Patents Assigned to The University of Cincinnati
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Publication number: 20230279434Abstract: A method for slowing the progression of amyotrophic lateral sclerosis (ALS) in an adult subject in need thereof is provided herein, the method including inhibiting motor neuron degeneration by administering to the subject a modified adeno-associated virus (AAV) vector having a recombinant AAV (rAAV)-based genome with an AAV backbone, a control element, and a ciliary neurotrophic factor receptor alpha (CNTFR?) cDNA insert, wherein the modified AAV vector is engineered to direct enhanced skeletal muscle expression of CNTFR?.Type: ApplicationFiled: December 21, 2022Publication date: September 7, 2023Applicant: University of CincinnatiInventor: Alexander John MacLennan
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Publication number: 20230247982Abstract: A storage solution for packed red blood cells is disclosed where the solution is alkaline and has a viscosity at 4° C. greater than about 20 millipascal seconds. In one embodiment, the storage solution comprises from about 0.1 percent to about 10 percent of hydroxy-propyl-methyl-cellulose. In another embodiment, the storage solution has a pH greater than about 8.Type: ApplicationFiled: July 13, 2021Publication date: August 10, 2023Applicant: University of CincinnatiInventors: Bernardin Joseph, Kasiemobi Pulliam, Timothy A Pritts, Salwa Arafa, Charles Caldwell, Alex Lentsch, Michael Goodman
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Publication number: 20230240663Abstract: A method of simultaneously outputting a plurality of cavitation types on a digital image is provided. The method includes detecting acoustic emissions corresponding to the plurality of cavitation types, the plurality of cavitation types including at least some combination of linear scatter, stable cavitation, and inertial cavitation, generating, based on the acoustic emissions, a two-dimensional color map of the plurality of cavitation types on the digital image, the two-dimensional color map includes a first acoustic emission corresponding to linear scatter or stable cavitation and a second acoustic emission corresponding to linear scatter or inertial cavitation, and outputting on the digital image, displayed on the display of the computing device, the two-dimensional color map of the plurality of cavitation types.Type: ApplicationFiled: July 2, 2021Publication date: August 3, 2023Applicant: University of CincinnatiInventors: Maxime Lafond, Kevin Joseph Haworth, Nuria Gonzalez Salido, Christy Katherine Holland
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Publication number: 20230228761Abstract: A method for detecting labile zinc (Zn2+) in a biological material is provided herein, the method including: (a) contacting the biological material with a composition including NapBu-BPEA; and (b) imaging the biological material via molecular fluorescence imaging to detect the labile zinc in the biological material. Also provided herein are methods for morphology-correlated detection of labile zinc localization in a subcellular organelle of a living cell and methods for tracking a change in labile zinc localization in a biological material.Type: ApplicationFiled: May 28, 2021Publication date: July 20, 2023Applicant: University of CincinnatiInventor: Jiajie Diao
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Publication number: 20230227183Abstract: A remote health care apparatus is disclosed that incorporates a drone device and a health kit. The drone device includes one or more communication devices, and the drone device is capable of two-way auditory and visual communication. The health kit is capable of being transported by the drone device and can be detached from the drone device. In one embodiment, the health kit contains one or more medical devices selected from the group consisting of biometric measuring devices, specimen collection devices and lab testing tools.Type: ApplicationFiled: June 2, 2021Publication date: July 20, 2023Applicant: University of CincinnatiInventors: Debi Sampsel, Manish Kumar, Seung-Yeon Lee, Victoria Wangia Anderson
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Publication number: 20230211103Abstract: A feedback providing facial mask is provided. The mask includes a facial adaptive component including a deformable member embedded in an interior region of the facial adaptive component and circuits, each of the circuits being operable in an open-circuit state or a closed-circuit state. The mask also includes a battery, light elements coupled to the battery and positioned within the deformable member, and sensors positioned at a plurality of locations within the deformable member. The sensors are connected to one of the light elements, wherein each of the circuits include the battery, one of the light elements, and at least one of the plurality of sensors, and wherein one or more of the circuits change from operating in the open-circuit state to the closed-circuit state in response o the one or more of the sensors contacting skin on an object that is external to the mask.Type: ApplicationFiled: June 4, 2021Publication date: July 6, 2023Applicant: University of CincinnatiInventors: Jason McMullan, Justin Benoit, Ephraim J. Gutmark
