Patents Assigned to The University of Durham
  • Publication number: 20200331924
    Abstract: A thermally activated delayed fluorescence (TADF) molecule comprising: a central electron donor moiety, wherein the central electron donor moiety is formed of a conjugated multi-ring system comprising three nitrogen atoms; and three electron acceptor moieties, each bonded to the central electron donor moiety via one of the three nitrogen atoms, wherein at least one of the three electron acceptor moieties is twisted relative to the central electron donor moiety defining a torsion angle in a range 40° to <90° whereby the TADF molecule has a photoluminescence quantum yield of >60% and a rate of reverse intersystem crossing from a lowest excited triplet state to a lowest excited singlet state of at least 1×10 s?1.
    Type: Application
    Filed: October 17, 2018
    Publication date: October 22, 2020
    Applicant: THE UNIVERSITY OF DURHAM
    Inventors: Andrew P. MONKMAN, Jonathan S. WARD, Martin R. BRYCE, Daniel G. CONGRAVE, Lays DOS-SANTOS
  • Publication number: 20190352605
    Abstract: A method of creating skin tissue is described, particularly, an in vitro or ex vivo method for creating skin tissue. The invention extends to the use of agents that disrupt the LINC complex in a skin cell to create the skin tissue, and to using the created tissue in an assay to identify or screen anti-ageing compounds. The invention further extends to model skin tissues per se, uses thereof and to kits for creating such model skin tissues.
    Type: Application
    Filed: January 17, 2018
    Publication date: November 21, 2019
    Applicant: THE UNIVERSITY OF DURHAM
    Inventors: Martin GOLDBERG, Iakowos KARAKESISOGLOU, James CARTHEW
  • Patent number: 10465310
    Abstract: A method and apparatus for electrochemical etching are disclosed. The method comprises immersing parts of objects (2) to be etched in an electrolyte (4), applying a voltage between the objects (2) and at least one electrode (6) to cause an electrochemical reaction between the objects (2) and the electrolyte (4), and positioning the objects (2) and electrodes (6) relative to each other such that a reaction product accumulates on the objects (2) during the reaction to reduce the rate of the reaction.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: November 5, 2019
    Assignee: THE UNIVERSITY OF DURHAM
    Inventors: Richard Stone, Dagou Zeze
  • Patent number: 10449473
    Abstract: The invention provides a coating which exhibits fast oleophobic-hydrophilic switching behaviour with, for example, equilibration of high oil contact angle (hexadecane=80°) and low water contact angle (<10°) values which occur within 10 s of droplet impact. These optically transparent surfaces display excellent anti-fogging and self-cleaning properties. The magnitude of oleophobic-hydrophilic switching can be further enhanced by the incorporation of surface roughness and in one embodiment the coating is applied to a surface in the form of a mesh in order to form an effective filter.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 22, 2019
    Assignee: The University of Durham
    Inventors: Jas Pal Singh Badyal, Olivia Diane Louise Amy Atkinson, Philip Simon Brown
  • Patent number: 10406166
    Abstract: The invention relates to compounds of formula (I), and pharmaceutical uses thereof. Particular aspects of the invention relate to methods of synthesizing the compounds and the use of those compounds in treating, ameliorating, or preventing a microbial infection.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 10, 2019
    Assignee: The University of Durham
    Inventors: Stuart Cockerill, Jonathan Harburn
  • Publication number: 20190209685
    Abstract: There are described novel compounds of formula I: (I) in which, in which A1, A2, A3, A4, R1 and R2 are each as herein defined, for use in the treatment or alleviation of an RAR mediated condition; and methods related thereto.
    Type: Application
    Filed: March 19, 2019
    Publication date: July 11, 2019
    Applicant: University of Durham
    Inventors: Andrew Whiting, Carrie Ambler, Mark Coles, David Chisholm
  • Publication number: 20190209684
    Abstract: There are described novel compounds of formula I: (I) in which, in which A1, A2, A3, A4, R1 and R2 are each as herein defined, for use in the treatment or alleviation of an RAR mediated condition; and methods related thereto.
