Patents Assigned to The University of Colorado, a body corporate
  • Patent number: 12241305
    Abstract: Insulated assemblies, insulation units including an assembly, and methods of forming the assemblies and units are disclosed. Exemplary assemblies include a first pane of material, a second pane of material, and one or more monolithic insulating layers interposed between the first pane of material and the second pane of material. The insulating layer can exhibit a thermal conductivity less than 26 mW/(K.m).
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: March 4, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Blaise Fleury, Ivan I. Smalyukh, Jan Bart ten Hove, Vladyslav Cherpak, Eldho Abraham, Taewoo Lee, Bohdan Senyuk
  • Patent number: 12241013
    Abstract: Isotropic (amorphous) elastomers and methods of preparation are described. The isotropic elastomer may include a first monomer having an alkene functionality and a second monomer having a thiol functionality. The first monomer may be a liquid crystal monomer and the second monomer may be an isotropic monomer. Unlike polydomain LCEs, the isotropic elastomers may rapidly recover after deformation and have increased toughness relative to conventional elastomers prepared from wholly isotropic precursors.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Timothy White, Brian Richard Donovan
  • Patent number: 12226450
    Abstract: Bioactive peptides and methods for their use for preventing, treating, and/or reducing the incidence and/or symptoms of an autoimmune disease or disorder that may result from chronic inflammation, damage to ?-cells of the pancreas, and other conditions that are implicated by the CD40-CD154 dyad. In particular, small peptides that are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD154, which impacts inflammation, autoimmunity, and disease progression. The use of such peptides in reducing diabetes mellitus, and in particular, the autoimmune inflammatory response that may be a driving factor thereof. Methods and materials for preventing and modulating diabetes mellitus and autoimmune diseases especially in dogs, cats, and horses.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: February 18, 2025
    Assignees: OP-T LLC, The Regents of the University of Colorado, A Body Corporate
    Inventors: David Hal Wagner, Jr., Martin Glenn Yussman, Charles W. Henry
  • Patent number: 12220415
    Abstract: A compound, or a pharmaceutically acceptable salts or prodrugs thereof, having the chemical structure: and methods of using these compounds to inhibit WEE1 kinase and treat cancer in a subject.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: February 11, 2025
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Philip Reigan, Donald S. Backos, Christopher J. Matheson, Kimberly A. Casalvieri
  • Publication number: 20250041047
    Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.
    Type: Application
    Filed: October 21, 2024
    Publication date: February 6, 2025
    Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. KAHOOK, Glenn SUSSMAN, Rudolph F. ZACHER, Paul J. McLEAN, Harvey UY, Robert CIONNI, Kerry SOLOMON
  • Patent number: 12215060
    Abstract: Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christopher Bartel, Alan W. Weimer, Rebecca Jean O'Toole, Maila Kodas
  • Patent number: 12213915
    Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: February 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Malik Y. Kahook
  • Patent number: 12203492
    Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: January 21, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell
  • Patent number: 12201480
    Abstract: Diagnostic imaging of deep targets in the body requires sufficient signal amplitude to overcome effects such as attenuation with depth and thermal noise produced in signal reception. Coded excitation provides several strategies to increase the total transmitted energy without exceeding peak amplitude safety limits. Temporal coding has proven particularly effective, but these frequency or amplitude modulation techniques require additional transmit capabilities and often require complex processing to reduce decoding artifacts. An alternative code is presented based on time delays that relies on repeated transmit pulses that can be decoded using spatiotemporal synthetic aperture processing. A 16-pulse code is demonstrated that achieves an 11.1 dB improvement in signal-to-noise ratio (SNR) while maintaining axial resolution and sufficient range lobe performance.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: January 21, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Nick Bottenus
  • Patent number: 12201405
    Abstract: Novel tools and techniques are provided for assessing, predicting and/or effectiveness of cardiopulmonary resuscitation (“CPR”), in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid estimation of a patient's compensatory reserve index (“CRI”) before, during, and after CPR is performed, and using the CRI and variations in CRI values to determine, in some instances, in real-time, the effectiveness of CPR that is performed.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: January 21, 2025
    Assignees: Flashback Technologies, Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Isobel Jane Mulligan, Gregory Zlatko Grudic, Steven L. Moulton
  • Patent number: 12196627
    Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 14, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Jianliang Xiao, Wei Zhang, Chuanqian Shi
  • Patent number: 12194082
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: August 23, 2023
    Date of Patent: January 14, 2025
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Publication number: 20250009353
    Abstract: A system and method for end-to-side anastomosis to an anatomical passageway is disclosed. The system and method are particularly useful in coupling an LVAD pump to an aorta. The system and method include using a tubular graft member having a skirt flange that engages the side of the aorta, a seating assembly and a flanged stent for securing the tubular graft to the side of the anatomical passageway. An assembly for creating an opening in the side of the anatomical passageway and an assembly for delivering the tubular graft is also disclosed.
    Type: Application
    Filed: March 18, 2024
    Publication date: January 9, 2025
    Applicant: Regents of the University of Colorado, a body corporate
    Inventor: Max Bannister Mitchell
  • Patent number: 12187851
    Abstract: The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: January 7, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christopher N. Bowman, Brady T. Worrell, Gayla Berg Lyon, Matthew K. McBride, Chen Wang
  • Patent number: 12186384
    Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens.
    Type: Grant
    Filed: May 11, 2022
    Date of Patent: January 7, 2025
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Theodore W. Randolph, Robert Garcea, Alan W. Weimer
  • Publication number: 20240424673
    Abstract: Systems and methods for human-robot communication. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.
    Type: Application
    Filed: May 20, 2024
    Publication date: December 26, 2024
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Daniel Szafir, Michael E. Walker, Hooman Hedayati
  • Patent number: 12171694
    Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).
    Type: Grant
    Filed: August 24, 2023
    Date of Patent: December 24, 2024
    Assignees: The Regents of the University of Colorado, a body corporate, New World Medical, Inc.
    Inventors: Malik Y. Kahook, Khalid Mansour, Suhail Abdullah, Eric Porteous, Vijay R. Balan
  • Patent number: 12176805
    Abstract: A control architecture that overcomes limitations of conventional ac-dc converters and enables bidirectional active and reactive power processing is provided. In one implementation, for example, this may be achieved through the use of unrectified sensed ac signals in the generation of the control commands for the converter. This control architecture, in this example implementation, eliminates or at least reduces zero crossing distortions in the ac current of the converter even with relatively low bandwidth controllers. The concept can be applied to different power stage topologies.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: December 24, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Khurram K. Afridi, Usama Anwar, Dragan Maksimovic, Robert W. Erickson
  • Publication number: 20240416000
    Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.
    Type: Application
    Filed: January 12, 2024
    Publication date: December 19, 2024
    Applicant: The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Robin SHANDAS, Steven LEWIS, Daewon PARK, Omid JAZAERI, Steven LAMMERS, James BARDILL, Brisa PENA-CASTELLANOS
  • Patent number: 12161548
    Abstract: An intraocular drug delivery platform including a ring having an anterior surface and a posterior surface opposite the anterior surface, a central aperture formed by the ring, a first haptic coupled to and extending outwards from the ring, a second haptic coupled to and extending outwards from the ring, a first drug eluting mass operably coupled to the anterior surface of the ring, and a second drug eluting mass operably coupled to the anterior surface of the ring and positioned directly opposite of the first drug eluting mass.
    Type: Grant
    Filed: October 12, 2023
    Date of Patent: December 10, 2024
    Assignees: SpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Glenn Robert Sussman, Craig Alan Cable, II, Malik Y. Kahook