Patents Assigned to The University of Dundee
  • Patent number: 11261179
    Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: March 1, 2022
    Assignee: University of Dundee
    Inventors: Alessio Ciulli, Chiara Maniaci, Scott J. Hughes, Andrea Testa
  • Patent number: 11254966
    Abstract: The present invention relates to the production of activated biological molecules for use in profiling biological molecule interactions. The activated biological molecule may be a ubiquitin (Ub) and ubiquitin-like conjugation enzyme as well as other proteins with internal reactive cysteine residues.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: February 22, 2022
    Assignee: University Court of the University of Dundee
    Inventors: Satpal Virdee, Mathew Stanley, Kuan-Chuan Pao
  • Patent number: 11255352
    Abstract: A transmission system (10) includes a first piston (12), a second piston (14) and a modulator piston (16). The first piston (12) receives an input force (FIN), the second piston (14) transmits an output force (FOUT), and the modulator piston (16) transmits a modulating force (FACT>which modulates the input force (FIN) received by the second piston (14) to implement tremor cancellation and force and/or provide variable motion scaling.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF DUNDEE
    Inventor: Luigi Manfredi
  • Patent number: 11234988
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: February 1, 2022
    Assignee: University of Dundee
    Inventors: Alessio Ciulli, Andrea Testa
  • Patent number: 11179373
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 23, 2021
    Assignee: University of Dundee
    Inventors: Alessio Ciulli, Michael Zengerle, Kwok-Ho Chan
  • Patent number: 11123100
    Abstract: An ultrasonically actuated medical implement is used in improving medical interventions and in certain instances to the generation of image data, in particular data acquired during a medical intervention or procedure. The medical implement employs a piezoelectric element which causes reciprocation between first and second mass assemblies in order to ultrasonically actuate a probe member and improve the visibility of the probe member to imaging methods. The invention also concerns the visibility of structures in target regions to be imaged and how this may be enhanced using the medical implement of the invention.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: September 21, 2021
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE
    Inventors: Muhammad Sadiq, Sandy Cochran, Zhihong Huang, George Corner, Graeme McLeod, Patrick Carena
  • Patent number: 11034017
    Abstract: An actuator includes first and second ends defining an axis there between, and at least four inflatable chambers. Each inflatable chamber is resiliently deformable, elongate, and extends axially between the first and second ends and circumferentially about a central core defined between the ends and by the inflatable chambers. A first pair of the four inflatable chambers is contra rotatory about the core to a second pair of the four inflatable chambers. A pressure change in one or more of the inflatable chambers causes motion of the first end relative to the second end. The actuators can be employed in robots or robotic arms.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: June 15, 2021
    Assignee: UNIVERSITY OF DUNDEE
    Inventor: Luigi Manfredi
  • Patent number: 11033985
    Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a surface of a target (10), comprises applying laser radiation to the surface of the target (10) to produce a periodic arrangement of structures on the surface, wherein the laser radiation comprises pulsed laser radiation comprising a series of laser pulses and the power density of the pulses is in a range 0.01 TW/cm2 to 3 TW/cm2, optionally 0.1 TW/cm2 to 3 TW/cm2.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 15, 2021
    Assignee: UNIVERSITY OF DUNDEE
    Inventor: Amin Abdolvand
  • Patent number: 10994369
    Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a ceramic surface comprises applying pulsed laser radiation comprising a series of laser pulses emitted by a laser (4) to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10).
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 4, 2021
    Assignee: UNIVERSITY OF DUNDEE
    Inventor: Amin Abdolvand
  • Publication number: 20200402307
    Abstract: The patent describes the innovation that allows users to virtually try clothes on their 3D-models. The system uses photogrammetry to construct a 3D projection from images followed by modeling and character building. The body measures are derived from 3D constructions. The innovation lets users build their 3D characters from 3D-models that has applications like academic, research, 3D printing, designing decorative items, and digital media. The system provides a RESTful service that allows webmasters to send the cloth dimensions and with user identifier through a web client. The system identifies the user from the identifier and compares the dimensions of the user body and clothes and try to perform a virtual fitting generating the fitting information. Both character and fitting information are sent to the web client that displays the fitting information mapped on the character on a 3D viewer.
