Patents Assigned to The University of Hawaii
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Patent number: 9995282Abstract: A selectively perceptible wind turbine system provides illumination in a low intensity and wavelength invisible to the human eye, but visible to certain bats. This illumination deters bats and other flying animals from going near the turbine without becoming a nuisance. At least one ultraviolet (UV) illumination source produces at least one UV beam with a wavelength of approximately 200 nm to approximately 400 nm. This UV beam extends between the UV illumination source and at least one turbine blade surface of a turbine blade. Contact between the UV beam and the turbine blade surface forms an illumination interface with a power density of less than 100 ?W/cm2.Type: GrantFiled: December 9, 2015Date of Patent: June 12, 2018Assignees: The United States of America as Represented by the Secretary of the Department of the Interior, University of Hawaii, Bat Reseach and ConsultingInventors: Paul Michael Cryan, David Charles Dalton, Paulo Marcos Gorresen
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Patent number: 9867549Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: August 17, 2015Date of Patent: January 16, 2018Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Publication number: 20180011098Abstract: In accordance with some embodiments herein, methods of determining signatures of HMGB1 isoforms in a subject are provided. In some embodiments, antibodies that bind specifically to HMGB1 isoforms are provided. In some embodiments, immunoassay kits are provided.Type: ApplicationFiled: January 19, 2016Publication date: January 11, 2018Applicant: University of HawaiiInventors: Haining Yang, Michele Carbone
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Patent number: 9801562Abstract: The disclosure herein provides cardiac monitoring and diagnostic system, methods, and devices. A cardiac diagnostic system for detecting potential indicators of cardiac disease comprises: a cardiac monitoring device comprising at least one electrode configured to detect an analog electrical cardiac signal of a user; a cardiac signal filter configured to convert the analog electrical cardiac signal to digital electrocardiogram data; an atypical cardiac sequence detector configured to detect atypical cardiac patterns in the electrocardiogram data that are potentially indicative of cardiac disease; and a notification transmitter configured to generate an alert when a detected atypical cardiac pattern is determined to be indicative of cardiac disease.Type: GrantFiled: June 1, 2015Date of Patent: October 31, 2017Assignee: UNIVERSITY OF HAWAIIInventor: Anders Host-Madsen
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Patent number: 9802888Abstract: The present disclosure provides pharmaceutical compositions comprising Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of use.Type: GrantFiled: March 21, 2014Date of Patent: October 31, 2017Assignee: UNIVERSITY OF HAWAIIInventors: James Turkson, Patrick Gunning, Sina Haftchenary
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Patent number: 9782141Abstract: The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion.Type: GrantFiled: January 29, 2014Date of Patent: October 10, 2017Assignees: KINETICOR, INC., THE UNIVERSITY OF HAWAII, THE QUEEN'S MEDICAL CENTERInventors: Jeffrey N. Yu, Thomas Michael Ernst
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Patent number: 9676788Abstract: Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).Type: GrantFiled: February 5, 2015Date of Patent: June 13, 2017Assignees: The United States of America, as represented by the Secretary of Health and Human Services, University of HawaiiInventors: William J. Chain, John A. Beutler, David Fash, William D. Figg, Zhenwu Li, Cody John Peer, Joe William Ramos, Florian J. Sulzmaier
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Patent number: 9664563Abstract: A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.Type: GrantFiled: December 1, 2010Date of Patent: May 30, 2017Assignee: University of HawaiiInventor: Paul Lucey
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Patent number: 9567597Abstract: Embodiments provided herein generally relate to methods and materials for ultrasound-mediated introduction of exogenous substances into microorganisms. Some embodiments relate to methods of introducing an exogenous material into a microorganism such as an algae. The methods can include, for example, providing a microorganism (e.g., algae); providing a population of bubbles that comprise one or more nucleic acid molecules and/or one or more polypeptide or one or more protein molecules; contacting the population of bubbles with the algae; applying ultrasound to the bubbles and algae with sufficient energy to cavitate one or more of bubbles comprising the one or more nucleic acid molecules in proximity to the algae; and maintaining the algae and the one or more burst bubbles comprising the one or more nucleic acid molecules in contact for a period of time sufficient to permit entry of at least one nucleic acid molecule into the algae.Type: GrantFiled: May 11, 2013Date of Patent: February 14, 2017Assignee: UNIVERSITY OF HAWAIIInventors: Eric Liaw, Chad B. Walton, Ralph V. Shohet
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Patent number: 9561274Abstract: Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of high-mobility group box 1 (HMGB1).Type: GrantFiled: June 7, 2012Date of Patent: February 7, 2017Assignee: UNIVERSITY OF HAWAIIInventors: Haining Yang, Michele Carbone, Marco E. Bianchi
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Patent number: 9526438Abstract: A microwave stethoscope measurement method and sensor design employ a microwave transmission sensor and a microwave reception sensor placed on a patient's chest in spaced-apart side-by-side configuration for monitoring patient vital signs, lung water content and other critical measurements. The side-by-side sensors are spaced apart a separation distance of about 1-3 cm in lateral chest orientation. The sensors may be formed with a textile fabric for wearer comfort and to improve contact with the patient's skin. The microwave sensor measurements are digitally processed using a modified short time Fourier Transform (STFT) spectrum windowed-averaged algorithm. Output data extracted from the microwave sensor measurements may be transmitted wirelessly to a mobile device such as a smartphone for remote monitoring of the patient's medical condition.Type: GrantFiled: April 25, 2014Date of Patent: December 27, 2016Assignee: University of HawaiiInventors: Magdy F. Iskander, Nuri Celik, Ruthsenne Gagarin, Gui Chao Huang, Darcy Alan Bibb