    Type: Application
    Filed: August 9, 2017
    Publication date: July 11, 2019
    Applicant: University of Durham
    Inventors: Andrew Whiting, Carrie Ambler, Mark Coles, David Chisholm
  • Publication number: 20190134264
    Abstract: A method of forming a scaffold comprises the steps of: preparing a high internal phase emulsion (HIPE) comprising an aqueous solution of: proteins selected from the group consisting of collagen and mixtures of collagen and chitosan; and a cross-linking agent; by addition of an immiscible solvent to the solution to form the HIPE; reducing the temperature of the HIPE to solidify the HIPE; removing water and solvent by vaporisation at a temperature above the melting point of the solvent to form a porous structure; and before or after removal of solvent, causing cross-linking of the protein with the cross-linking agent to form a crosslinked scaffold structure.
    Type: Application
    Filed: May 12, 2017
    Publication date: May 9, 2019
    Applicant: University of Durham
    Inventors: Junjie WU, Ross CARNACHAN, Stefan PRZYBORSKI
  • Patent number: 10117433
    Abstract: The present invention relates to the development of fusion proteins based on peptide toxins as pesticides. The invention also relates to transgenic plants encoding said peptides and their utility in pest management.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: November 6, 2018
    Assignees: University of Durham, The Secretary of State for Environment, Food and Rural Affairs
    Inventors: John A. Gatehouse, Elaine C. Fitches
  • Patent number: 10040819
    Abstract: A method for chemically modifying a peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof with a fluoro-heteroaromatic compound to activate the peptide, derivative or analogue thereof. The activated peptide, derivative or analogue thereof is then contacted with a nucleophile or base to create a chemically modified peptide, derivative or analogue thereof.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: August 7, 2018
    Assignee: The University of Durham
    Inventors: Steven Cobb, Christopher Coxon, Graham Sandford
  • Publication number: 20170298028
    Abstract: The present invention relates to a method of manufacturing a fluorocytosine-based compound of Formula I. The invention also relates to a compound obtained by such a method, a pharmaceutical drug substance and a method for its manufacture, a pharmaceutical composition, and also various uses in therapy of the compounds, pharmaceutical drug substances, and pharmaceutical compositions of the invention.
    Type: Application
    Filed: August 13, 2015
    Publication date: October 19, 2017
    Applicant: University of Durham
    Inventors: Graham SANDFORD, Antal HARSANYI
  • Patent number: 9487631
    Abstract: A polymer comprising a bulk polymer or copolymer PB together with an amount of a polymer-dendron additive D-PD of formula (I): is provided, such that the polymer comprises from 0.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 8, 2016
    Assignee: University of Durham
    Inventors: Lian Richard Hutchings, William James Feast, Richard Lewis Thompson, Amilcar Pillay-Narrainen
  • Patent number: 9448225
    Abstract: The invention provides a compound of formula (I): (wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each —R2 is independently of the formula —CH2—C(?O)—R4, wherein R4 is an amino acid or a salt thereof, attached to the remainder of R2 through the nitrogen atom of the amino group; and R3 is hydrogen or a C1-6 alkyl group); or (wherein: R1 is an optionally substituted 2-(1-azaxanthone); each R2 is independently an optionally substituted glutaric or succinic acid, or a salt or ester thereof; and R3 is hydrogen or a C1-6 alkyl group).
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 20, 2016
    Assignee: University of Durham
    Inventors: David Parker, Robert Pal
  • Patent number: 9165734
    Abstract: A microgripper (2) comprises a pair of opposed actuator devices (4, 6) connected to an electronic control unit (8). Each actuator (4, 6) includes an actuator body 10 of transparent flexible epoxy based photoresist material forming a “hot” arm (12) and a “cold” arm (14) joined together at their ends, and an electrical heating element wire (18) is embedded in the “hot” arm (12). A gripper arm (32) extends from the substrate and has a gripping portion (34) such that the gripper portions of the two gripper arms (32) face each other. When electrical current is supplied to the heating element (18), electrical heating of the “hot” arm (12) occurs, as a result of which thermal expansion of the “hot” arm (12) causes its length to become greater than that of the “cold” arm (14).