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Patent number: 11688294Abstract: Systems and methods for an enhanced ultrasound biofeedback therapy for an improved speech remediation treatment for an individual include transmitting a plurality of ultrasound (US) waves toward a tongue of the individual; receiving a plurality of reflected US waves; converting the plurality of reflected US waves into a plurality of US signals to transmit to an ultrasound machine; and generating one or more enhanced images of the tongue at least partially based on the US signals in real-time, the enhanced images including identified Regions of Interest (ROIs) along tongue sub-parts comprising the tongue root, the tongue dorsum, and the tongue blade and respective ROI points identified therein. An interactive visual story is generated and updated in real-time with a tongue-mapping trajectory of the individual on a display based on the enhanced one or more images to determine a successful or unsuccessful sound production.Type: GrantFiled: December 21, 2018Date of Patent: June 27, 2023Assignee: UNIVERSITY OF CINCINNATIInventors: Suzanne Boyce, Sarah Hamilton Dugan, T. Douglas Mast, Michael Riley
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Patent number: 11686004Abstract: A tandem electrode for electrochemically reducing carbon dioxide is described. The electrode includes a first distinct catalyst layer and a second distinct catalyst layer. The first distinct catalyst layer is made of a C1 hydrocarbon or C2+ product selective catalyst and the second distinct catalyst layer is comprised of a CO selective catalyst. In one embodiment, the second distinct catalyst layer is concentrated at one end of the tandem electrode. In another embodiment, the tandem electrode also includes a microporous layer and a substrate layer.Type: GrantFiled: October 22, 2020Date of Patent: June 27, 2023Assignee: University of CincinnatiInventors: Jingjie Wu, Xiaojie She, Tianyu Zhang
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Patent number: 11660329Abstract: The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.Type: GrantFiled: June 28, 2019Date of Patent: May 30, 2023Assignees: University of Cincinnati, Ohio State Innovation FoundationInventors: Balveen Kaur, Jeffrey Wojton, Xiaoyang Qi
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Publication number: 20230130698Abstract: The present disclosure concerns methods for treating pancreatic cancer cells with a combination of gemcitabine (GEM) and SapC-DOPS. In some aspects, GEM treatment preferentially targets G1 phase cells which are low in surface phosphatidylserine (PS), resulting in an increased median surface PS level of PDAC cells. Inversely, SapC-DOPS targets high surface PS cells which are predominantly in the G2/M phase. In other aspects, a combination therapy on tumors in vivo with SapC-DOPS and GEM or Abraxane® (Abr)/GEM is demonstrated to significantly inhibit tumor growth and increases survival.Type: ApplicationFiled: March 10, 2021Publication date: April 27, 2023Applicant: University of CincinnatiInventors: Xiaoyang Qi, Kombo Flore N'guessan
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Publication number: 20230127599Abstract: A novel cooling system is disclosed. It includes one or more thermoelectric (TE) modules, each TE module having at least one semiconductor element located between two ceramic plates. The ceramic plates also include one or more electrodes. The cooling system further includes one or more heat exchangers, where the heat exchangers are in contact with at least one ceramic plate. In addition, the system includes one or more solid desiccant-based dehumidification compartments. Further, the cooling system is configured to direct air over both the TE modules and the desiccant dehumidifier.Type: ApplicationFiled: October 25, 2022Publication date: April 27, 2023Applicant: University of CincinnatiInventors: Je-Hyeong Bahk, Sarah J. Watzman, Raj M. Manglik
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Publication number: 20230124475Abstract: Provided herein are compositions including a combination of therapeutic agents comprising a therapeutically effective amount of merestinib and a therapeutically effective amount of LY2584702. Also provided herein are methods of treating glioblastomas in a subject by administering the disclosed compositions, as well as methods of inducing cell death in a PTEN-deficient glioblastoma cell by administering the disclosed compositions.Type: ApplicationFiled: March 12, 2021Publication date: April 20, 2023Applicant: University of CincinnatiInventors: David Plas, Kelli Ennis
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Publication number: 20230116974Abstract: A complex of curcumin with a polyphenolic macrocyclic host is disclosed. The macrocyclic host is a resorcin[4]arene. In one approach, the polyphenolic macrocyclic host is calix[8]arene. In another approach, the polyphenolic macrocyclic host is tert-butylcalix[8]arene.Type: ApplicationFiled: June 27, 2022Publication date: April 20, 2023Applicant: University of CincinnatiInventors: Harshita Kumari, Xu Kang
