Patents Assigned to The University of Dundee
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Patent number: 8207175Abstract: The present invention relates to compounds and uses of compounds which interact with chitinase enzymes, in particular the inhibition of those enzymes.Type: GrantFiled: June 21, 2006Date of Patent: June 26, 2012Assignee: University Court of the University of DundeeInventors: Daniel Marinus Ferdinand Van Aalten, Ian Michael Eggleston
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Publication number: 20120085647Abstract: An apparatus and method for mineralising demineralised and hypo-mineralised biological material such as tooth or bone. The apparatus has a probe electrode for receiving a mineralisation agent and a counter electrode. It is also provided with a controller to control the electrical signal provided to the probe such that the extent of mineralisation of the biological material is controlled by modulating or changing the electrical signal provided by the probe based upon the measured output of the circuit formed from the probe, counter electrode and biological material. The electrical output provides a measure of the extent of mineralisation of the biological material which is compared with data from a reference technique which gives 3D structural information on an area of interest in the biological material.Type: ApplicationFiled: August 18, 2009Publication date: April 12, 2012Applicants: The University of Dundee, The University Court of the University of St. Andrews, The University of Abertay DundeeInventors: Christopher Longbottom, Joseph Crayston, Nigel Berry Pitts, Dmitri Grinev, Iain Young
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Publication number: 20120082684Abstract: The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially useful in the treatment of cell proliferation and/or differentiation disorders.Type: ApplicationFiled: March 15, 2010Publication date: April 5, 2012Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Sonia Rocha, Angus Iain Lamond, Motoharu Ono, Kayo Yamada
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Publication number: 20120082179Abstract: An optical system (31) with an input optical source (33) for projecting an input beam along an optical axis and an optical element (37, 43) which creates a cone refracted beam (41) from the input beam (35) then reconstructs the input beam (49). The optical element may comprise a first cone refractive element (37) which creates a cone refracted beam and reconstructs the beam using a reconstructing optical element (43) to apply a phase shift to the cone refracted beam. The optical system may be used to form a laser or a gain medium for a laser.Type: ApplicationFiled: January 21, 2010Publication date: April 5, 2012Applicant: THE UNIVERSITY OF DUNDEEInventors: Edik Rafailov, Amin Abdolvand, Todor Kalkandjiev
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Publication number: 20110288395Abstract: A non-invasive device adapted to measure intraocular pressure (IOP) comprising: a pressure sensor mounted on a soft contact lens to be worn on the eye of a subject, wherein the device is adapted such that, when worn on the eye, the pressure sensor is located at or near the transitional region of the cornea. The pressure sensor communicates wirelessly to an external controlling device through a magnetic field-based telemetry system that serves to power the pressure sensor and transmit the pressure measurements to the external device.Type: ApplicationFiled: October 30, 2009Publication date: November 24, 2011Applicant: University of DundeeInventors: Ahmed Elsheikh, David Pye
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Publication number: 20110130637Abstract: A composition for use in the treatment or prophylaxis of conditions mediated by endothelial function in mammals is provided. The composition includes a milk protein hydrolysate generated by treating milk or milk whey protein with a proteolytic enzyme having subtilisin or subtilisin-like activity and/or glutamyl endopeptidase or glutamyl endopeptidase-like activity. The composition is useful in the management of vascular conditions.Type: ApplicationFiled: March 19, 2009Publication date: June 2, 2011Applicant: University of DundeeInventors: Dick Fitzgerald, Allan Struthers
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Publication number: 20110104149Abstract: The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.Type: ApplicationFiled: September 16, 2010Publication date: May 5, 2011Applicant: University Court of the University of DundeeInventors: Paul Richard Crocker, Bjoern Biedermann, David Bowen
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Patent number: 7896900Abstract: A medical instrument for grasping an object, in particular a surgical needle holder, including an elongated shaft, two jaw parts arranged at a distal end of the shaft, at least one of the jaw parts being pivotable with respect to the other of the jaw parts between a grasp state for grasping the object between the jaw parts and a release state for releasing the object. A handle is arranged at a proximal end of the shaft and has at least one operating element for moving the at least one pivotable jaw part between the grasp state and the release state via an axially movable force transmission element operatively connected with the at least one operating element and with the at least one pivotable jaw part via an articulated joint. The instrument further includes a latching mechanism for immobilizing the at least one pivotable jaw part in the grasp state.Type: GrantFiled: June 29, 2007Date of Patent: March 1, 2011Assignee: University of DundeeInventors: Timothy Graham Frank, J. Duncan S. Martin, Ian Rutherford, Stuart I. Brown, James Gove, Leslie Kelly
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Publication number: 20110027385Abstract: A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.Type: ApplicationFiled: November 21, 2008Publication date: February 3, 2011Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: James Anthony Cairns, Graham James Berry, Roderick Allan George Gibson
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Publication number: 20110021529Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).Type: ApplicationFiled: September 4, 2007Publication date: January 27, 2011Applicants: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE, UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWSInventors: Sonia Lain, David Phillip Lane, Michael John Raymond Stark, Anna Rose McCarthy, Jonathan James Hollick, Nicholas James Westwood
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Publication number: 20100305070Abstract: The disclosure relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. Also provided are pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. Provided are methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1B1 and allelic variants thereof. Finally, provided is a method for determining the efficacy of a compound as described herein in treating cancer.Type: ApplicationFiled: April 30, 2010Publication date: December 2, 2010Applicant: The University Court of the University of DundeeInventors: Steven Albert Everett, Saraj Ulhaq
