Patents Assigned to The University of Cincinnati
  • Publication number: 20230279434
    Abstract: A method for slowing the progression of amyotrophic lateral sclerosis (ALS) in an adult subject in need thereof is provided herein, the method including inhibiting motor neuron degeneration by administering to the subject a modified adeno-associated virus (AAV) vector having a recombinant AAV (rAAV)-based genome with an AAV backbone, a control element, and a ciliary neurotrophic factor receptor alpha (CNTFR?) cDNA insert, wherein the modified AAV vector is engineered to direct enhanced skeletal muscle expression of CNTFR?.
    Type: Application
    Filed: December 21, 2022
    Publication date: September 7, 2023
    Applicant: University of Cincinnati
    Inventor: Alexander John MacLennan
  • Publication number: 20230247982
    Abstract: A storage solution for packed red blood cells is disclosed where the solution is alkaline and has a viscosity at 4┬░ C. greater than about 20 millipascal seconds. In one embodiment, the storage solution comprises from about 0.1 percent to about 10 percent of hydroxy-propyl-methyl-cellulose. In another embodiment, the storage solution has a pH greater than about 8.
    Type: Application
    Filed: July 13, 2021
    Publication date: August 10, 2023
    Applicant: University of Cincinnati
    Inventors: Bernardin Joseph, Kasiemobi Pulliam, Timothy A Pritts, Salwa Arafa, Charles Caldwell, Alex Lentsch, Michael Goodman
  • Publication number: 20230240663
    Abstract: A method of simultaneously outputting a plurality of cavitation types on a digital image is provided. The method includes detecting acoustic emissions corresponding to the plurality of cavitation types, the plurality of cavitation types including at least some combination of linear scatter, stable cavitation, and inertial cavitation, generating, based on the acoustic emissions, a two-dimensional color map of the plurality of cavitation types on the digital image, the two-dimensional color map includes a first acoustic emission corresponding to linear scatter or stable cavitation and a second acoustic emission corresponding to linear scatter or inertial cavitation, and outputting on the digital image, displayed on the display of the computing device, the two-dimensional color map of the plurality of cavitation types.
    Type: Application
    Filed: July 2, 2021
    Publication date: August 3, 2023
    Applicant: University of Cincinnati
    Inventors: Maxime Lafond, Kevin Joseph Haworth, Nuria Gonzalez Salido, Christy Katherine Holland
  • Publication number: 20230228761
    Abstract: A method for detecting labile zinc (Zn2+) in a biological material is provided herein, the method including: (a) contacting the biological material with a composition including NapBu-BPEA; and (b) imaging the biological material via molecular fluorescence imaging to detect the labile zinc in the biological material. Also provided herein are methods for morphology-correlated detection of labile zinc localization in a subcellular organelle of a living cell and methods for tracking a change in labile zinc localization in a biological material.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 20, 2023
    Applicant: University of Cincinnati
    Inventor: Jiajie Diao
  • Publication number: 20230227183
    Abstract: A remote health care apparatus is disclosed that incorporates a drone device and a health kit. The drone device includes one or more communication devices, and the drone device is capable of two-way auditory and visual communication. The health kit is capable of being transported by the drone device and can be detached from the drone device. In one embodiment, the health kit contains one or more medical devices selected from the group consisting of biometric measuring devices, specimen collection devices and lab testing tools.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 20, 2023
    Applicant: University of Cincinnati
    Inventors: Debi Sampsel, Manish Kumar, Seung-Yeon Lee, Victoria Wangia Anderson
  • Publication number: 20230211103
    Abstract: A feedback providing facial mask is provided. The mask includes a facial adaptive component including a deformable member embedded in an interior region of the facial adaptive component and circuits, each of the circuits being operable in an open-circuit state or a closed-circuit state. The mask also includes a battery, light elements coupled to the battery and positioned within the deformable member, and sensors positioned at a plurality of locations within the deformable member. The sensors are connected to one of the light elements, wherein each of the circuits include the battery, one of the light elements, and at least one of the plurality of sensors, and wherein one or more of the circuits change from operating in the open-circuit state to the closed-circuit state in response o the one or more of the sensors contacting skin on an object that is external to the mask.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Applicant: University of Cincinnati
    Inventors: Jason McMullan, Justin Benoit, Ephraim J. Gutmark
  • Patent number: 11688294
