Abstract: An apparatus may include a processor configured to synthesize a first configuration file associated with a target field-programmable gate array (FPGA), and a second configuration file associated with the target FPGA, wherein first look-up-table (LUT) bits of the first configuration file are the logical inverse of second LUT bits of the second configuration file, and first non-LUT bits of the first configuration file are the same as second non-LUT bits of the second configuration file, and generate a LUT mask indicating which bits of the first configuration file and the second configuration file correspond to the first LUT bits and the second LUT bits by performing a bit-wise exclusive OR operation between the first configuration file and the second configuration file.

Abstract: The present disclosure concerns open-end carbon nanotubes assembled as a microelectrode array in electrode sets/micro-electrode sets (ES/micro-ES). The ES/micro-ES includes three electrodes that are made of highly densified multi-walled carbon nanotubes fibers (HD-CNTfs) sectioned into rods embedded in an inert polymer film with exposed open ends of CNTs at the electrode-electrolyte interface. The ES/micro-ES provide miniature electrochemical sensing devices in which all electrodes are based on carbon nanomaterials. The combination of dimensions and orientation provides for highly sensitive electrochemical determination (picomolar) of different electroactive analytes in different electrolyte mediums, where even a single drop of desired analyte solution will be enough for electrochemical characterization.

Abstract: A positive expiratory pressure-generating device for reducing breathlessness in a subject with one or more pulmonary disorders is disclosed. The device is rigid and hollow and can be held in the mouth of the subject. The device has at least one air chamber, at least one opening in the portion of the device that is held in the mouth and at least one additional airflow orifice. The device is configured to increase expiratory resistance and can be supported by the mouth of the subject without the need for additional support by hands, another device or other means.

Abstract: An intravascular ultrasound (IVUS) catheter-based device for targeted delivery of ultrasound-activated emulsions of oxygen-scavenging droplets into a bloodstream of patients suffering from a hypoxic condition and methods utilizing the device to protect the patients from reperfusion injury upon restoration of oxygenated blood to a hypoxic tissue.

Abstract: A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

Abstract: Provided herein are methods for treating diabetic cardiomyopathy in a patient in need thereof, such as a patient diagnosed with type 1 or type 2 diabetes. The methods generally include administering a therapeutically effective amount of one or more glucose transporter isoform 1 (GLUT1) inhibitors to the patient. Exemplary GLUT1 inhibitors include STF-31, WZB117, phloretin, and BAY-876.

Abstract: The present disclosure concerns RNA aptamers that specifically inhibit the protein-protein interaction between MED1 and an estrogen receptor. As shown herein, the aptamers are specific for the LXXLL recognition motif between MED 1 and an estrogen receptor. The present disclosure further concerns pRNA nanoparticles of the RNA aptamers coupled with a further HER2 aptamer that show HER2 specific uptake and subsequent inhibition of cellular proliferation and metastasis in vitro and in vivo. Furthermore, the pRNA nanoparticles showed no adverse effects, signifying a safe and effective composition to specifically target and control HER2 expressing cells.

Abstract: Provided herein are implantable biomaterials for promoting regeneration of an injured biological tissue, the biomaterials including piezoelectric materials and an extracellular matrix specific to the injured biological tissue, wherein the piezoelectric materials and the extracellular matrix are electrospun together to provide tissue-specific bioactive piezoelectric nanofiber scaffolds. Also provided herein are methods of fabricating a tissue-specific bioactive piezoelectric nanofiber scaffold and methods of promoting regeneration of injured biological tissue by implanting the disclosed bioactive piezoelectric scaffolds.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: The present invention involves a compartmentalized microfluidic device using one or more separators. Each separator has a plurality of microfluidic channels and the separators are oriented in a perpendicular direction to the substrate. The vertical integration of the microfluidic components enables realization of 3D device features with high aspect ratio.

Abstract: A method of forming a yellow grease is provided. The method includes delivering a FOG lipid extraction agent into a processing tank. The method further includes preheating a waste grease to a temperature of between 35° C. and 95° C. The method further includes mixing the preheated waste grease with the FOG lipid extraction agent in the processing tank to form the yellow grease.

Abstract: A savonius wind turbine including a rotational shaft and a compound blade operatively coupled to the rotational shaft is provided. The compound blade includes a primary blade portion and a secondary blade portion. The primary blade portion extends between a first end and a second end and defines a primary concave surface therebetween. The secondary blade portion is coupled to the primary blade portion between the first end and the second end. The secondary blade portion defines a secondary concave surface configured to generate a torque about the rotational shaft.

Abstract: A method of inducing cell death in a glioblastoma multiforme cancer cell is provided, the method comprising administering to the cell a combination of therapeutic agents comprising: saposin C and dioleoylphosphatidylserine (SapC-DOPS), and nucleolin aptamer AS1411, wherein cell death of the cancer cell is induced. Also provided are methods of treating glioblastoma multiforme, methods of inhibiting growth of a glioblastoma multiforme tumor, kits, and pharmaceutical compositions comprising SapC-DOPS and AS1411.

Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

Abstract: A vertical axis wind turbine including a nozzle is provided. The nozzle includes a first airfoil and a second airfoil. The first airfoil includes a first airfoil leading edge and a first airfoil trailing edge, and the second airfoil includes a second airfoil leading edge and a second airfoil trailing edge. The nozzle defines an inlet area disposed between the first airfoil leading edge and the second airfoil leading edge and an exit area disposed between the first airfoil trailing edge and the second airfoil trailing edge, wherein the exit area is smaller than the inlet area.

Abstract: Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.

Abstract: Systems and methods of use and fabrication are described for a THx2 threshold gate cell for a programmable gate array including a mode-independent PMOS configuration and an NMOS configuration configured to operate in one of a TH12 mode and a TH22 mode, wherein x is set to a threshold of 1 for the TH12 mode and x is set to a threshold of 2 for the TH22 mode.

Abstract: A system comprises an nMOS active resistor, nMOS transistors, a pMOS active resistor, and pMOS transistors, wherein a subset of the nMOS transistors a subset of the pMOS transistors are coupled to each other, respectively, according to a parallel OR configuration, a source terminal of the nMOS active resistor is coupled to respective drain terminals of the nMOS transistors, and a source terminal of the pMOS active resistor is coupled to respective drain terminals of the pMOS transistors. The transistor level delay based circuit further includes a write subcircuit component includes one of the nMOS transistors coupled to at least one of the pMOS transistors, wherein the write subcircuit is controlled by reverse logic signals, and a gate component includes an additional subset of the plurality of nMOS transistors coupled to an additional subset of the pMOS transistors, the gate component corresponding to a semistatic cross coupled inverter circuit.

Abstract: Methods and model equations are provided for predicting a risk of a subject who experiences adverse medical events associated with the weather, of experiencing a new-onset event.

Abstract: A method to treat pneumothorax or malignant pleural effusion by pleurodesis in a mammalian subject is disclosed. The method involves administering particles to the lungs, the pleural space or both. The particles comprise a crystalline material that is non-toxic and is cleared over time by biodegradation. In some embodiments, the biodegraded crystalline material is readily cleared by the kidneys. In one embodiment, the crystalline material is essentially cleared from the lungs a few months after treatment.