Patents Assigned to The University of Colorado
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Patent number: 12384829Abstract: Methods of preventing or treating autoimmune disease are disclosed. In some cases, subjects with having or at risk of developing autoimmune disease are identified as possessing one or more autoimmunity-susceptibility HLA alleles at one or more HLA loci. In many cases, the HLA loci are selected from Class I and Class II loci, for example Class I A, B, and C, and Class II DQ, DR, and DP. In many cases, subjects suffering from or at risk of developing an autoimmune disease may be administered a plurality engineered autologous HSCs modified to carry and express a variant susceptibility allele having at least one mutation in the antigen binding cleft that alters antigen binding and/or specificity of that variant HLA molecule. In many embodiments, the engineered HSCs are CD34+ immune cells that express one or more modified HLA proteins.Type: GrantFiled: January 19, 2023Date of Patent: August 12, 2025Assignee: The Regents of The University of Colorado, A Body CorporateInventors: Brian Freed, Christina Roark, Elizabeth Sunderhaus
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Publication number: 20250177258Abstract: The present disclosure provides a securement assembly for an enteral access device or vesical access device (“access device”). The securement assembly includes a base and a lid. The base is generally configured to support an external port of the access device and the lid is pivotably coupled to the base. The base comprises a border rim and a central portion, wherein the border rim is configured to engage a skin surface of a patient around a stoma and the central portion is configured to engage the external port of the access device. The central portion may comprise opposing side arms defining an aperture through which a tube of the access device extends.Type: ApplicationFiled: February 10, 2025Publication date: June 5, 2025Applicant: The Regents of The University of Colorado, a body corporateInventors: Steven Lee Moulton, Tyler Mironuck, Brian J. Heckman
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Patent number: 12220383Abstract: The present disclosure provides a securement assembly for an enteral access device or vesical access device (“access device”). The securement assembly includes a base and a lid. The base is generally configured to support an external port of the access device and the lid is pivotably coupled to the base. The base comprises a border rim and a central portion, wherein the border rim is configured to engage a skin surface of a patient around a stoma and the central portion is configured to engage the external port of the access device. The central portion may comprise opposing side arms defining an aperture through which a tube of the access device extends.Type: GrantFiled: November 20, 2019Date of Patent: February 11, 2025Assignee: The Regents of The University of ColoradoInventors: Steven Lee Moulton, Tyler Mironuck, Brian J. Heckman
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Publication number: 20240416000Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.Type: ApplicationFiled: January 12, 2024Publication date: December 19, 2024Applicant: The Regents Of The University Of Colorado, A Body CorporateInventors: Robin SHANDAS, Steven LEWIS, Daewon PARK, Omid JAZAERI, Steven LAMMERS, James BARDILL, Brisa PENA-CASTELLANOS
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Patent number: 12042394Abstract: A spinal implant device comprising a frame and a plurality of mechanical stiffness members extending from the frame, with the plurality of mechanical stiffness members being individually customized to provide a specific axial stiffness. The plurality of mechanical stiffness members may be coupled to the frame, and the plurality of mechanical stiffness members may be a plurality of wave-spring modules. A method of treating spinal disease includes determining actual spatial mechanical properties across a vertebral contact surface of a vertebra of a patient. The method may also include manufacturing a spinal implant device that has conforming spatial mechanical properties that are specific to the patient and that are based on the actual spatial mechanical properties of the vertebral contact surface. The method may include surgically implanting the spinal implant device against the vertebral contact surface such that the actual spatial mechanical properties and the conforming spatial mechanical properties align.Type: GrantFiled: August 8, 2019Date of Patent: July 23, 2024Assignee: The Regents of The University of Colorado, A Body CorporateInventors: Andriy G. Noshchenko, Evalina Burger-(Van Der Walt), Vikas V. Patel, Christopher J. Kleck, Ji Ma
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Patent number: 12042529Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.Type: GrantFiled: April 5, 2022Date of Patent: July 23, 2024Assignees: The Regents Of The University Of Colorado, A Body Corporate, Travere Therapeutics Switzerland GmbHInventors: Tomas Majtan, Jan P. Kraus, Erez M. Bublil, Frank Glavin, Marcia Sellos-Moura
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Patent number: 11911532Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.Type: GrantFiled: March 29, 2018Date of Patent: February 27, 2024Assignee: The Regents Of The University of Colorado, A Body CorporateInventors: Robin Shandas, Steven Lewis, Daewon Park, Omid Jazaeri, Steven Lammers, James Bardill, Brisa Pena-Castellanos
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Patent number: 11842813Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.Type: GrantFiled: October 23, 2020Date of Patent: December 12, 2023Assignee: The Regents Of The University Of ColoradoInventors: Robin Deterding, Tam Vu
