Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.

Abstract: The present invention relates to the production of activated biological molecules for use in profiling biological molecule interactions. The activated biological molecule may be a ubiquitin (Ub) and ubiquitin-like conjugation enzyme as well as other proteins with internal reactive cysteine residues.

Abstract: A transmission system (10) includes a first piston (12), a second piston (14) and a modulator piston (16). The first piston (12) receives an input force (FIN), the second piston (14) transmits an output force (FOUT), and the modulator piston (16) transmits a modulating force (FACT>which modulates the input force (FIN) received by the second piston (14) to implement tremor cancellation and force and/or provide variable motion scaling.

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.

Abstract: An ultrasonically actuated medical implement is used in improving medical interventions and in certain instances to the generation of image data, in particular data acquired during a medical intervention or procedure. The medical implement employs a piezoelectric element which causes reciprocation between first and second mass assemblies in order to ultrasonically actuate a probe member and improve the visibility of the probe member to imaging methods. The invention also concerns the visibility of structures in target regions to be imaged and how this may be enhanced using the medical implement of the invention.

Abstract: An actuator includes first and second ends defining an axis there between, and at least four inflatable chambers. Each inflatable chamber is resiliently deformable, elongate, and extends axially between the first and second ends and circumferentially about a central core defined between the ends and by the inflatable chambers. A first pair of the four inflatable chambers is contra rotatory about the core to a second pair of the four inflatable chambers. A pressure change in one or more of the inflatable chambers causes motion of the first end relative to the second end. The actuators can be employed in robots or robotic arms.

Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a surface of a target (10), comprises applying laser radiation to the surface of the target (10) to produce a periodic arrangement of structures on the surface, wherein the laser radiation comprises pulsed laser radiation comprising a series of laser pulses and the power density of the pulses is in a range 0.01 TW/cm2 to 3 TW/cm2, optionally 0.1 TW/cm2 to 3 TW/cm2.

Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a ceramic surface comprises applying pulsed laser radiation comprising a series of laser pulses emitted by a laser (4) to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10).

Abstract: The patent describes the innovation that allows users to virtually try clothes on their 3D-models. The system uses photogrammetry to construct a 3D projection from images followed by modeling and character building. The body measures are derived from 3D constructions. The innovation lets users build their 3D characters from 3D-models that has applications like academic, research, 3D printing, designing decorative items, and digital media. The system provides a RESTful service that allows webmasters to send the cloth dimensions and with user identifier through a web client. The system identifies the user from the identifier and compares the dimensions of the user body and clothes and try to perform a virtual fitting generating the fitting information. Both character and fitting information are sent to the web client that displays the fitting information mapped on the character on a 3D viewer.

Abstract: The present invention relates to the production of activated biological molecules for use in profiling biological molecule interactions. The activated biological molecule may be a ubiquitin (Ub) and ubiquitin-like conjugation enzyme as well as other proteins with internal reactive cysteine residues.

Abstract: A method of blackening a surface, comprises applying laser radiation to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10), wherein the laser radiation comprises pulsed laser radiation comprising a series of laser pulses and the power density of the pulses is in a range 2 GW/cm2 to 50 GW/cm2 or 0.1 TW/cm2 to 3 TW/cm2, and/or a pulse duration between 200 femtoseconds to 1000 picoseconds.

Abstract: An actuator includes first and second ends defining an axis there between, and at least four inflatable chambers. Each inflatable chamber is resiliently deformable, elongate, and extends axially between the first and second ends and circumferentially about a central core defined between the ends and by the inflatable chambers. A first pair of the four inflatable chambers is contra rotatory about the core to a second pair of the four inflatable chambers. A pressure change in one or more of the inflatable chambers causes motion of the first end relative to the second end. The actuators can be employed in robots or robotic arms.

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

Abstract: A medical instrument has a tubular shaft, a handle at a proximal end of the shaft and a movable working part at a distal end of the shaft, the shaft includes a shaft section having a curvature and being arranged between the distal end and the proximal end of the shaft. The handle and the working part are operatively connected via a force transmission element extending through the shaft. The force transmission element has a section arranged within the curved shaft section of the shaft, the section being guided on an inner surface of the shaft and having a plurality of interconnected single elements arranged one after the other along the longitudinal direction of the shaft. The single elements are pairwise connected by a pin forming a hinged joint, such that each of the pins defines a rotation axis oriented substantially perpendicular relative to the shaft.

Abstract: A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectives (OA1-n), where n is at least one; defining a population (PG=0) of at least one molecule; selecting an initial population (Pparent) of at least one molecule (I1-In) from the population (PG=0); and evaluating members (I1-In) of the initial population (Pparent) against at least one of the n achievement objectives (OA1-x), where x is from 1 to n.

Abstract: An actuator (12) includes a moving member (18) pivotally connected to a base unit (14) for rotation about an axis. The driving force for rotation of the moving member (18) relative to the base unit (14) is provided by a pair of antagonistically operating shape memory alloy (SMA) wires (48, 50) and transmitted via a torsional spring (56). An endoscope, or a snake-like robot (66), may include one or more of the actuators (12).

Abstract: The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.

Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a ceramic surface comprises applying pulsed laser radiation comprising a series of laser pulses emitted by a laser (4) to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10).