea Marziali, Joel Pel, Jason Donald Thompson, Gosuke Shibahara
  • Patent number: 10466241
    Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: November 5, 2019
    Assignee: The University of British Columbia
    Inventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
  • Patent number: 10458892
    Abstract: An apparatus for monitoring particulate matter includes a fluid flow passage. Some embodiments include a cartridge defining a part of the fluid flow passage extending from a cartridge inlet to a cartridge outlet and a particle size selector in the fluid-flow passage between the cartridge inlet and the cartridge outlet. The particle size selector comprises a curve section in the fluid flow passage where the flow of fluid undergoes a change in direction and an impact surface extending transversely to the fluid flow passage on an outside of the curve. A particle counter is located downstream from the particle size selector. A pump is connected to drive a flow of a fluid containing the particulate matter through the fluid flow passage. The apparatus may be made compact. Embodiments may be worn and used to monitor exposure of persons to particulate matter.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: October 29, 2019
    Assignee: The University of British Columbia
    Inventors: Boris Stoeber, Winnie Chu, Leon Yuen
  • Patent number: 10451637
    Abstract: The present invention provides a synthetic blood vessel and use thereof in drug screening, drug delivery and prognoses of cerebrovascular dysfunction.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 22, 2019
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Cheryl Wellington, Jerome Robert
  • Publication number: 20190315823
    Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 17, 2019
    Applicant: The University of British Columbia
    Inventors: Robert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
  • Patent number: 10441606
    Abstract: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: October 15, 2019
    Assignee: University of British Columbia
    Inventors: Jayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Cedric J. Carter, Donald E. Brooks
  • Publication number: 20190307689
    Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and, small molecule drugs, to cells.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Applicant: The University of British Columbia
    Inventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis, Timothy Leaver, Andre Wild
  • Patent number: 10436928
    Abstract: A system for detecting an object in a subsurface environment includes a first recorder of a vertical electromagnetic component, including first pair of polarization orientation components, of an electromagnetic field in a region of interest, a second recorder of an orthogonal electromagnetic component, including second pair of polarization orientation components, of the electromagnetic field in the region of interest, at least one processor configured to derive a pair of transfer functions that relates the vertical electromagnetic component and the orthogonal electromagnetic component of the electromagnetic field for each of the polarization orientation components, at least one processor configured to determine a simulation of the pair of transfer functions for a given impedance distribution, and at least one processor configured to infer a subsurface impedance map using the pair of transfer functions of the recorded data and the simulation of the pair of transfer functions.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 8, 2019
    Assignees: International Business Machines Corporation, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Eldad Haber, Lior Horesh
  • Patent number: 10429628
    Abstract: Methods and apparatus for deep microscopic super resolution imaging use two independent and variable focal planes. Movements of fiducial markers imaged using one focal plane are monitored and used to provide real-time or near real-time correction for sample drift. A second focal plane may be used to collect light for super-resolution imaging of a sample. A prototype embodiment has produced low drift when imaging many microns deeper than the fiducial markers.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 1, 2019
    Assignee: The University of British Columbia
    Inventors: Keng C. Chou, Reza Tafteh
  • Patent number: 10426846
    Abstract: Isolated polynucleotides comprising an OLIG1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, guide RNA, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 1, 2019
    Assignee: University of British Columbia
    Inventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Daniel Goldowitz
  • Patent number: 10423736
    Abstract: A computer implemented method simulates the behavior of a gas-solid mixture in a fluidized bed having a particulate comprising Geldart group A particles using a Eulerian model comprising, for each time step (a current time step) and for each cell: obtaining an initial value of an agglomerate diameter corresponding to the cell and corresponding to the beginning of the current time step; performing a force-balance procedure for the cell to determine a first agglomerate diameter corresponding to the cell and corresponding to the current time step, wherein performing the force-balance procedure comprises determining a plurality of forces for the cell based at least in part on the initial value of the agglomerate diameter; updating one or more drag relationships for the current time step based at least in part on the first agglomerate diameter; and performing a computational fluid dynamic (CFD) solve procedure to determine, for the current time, the any one or more of: one or more of: a gas velocity {right arrow o
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 24, 2019
    Assignee: University of British Columbia
    Inventors: John Grace, Amir Hossein Ahmadi-Motlagh, Martha Salcudean, Christine Hrenya
  • Patent number: 10421936
    Abstract: Microfluidic devices and methods for perfusing a cell with perfusion fluid are provided herein, wherein the gravitational forces acting on the cell to keep the cell at or near a retainer or a retaining position exceed the hydrodynamic forces acting on the cell to move it toward an outlet. Also provided, are methods for assaying cell products within the microfluidic device.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: September 24, 2019
    Assignee: The University of British Columbia
    Inventors: Carl L. G. Hansen, Veronique Lecault, James M. Piret, Anupam Singhal
  • Publication number: 20190282280
    Abstract: Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.
    Type: Application
    Filed: May 16, 2019
    Publication date: September 19, 2019
    Applicants: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Edward Scott Harshman, Steven Charles Dimmer, Daniel Reed Baker, David Thomas Stinson, Robert N. Meek, Robin John Noel Coope, Lok Tin Lam
  • Patent number: 10401241
    Abstract: Sensor arrays are provided for sensing pressure and/or moisture over a two-dimensional sensing surface. The sensor arrays comprise ionically conductive materials. Individual sensor elements in the sensor arrays may comprise piezoionic ionically conductive materials, piezoresistive ionically conductive materials and/or capacitive sensor elements having electrodes fabricated from ionically conductive materials. Two-dimensional pressure maps and/or moisture maps of the sensing surface may be obtained by implementing methods comprising scanning over individual sensor elements in the sensor arrays.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: September 3, 2019
    Assignee: The University of British Columbia
    Inventors: John Madden, Yuta Dobashi, Mirza Saquib Sarwar
  • Patent number: 10403402
    Abstract: A system permits a medical practitioner to interact with medically relevant information during a medical procedure. The system comprises: a projector for projecting a user interface menu image onto a projection surface; a three-dimensional optical imaging system for capturing three-dimensional location information for objects in a sensing volume which includes the projection surface; and a controller connected to receive the three-dimensional location information from the three-dimensional optical imaging system and configured to interpret one or more gestures made by the practitioner in a space between the three-dimensional optical imaging system and the projection surface based on a location of the gesture relative to the projected user interface menu image.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: September 3, 2019
    Assignee: The University of British Columbia
    Inventors: Nima Ziraknejad, Behrang Homayoon, Peter Lawrence, David Ming-Teh Liu
  • Patent number: 10400266
    Abstract: Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: September 3, 2019
    Assignee: The University of British Columbia
    Inventors: Andrea Marziali, Joel Pel, Jason Donald Thompson, Gosuke Shibahara
  • Patent number: 10400281
    Abstract: Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: September 3, 2019
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Carl Lars Genghis Hansen, Georgia Elizabeth Mewis, Kevin Albert Heyries, Michael Andrew Vaninsberghe, Daniel Jay Da Costa, Marketa Ricicova
  • Patent number: 10392474
    Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 27, 2019
    Assignees: FREIE UNIVERSITAET BERLIN, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Donald Brooks, Jayachandran Kizhakkedathu, Rajesh Shenoi, Marie Weinhart, Benjamin Lai, Rainer Haag, Dominic Groeger