Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: Methods of using the small molecule STAT3 inhibitor LLL 12B in the treatment of cancer, such as triple-negative breast cancer (TNBC) and pancreatic cancer, either alone or in combination with additional therapeutic agents, such as PARP inhibitors and CDK inhibitors, are provided.

Abstract: In one aspect, the disclosure relates to a smart pseudo-palate for use in a Smart Electropalatograph (EPG) for Linguistic and Medical Applications (SELMA) system. In one aspect, the pseudo-palate is constructed from a thin, flexible polymer membrane and having an embedded electrode array. The pseudo-palate is configured to detect tongue contacts during speech while causing minimal disturbance or interference with speech motion. The disclosed pseudo-palate in the SELMA system is integrated with a microcontroller, wireless electronic module, and external readout app. The disclosure, in another aspect, relates to integration of the pseudo-palate with a smart sports/health mouth guard containing a series of sensors for monitoring head impacts, body temperature, and heart rate.

Abstract: Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for ?9, ?9?10, and ?7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for ?9-containing receptors than for ?7, and the majority were either full or strong partial agonists for ?9-containing nAChR.

Abstract: The present disclosure describes various embodiments of systems, apparatuses, and methods of monitoring wind and water properties. For one such weather monitoring system, a weather monitoring station comprises an upper mast section having an instrumentation package, wherein the instrumentation package includes an orientation sensor, communications circuitry, a wind velocity sensor, and a control unit that is configured to at least receive sensor data and transmit communication data via the communications circuitry. The weather monitoring station further includes at least one lower mast section that is coupled to the upper mast section, and an anchoring system that is coupled to the lower mast section, wherein the anchoring system includes at least one subsurface anchor for inserting into a ground surface within a littoral zone of a coastal area. Other systems, apparatuses, and methods are also provided.

Abstract: The present invention provides antibody compounds that contain a substitution of arginine for the reactive lysine residue (Lys99) in the hydrophobic cleft (38C2_Arg). The invention also provides antibody drug conjugate compounds (ADCs) that contain cargo moieties that are site-specifically conjugated to the engineered arginine residue in the 38C2_Arg variant antibody. Further provided in the invention are therapeutic applications of the compounds.

Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: The present disclosure describes digital watermark detection systems and methods. In one such system, a plurality of intellectual property cores are integrated on a system-on-chip, such that the intellectual property cores comprise a first intellectual property core and a second intellectual property core. The system further includes a first network interface connected to the first intellectual property core that can encode a first digital watermark into a packet stream designated for the second intellectual property core. The system further includes a second network interface connected to the second intellectual property core that can receive the packet stream and decode the packet stream to generate a second digital watermark. The second network interface is further configured to perform a validation test on the packet stream and deliver the packet stream to the second intellectual property core when the first digital watermark is determined to match the second digital watermark.

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. This disclosure also relates to recombinant adeno associated virus (rAAV) capsid proteins comprising one or more amino acid substitutions in the 5-fold region of the rAAV capsid that result in decreased reactivity to neutralizing antibodies, and their use as gene delivery vehicles.

Abstract: A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed in (e.g., continuously printed using a moving dispensing nozzle) a yield-stress support bath to form an intermediate article. The intermediate article may be liquid or only partially coagulated after being printed into the yield-stress support bath. The yield-stress support bath may be at least partially disposed within a container, and the container may be immersed in a post-treatment coagulation solution to remove some or all of the solvent, causing the build material to fully solidify to form a finished article from the intermediate article.

Abstract: Provided herein are AAV inverted terminal repeats (ITRs) comprising modifications that are useful for improved expression of a transgene to muscle cells/tissue. ITRs as described herein comprise a myoblast determination protein (MyoD) binding site and/or myocyte enhancer factor (MEF) binding site. to improve transgene expression in muscle cells/tissue. Provided herein are also AAV particles comprising modified ITRs. and method of making and using them.