    Abstract: Systems and methods for an enhanced ultrasound biofeedback therapy for an improved speech remediation treatment for an individual include transmitting a plurality of ultrasound (US) waves toward a tongue of the individual; receiving a plurality of reflected US waves; converting the plurality of reflected US waves into a plurality of US signals to transmit to an ultrasound machine; and generating one or more enhanced images of the tongue at least partially based on the US signals in real-time, the enhanced images including identified Regions of Interest (ROIs) along tongue sub-parts comprising the tongue root, the tongue dorsum, and the tongue blade and respective ROI points identified therein. An interactive visual story is generated and updated in real-time with a tongue-mapping trajectory of the individual on a display based on the enhanced one or more images to determine a successful or unsuccessful sound production.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 27, 2023
    Assignee: UNIVERSITY OF CINCINNATI
    Inventors: Suzanne Boyce, Sarah Hamilton Dugan, T. Douglas Mast, Michael Riley
  • Patent number: 11686004
    Abstract: A tandem electrode for electrochemically reducing carbon dioxide is described. The electrode includes a first distinct catalyst layer and a second distinct catalyst layer. The first distinct catalyst layer is made of a C1 hydrocarbon or C2+ product selective catalyst and the second distinct catalyst layer is comprised of a CO selective catalyst. In one embodiment, the second distinct catalyst layer is concentrated at one end of the tandem electrode. In another embodiment, the tandem electrode also includes a microporous layer and a substrate layer.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: June 27, 2023
    Assignee: University of Cincinnati
    Inventors: Jingjie Wu, Xiaojie She, Tianyu Zhang
  • Patent number: 11660329
    Abstract: The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 30, 2023
    Assignees: University of Cincinnati, Ohio State Innovation Foundation
    Inventors: Balveen Kaur, Jeffrey Wojton, Xiaoyang Qi
  • Publication number: 20230130698
    Abstract: The present disclosure concerns methods for treating pancreatic cancer cells with a combination of gemcitabine (GEM) and SapC-DOPS. In some aspects, GEM treatment preferentially targets G1 phase cells which are low in surface phosphatidylserine (PS), resulting in an increased median surface PS level of PDAC cells. Inversely, SapC-DOPS targets high surface PS cells which are predominantly in the G2/M phase. In other aspects, a combination therapy on tumors in vivo with SapC-DOPS and GEM or Abraxane® (Abr)/GEM is demonstrated to significantly inhibit tumor growth and increases survival.
    Type: Application
    Filed: March 10, 2021
    Publication date: April 27, 2023
    Applicant: University of Cincinnati
    Inventors: Xiaoyang Qi, Kombo Flore N'guessan
  • Publication number: 20230127599
    Abstract: A novel cooling system is disclosed. It includes one or more thermoelectric (TE) modules, each TE module having at least one semiconductor element located between two ceramic plates. The ceramic plates also include one or more electrodes. The cooling system further includes one or more heat exchangers, where the heat exchangers are in contact with at least one ceramic plate. In addition, the system includes one or more solid desiccant-based dehumidification compartments. Further, the cooling system is configured to direct air over both the TE modules and the desiccant dehumidifier.
    Type: Application
    Filed: October 25, 2022
    Publication date: April 27, 2023
    Applicant: University of Cincinnati
    Inventors: Je-Hyeong Bahk, Sarah J. Watzman, Raj M. Manglik
  • Publication number: 20230124475
    Abstract: Provided herein are compositions including a combination of therapeutic agents comprising a therapeutically effective amount of merestinib and a therapeutically effective amount of LY2584702. Also provided herein are methods of treating glioblastomas in a subject by administering the disclosed compositions, as well as methods of inducing cell death in a PTEN-deficient glioblastoma cell by administering the disclosed compositions.
    Type: Application
    Filed: March 12, 2021
    Publication date: April 20, 2023
    Applicant: University of Cincinnati
    Inventors: David Plas, Kelli Ennis
  • Publication number: 20230116974
    Abstract: A complex of curcumin with a polyphenolic macrocyclic host is disclosed. The macrocyclic host is a resorcin[4]arene. In one approach, the polyphenolic macrocyclic host is calix[8]arene. In another approach, the polyphenolic macrocyclic host is tert-butylcalix[8]arene.
    Type: Application
    Filed: June 27, 2022
    Publication date: April 20, 2023
    Applicant: University of Cincinnati
    Inventors: Harshita Kumari, Xu Kang
  • Publication number: 20230119248
    Abstract: Many tumors induce and maintain an immunosuppressive tumor microenvironment (TME) that enables tumor to escape host immune system. The present disclosure identifies that cancer cells secrete exosome/microparticle-free, soluble, phosphorylated Hsp70 (pHsp70 (Heat Shock Protein 70 (Hsp70))), which triggers macrophage (M) M2 polarization. It is a further aspect that lipid nanovesicles (NVs) made of dioleoylphosphatidylglycerol (DOPG) and of DOPG complexed with saposin C (SapC) bind to cancer secreted Hsp70, inhibit M differentiation and polarization, and reduce tumor growth. In addition, administration of DOPG-NVs rendered monocytes insensitive to TLR2 (Toll Like Receptor 2) and TLR6 (Toll Like Receptor 6) ligands, suggesting that administration of DOPG-NVs interferes with TLR function.