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Publication number: 20160347764Abstract: Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).Type: ApplicationFiled: February 5, 2015Publication date: December 1, 2016Applicants: The United State of America, as represented by the Secretary, Department of Health and Human Service, University of HawaiiInventors: William J. Chain, John A. Beutler, David Fash, William D. Figg, Zhenwu Li, Cody John Peer, Joe William Ramos, Florian J. Sulzmaier
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Patent number: 9475766Abstract: Compounds of formula II are described: wherein D, n, Ra, Rb, and Rc are as herein defined, along with pharmaceutical compositions and methods of using compounds of formula II for treating or reducing the risk of peritoneal carcinomatosis in a patient.Type: GrantFiled: August 26, 2013Date of Patent: October 25, 2016Assignees: Cephalon, Inc., University of Utah Research Foundation, University of HawaiiInventors: Bruce D. Dorsey, Scott K. Kuwada, Jay P. Theroff, Craig A. Zificsak
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Patent number: 9425799Abstract: The present invention provides apparatuses and methods for chaos computing. For example, a chaos-based logic block comprises an encoding circuit block, at least one chaotic circuit block, a bias voltage generating circuit block, and a threshold circuit block. The encoding circuit block converts a plurality of digital inputs to an analog output. The plurality of digital inputs may comprise at least one data input and at least one control input. At least one chaotic circuit block is configured to iterate converting an input signal to an output signal by feeding the output signal to at least one chaotic circuit as the input signal at each iteration. The bias voltage generating circuit block converts a plurality of binary control inputs to a bias voltage. The threshold circuit block compares the output signal with a predetermined threshold, thereby generating a digital signal.Type: GrantFiled: March 6, 2015Date of Patent: August 23, 2016Assignee: University of HawaiiInventors: William Ditto, Behnam Kia
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Patent number: 9355716Abstract: A method for determining decision metrics in a detector for a memory device. The method includes receiving a plurality of signal samples and extracting a set of statistics from the signal samples, wherein at least one of the statistics is non-linear or complex, is derived from a plurality of the signal samples, and is not a function of at least one real linear statistic that is derived from a plurality of the signal samples. The method also includes applying at least one decision metric function to the set of statistics to determine at least one decision metric value corresponding to at least one postulated symbol.Type: GrantFiled: January 17, 2014Date of Patent: May 31, 2016Assignee: University of HawaiiInventors: Meysam Asadi, Xiujie Huang, Aleksandar Kavcic
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Publication number: 20160137663Abstract: The present disclosure provides a method of purifying pharmaceutical compositions consisting essentially of STAT3 inhibitors from a mixture of compounds, pharmaceutical compositions comprising STAT3 inhibitors used to inhibit STAT3 in tumor cells, and certain pharmaceutically acceptable salts thereof, and methods of use.Type: ApplicationFiled: June 20, 2014Publication date: May 19, 2016Applicant: UNIVERSITY OF HAWAIIInventors: Leng Chee CHANG, James TURKSON, Spuakit WONGWIWATTHANANUKIT, Ui Joung YOUN, Dianqing SUN
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Patent number: 9315531Abstract: Titanocene-gold compounds are provided that are useful for treating cancers.Type: GrantFiled: June 5, 2015Date of Patent: April 19, 2016Assignees: Research Foundation of the City University of New York, University of HawaiiInventors: Maria Contel, Jacob Fernandez-Gallardo, Benelita T. Elie, Joe W. Ramos
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Patent number: RE45911Abstract: Embodiments of the present invention provide polymer matrix nanocomposites reinforced with nano-scale materials such as nanoparticles and carbon nanotubes and methods of fabricating. The nanomaterials are provided within relatively low weight fractions, for example in the range of approximately 0.01 to about 0.4% by weight and distributed within the matrix by a magnetic mixing procedure to provide substantially uniform reinforcement of the nanocomposites. Advantageously, these nanocomposites provide significantly enhanced tensile strength, strain to failure, and fracture toughness over corresponding neat matrices.Type: GrantFiled: September 9, 2011Date of Patent: March 1, 2016Assignee: University of HawaiiInventors: Mohammad Naghi Ghasemi Nejhad, Vinod P. Veedu, Andrea Yuen, Davood Askari
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Patent number: PP28567Abstract: A new cultivar of Colocasia plant named ‘Tropical Storm’ that is characterized by very compact, prolific basal branching and leaves which are purple-black in color except for a prominent contrasting cream-yellow central streak.Type: GrantFiled: July 7, 2016Date of Patent: October 24, 2017Assignee: University of HawaiiInventor: John J. Cho
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Patent number: PP29636Abstract: A new cultivar of Leucadendron plant named ‘Hawaii Magic’ that is distinguished by compact bushy plant habit, foliage color which changes from olive green in summer months to orange-red in the fall and becoming plum colored in spring. The branch stems of ‘Hawaii Magic’ are bright red in color. ‘Hawaii Magic’ bears only male flowers which are yellow in color.Type: GrantFiled: March 29, 2017Date of Patent: September 4, 2018Assignee: University of HawaiiInventor: John J. Cho