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: October 20, 2015
    Assignee: University Of Durham
    Inventors: David Wood, Belen Pilar Solano Hermosilla, Mary Herbert
  • Patent number: 9046874
    Abstract: A light beam collimated by illumination optics (4) from a radiation source (6) illuminates the surface of a wave front modulator (8) such as an Spatial Light Modulator (SLM) or Computer Generated Hologram photomask (CGH). The resulting wave travels via projection optics (10) to the substrate (12), passing through a projection lens assembly (14). The SLM (8) is programmed or CGH configured with a modulation pattern that is determined by the substrate (12) topography and desired pattern. The substrate topography is provided by Digital Holography (DH) surface profilometery performed by a DH microscope (18), which provides geometrical or topographical input to the CGH calculation routines (16). An arrangement for vertical or sloping surface patterning has a grating (22) superimposed onto the CGH pattern (24) to generate +1 and ?1 orders.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: June 2, 2015
    Assignees: University of Durham, University of Sheffield
    Inventors: Peter Anthony Ivey, Richard Peter McWilliam, Alan Purvis, Gavin Lewis Williams, Nicholas Luke Seed, Richard Ian Curry, Jose Juan De Jesus Toriz-Garcia
  • Publication number: 20140366227
    Abstract: The present invention relates to the development of fusion proteins based on peptide toxins as pesticides. The invention also relates to transgenic plants encoding said peptides and their utility in pest management.
    Type: Application
    Filed: March 29, 2012
    Publication date: December 11, 2014
    Applicants: The Food and Environment Research Agency (FERA), representing the Sec.of State for Environment, etc, UNIVERSITY OF DURHAM
    Inventors: John A. Gatehouse, Elaine C. Fitches
  • Publication number: 20140179015
    Abstract: The invention provides a compound of formula (I): (wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each —R2 is independently of the formula —CH2—C(?O)—R4, wherein R4 is an amino acid or a salt thereof, attached to the remainder of R2 through the nitrogen atom of the amino group; and R3 is hydrogen or a C1-6 alkyl group); or (wherein: R1 is an optionally substituted 2-(1-azaxanthone); each R2 is independently an optionally substituted glutaric or succinic acid, or a salt or ester thereof; and R3 is hydrogen or a C1-6 alkyl group).
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Applicant: University of Durham
    Inventors: David PARKER, Robert Pal
  • Publication number: 20140154326
    Abstract: The invention provides a micro-organ composite which comprises a core group of cells and an outer layer of cells, wherein the cells of the core group are mesenchymal cells and the cells of the outer layer are epithelial cells or wherein the cells of the core group are epithelial cells and the cells of the outer layer are mesenchymal cells, and wherein the core group of cells is at least partially encapsulated by the outer layer of cells.
    Type: Application
    Filed: July 23, 2012
    Publication date: June 5, 2014
    Applicant: University of Durham
    Inventors: Aihua Guo, Colin Albert Buchanan Jahoda
  • Patent number: 8628978
    Abstract: A compound of formula (I) is provided: wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each —R2 is independently of the formula —CH2—C(?O)—R4, wherein R4 is an amino acid or a salt thereof, attached to the remainder of R2 through the nitrogen atom of the amino group; and R3 is hydrogen or a C1-6 alkyl group; or wherein: R1 is an optionally substituted 2-(1-azaxanthone); each R2 is independently an optionally substituted glutaric or succinic acid, or a salt or ester thereof; and R3 is hydrogen or a C1-6 alkyl group.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: January 14, 2014
    Assignee: University of Durham
    Inventors: David Parker, Robert Pal
  • Patent number: 8501398
    Abstract: The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime, at two or more wavelengths, from a sample comprising said analyte and two or more different macrocyclic lanthanide (III) complexes, wherein each of said macrocyclic lanthanide (III) complexes comprises a different lanthanide ion but the same macrocyclic ligand, and using a ratio of emission intensities or emission lifetimes measured at two different wavelengths to calculate the amount of analyte in said sample.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: August 6, 2013
    Assignee: University of Durham
    Inventors: David Parker, Robert Anthony Poole, Filip Kielar