    Type: Application
    Filed: June 21, 2019
    Publication date: December 24, 2020
    Applicants: University of Dundee
    Inventor: Ashish Tanwer,
  • Patent number: 10829799
    Abstract: The present invention relates to the production of activated biological molecules for use in profiling biological molecule interactions. The activated biological molecule may be a ubiquitin (Ub) and ubiquitin-like conjugation enzyme as well as other proteins with internal reactive cysteine residues.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 10, 2020
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE
    Inventors: Satpal Virdee, Mathew Stanley, Kuan-Chuan Pao
  • Patent number: 10807197
    Abstract: A method of blackening a surface, comprises applying laser radiation to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10), wherein the laser radiation comprises pulsed laser radiation comprising a series of laser pulses and the power density of the pulses is in a range 2 GW/cm2 to 50 GW/cm2 or 0.1 TW/cm2 to 3 TW/cm2, and/or a pulse duration between 200 femtoseconds to 1000 picoseconds.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 20, 2020
    Assignee: University of Dundee
    Inventor: Amin Abdolvand
  • Publication number: 20200039065
    Abstract: An actuator includes first and second ends defining an axis there between, and at least four inflatable chambers. Each inflatable chamber is resiliently deformable, elongate, and extends axially between the first and second ends and circumferentially about a central core defined between the ends and by the inflatable chambers. A first pair of the four inflatable chambers is contra rotatory about the core to a second pair of the four inflatable chambers. A pressure change in one or more of the inflatable chambers causes motion of the first end relative to the second end. The actuators can be employed in robots or robotic arms.
    Type: Application
    Filed: October 24, 2017
    Publication date: February 6, 2020
    Applicant: University of Dundee
    Inventor: Luigi MANFREDI
  • Patent number: 10479792
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: November 19, 2019
    Assignees: GiaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Stephen Brand, Peter George Dodd, Eun Jung Ko, Maria Marco Martin, Timothy James Miles, Lars Henrik Sandberg, Michael George Thomas, Stephen Thompson
  • Publication number: 20190255066
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 22, 2019
    Applicant: UNIVERSITY OF DUNDEE
    Inventors: Alessio CIULLI, Andrea TESTA
  • Patent number: 10383536
    Abstract: A medical instrument has a tubular shaft, a handle at a proximal end of the shaft and a movable working part at a distal end of the shaft, the shaft includes a shaft section having a curvature and being arranged between the distal end and the proximal end of the shaft. The handle and the working part are operatively connected via a force transmission element extending through the shaft. The force transmission element has a section arranged within the curved shaft section of the shaft, the section being guided on an inner surface of the shaft and having a plurality of interconnected single elements arranged one after the other along the longitudinal direction of the shaft. The single elements are pairwise connected by a pin forming a hinged joint, such that each of the pins defines a rotation axis oriented substantially perpendicular relative to the shaft.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: August 20, 2019
    Assignee: University of Dundee
    Inventors: Timothy Graham Frank, Stuart Coleman
  • Patent number: 10381110
    Abstract: A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectives (OA1-n), where n is at least one; defining a population (PG=0) of at least one molecule; selecting an initial population (Pparent) of at least one molecule (I1-In) from the population (PG=0); and evaluating members (I1-In) of the initial population (Pparent) against at least one of the n achievement objectives (OA1-x), where x is from 1 to n.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF DUNDEE
    Inventors: Andrew Lee Hopkins, Jérémy Besnard
  • Patent number: 10371128
    Abstract: An actuator (12) includes a moving member (18) pivotally connected to a base unit (14) for rotation about an axis. The driving force for rotation of the moving member (18) relative to the base unit (14) is provided by a pair of antagonistically operating shape memory alloy (SMA) wires (48, 50) and transmitted via a torsional spring (56). An endoscope, or a snake-like robot (66), may include one or more of the actuators (12).
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 6, 2019
    Assignee: UNIVERSITY OF DUNDEE
    Inventors: Luigi Manfredi, Alfred Cuschieri
  • Patent number: 10253028
    Abstract: The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: April 9, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Timothy James Miles, Michael George Thomas
  • Publication number: 20190084081
    Abstract: A method of reducing photoelectron yield (PEY) and/or secondary electron yield (SEY) of a ceramic surface comprises applying pulsed laser radiation comprising a series of laser pulses emitted by a laser (4) to the surface of a target (10) to produce a periodic arrangement of structures on the surface of the target (10).
    Type: Application
    Filed: March 8, 2017
    Publication date: March 21, 2019
    Applicant: University of Dundee
    Inventor: Amin ABDOLVAND