Patents Assigned to The University of Chicago
  • Applying a trained model to predict a future value using contextualized sentiment data
    Patent number: 11461847
    Abstract: Systems, methods, and computer-readable storage media facilitating automated testing of datasets including natural language data are disclosed. In the disclosed embodiments, rule sets may be used to condition and transform an input dataset into a format that is suitable for use with one or more artificial intelligence processes configured to extract parameters and classification information from the input dataset. The parameters and classes derived by the artificial intelligence processes may then be used to automatically generate various testing tools (e.g., scripts, test conditions, etc.) that may be executed against a test dataset, such as program code or other types of data.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: October 4, 2022
    Assignees: The University of Chicago, President and Fellows of Harvard College, Yale University
    Inventors: Dacheng Xiu, Zheng Tracy Ke, Bryan Kelly
  • METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-TARGETED ADJUVANTS
    Publication number: 20220305135
    Abstract: Here, the inventors describe methods and compositions for targeting a TLR agonist to the tumor cell or stroma. Aspects of the disclosure relate to a polypeptide comprising a tumor targeting agent operatively linked to p(Man-TLR). Also disclosed are compositions and methods for treating cancer in a subject comprising administration of the polypeptide comprising the tumor targeting agent linked to p(Man-TLR) to the subject.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 29, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, David S. WILSON, Tiffany M. MARCHELL, Laura T. GRAY
  • METHODS AND COMPOSITIONS FOR TREATING CANCER WITH COLLAGEN BINDING DRUG CARRIERS
    Publication number: 20220298225
    Abstract: This disclosure relates to tumor-targeted drug carriers that lead to improved anti-tumor efficacy by efficient delivery of a cytotoxic agent to the tumor microenvironment. Aspects of the disclosure relate to a polypeptide comprising an albumin or IgG Fc domain polypeptide operatively linked to a collagen binding domain. Further aspects relate to a composition comprising a polypeptide, nucleic acid, or cell of the disclosure.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 22, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Koichi SASAKI
  • Combined learned and dynamic control system
    Patent number: 11449014
    Abstract: Example embodiments allow for networks of hybrid controllers that can be computed efficiently and that can adapt to changes in the system(s) under control. Such a network includes at least one hybrid controller that includes a dynamic sub-controller and a learned system sub-controller. Information about the ongoing performance of the system under control is provided to both the hybrid controller and to an over-controller, which provides one or more control inputs to the hybrid controller in order to modify the ongoing operation of the hybrid controller. These inputs can include the set-point of the hybrid controller, one or more parameters of the dynamic controller, and an update rate or other parameter of the learned system controller. The over-controller can control multiple hybrid controllers (e.g., controlling respective sub-systems of an overall system) and can, itself, be a hybrid controller.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: September 20, 2022
    Assignee: The University of Chicago
    Inventors: Henry Hoffmann, Lester Teichner, Benjamin Vear
  • COMPOSITIONS AND METHODS COMPRISING PROTEASE-ACTIVATED THERAPEUTIC AGENTS
    Publication number: 20220281936
    Abstract: he disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 8, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey HUBBELL, Jun ISHIHARA, Juan MENDOZA, Aslan MANSUROV
  • Millifluidic system for thrombosis analysis under patient-specific physiological conditions
    Patent number: 11436945
    Abstract: The present disclosure includes millifluidic cephalic arch (mCA) device having a patient-specific vessel that includes an outer surface; an inner surface that defines a vessel lumen extending through the patient-specific vessel and configured to correspond to a patient's Cephalic vein, and a curved section.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: September 6, 2022
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Anindita Basu, Mary Hammes, Andres Moya-Rodriguez
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 11413614
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: August 16, 2022
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 11413615
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 16, 2022
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • System and method of optimizing instructions for quantum computers
    Patent number: 11416228
    Abstract: A quantum computing system includes a quantum processor having a plurality of qubits, a classical memory, and a classical processor.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: August 16, 2022
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Frederic T. Chong, Yunong Shi, I, Nelson Leung, Pranav Gokhale, Henry Hoffmann, David Schuster
  • Separation of isotopes in space and time by gas-surface atomic diffraction
    Patent number: 11413579
    Abstract: Methods for separating isotopes are provided. An embodiment of such a method comprises directing a supersonic beam characterized by an average velocity v and velocity distribution ?v/v, the beam comprising a first isotope and a second isotope, at a single-crystalline surface at an angle of incidence ?i such that the first isotope elastically scatters from the surface with a peak angle ?f1 and the second isotope elastically scatters from the surface with a peak angle ?f2; and selectively collecting the scattered first isotope, the scattered second isotope, or both. Apparatus for carrying out the methods are also provided.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: August 16, 2022
