Patents Assigned to The University of British Columbia
-
Publication number: 20240141357Abstract: The present disclosure provides a duplex or single-stranded siRNA molecule against plasminogen, the siRNA molecule containing modified or unmodified nucleotides and wherein at least one strand of the duplex or the single-stranded siRNA has a sequence that has at least 80% sequence identity to any one of SEQ NOs: 1 to 28. Further provided is a duplex or single-stranded siRNA molecule against plasminogen, the siRNA molecule containing modified or unmodified nucleotides and is between 25 and 35 nucleotides in length. The siRNA molecule may be formulated in a lipid nanoparticle as described herein.Type: ApplicationFiled: February 14, 2022Publication date: May 2, 2024Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Christian J. Kastrup, Amy W. Strilchuk, Jerry Leung, Pieter R. Cullis, Madelaine Robertson
-
Patent number: 11970522Abstract: The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.Type: GrantFiled: August 28, 2020Date of Patent: April 30, 2024Assignee: The University of British ColumbiaInventors: Neil R. Cashman, Steven S. Plotkin
-
Publication number: 20240116862Abstract: Provided herein is a compound having a structure of Formula (I): (Formula (I)) wherein: D is S, O or an ester; p is 1 to 6; L1 and/or L2 are independently linear or branched C1-C30 alkyl, optionally having one or more C?C double bonds of E or Z geometry; and wherein: if D is S then L1 and/or L2 are unsubstituted or substituted with one or more S; and if D is O or an ester, then L1 and/or L2 are substituted with one more S. The compound may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acid. Further provided are methods for making the compound.Type: ApplicationFiled: January 12, 2022Publication date: April 11, 2024Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Marco Ciufolini, Mai Lam Ferguson
-
Patent number: 11938454Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.Type: GrantFiled: December 18, 2020Date of Patent: March 26, 2024Assignee: The University of British ColumbiaInventors: Euan Ramsay, Robert James Taylor, Timothy Leaver, Andre Wild, Kevin Ou, Colin Walsh
-
Patent number: 11940386Abstract: A sensor architecture that uses fixed wavelength light and tunes a wavelength dependent response of a sensor may be used for detecting analytes in a wide range of applications. The sensor architecture is based on optical resonators or interferometers comprising optical waveguides. A resonance wavelength and/or transmission/reflection spectrum are affected by presence of an analyte adsorbed on a surface of the waveguide, and a setting of a phase modulator. The sensors include a sensor portion where part of the waveguide is exposed to a sample for sensing, and a phase modulator part. The phase modulator part may include a heater that is controlled to tune, or sweep, or modulate the resonant wavelength and/or spectrum of the sensor.Type: GrantFiled: September 6, 2022Date of Patent: March 26, 2024Assignee: The University of British ColumbiaInventors: Lukas Chrostowski, Sudip Shekhar, Samantha Grist, Karen C. Cheung, Mohammed Ali Al-Qadasi
-
Patent number: 11936270Abstract: Displacement devices comprise a stator and a moveable stage. The stator comprises a plurality of coils shaped to provide pluralities of generally linearly elongated coil traces in one or more layers. Layers of coils may overlap in the Z-direction. The moveable stage comprises a plurality of magnet arrays. Each magnet array may comprise a plurality of magnetization segments generally linearly elongated in a corresponding direction. Each magnetization segment has a magnetization direction generally orthogonal to the direction in which it is elongated and at least two of the magnetization directions are different from one another. One or more amplifiers may be connected to selectively drive current in the coil traces and to thereby effect relative movement between the stator and the moveable stage.Type: GrantFiled: December 6, 2021Date of Patent: March 19, 2024Assignee: The University of British ColumbiaInventors: Xiaodong Lu, Irfan-Ur-Rab Usman
-
Patent number: 11919874Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.Type: GrantFiled: August 17, 2021Date of Patent: March 5, 2024Assignees: The University of British Columbia, Provincial Health Services AuthorityInventors: Raymond J. Andersen, Marianne Dorothy Sadar, Kunzhong Jian, Nasrin R. Mawji, Jun Wang, Carmen Adriana Banuelos, Yu-Chi Yang
-
Publication number: 20240067732Abstract: The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.Type: ApplicationFiled: September 27, 2023Publication date: February 29, 2024Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, SANGAMO THERAPEUTICS FRANCEInventors: Li Zhou, Tobias Abel, François Meyer, Megan Levings, Nicolas Dawson, Caroline Lamarche
-
Patent number: 11905318Abstract: The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.Type: GrantFiled: September 3, 2020Date of Patent: February 20, 2024Assignee: The University of British ColumbiaInventors: Neil R. Cashman, Steven S. Plotkin
-
Patent number: 11906372Abstract: The capacitance sensor 1 includes a self-capacitance electrode 5, first electrodes 3 (3(1) to 3(4)), and a second electrode 4 which are arranged being separated from each other in a thickness direction of an elastically deformable base material 2 formed by a dielectric. The self-capacitance electrode 5 is connected to a first connection portion 10a for measuring capacitance by a self-capacitance method and a grounded second connection portion 10b via a switch 10 so as to be selectively connected to the first connection portion 10a and the second connection portion 10b.Type: GrantFiled: January 12, 2022Date of Patent: February 20, 2024Assignees: Honda Motor Co., Ltd., The University of British ColumbiaInventors: Ryusuke Ishizaki, Mirza Saquib Sarwar, John D. W. Madden
-