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Patent number: 11738022Abstract: The present invention provides methods for inducing or enhancing rapid and significant dilation of a subject's pupils. In certain embodiments, the method comprises upregulating the alpha-1 receptors in the eye of the subject, thereby increasing sensitivity to alpha-1 agonists. In other embodiments, such upregulation is achieved through administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists for a period of time prior to the intended time of dilation. After inducing the upregulation of alpha-1 receptors through the administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists, alpha-1 agonists can be administered to induce or enhance rapid and strong pupil dilation.Type: GrantFiled: November 6, 2018Date of Patent: August 29, 2023Assignee: The University of Colorado, a body corporateInventor: Cristos Ifantides
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Patent number: 11725937Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.Type: GrantFiled: April 25, 2022Date of Patent: August 15, 2023Assignees: The Regents Of The University Of Colorado, A Body Corporate, Astra Lite, Inc.Inventors: Jeffrey P. Thayer, Geoffrey Crowley, Andrew W. Gisler, Steven Mitchell, Matthew Hayman
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Patent number: 11679546Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.Type: GrantFiled: February 11, 2019Date of Patent: June 20, 2023Assignee: The Regents Of The University Of Colorado, A Body CorporateInventors: Kambez Benam, Alexander Kaiser
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Patent number: 11549193Abstract: A metal-assisted chemical imprinting stamp includes a porous polymer substrate and a noble metal coating formed directly on the porous polymer substrate. Fabricating the metal-assisted chemical imprinting stamp includes providing a porous polymer substrate, and disposing a noble metal on the porous polymer substrate. Metal-assisted chemical imprinting includes positioning a silicon substrate in an etching solution, contacting a surface of the silicon substrate with a stamp comprising a noble metal layer on a surface of a porous polymer substrate, and separating the silicon substrate from the stamp to yield a pattern corresponding to the noble metal layer on the silicon substrate.Type: GrantFiled: February 11, 2021Date of Patent: January 10, 2023Assignees: Arizona Board of Regents on behalf of Arizona State University, The Regents of The University of Colorado, a Body CorporateInventors: Jasmina Markovski, Aliaksandr Sharstniou, Stanislau Niauzorau, Bruno Azeredo, Yifu Ding
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Patent number: 11407820Abstract: Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.Type: GrantFiled: June 21, 2018Date of Patent: August 9, 2022Assignee: The Regents of The University of ColoradoInventors: Joshua M. Thurman, V. Michael Holers
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Publication number: 20210213110Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.Type: ApplicationFiled: December 7, 2020Publication date: July 15, 2021Applicant: The Regents of The University of Colorado, A Body CorporateInventors: V. Michael Holers, Nirmal Banda, Liudmila Kulik
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Patent number: 10955331Abstract: Imaging or measurement methods and systems including methods and systems for finding the three-dimensional orientation and position of multiple dipole-like particles and single molecules, methods and systems for generating helical beams and helical spread functions, and methods and systems for super-resolution and super-localization of dense arrays of emitters.Type: GrantFiled: June 24, 2013Date of Patent: March 23, 2021Assignee: The Regents of The University of Colorado, a body corporateInventors: Rafael Piestun, Anurag Agrawal, Sean Quirin, Anthony Barsic, Ginni Grover
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Publication number: 20200276203Abstract: Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.Type: ApplicationFiled: May 15, 2020Publication date: September 3, 2020Applicant: The Regents Of The University Of Colorado, a body corporateInventors: Thomas LAROCCA, Douglas SEALS
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Publication number: 20200246502Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.Type: ApplicationFiled: March 29, 2018Publication date: August 6, 2020Applicant: The Regents Of The University Of Colorado, A Body CorporateInventors: Robin SHANDAS, Steven LEWIS, Daewon PARK, Omid JAZAERI, Steven LAMMERS, James BARDILL, Brisa PENA-CASTELLANOS
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Patent number: 10657346Abstract: Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary coefficients.Type: GrantFiled: December 28, 2017Date of Patent: May 19, 2020Assignee: The Regents of The University of Colorado, a Body CorporateInventors: Rafael Piestun, Anthony Barsic
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Patent number: 10573884Abstract: Various embodiments of the present disclosure describe energy storage devices. In one example, an energy storage device includes an anode having a plurality of active material particles, a cathode having a transition metal oxide material, and an electrolyte including a room temperature ionic liquid to couple the anode to the cathode. Each of the plurality of anode active material particles have a particle size of between about one micrometer and about fifty micrometers. One or more of the plurality of anode active material particles are enclosed by and in contact with a membrane coating permeable to lithium ions.Type: GrantFiled: January 28, 2016Date of Patent: February 25, 2020Assignee: Regents Of The University Of Colorado, A Body CorporateInventors: Se-Hee Lee, Daniela Molina Piper, Tyler Evans
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Patent number: RE49339Abstract: The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both.Type: GrantFiled: April 10, 2019Date of Patent: December 20, 2022Assignees: The Regents of The University of Colorado, A Body Corporate, MUSC Foundation For Research DevelopmentInventors: V. Michael Holers, Joshua M. Thurman, Liudmila Kulik, Stephen Tomlinson