Patents Assigned to The University of Florida
  • Publication number: 20230227452
    Abstract: The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II.
    Type: Application
    Filed: February 15, 2023
    Publication date: July 20, 2023
    Applicant: The University of Florida Research Foundation, Inc.
    Inventors: Courtney Anne MILLER, Patrick Robert GRIFFIN, Theodore Mark KAMENECKA, Gavin Rumbaugh, Matthew Surman, Steve Young, Steven Duddy, Laszlo Radnai
  • Publication number: 20230002329
    Abstract: Small molecule compounds and corresponding dimers having inhibitory activity against pre-miR-21 RNA and related methods for treatment of neoplastic disease such as cancer and especially cancers expressing miR-21 are disclosed.
    Type: Application
    Filed: October 29, 2020
    Publication date: January 5, 2023
    Applicant: The University of Florida Research Foundation, Inc.
    Inventors: Matthew David DISNEY, Jessica L. CHILDS-DISNEY
  • Patent number: 10577617
    Abstract: The impact of plastid size change in both monocot and dicot plants has been examined. In both, when plastid size is increased there is an increase in biomass relative to the parental lines. Thus, provided herein are methods for increasing the biomass of a plant, comprising decreasing the expression of at least one plastid division protein in a plant. Optionally, the level of chlorophyll in the plant is also reduced.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: March 3, 2020
    Assignees: The Board of Trustees of the University of Illinois, The United States of America, as Represented by the Secretary of Agriculture, The Board of Regents of the University of Nebraska, The University of Florida Research Foundation, Incorporated
    Inventors: Aleel K. Grennan, Donald R. Ort, Stephen Patrick Moose, Damla D. Bilgin, Thomas Clemente, Fredy Altpeter, Stephen P. Long
  • Patent number: 9629848
    Abstract: The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: April 25, 2017
    Assignees: The Regents of the University of Colorado, a body corporate, The University of Florida Research Foundation Incorporated
    Inventors: Aaron Michels, Maki Nakayama, David Ostrov
  • Patent number: 9012224
    Abstract: The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: April 21, 2015
    Assignees: The University of North Carolina at Chapel Hill, The University of Florida Research Foundation
    Inventors: Dawn E. Bowles, Chengwen Li, Joseph E. Rabinowitz, Josh Grieger, Mavis Agbandje-McKenna, Richard Jude Samulski
  • Publication number: 20130172219
    Abstract: A PTFE-based composite material includes a PTFE major phase filled with a metal oxide minor phase. The major phase is intermixed with the metal oxide minor phase, wherein the minor phase includes a plurality of irregularly shaped metal oxide nanoparticles. The irregularly shaped nanoparticles provide substantial reductions in steady state wear rate over otherwise similar nanocomposites. The metal oxide can comprise aluminum oxide.
    Type: Application
    Filed: January 11, 2013
    Publication date: July 4, 2013
    Applicant: The University of Florida Research Foundation, Inc.
    Inventor: The University of Florida Research Foundation, Inc.
  • Patent number: 8461192
    Abstract: PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1?,2?,3?,4?)], (ICA-1), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to selectively inhibit the proliferation of cells that overexpress PKCiota.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: June 11, 2013
    Assignees: The University of South Florida, The United States of America Department of Veterans Affairs, The University of Florida Research Foundation, Inc.
    Inventors: Mildred Acevedo-Duncan, Shraddha R. Desai, Hla Yee Win, David A. Ostrov, Prajit P. Pillai, Diondra D. Hill
  • Patent number: 8295951
    Abstract: Techniques, systems and methods for designing, implementing, and operating model predictive controllers that can deliver perfect tracking of set points and that can reject the effect of disturbances when steady-state operation is reached are disclosed. High performance is achieved through the incorporation of set-point tracking costs, integral costs, and velocity costs, as well as the adoption of incremental model systems for prediction purposes. Embodiments can deliver offset-free performance for tracking set points with constant final values, set points of a ramp type, and set points of a parabolic form, while rejecting disturbances that have a constant final value. The approach reduces the complexity of model predictive control design, delivers improved performance, and requires modest computational power.