Patent number: 11898924Abstract: A sensor unit to be incorporated in a skin-like layer of machines such as robots employs a set of sensor electrodes supported in a first deformable sheet and a base electrode supported in a second deformable sheet, each of the sensor electrodes partially overlapping the base electrode so that application of a shear force causes the overlap of the electrodes to differentially change modifying the capacitance of the electrodes and permitting the detection of the shear force.Type: GrantFiled: May 7, 2021Date of Patent: February 13, 2024Assignee: The University of British ColumbiaInventors: Mirza Saquib Sarwar, John D. W. Madden, Garth Eden Claire Preston
-
Patent number: 11884714Abstract: The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.Type: GrantFiled: June 8, 2022Date of Patent: January 30, 2024Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, PROVINCIAL HEALTH SERVICES AUTHORITYInventors: David Perrin, Mihajlo Todorovic, François Bénard, Chengcheng Zhang
-
Patent number: 11883631Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.Type: GrantFiled: February 1, 2022Date of Patent: January 30, 2024Assignee: The University of British ColumbiaInventors: Guy Dumont, Mark Ansermino, Sara Khosravi, Nicholas West
-
Patent number: 11878961Abstract: Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.Type: GrantFiled: January 20, 2021Date of Patent: January 23, 2024Assignees: Board of Regents, The University of Texas System, The University of British ColumbiaInventors: Marc Cox, Artem Cherkasov, Fuqiang Ban
-
Patent number: 11874501Abstract: A photonic device configured to perform matrix vector multiplication operations at high frequencies is provided. The vector being multiplied by the matrix is defined by vector components at specific wavelengths. The device includes a first waveguide and a second waveguide. A series of tunable microring resonators (MRRs) are coupled to the first waveguide and to a respective series of passive delay rings (PDRs), which are coupled to the second waveguide. Each MRR/PDR pair defines a tunable matrix component (tunable weight) for a respective wavelength component of the vector. A series of controllable delay elements (CDEs) such as all-pass filters are coupled to the first waveguide, upstream from the tunable MRRs. Any tuning dependent group delay caused by the MRR/PDR pairs can be compensated by controlling the CDEs such that each wavelength components has substantially a same delay as the other wavelength components.Type: GrantFiled: August 19, 2022Date of Patent: January 16, 2024Assignees: HUAWEI TECHNOLOGIES CANADA CO., LTD., QUEEN'S UNIVERSITY AT KINGSTON, THE UNIVERSITY OF BRITISH COLUMBIAInventors: Mitchell Nichols, Enxiao Luan, Mahsa Salmani, Armaghan Eshaghi, Lutz Hans-Joachim Lampe
-
Patent number: 11865190Abstract: Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.Type: GrantFiled: September 9, 2022Date of Patent: January 9, 2024Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Blair Leavitt, Pieter Cullis, Terri Petkau, Austin Hill, Pamela Wagner, Jayesh Kulkarni
-
Publication number: 20240001002Abstract: The present disclosure relates to methods of preparing protein hydrogels and to protein hydrogels which may, for example, be prepared from such methods. The methods comprise denaturing a protein in an aqueous environment to produce an aqueous composition comprising overlapping polypeptide chains; crosslinking the polypeptide chains to produce a denatured protein hydrogel comprising a crosslinked network of entangled polypeptide chains; and optionally at least partially renaturing the denatured protein hydrogel.Type: ApplicationFiled: November 16, 2021Publication date: January 4, 2024Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: HONGBIN LI, LINGLAN FU
-
Publication number: 20230405035Abstract: Functional food comprising montbretin A and use of the functional food for limiting polysaccharide processing in a human subject and for treating conditions treatable by inhibiting pancreatic a-amylase.Type: ApplicationFiled: October 21, 2021Publication date: December 21, 2023Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: John-paul Heale, Spence Stott Skene MacDonald, Kyle Brian Robinson
-
Patent number: 11845654Abstract: According to at least one embodiment, a method of fabricating a micro electro-mechanical systems (MEMS) structure is disclosed. The method involves causing an etchant to remove a portion of a sacrificial layer of the MEMS structure, the sacrificial layer between a structural layer of the MEMS structure and a substrate of the MEMS structure. In this embodiment, causing the etchant to remove the portion of the sacrificial layer involves causing a target portion of the substrate to be released from the MEMS structure. According to another embodiment, another method of fabricating a MEMS structure is disclosed. The method involves causing an etchant including water to remove a portion of a sacrificial layer of the MEMS structure, the sacrificial layer between a structural layer of the MEMS structure and a substrate of the MEMS structure. In this embodiment, the sacrificial layer and the substrate are hydrophobic.Type: GrantFiled: June 18, 2021Date of Patent: December 19, 2023Assignee: The University of British ColumbiaInventors: Edmond Cretu, Chang Ge
-
Patent number: 11832856Abstract: The current invention features a rod screw for medical application that can be configured and used to fixate fracture of bones varying in shape and dimension, and treating maladies such as scoliosis, and securing an implanted device, to tissue such as bone. This is achieved by designing a flexible rod screw with a mechanism to lock the configuration in a rigid state. In an embodiment, a bone-fracture fixation device, such as a rod screw, includes a flexible body, a plurality of flexible members, and first and second interfaces. The flexible members are disposed longitudinally within the flexible body, such that the flexible body is rigid when the flexible members are fixed into position. And the first and second interfaces are respectively coupled to the flexible body, each of at least one of the first and second interfaces including a respective at least one hole each configured to receive a respective attachment member configured to engage a bone.Type: GrantFiled: October 17, 2019Date of Patent: December 5, 2023Assignee: The University of British ColumbiaInventors: Robert N. Meek, Carly Anderson Thaler, Steven Charles Dimmer