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Publication number: 20230119248Abstract: Many tumors induce and maintain an immunosuppressive tumor microenvironment (TME) that enables tumor to escape host immune system. The present disclosure identifies that cancer cells secrete exosome/microparticle-free, soluble, phosphorylated Hsp70 (pHsp70 (Heat Shock Protein 70 (Hsp70))), which triggers macrophage (M) M2 polarization. It is a further aspect that lipid nanovesicles (NVs) made of dioleoylphosphatidylglycerol (DOPG) and of DOPG complexed with saposin C (SapC) bind to cancer secreted Hsp70, inhibit M differentiation and polarization, and reduce tumor growth. In addition, administration of DOPG-NVs rendered monocytes insensitive to TLR2 (Toll Like Receptor 2) and TLR6 (Toll Like Receptor 6) ligands, suggesting that administration of DOPG-NVs interferes with TLR function.Type: ApplicationFiled: April 1, 2021Publication date: April 20, 2023Applicant: University of CincinnatiInventors: Xiaoyang Qi, Subrahmanya Duttu Vallabhapurapu
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Patent number: 11629113Abstract: A one pot synthesis of a mixed macrocycle of resorcinol and pyrogallol is disclosed using an acidic catalyst by conventional as well as by microwave assisted methods. Compared with traditional synthesis, the microwave mediated tactic provides a simple, greener route and affords higher compound yields in a shorter period. Moreover, the catalyst can be efficiently reused without any loss in activity.Type: GrantFiled: November 1, 2021Date of Patent: April 18, 2023Assignee: University of CincinnatiInventor: Harshita Kumari
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Patent number: 11627893Abstract: Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.Type: GrantFiled: August 10, 2018Date of Patent: April 18, 2023Assignee: University of CincinnatiInventor: Jason C. Heikenfeld
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Publication number: 20230112711Abstract: A method of curing polyimide, polyimide copolymers, polyimide composites or combinations is provided. The method involves preparing a reaction system comprising poly(amic acid) and at least one other compound selected from the group consisting of copolymers, solvents, fillers and nanofillers. Then, a combined overall microwave absorptivity of the reaction system is determined. A temperature ramp rate is calculated for a microwave power level and time using the combined overall microwave absorptivity. The reaction system is then exposed to microwave radiation according to the calculated temperature ramp rate, producing a cured product.Type: ApplicationFiled: September 15, 2022Publication date: April 13, 2023Applicant: University of CincinnatiInventors: Jude Onwuegbu Iroh, Shengdong Xiao, Ruchinda Seth Gooneratne, Xuemei Cui
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Publication number: 20230116697Abstract: A cocrystal complex of pirfenidone with a polyphenolic macrocycle host is disclosed. The composition is useful, in some embodiments, as an acne treatment. In one embodiment, the macrocycle is calixarene or a calixarene derivative. In another embodiment, the macrocycle is resorcin[4]arene. In one embodiment, the macrocycle is C-methylresorcin[4]arene (RsC1). In another embodiment, the macrocycle is C-butylresorcin[4]arene (RsC4).Type: ApplicationFiled: June 10, 2022Publication date: April 13, 2023Applicant: University of CincinnatiInventors: Harshita Kumari, Suchitra Panigrahi
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Publication number: 20230110450Abstract: A method of making a three-dimensional object comprising one or more polyimide copolymers, polyimide composites or combinations thereof is provided. The method involves 3D printing a solution comprising polyamic acid (PAA), tetraethyl orthosilicate (TEOS), and a silane selected from the group consisting of aminopropyl trimethoxysilane (APTMS), aminopropyl triethoxysilane (APTES), N-[3-(trimethoxysilyl)propyl]-ethylene diamine (ETDA), and glycidoxypropyl trimethoxysilane (GPTMS) to produce a three-dimensional form, and thermosetting the three-dimensional form.Type: ApplicationFiled: July 26, 2022Publication date: April 13, 2023Applicant: University of CincinnatiInventors: Jude Onwuegbu Iroh, Xuemei Cui, Shengdong Xiao, Ruchinda S. Gooneratne
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Publication number: 20230096781Abstract: A method for treating a metabolic disorder associated with abnormal bodyweight in a subject is provided, the method including administering to the subject an effective amount of a compound that modulates phosphatidylinositol 5-phosphate 4-kinase beta (PI5P4K?) activity, wherein a PI5P4K? inhibitor is administered when the subject suffers from a metabolic disorder associated with an underweight bodyweight; and wherein a PI5P4K? agonist is administered when the subject suffers from a metabolic disorder associated with an overweight or obese bodyweight. Also provided herein are methods of increasing meat quality and/or yield in livestock or domesticated poultry by administering to an animal an effective amount of a PI5P4K? inhibitor, and genetically engineered animals having a substitution in PI5P4K? that reduces its GTP-sensing activity.Type: ApplicationFiled: March 2, 2021Publication date: March 30, 2023Applicant: University of CincinnatiInventor: Atsuo Sasaki