    Type: Grant
    Filed: December 20, 2008
    Date of Patent: October 23, 2012
    Assignee: The University of Florida Research Foundation, Inc.
    Inventors: Oscar D. Crisalle, Ricardo Gomez Gonzalez, Christopher S. Peek
  • Patent number: 8231948
    Abstract: A method of forming integral articles having non-line-of-site contours includes the steps of providing a plurality of molds, the molds having at least one mold channel therethrough. The plurality of molds are stacked on one another to form a mold stack, wherein at least one portion of the mold stack provides a non-line of sight multi-level channel through at least partial overlap of the mold channels between adjacent ones of the plurality of molds. A flowable material is applied to the mold stack. The flowable material is pressed to fill the mold channels in each of the plurality of molds to form an integral article comprising a plurality of stacked integrally connected levels of the material, wherein through interconnection of the integrally connected levels the integral article provides at least one non-line of sight contour traversing in its thickness direction. The mold stack is then separated or removed to free the integral article.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: July 31, 2012
    Assignee: The University of Florida Research Foundation, Inc.
    Inventors: Wallace Gregory Sawyer, Tony L. Schmitz, John C. Ziegert, Jeffrey Alan Bardt, Gerald R. Bourne
  • Patent number: 7919577
    Abstract: ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: April 5, 2011
    Assignees: Colorado Seminary, Oklahoma Medical Research Foundation, The University of Florida Research Foundation, Inc.
    Inventors: Miles B. Brennan, Jessica L Costa, Robert M. Dores, Ute H. Hochgeschwender, Carrie Haskell-Luevano
  • Patent number: 7892809
    Abstract: The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: February 22, 2011
    Assignees: The University of North Carolina at Chapel Hill, The University of Florida Research Foundation
    Inventors: Dawn E. Bowles, Chengwen Li, Joseph E. Rabinowitz, Josh Grieger, Mavis Agbandje-McKenna, Richard Jude Samulski
  • Publication number: 20100196978
    Abstract: Disclosed are recombinant host cells suitable for degrading an oligosaccharide that have been optimized for growth and production of high yields of ethanol, and methods of making and using these cells. The invention further provides minimal media comprising urea-like compounds for economical production of ethanol by recombinant microorganisms. Recombinant host cells in accordance with the invention are modified by gene mutation to eliminate genes responsible for the production of unwanted products other than ethanol, thereby increasing the yield of ethanol produced from the oligosaccharides, relative to unmutated parent strains. The new and improved strains of recombinant bacteria are capable of superior ethanol productivity and yield when grown under conditions suitable for fermentation in minimal growth media containing inexpensive reagents. Systems optimized for ethanol production combine a selected optimized minimal medium with a recombinant host cell optimized for use in the selected medium.
    Type: Application
    Filed: June 30, 2006
    Publication date: August 5, 2010
    Applicant: The University of Florida Research Foundation, Inc
    Inventors: Brent E. Wood, Lonnie O. Ingram, Lorraine P. Yomano, Sean W. York
  • Publication number: 20100154565
    Abstract: Exemplary embodiments provide a micro-scale optical force sensor. The device includes a scale grating, a linearly displaceable index grating positioned above and in initial alignment with the scale grating, the index grating aligned with the scale grating absent a force applied to the index grating, and a compliant linkage assembly joined coplanar to the displaceable index grating. The linkage assembly includes at least three rigid support links laterally extending from each of opposing longitudinal edges of the index grating, a displaceable rigid link formed between adjacent support links, and compliant links interposed between a distal end of rigid support links and an inner end of each displaceable rigid link, and interposed between an outer end of rigid support links and the substrate, the compliant links normally biasing the displaceable rigid link parallel to the rigid support links and perpendicular to a longitudinal axis of the index grating.