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Publication number: 20100303925Abstract: The disclosure concerns cosmetic and therapeutic treatment of tissue, such as tooth, to effect, for instance, whitening and tissue re-building through mineralisation and including kits for use in the methods.Type: ApplicationFiled: April 21, 2009Publication date: December 2, 2010Applicants: The University of Dundee, The University of Abertay, University Court of the University of Saint AndrewsInventors: Nigel Pitts, Christopher Longbottom, Joseph Crayston, Dmitri Grinev, Ian McEwing Young
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Patent number: 7811789Abstract: A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinguish MSF and fibronectin, and which can distinguish polynucleotides which encode MSF or fibronectin. These reagents are believed to be useful in, for example, diagnosing cancer. MSF or variants or fragments or derivatives or fusions thereof, or fusions of said variants or fusions or derivatives, are useful in modulating cell migration and in wound healing.Type: GrantFiled: October 30, 2007Date of Patent: October 12, 2010Assignee: University of DundeeInventors: Seth Lawrence Schor, Ana Maria Schor
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Publication number: 20100210578Abstract: The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.Type: ApplicationFiled: January 17, 2007Publication date: August 19, 2010Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: William Henry Irwin McLean, Frances Jan Dorothy Smith
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Patent number: 7727950Abstract: A kit of parts comprising two or more protein kinase substrate polypeptides, each said substrate polypeptide comprising a specificity conferring portion (which is different for each said kinase substrate polypeptide) and a phosphorylatable portion, wherein the phosphorylatable portions of each polypeptide are capable of being bound in a phosphorylation state-sensitive manner by the same specific binding partner, for example and antibody preparation, and wherein the said specific binding partner is not an antibody specific for phosphotyrosine, phosphoserine or phosphothreonine. The phosphorylatable portion preferably comprises the amino acid sequence LSFAEPG.Type: GrantFiled: March 26, 2003Date of Patent: June 1, 2010Assignee: The University of DundeeInventors: Chris Armstrong, Philip Cohen
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Patent number: 7699868Abstract: The invention relates to a medical gripping and/or cutting instrument with an instrument shaft (1), with a handle (3) that can be fixed movably on the instrument shaft (1), and with a tool (2) mounted on the distal end of the instrument shaft (1) and consisting of two jaw member (2a, 2b), where at least one jaw member (2a or 2b) of the tool (2) can move in relation to the other jaw member (2b or 2a). In order to provide a medical instrument that, along with good cleaning properties and compact structure, also ensures simple and safe operation, the invention proposes that the handle (3) should include a coupling mechanism both to fix the handle (3) to the instrument shaft (1) and also to operate the at least one movable jaw member (2a or 2b) of the tool (2).Type: GrantFiled: July 14, 2004Date of Patent: April 20, 2010Assignee: University of DundeeInventors: Timothy Graham Frank, Stuart I. Brown, Ian Rutherford
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Publication number: 20100057168Abstract: A body part heating system (10) comprises a temperature sensor (28) adapted to measure the temperature of a body part, and a heater (34a, 34b) in communication with the temperature sensor (28). The heater (34a, 34b) is adapted to be activated to heat the body part in response to the temperature sensor (28) sensing the occurrence of a predefined thermal event such as a temperature drop below a predefined level. The heating system (10) may be in the form of a glove and may be used to treat the symptoms of Raynaud's phenomenon.Type: ApplicationFiled: November 22, 2007Publication date: March 4, 2010Applicant: University of DundeeInventors: Alan P. Slade, Robert P. Keatch, Aneel Gill, Jill Belch, Faisel Khan
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Publication number: 20100017896Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).Type: ApplicationFiled: December 15, 2006Publication date: January 21, 2010Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: William Henry Irwin McLean, Frances Jane Dorothy Smith
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Publication number: 20090313024Abstract: A system and a method for speech generation which assist the speech of those with a disability or a medical condition such as cerebral palsy, motor neurone disease or a dysarthia following a stroke. The system has a user interface having a multiplicity of states each of which correspond to a sound and a selector for making a selection of a state or a combination of states. The system also has a processor for processing the selected state or combination of states and an audio output for outputting the sound or combination of sounds. The sounds associated with the states can be phonemes or phonics and the user interface is typically a manually operable device such as a mouse, trackball, joystick or other device that allows a user to distinguish between states by manipulating the interface to a number of positions.Type: ApplicationFiled: February 1, 2007Publication date: December 17, 2009Applicant: The University of DundeeInventors: Rolf Black, Annula Waller, Eric Abel, Iain Murray, Graham Pullin
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Patent number: 7592191Abstract: A field emission backplate formed by laser crystallizing of an area of amorphous semiconductor based material. Emitter sites result from the rough surface texture caused by the crystallization process. The crystallization may be localized using laser interferometry, and profiled emitter tips grown on the localized crystalline areas. Such backplates can be used in field emission devices emitting into either a vacuum or a wide band gap light-emitting polymer. Furthermore, a backplate having self-aligned gates can be formed by depositing an insulator layer and a metal layer over the emitter tips, removing the top of the metal layer and etching away the insulator, leaving each tip surrounded by a metal rim. A planarizing agent can be used to refine this process.Type: GrantFiled: February 6, 2004Date of Patent: September 22, 2009Assignee: The University Court of the University of DundeeInventors: Mervyn John Rose, Ravi Silva, John Shannon