Patents Assigned to The University of Colorado
  • Patent number: 12384829
    Abstract: Methods of preventing or treating autoimmune disease are disclosed. In some cases, subjects with having or at risk of developing autoimmune disease are identified as possessing one or more autoimmunity-susceptibility HLA alleles at one or more HLA loci. In many cases, the HLA loci are selected from Class I and Class II loci, for example Class I A, B, and C, and Class II DQ, DR, and DP. In many cases, subjects suffering from or at risk of developing an autoimmune disease may be administered a plurality engineered autologous HSCs modified to carry and express a variant susceptibility allele having at least one mutation in the antigen binding cleft that alters antigen binding and/or specificity of that variant HLA molecule. In many embodiments, the engineered HSCs are CD34+ immune cells that express one or more modified HLA proteins.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: August 12, 2025
    Assignee: The Regents of The University of Colorado, A Body Corporate
    Inventors: Brian Freed, Christina Roark, Elizabeth Sunderhaus
  • Publication number: 20250177258
    Abstract: The present disclosure provides a securement assembly for an enteral access device or vesical access device (“access device”). The securement assembly includes a base and a lid. The base is generally configured to support an external port of the access device and the lid is pivotably coupled to the base. The base comprises a border rim and a central portion, wherein the border rim is configured to engage a skin surface of a patient around a stoma and the central portion is configured to engage the external port of the access device. The central portion may comprise opposing side arms defining an aperture through which a tube of the access device extends.
    Type: Application
    Filed: February 10, 2025
    Publication date: June 5, 2025
    Applicant: The Regents of The University of Colorado, a body corporate
    Inventors: Steven Lee Moulton, Tyler Mironuck, Brian J. Heckman
  • Patent number: 12220383
    Abstract: The present disclosure provides a securement assembly for an enteral access device or vesical access device (“access device”). The securement assembly includes a base and a lid. The base is generally configured to support an external port of the access device and the lid is pivotably coupled to the base. The base comprises a border rim and a central portion, wherein the border rim is configured to engage a skin surface of a patient around a stoma and the central portion is configured to engage the external port of the access device. The central portion may comprise opposing side arms defining an aperture through which a tube of the access device extends.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: February 11, 2025
    Assignee: The Regents of The University of Colorado
    Inventors: Steven Lee Moulton, Tyler Mironuck, Brian J. Heckman
  • Publication number: 20240416000
    Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.
    Type: Application
    Filed: January 12, 2024
    Publication date: December 19, 2024
    Applicant: The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Robin SHANDAS, Steven LEWIS, Daewon PARK, Omid JAZAERI, Steven LAMMERS, James BARDILL, Brisa PENA-CASTELLANOS
  • Patent number: 12042394
    Abstract: A spinal implant device comprising a frame and a plurality of mechanical stiffness members extending from the frame, with the plurality of mechanical stiffness members being individually customized to provide a specific axial stiffness. The plurality of mechanical stiffness members may be coupled to the frame, and the plurality of mechanical stiffness members may be a plurality of wave-spring modules. A method of treating spinal disease includes determining actual spatial mechanical properties across a vertebral contact surface of a vertebra of a patient. The method may also include manufacturing a spinal implant device that has conforming spatial mechanical properties that are specific to the patient and that are based on the actual spatial mechanical properties of the vertebral contact surface. The method may include surgically implanting the spinal implant device against the vertebral contact surface such that the actual spatial mechanical properties and the conforming spatial mechanical properties align.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: July 23, 2024
    Assignee: The Regents of The University of Colorado, A Body Corporate
    Inventors: Andriy G. Noshchenko, Evalina Burger-(Van Der Walt), Vikas V. Patel, Christopher J. Kleck, Ji Ma
  • Patent number: 12042529
    Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: July 23, 2024
    Assignees: The Regents Of The University Of Colorado, A Body Corporate, Travere Therapeutics Switzerland GmbH
    Inventors: Tomas Majtan, Jan P. Kraus, Erez M. Bublil, Frank Glavin, Marcia Sellos-Moura
  • Patent number: 11911532
    Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: February 27, 2024
    Assignee: The Regents Of The University of Colorado, A Body Corporate
    Inventors: Robin Shandas, Steven Lewis, Daewon Park, Omid Jazaeri, Steven Lammers, James Bardill, Brisa Pena-Castellanos
  • Patent number: 11842813
    Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: December 12, 2023
    Assignee: The Regents Of The University Of Colorado
    Inventors: Robin Deterding, Tam Vu
  • Patent number: 11738022
    Abstract: The present invention provides methods for inducing or enhancing rapid and significant dilation of a subject's pupils. In certain embodiments, the method comprises upregulating the alpha-1 receptors in the eye of the subject, thereby increasing sensitivity to alpha-1 agonists. In other embodiments, such upregulation is achieved through administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists for a period of time prior to the intended time of dilation. After inducing the upregulation of alpha-1 receptors through the administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists, alpha-1 agonists can be administered to induce or enhance rapid and strong pupil dilation.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: August 29, 2023
    Assignee: The University of Colorado, a body corporate
    Inventor: Cristos Ifantides
  • Patent number: 11725937
    Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: August 15, 2023
    Assignees: The Regents Of The University Of Colorado, A Body Corporate, Astra Lite, Inc.