    Type: Application
    Filed: January 16, 2008
    Publication date: June 24, 2010
    Applicant: The University of Florida Research Foundation, Inc
    Inventors: Gloria J. Wiens, Gustavo Andres Roman
  • Publication number: 20090286321
    Abstract: Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also disclosed are pharmaceutical compositions, virus particles, host cells, and pharmaceutical formulations that comprise these modified vectors useful in the expression of therapeutic proteins, polypeptides, peptides, antisense oligonucleotides and/or ribozymes in the cells and tissues of selected mammals, including, for example, human tissues and host cells.
    Type: Application
    Filed: January 30, 2009
    Publication date: November 19, 2009
    Applicant: The University of Florida Research Foundation, Inc.
    Inventors: Kenneth H. Warrington, Shaun R. Opie, Nicholas Muzyczka
  • Publication number: 20090148411
    Abstract: Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also disclosed are pharmaceutical compositions, virus particles, host cells, and pharmaceutical formulations that comprise these modified vectors useful in the expression of therapeutic proteins, polypeptides, peptides, antisense oligonucleotides and/or ribozymes in the cells and tissues of selected mammals, including, for example, human tissues and host cells.
    Type: Application
    Filed: January 30, 2009
    Publication date: June 11, 2009
    Applicant: The University of Florida Research Foundation, Inc
    Inventors: Kenneth H. Warrington, Shaun R. Opie, Nicholas Muzyczka
  • Patent number: 7514249
    Abstract: The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: April 7, 2009
    Assignee: The University of Florida Research Foundation, Inc.
    Inventors: Laurie B. Gower, Matthew J. Olszta, Elliot P. Douglas, Sivakumar Munisamy, Donna L. Wheeler
  • Publication number: 20090074723
    Abstract: A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.
    Type: Application
    Filed: October 18, 2008
    Publication date: March 19, 2009
    Applicants: The Trustees of the University of Pennsylvania, The University of Florida Research Foundation, Inc., Cornell Research Foundation, Inc.
    Inventors: Gregory M. Acland, Gustavo D. Aguirre, Jean Bennett, William W. Hauswirth, Samuel G. Jacobson, Albert M. Maguire
  • Patent number: PP19341
    Abstract: A southern highbush blueberry (Vaccinium corymbosum) cultivar particularly distinguished by having a low chilling requirements (300 hours below 7° C.) with prolific early-spring leafing, a vigorous, dense bush with numerous canes, dark green leaves and good survival in the field, early ripening (50% ripe berries in north Florida by May 5) and a high yield of berries that are sweet and firm with a small, dry picking scar.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: October 14, 2008
    Assignee: The University of Florida Board of Trustees
    Inventor: Paul M. Lyrene
  • Patent number: PP19381
    Abstract: A southern highbush blueberry (Vaccinium corymbosum) cultivar particularly distinguished by having a very low chilling requirement (300 hours below 7° C.) with leaves that are evergreen to semi-evergreen and smaller than typical southern highbush leaves with a striking blue-green color, plants flowers early in the spring and produces medium sized, light-blue colored berries that have excellent flavor and texture is disclosed.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: October 28, 2008
    Assignee: The University of Florida Board of Trustees
    Inventor: Paul M. Lyrene
  • Patent number: PP27128
    Abstract: A new and distinct variety of peach tree, denominated ‘GulfAtlas’, has a winter chilling requirement estimated at approximately 400 chill units (cu). The tree is medium size, moderately vigorous, and semi-spreading in growth habit. It bears showy, pink flowers, and leaves with reniform glands. Trees of ‘GulfAtlas’ are self-fertile and regularly bear heavy annual crops. Fruit are uniformly firm and have yellow, non-melting flesh. Fruit are nearly round, and uniform with substantially symmetrical shape, and have an attractive approximately 75% red skin. The fruit of ‘GulfAtlas’ typically ripen about 3 weeks after ‘Gulfcrimson’ in midJune at Attapulgus, Ga.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 6, 2016
    Assignees: The United States of America, as represented by the Secretary of Agriculture, The University of Georgia Research Foundation Inc., The University of Florida
    Inventors: Thomas G Beckman, Jose X Chaparro, Patrick J Conner