    Type: Application
    Filed: April 1, 2021
    Publication date: April 20, 2023
    Applicant: University of Cincinnati
    Inventors: Xiaoyang Qi, Subrahmanya Duttu Vallabhapurapu
  • Patent number: 11629113
    Abstract: A one pot synthesis of a mixed macrocycle of resorcinol and pyrogallol is disclosed using an acidic catalyst by conventional as well as by microwave assisted methods. Compared with traditional synthesis, the microwave mediated tactic provides a simple, greener route and affords higher compound yields in a shorter period. Moreover, the catalyst can be efficiently reused without any loss in activity.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: April 18, 2023
    Assignee: University of Cincinnati
    Inventor: Harshita Kumari
  • Patent number: 11627893
    Abstract: Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: April 18, 2023
    Assignee: University of Cincinnati
    Inventor: Jason C. Heikenfeld
  • Publication number: 20230112711
    Abstract: A method of curing polyimide, polyimide copolymers, polyimide composites or combinations is provided. The method involves preparing a reaction system comprising poly(amic acid) and at least one other compound selected from the group consisting of copolymers, solvents, fillers and nanofillers. Then, a combined overall microwave absorptivity of the reaction system is determined. A temperature ramp rate is calculated for a microwave power level and time using the combined overall microwave absorptivity. The reaction system is then exposed to microwave radiation according to the calculated temperature ramp rate, producing a cured product.
    Type: Application
    Filed: September 15, 2022
    Publication date: April 13, 2023
    Applicant: University of Cincinnati
    Inventors: Jude Onwuegbu Iroh, Shengdong Xiao, Ruchinda Seth Gooneratne, Xuemei Cui
  • Publication number: 20230116697
    Abstract: A cocrystal complex of pirfenidone with a polyphenolic macrocycle host is disclosed. The composition is useful, in some embodiments, as an acne treatment. In one embodiment, the macrocycle is calixarene or a calixarene derivative. In another embodiment, the macrocycle is resorcin[4]arene. In one embodiment, the macrocycle is C-methylresorcin[4]arene (RsC1). In another embodiment, the macrocycle is C-butylresorcin[4]arene (RsC4).
    Type: Application
    Filed: June 10, 2022
    Publication date: April 13, 2023
    Applicant: University of Cincinnati
    Inventors: Harshita Kumari, Suchitra Panigrahi
  • Publication number: 20230110450
    Abstract: A method of making a three-dimensional object comprising one or more polyimide copolymers, polyimide composites or combinations thereof is provided. The method involves 3D printing a solution comprising polyamic acid (PAA), tetraethyl orthosilicate (TEOS), and a silane selected from the group consisting of aminopropyl trimethoxysilane (APTMS), aminopropyl triethoxysilane (APTES), N-[3-(trimethoxysilyl)propyl]-ethylene diamine (ETDA), and glycidoxypropyl trimethoxysilane (GPTMS) to produce a three-dimensional form, and thermosetting the three-dimensional form.
    Type: Application
    Filed: July 26, 2022
    Publication date: April 13, 2023
    Applicant: University of Cincinnati
    Inventors: Jude Onwuegbu Iroh, Xuemei Cui, Shengdong Xiao, Ruchinda S. Gooneratne
  • Publication number: 20230096781
    Abstract: A method for treating a metabolic disorder associated with abnormal bodyweight in a subject is provided, the method including administering to the subject an effective amount of a compound that modulates phosphatidylinositol 5-phosphate 4-kinase beta (PI5P4K?) activity, wherein a PI5P4K? inhibitor is administered when the subject suffers from a metabolic disorder associated with an underweight bodyweight; and wherein a PI5P4K? agonist is administered when the subject suffers from a metabolic disorder associated with an overweight or obese bodyweight. Also provided herein are methods of increasing meat quality and/or yield in livestock or domesticated poultry by administering to an animal an effective amount of a PI5P4K? inhibitor, and genetically engineered animals having a substitution in PI5P4K? that reduces its GTP-sensing activity.
    Type: Application
    Filed: March 2, 2021
    Publication date: March 30, 2023
    Applicant: University of Cincinnati
    Inventor: Atsuo Sasaki