Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.
Type:
Grant
Filed:
November 27, 2017
Date of Patent:
March 2, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
February 2, 2021
Assignees:
Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.
Inventors:
Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
Abstract: Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.
Type:
Grant
Filed:
April 8, 2015
Date of Patent:
February 2, 2021
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: Herein provided is a new soybean variety designated ‘G13LL-44’ as well as the seeds, plants and derivatives of the new soybean variety ‘G13LL-44’. Also provided are tissue cultures of the new soybean variety ‘G13LL-44’ and the plants regenerated therefrom. Methods for producing soybean plants by crossing the new soybean variety ‘G13LL-44’ with itself or another soybean variety and plants produced by such methods are also provided. ‘G13LL-44’ is a MG VII line with glufosinate tolerance technology, and with resistance to race 3 of the soybean cyst nematode and frogeye leaf spot, and moderate resistance to southern root-knot nematode. ‘G13LL-44’ yielded 1.4 bu/ac (2.3%) greater than its recurrent parent ‘G00-3213’, across 11 environments and 0.5 bu/ac more than the high-yielding check cultivar ‘AG738 RR’. ‘G13LL-44’ provides a high yielding glufosinate tolerant soybean cultivar with superior nematode resistance.
Type:
Grant
Filed:
March 20, 2019
Date of Patent:
January 5, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Zenglu Li, Edwin D. Wood, H. Roger Boerma, James P. Noe, James W. Buck
Abstract: This disclosure relates to synthetic oligosaccharide subunits of the Pseudomonas exosaccharide Psi and uses thereof, e.g., for epitope mapping of anti-Psl antibodies, for identification of anti-Psl antibodies, and for use as vaccines. In one aspect a synthetic oligosaccharide subunit of a Pseudomonas aeruginosa Psl oligosaccharide is provided, comprising the trisaccharide of formula I.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
December 22, 2020
Assignees:
MedImmune Limited, University of Georgia Research Foundation, Inc.
Inventors:
Antonio DiGiandomenico, Qun Wang, Charles K. Stover, Geert-Jan Boons, Kai-For Mo, Huiqing Li
Abstract: Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.
Type:
Grant
Filed:
August 2, 2019
Date of Patent:
November 24, 2020
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
November 3, 2020
Assignees:
University of Georgia Research Foundation, Inc., Augusta University Research Institute, Inc.
Abstract: The present application provides methods of igniting a fuel source with a lighter fluid composition including fusel oil; self-lighting charcoal briquettes infused with fusel oil, flammable compositions including fusel oil, methods of making flammable compositions including fusel oil, and lighter devices including fusel oil.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
October 13, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Ryan B. Adolphson, Daniel P. Geller, Levi T. Mills, Marcus Leonard Smith, Fredrick W. Huszagh, II
Abstract: The subject invention relates in part to a combination of a cadherin peptide derived from Alphitobius diaperinus and a Cry protein capable of inhibiting an insect. In certain embodiments, the combination is capable of overcoming Cry protein resistance in insects that are resistant to the Cry protein alone.
Type:
Grant
Filed:
February 6, 2017
Date of Patent:
September 29, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new and distinct cultivar of Nandina plant named ‘ZhNan28’, characterized by a combination of compact growing form, dense foliage, orange red (apricot) fall foliage persistent to 6 months, no seed, and no notable disease and pest.
Type:
Grant
Filed:
December 18, 2019
Date of Patent:
October 27, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Donglin Zhang, Matthew Dirr, Jinying Dong
Abstract: A new and distinct cultivar of Nandina plant named ‘ZhNan53’, characterized by a combination of compact growing form, dense foliage, red fall foliage persistent to 6 months, no seed, and no notable disease and pest.
Type:
Grant
Filed:
December 18, 2019
Date of Patent:
November 3, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Donglin Zhang, Matthew Dirr, Jinying Dong
Abstract: A new and distinct cultivar of Nandina plant named ‘ZhNan102’, characterized by a combination of compact growing form, dense foliage, golden yellow fall foliage persistent to 6 months, no seed, and no notable disease and pest.
Type:
Grant
Filed:
December 18, 2019
Date of Patent:
November 17, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Donglin Zhang, Matthew Dirr, Jinying Dong
Abstract: The new variety ‘TH-1334’ ripens around mid-April in southeastern Georgia. The fruit of the new variety ‘TH-1334’ are very large, firm, have good flavor and scar. The new variety ‘TH-1334’ is vigorous with an estimated chilling requirement of about 50 to 100 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
Type:
Grant
Filed:
November 7, 2019
Date of Patent:
January 5, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new Ilex plant named ‘RutHol4’ is characterized by a combination of an attractive pyramidal growth habit, potential for use in containers or as a small hedge.
Type:
Grant
Filed:
December 5, 2019
Date of Patent:
January 19, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new and distinct cultivar of Abelia plant named ‘00-BC-46-4’, characterized by a combination of attractive foliage, compact form, large flower panicles, heavy blooming, and low maintenance requirements.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
February 16, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Carol Robacker, Sloane Michele Scheiber, Sherrod Baden, Allen Byous
Abstract: A new and distinct cultivar of Abelia plant named ‘99-6-7’, characterized by a combination of large flower panicles of pink/purple flowers and sepals, earliness to flower, and heavy blooming from May to September.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
February 16, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Carol Robacker, Sloane Michele Scheiber, Sherrod Baden, Allen Byous
Abstract: A new cultivar of Ilex plant named ‘RutHol2’ is characterized by a combination of its compact, rounded growth habit, its resistance to damage from spider mites, its need for little pruning, its burgundy color new growth, and its ability to be used in large containers with other plants.
Type:
Grant
Filed:
December 5, 2019
Date of Patent:
February 16, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A new Ilex plant named ‘RutHol3’ is characterized by a combination of its upright, narrow growth habit, its attractive burgundy new growth, its glossy green mature foliage, its quick growth and resistance to spider mites.
Type:
Grant
Filed:
December 5, 2019
Date of Patent:
March 2, 2021
Assignee:
University of Georgia Research Foundation, Inc.