Abstract: Disclosed are saturated cyclic monopolymers derived from hexyne, octyne, nonyne, pentadecyne and saturated cyclic copolymers derived from acetylene and a second alkyne monomer that is hexyne, octyne, nonyne, or pentadecyne.

Abstract: The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.

Abstract: The present disclosure provides systems and methods for timed unlocking and locking of hardware intellectual properties obfuscation. One such method includes determining whether received key inputs match a functional key sequence of an integrated circuit or a test key sequence of the integrated circuit; permanently enabling operation of the integrated circuit responsive to the received key inputs being determined to be a functional key sequence for permanently enabling operation of the integrated circuit; temporarily enabling operation of the integrated circuit responsive to the received key inputs being determined to be the test key sequence for temporarily enabling operation of the integrated circuit to perform testing of the functionality and disable thereafter; and locking sequential logic and combinational logic of the integrated circuit if the received key inputs are determined to not be either the functional key sequence or the test key sequence. Other systems and methods are also provided.

Abstract: The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)).

Abstract: Disclosed herein are novel methods for administration of rAAV particles having enhanced transduction properties, comprising the pre-incubation and co-administration of AAV capsids and polyvinyl alcohol (PVA). The disclosed methods of rAAV particle administration have improved efficiency in transducing mammalian liver and hematopoetic cells in vivo. The disclosed methods are suitable for use with a variety of AAV capsid serotypes and presudotypes and improve vector potency, thus lowering the concentration of rAAV particle required to achieve the desired effect. Further disclosed herein are buffers for storage and manufacturing of rAAV particles comprising PVA.

Abstract: Embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for detecting objects located in an area of interest. In accordance with one embodiment, a method is provided comprising: receiving, via an interface provided through a general instance on a cloud environment, imaging data comprising raw images collected on the area of interest; upon receiving the images: activating a central processing unit (CPU) focused instance on the cloud environment and processing, via the image, the raw images to generate an image map of the area of interest; and after generating the image map: activating a graphical processing unit (GPU) focused instance on the cloud environment and performing object detection, via the image, on a region within the image map by applying one or more object detection algorithms to the region to identify locations of the objects in the region.

Abstract: The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II.

Abstract: Embodiments herein provide for reverse engineering of integrated circuits (ICs) for design verification. In example embodiments, an apparatus receives a gate-level netlist for an integrated circuit (IC), generates a list of equivalence classes related to signals included in the gate-level netlist, determines control signals of the gate-level netlist based at least in part on the list of equivalence classes, determines a logic flow of a finite state transducer (FST) based at least in part on the control signals, and generates register transfer level (RTL) source code for the IC based on the FST.

Abstract: Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.

Abstract: Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm.

Abstract: Methods, apparatus and computer program product for protecting a confidential integrated circuit design process.

Abstract: Provided herein are methods and compositions useful in the production of recombinant AAV (rAAV) in host producer cells, such as insect cells. In some embodiments, methods, uses and compositions are provided that comprise recombinant VP1 genes comprising modified Kozak sequences to express AAV VP1 proteins in amounts that are useful for producing infective rAAV particles. These infective rAAV particles may comprise a gene of interest.

Abstract: Aspects of the disclosure relate to compositions and methods for eliciting (or enhancing) anti-repeat-associated non-ATG (RAN) protein antibody expression or production in a subject. Administration of the compositions according to the methods of the present disclosure may in some embodiments result in decreased levels of RAN protein expression and/or aggregation. Such compositions and methods may therefore be useful for the treatment of diseases and disorders known to be associated with RAN proteins.

Abstract: A series of PRMT5 inhibitor compounds are described. The compounds are useful as PRMT5 inhibitor compounds and in the treatment of PRMT5 mediated diseases, disorders, and symptoms thereof.

Abstract: A method is provided for identifying synthetic “deep-fake” audio samples versus organic audio samples. Methods may include: generating a model of a vocal tract using one or more organic audio samples from a user; identifying a set of bigram-feature pairs from the one or more audio samples; estimating the cross-sectional area of the vocal tract of the user when speaking the set of bigram-feature pairs; receiving a candidate audio sample; identifying bigram-feature pairs of the candidate audio sample that are in the set of bigram-feature pairs; calculating a cross-sectional area of a theoretical vocal tract of a user when speaking the identified bigram-feature pairs; and identifying the candidate audio sample as a deep-fake audio sample in response to the calculated cross-sectional area of the theoretical vocal tract of a user failing to correspond within a predetermined measure of the estimated cross sectional area of the vocal tract of the user.

Abstract: Provided herein are methods and compositions useful in the screening and production of recombinant AAV (rAAV) that have structural fitness and potency in insect cells and mammalian cells. The disclosure provides a directed evolution system for generating and selecting rAAV variants based on their Kozak sequences. In some embodiments, methods disclosed herein comprise the use of modified Kozak sequences to express AAV2 VP1 proteins in amounts that are useful for producing rAAV particles having high infectivities and/or transduction efficiencies. In some embodiments, methods of producing, and methods of screening, rAAV are provided that comprise the steps of infecting insect cells by administering rAAV to these cells, recovering rAAV-integrated DNA from these insect cells, and transfecting recovered rAAV into mammalian cells. Also provided herein are nucleic acids comprising nucleotide sequences encoding novel Kozak sequences.

Abstract: The present disclosure describes systems and methods for identifying defective components in a power integrated circuit. In one such system, a voltage regulator circuit is embedded in an integrated circuit device, wherein the voltage regulator circuit includes a control feedback loop having a compensation capacitor that is configured to maintain a stable output voltage of the voltage regulator voltage at a set value or range. Additionally, a test circuitry is embedded in the integrated circuit device, wherein the test circuitry comprises a voltage source that is configured to generate a cyclical test input signal that passes through the control feedback loop. Accordingly, the test circuitry is configured to provide a test output signal to an output pin of the integrated circuit device that indicates a performance level of the compensation capacitor in the control feedback loop of the voltage regulator circuit. Other systems and methods are also included.

Abstract: An acoustic waveguide having high-Q resonator characteristics is disclosed and a fabrication method is described. Various waveguide-based test-vehicles, implemented in single crystal silicon and transduced by thin aluminum nitride films, are demonstrated. Silicon resonators with type-I and type-II dispersion characteristics are presented to experimentally justify the analytical mode synthesis technique for realization of high quality-factor silicon Lamb wave resonators. An analytical design procedure is also presented for geometrical engineering of the waveguides to realize high-Q resonators without the need for geometrical suspension through narrow tethers or rigid anchors. The effectiveness of the dispersion engineering methodology is verified through development of experimental test-vehicles in 20 ?m-thick single-crystal silicon (SCS) waveguides with 500 nm aluminum nitride transducers.

Abstract: Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders.

Abstract: Wireless power transmission (WPT) systems are provided. For example, the WPT system can use one or more power transmitting coils and a receiver for electromagnetically coupled wireless power transfer. The electrodynamic receiver can be in the form of an electrodynamic transducer where a magnet is allowed to oscillate near a receiving coil to induce a voltage in the receiving coil, a piezoelectric transducer where the magnet causes a vibrating structure with a piezoelectric layer to move, an electrostatic transducer where movement of the magnet causes a capacitor plate to move, or a combination thereof. An alternating magnetic field from the transmitting coil(s) excites the magnet in the receiver into mechanical resonance. The vibrating magnet then functions similar to an energy harvester to induce voltage/current on an internal coil, piezoelectric material, or variable capacitor.