Abstract: In some aspects, the disclosure relates to compositions and methods that are useful for treating inflammatory disorders and conditions. In some embodiments, the disclosure provides recombinant adeno-associated virus (rAAV) vectors and particles encoding a transgene that expresses a Myxomavirus serine proteinase inhibitor (Serp) protein (e.g., Serp-1) and methods for treating inflammatory disorders using the same.

Abstract: Provided herein are methods of site-specific integration of a heterologous sequence into a host genome (e.g., by administering a recombinant adeno-associated virus (rAAV) to a host cell in the presence of a Rep protein), and methods for treating diseases and disorders by delivering an rAAV that comprises a nucleic acid vector comprising a Rep protein. Also provided herein are methods and compositions for producing rAAV particles with improved titer and transduction efficiencies.

Abstract: Disclosed herein are compositions, devices, and methods for isolating human Adipose-derived stem cells (ASCs) without either electricity or enzymatic digestion. In particular, a paramagnetic immunobead (PIB) for isolating human ASCs is disclosed. In some embodiments, the PIB displays on its surface one or more antibodies that selectively bind ASC-specific antigens. Also disclosed is a method for isolating human ASCs using the disclosed PIBs.

Abstract: Various examples are provided related to electrochemical phosphate/pH (P/pH) sensors, systems and related methods. In one example, a P/pH sensor includes a substrate and collocated phosphate (P) electrode and pH electrode formed on a surface of the substrate. The P electrode includes a cobalt (Co) sensing window disposed on a first copper (Cu) sensor pad; and the pH electrode includes an antimony (Sb) sensing window disposed on a second Cu sensor pad. The P/pH sensor can include a reference electrode, and may also include other sensor electrodes such as, e.g., a nitrate electrode.

Abstract: The present disclosure relates to systems and methods for tunable electrodynamic wireless power receivers. In some examples, a wireless power receiver electromechanically converts energy from a magnetic field using an oscillating or continuously rotating magnet. A sensing device detects an operational parameter of the receiver, and a tuning device initiates a tuning action based on the operational parameter.

Abstract: A universal insect trap having multiple points of entry is described being capable of capturing various types and sizes of insects. The universal insect trap may be used to capture and preserve target species such that genomes can be analyzed for specimens, which is beneficial in determining infection rates, strains of a vector or a pathogen, identifying associated microorganisms, determining or monitoring natural enemies, etc. The universal insect trap can include a base having a cone-shaped body, where the base includes a sloped surface. Further, the universal insect trap can include a dome portion and a trap portion. The trap portion can include an annular ring, a mounting portion, a vial, and an aggregation pheromone positioned in the trap portion, where the aggregation pheromone is one that emits a predetermined amount of pheromones over time to attract at least one predetermined type of insect.

Abstract: Disclosed herein are compositions and methods for treating obesity involving satiation gut peptide administration to the mouth of a subject for a predetermined dose and frequency. In other embodiments, materials and methods of treating certain psychological disorders are disclosed involving satiation gut peptides. In exemplary embodiments, the satiation gut peptide pertains to PYY.

Abstract: The present disclosure provides for porous polymer materials that include an ordered array of voids separated by a polymer framework. The porous polymer material can have a recovery state where the voids are in an uncollapsed state and iridescent color, and a deformed state having voids in a collapsed state that is non-iridescent or substantially transparent. The materials can have regions of both states simultaneously. Also described are methods for fabricating a polymer material as above, as well as chromogenic sensors including the polymer material. The sensors can have hidden anti-counterfeiting patterns, hydrophobic/oleophobic properties, and chromogenic transformation can be triggered by various stimuli such as solid target compounds, light energy, and more.

Abstract: Disclosed herein are materials and methods for the treatment of stress-related disorders and cancer. The disclosure provides an antibody, or antigen binding fragment thereof, that specifically binds to a region of corticotropin-releasing hormone (CRH). The disclosure also provides methods of treating a disorder associated with HPA axis activation, such as a stress-related disorder or cancer, comprising administering to a subject in need thereof an antibody or antigen binding fragment thereof described herein in an amount effective to treat the disorder.