    Assignee: The University of Chicago
    Inventors: Steven J. Sibener, Jacob D. Graham, Kevin J. Nihill
  • Systems and methods for computer-assisted search of image slices for indications of a finding
    Patent number: 11409786
    Abstract: The present disclosure pertains to computer-assisted search of image slices. In some embodiments, an image slice having a detected finding (and representing a cross section of at least a portion of an individual) may be determined. A search space may be reduce to a subset of image slices respectively representing a cross section corresponding to the cross section represented by the determined image slice. The search space reduction may comprise filtering a set of image slices based on the cross section represented by the determined image slice. Image slice information related to the determined image slice and related one or more image slices (of the image slices subset) may be obtained based on the search space reduction. A determination of whether indications of the detected finding exist in the image slices (of the image slices subset) may be effectuated based on the image slice information.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: August 9, 2022
    Assignees: KONINKLIJKE PHILIPS N.V., THE UNIVERSITY OF CHICAGO
    Inventors: Igor Trilisky, Merlijn Sevenster, Amir Mohammad Tahmasebi Maraghoosh, Paul Joseph Chang
  • Patient risk evaluation
    Patent number: 11410777
    Abstract: This disclosure includes various embodiments of apparatuses, systems and methods for evaluating a patient's cardiac risk and/or mental status. Cardiac risk evaluation may be based (e.g., only) on the patient's respiratory rate, heart rate, diastolic blood pressure, age, and/or mental status. An aggregate score, which is indicative likelihood of the patient's cardiac risk, may be calculated based (e.g., only) on the patient's respiratory rate, heart rate, diastolic blood pressure, age, and/or mental status. If the calculated aggregate score exceeds a predetermined threshold, the patient may be identified as having a critical cardiac risk, and actions may be taken to treat the patient. The cardiac risk evaluation may be based further on the patient's mental status, where the patient's mental status may be evaluated based on a game with visual indicators.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: August 9, 2022
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Dana P. Edelson, Matthew Churpek, Robert Gibbons
  • Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA)
    Patent number: 11400121
    Abstract: Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: August 2, 2022
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Cathryn R. Nagler, Gabriel Nunez, Yun-Gi Kim
  • BIOMARKERS FOR ASSESSING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20220235417
    Abstract: Disclosed are methods and kits for evaluating predicting whether an individual IPF has slowly or rapidly progressive IPF.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 28, 2022
    Applicants: The University of Chicago, The Board of Trustees of the University of Illinois, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Imre Noth, Yong Huang, Jose David Herazo-Maya, Naftali Kaminski, Kevin Gibson, Joe G.N. Garcia
  • Composition and methods for detecting adenosine modifications
    Patent number: 11396672
    Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence is adenosine.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: July 26, 2022
    Assignee: The University of Chicago
    Inventors: Chuan He, Kai Chen, Qing Dai
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20220227819
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.
    Type: Application
    Filed: December 21, 2021
    Publication date: July 21, 2022
    Applicants: The University of Chicago, Janssen Pharmaceuticals, Inc.
    Inventors: Dominique Missiakas, Olaf Schneewind, Carla Emolo, Lena Thomer, Molly McAdow, Jeroen Geurtsen, Mark De Been
  • Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy
    Patent number: 11389422
    Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: July 19, 2022
    Assignee: The University of Chicago
    Inventors: Wenbin Lin, Christina Chan, Wenbo Han
  • C-CBL mutations and uses thereof
    Patent number: 11390922
    Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. The invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-CBL.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 19, 2022
    Assignee: University of Chicago
    Inventors: Ravi Salgia, Soundarajan Krishnaswamy, Yi-Hung Carol Tan, Suvobroto Nandi
  • Method and system for assessing reading quality
    Patent number: 11386918
    Abstract: This disclosure generally relates to a system and method for assessing reading quality during a reading session. In one embodiment, system is disclosed that analyzes speech that corresponds to a reading session for the duration of the reading session, the consistency of the reading sessions, the speed of the speech during the reading session, the engagement level of the parent during the reading session, and the environment in which the reading session takes place in another embodiment, a method is disclosed for calculating an objective score for a reading session, communicating the score to a parent, and providing suggestions and challenges for improving future reading sessions.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 12, 2022
    Assignee: The University of Chicago
    Inventors: Jon Boggiano, Jonathan Simon, Alexandra Yorke, Rodrigo Rallo, Chris Boggiano, Nicola Boyd, Phil Balliet
  • LACTATE RESPONSE SYSTEM AND METHODS
    Publication number: 20220211822
    Abstract: Compositions and methods are provided concerning a lactate-responsive drug release system. In some embodiments, there are methods and compositions for treating cancer that take advantage of the tumor environment to deliver therapeutic agents to the tumor while reducing problems associated with circulating drugs in the patients body.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 7, 2022
    Applicant: The University of Chicago
    Inventors: Xiaoyang WU, Jian ZHANG