Abstract: A vascular access device and assembly characterized by a tubular access graft having at least one angled distal flange that forms a non-circular distal opening to the tubular access graft, with the angled distal flange having a reinforcement structure that expands the flange and abuts a luminal wall surface of a blood vessel. Optionally, an axial compression ring or cuff may be provided that concentrically engages the tubular access graft and is translatable into a position that abuts an abluminal wall surface of the blood vessel. Also optionally, the device and assembly may include an annular ring with a plurality of axially projecting tines arrayed about a circumference of the annular ring, the annular ring being adapted to evert upon engagement with vascular tissue and creation of an access open by either an arteriotomy or a venotomy. The plurality of tines are configured to engage vascular tissue and then rotate to a different axial orientation to evert the periphery of the access site.

Abstract: A portable computed tomography (CT) system includes an O-shaped gantry defining an opening, an x-ray source operably coupled to the O-shaped gantry, and a flat panel detector (FPD) coupled to the O-shaped gantry and having a two-dimensional anti-scatter grid (2D ASG) coupled to a side of the FPD facing the opening. With the O-shaped gantry having the FPD, the object may be imaged in a first field of view (FOV) with the detector arranged in a centered geometry. Then, the detector may be arranged in an offset geometry, through-holes of the ASG may be aligned with x-ray emission paths of the x-ray source, and the object may be imaged in a second FOV with the detector arranged in the offset geometry.

Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.

Abstract: Isotropic (amorphous) elastomers and methods of preparation are described. The isotropic elastomer may include a first monomer having an alkene functionality and a second monomer having a thiol functionality. The first monomer may be a liquid crystal monomer and the second monomer may be an isotropic monomer. Unlike polydomain LCEs, the isotropic elastomers may rapidly recover after deformation and have increased toughness relative to conventional elastomers prepared from wholly isotropic precursors.

Abstract: Insulated assemblies, insulation units including an assembly, and methods of forming the assemblies and units are disclosed. Exemplary assemblies include a first pane of material, a second pane of material, and one or more monolithic insulating layers interposed between the first pane of material and the second pane of material. The insulating layer can exhibit a thermal conductivity less than 26 mW/(K.m).

Abstract: Bioactive peptides and methods for their use for preventing, treating, and/or reducing the incidence and/or symptoms of an autoimmune disease or disorder that may result from chronic inflammation, damage to ?-cells of the pancreas, and other conditions that are implicated by the CD40-CD154 dyad. In particular, small peptides that are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD154, which impacts inflammation, autoimmunity, and disease progression. The use of such peptides in reducing diabetes mellitus, and in particular, the autoimmune inflammatory response that may be a driving factor thereof. Methods and materials for preventing and modulating diabetes mellitus and autoimmune diseases especially in dogs, cats, and horses.

Abstract: A compound, or a pharmaceutically acceptable salts or prodrugs thereof, having the chemical structure: and methods of using these compounds to inhibit WEE1 kinase and treat cancer in a subject.

Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.

Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

Abstract: Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.

Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or effectiveness of cardiopulmonary resuscitation (“CPR”), in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid estimation of a patient's compensatory reserve index (“CRI”) before, during, and after CPR is performed, and using the CRI and variations in CRI values to determine, in some instances, in real-time, the effectiveness of CPR that is performed.

Abstract: Diagnostic imaging of deep targets in the body requires sufficient signal amplitude to overcome effects such as attenuation with depth and thermal noise produced in signal reception. Coded excitation provides several strategies to increase the total transmitted energy without exceeding peak amplitude safety limits. Temporal coding has proven particularly effective, but these frequency or amplitude modulation techniques require additional transmit capabilities and often require complex processing to reduce decoding artifacts. An alternative code is presented based on time delays that relies on repeated transmit pulses that can be decoded using spatiotemporal synthetic aperture processing. A 16-pulse code is demonstrated that achieves an 11.1 dB improvement in signal-to-noise ratio (SNR) while maintaining axial resolution and sufficient range lobe performance.

Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

Abstract: A system and method for end-to-side anastomosis to an anatomical passageway is disclosed. The system and method are particularly useful in coupling an LVAD pump to an aorta. The system and method include using a tubular graft member having a skirt flange that engages the side of the aorta, a seating assembly and a flanged stent for securing the tubular graft to the side of the anatomical passageway. An assembly for creating an opening in the side of the anatomical passageway and an assembly for delivering the tubular graft is also disclosed.

Abstract: The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens.

Abstract: Systems and methods for human-robot communication. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).