Abstract: Method and systems are used to shape the water sorption properties of MOFs by utilizing a multivariate approach.

Abstract: A densely integrated and chiplet/dielet based networked memory pool with very high intra-pool bandwidth is provided. Chiplets are used to provide a common interface to the network. This means all memories (even those built with different process technologies) look the same from the network's perspective and vice versa: memory can be assembled in many different configurations while only changing the configuration at a high level of abstraction. The memory pool can easily be scaled in capacity and custom configurations that were previously impossible to achieve because of incompatibility of different technologies or level of integration are made possible.

Abstract: Optical photonic integrated optical clocks on photonic integrated circuits are described. The optical clocks can provide the timing stability of atomic clocks at ultra-low size and power. The optical clocks are be fabricated using CMOS foundry fabrication processes.

Abstract: Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments of the invention. Also described are novel tumor antigens that are useful as targets in various immunotherapeutic approaches to treating cancer as well as novel engineered T cell Receptors (TCRs) and chimeric antigen receptors (CARs) that target these antigenic peptides.

Abstract: In various embodiments, neuroprotective compositions and uses thereof are provided. In certain embodiments, a method of protecting mammalian neurons from neurotoxins, oxidative stress or protein aggregation, mitochondrial dysfunction, inflammatory gene expression, induced cell death is provided where the method involves contacting the cells, such as neurons, with an effective amount of: a plurality of proteins that are secreted by induced pluripotent stem cells (iPSCs) derived from a healthy mammal and/or from a mammal with a disease, such as neurodegenerative pathology, exemplified by amyotrophic lateral sclerosis (ALS) where said proteins are secreted when said iPSC cells are pluripotent; and/or biologically active fragments of said proteins; and/or biologically active analogs of said proteins.

Abstract: The present embodiments relate generally to the integration of boron arsenide (BAs) and boron phosphide (BP) into semiconductor devices and electronics, including with all semiconductors (Si, Ge, InP, InAs, GaAs), metals, wide-bandgap gallium nitride (GaN, AIGaN, SiC), ultrawide-bandgap (AIN, c-BN, diamond, Ga2O3), HEMT devices, electronics, optoelectronics, photonics, or any power devices for high-performance thermal management. Embodiments successfully develop the first experimental integration and atomic structural characterization of GaN-on-BAs structure for passive cooling of GaN devices, GaN/AIGaN HEMT transistors, and RF technologies, and measured a high thermal boundary conductance of 250 MW/m2K. Importantly, experimental measurement of operating AIGaN/GaN HEMT devices confirms the substantially reduced hot spot temperature and clear advantage for using BAs versus diamond or silicon carbide as cooling substrate.

Abstract: Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

Abstract: A particle isolation apparatus 100 for isolating particles from a suspension sample, includes a droplet dispenser device 10 for collecting the suspension sample from a carrier substrate 20 and for dispensing droplets onto a target substrate 30, a mechanical pump device 40 being coupled with the droplet dispenser device 10 for loading a dilution liquid into the droplet dispenser device 10 and for aspirating a first portion of the suspension sample into the droplet dispenser device 10, and a syphon pump device 50 being coupled with the droplet dispenser device 10 and being arranged for aspirating a second portion of the suspension sample into the droplet dispenser device 10. Preferably, the droplet dispenser device 10 is configured for dispensing single particle droplets on the target substrate 30. Furthermore, a method of isolating particles from a suspension sample is described.

Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.

Abstract: A system for charge sharing compensation for a photon counting detector. A plurality of comparators, each configured to generate comparator output data based on a threshold value, a plurality of energy bins, each of the plurality of energy bins coupled to one of the plurality of comparators, and a coincidence logic coupled to two or more of the plurality of comparators and configured to receive comparator output data associated with two or more of a plurality of pixels. The comparator output data for each pixel indicates when a signal associated with the pixel crosses a threshold value. The coincidence logic is configured to generate a coincidence output when the comparator output data for a first pixel is received within a predetermined time interval of the comparator output data for a second pixel. The system includes a coincidence counting bin coupled to the coincidence logic and configured to receive the coincidence output and generate count data based on the coincidence output.