    Inventors: Jeffrey P. Thayer, Geoffrey Crowley, Andrew W. Gisler, Steven Mitchell, Matthew Hayman
  • Patent number: 11679546
    Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: June 20, 2023
    Assignee: The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Kambez Benam, Alexander Kaiser
  • Patent number: 11549193
    Abstract: A metal-assisted chemical imprinting stamp includes a porous polymer substrate and a noble metal coating formed directly on the porous polymer substrate. Fabricating the metal-assisted chemical imprinting stamp includes providing a porous polymer substrate, and disposing a noble metal on the porous polymer substrate. Metal-assisted chemical imprinting includes positioning a silicon substrate in an etching solution, contacting a surface of the silicon substrate with a stamp comprising a noble metal layer on a surface of a porous polymer substrate, and separating the silicon substrate from the stamp to yield a pattern corresponding to the noble metal layer on the silicon substrate.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: January 10, 2023
    Assignees: Arizona Board of Regents on behalf of Arizona State University, The Regents of The University of Colorado, a Body Corporate
    Inventors: Jasmina Markovski, Aliaksandr Sharstniou, Stanislau Niauzorau, Bruno Azeredo, Yifu Ding
  • Patent number: 11407820
    Abstract: Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: August 9, 2022
    Assignee: The Regents of The University of Colorado
    Inventors: Joshua M. Thurman, V. Michael Holers
  • Publication number: 20210213110
    Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.
    Type: Application
    Filed: December 7, 2020
    Publication date: July 15, 2021
    Applicant: The Regents of The University of Colorado, A Body Corporate
    Inventors: V. Michael Holers, Nirmal Banda, Liudmila Kulik
  • Patent number: 10955331
    Abstract: Imaging or measurement methods and systems including methods and systems for finding the three-dimensional orientation and position of multiple dipole-like particles and single molecules, methods and systems for generating helical beams and helical spread functions, and methods and systems for super-resolution and super-localization of dense arrays of emitters.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: March 23, 2021
    Assignee: The Regents of The University of Colorado, a body corporate
    Inventors: Rafael Piestun, Anurag Agrawal, Sean Quirin, Anthony Barsic, Ginni Grover
  • Publication number: 20200276203
    Abstract: Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.
    Type: Application
    Filed: May 15, 2020
    Publication date: September 3, 2020
    Applicant: The Regents Of The University Of Colorado, a body corporate
    Inventors: Thomas LAROCCA, Douglas SEALS
  • Publication number: 20200246502
    Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.
    Type: Application
    Filed: March 29, 2018
    Publication date: August 6, 2020
    Applicant: The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Robin SHANDAS, Steven LEWIS, Daewon PARK, Omid JAZAERI, Steven LAMMERS, James BARDILL, Brisa PENA-CASTELLANOS
  • Patent number: 10657346
    Abstract: Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary coefficients.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: May 19, 2020
    Assignee: The Regents of The University of Colorado, a Body Corporate
    Inventors: Rafael Piestun, Anthony Barsic
  • Patent number: 10573884
    Abstract: Various embodiments of the present disclosure describe energy storage devices. In one example, an energy storage device includes an anode having a plurality of active material particles, a cathode having a transition metal oxide material, and an electrolyte including a room temperature ionic liquid to couple the anode to the cathode. Each of the plurality of anode active material particles have a particle size of between about one micrometer and about fifty micrometers. One or more of the plurality of anode active material particles are enclosed by and in contact with a membrane coating permeable to lithium ions.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 25, 2020
    Assignee: Regents Of The University Of Colorado, A Body Corporate
    Inventors: Se-Hee Lee, Daniela Molina Piper, Tyler Evans
  • Patent number: RE49339
    Abstract: The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 20, 2022
    Assignees: The Regents of The University of Colorado, A Body Corporate, MUSC Foundation For Research Development
    Inventors: V. Michael Holers, Joshua M. Thurman, Liudmila Kulik, Stephen Tomlinson