Abstract: Provided herein are separation processes for metal ions present in aqueous solutions based on methods involving liquid-liquid extraction. The separation process involves a chelator that can selectively bind to at least one of the metals at a relatively low pH. This can be used, for example, for recovery and purification of actinides from lanthanides, separation of metal ions based on their valence, and separation of metal ions based on the pH of the extraction conditions.

Abstract: Compositions comprising multivariate metal-organic frameworks and other single-linker metal-organic frameworks are used for containing and storing a gas or fluid or for water harvesting or water purification applications.

Abstract: The present disclosure relates to techniques for developing artificial intelligence algorithms by distributing analytics to multiple sources of privacy protected, harmonized data. Particularly, aspects are directed to a computer implemented method that includes receiving an algorithm and input data requirements associated with the algorithm, identifying data assets as being available from a data host based on the input data requirements, curating the data assets within a data storage structure that is within infrastructure of the data host, and integrating the algorithm into a secure capsule computing framework. The secure capsule computing framework serves the algorithm to the data assets within the data storage structure in a secure manner that preserves privacy of the data assets and the algorithm. The computer implemented method further includes running the data assets through the algorithm to obtain an inference.

Abstract: Atmospheric water harvesting systems utilize a sorbent cartridge configured to hold water capture material. The sorbent cartridge is made up of a plurality of permeable trays and a plurality of spacers that are arranged to provide cross-flow for adsorption and desorption airflow pathways. The systems are used for harvesting water from surrounding air.

Abstract: The disclosure provides for methylome profiling of animals and further using DNA methylation as a quantitative predictor of the age of an animal.

Abstract: Provided are methods of producing size-selected nucleic acid libraries. The methods include contacting a nucleic acid sample and a nucleic acid binding reagent including an affinity tag, under conditions in which nucleic acids of less than a desired length are substantially bound to the nucleic acid binding reagent and nucleic acids of the desired length are substantially not bound to the nucleic acid binding reagent. The conditions include the duration of the contacting, the concentration of the nucleic acid binding reagent, or both. The methods further include separating, using the affinity tag, the nucleic acids of less than the desired length bound to the nucleic acid binding reagent from the nucleic acids of the desired length not bound to the nucleic acid binding reagent, to produce a size-selected nucleic acid library. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure, are also provided.

Abstract: The invention provides compositions and methods for treating asthma in a subject in need thereof comprising administering chemically synthesized secoisolaricirecinol diglucoside (SDG), and in particular, a racemic mixture of the SDG (LGM2605), stereoisomers thereof, metabolites thereof, and analogs thereof. Also provided are methods for treating or preventing ozone-induced damage in a subject in need thereof.

Abstract: Systems and methods for wirelessly powered biomedical treatment systems with closed-loop wireless implantable treatment devices for recording and stimulation are described. In an embodiment, a treatment system, includes: at least one implantable treatment device implantable in a location with respect to a body part, where the at least one implantable treatment device includes: an energy harvesting circuit configured to harvest ambient energy, a sensing circuit configured to sense bioelectrical signals, an stimulator circuit coupled to a set of electrodes to deliver energy, and a communication circuit configured to control the stimulation delivery circuit to deliver energy via at least one electrode from the set of electrodes in response to wireless control signals received from an external controller.

Abstract: Systems and methods for federated learning are illustrated. A method for federated learning includes steps for identifying a first set of one or more devices as members of a master committee, identifying a second set of one or more devices as members of a differential privacy (DP)-noise committee, receiving a set of encrypted noise values for differential privacy from the members of the DP-noise committee, receiving, from a third set of one or more devices, a set of encrypted update values, and aggregating the encrypted noise values and the encrypted update values to produce encrypted aggregation results. The method further includes steps for receiving, from a fourth set of one or more devices, decrypted aggregation results based on cryptographic key shares of a private cryptographic key from the master committee, and updating model parameters of the model based on the decrypted aggregation results.

Abstract: A multimodality phantom apparatus includes a housing and a system of materials disposed within the housing. The system of material includes a first amount of abase material, a second amount of glass microspheres, a third amount of CaCO3, a fourth amount of gadolinium contrast and a fifth amount of agarose. The housing may include a plurality of compartments and at least one slot. The system of materials may be disposed within at least one compartment. The slot may be used to receive a dosimeter.