Patents Assigned to The University of Houston
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Patent number: 12203935Abstract: Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.Type: GrantFiled: February 14, 2019Date of Patent: January 21, 2025Assignee: The University of Houston SystemInventors: Shaun Xiaoliu Zhang, Xinping Fu
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Publication number: 20200363406Abstract: Assay compositions and methods for detection of analytes that include covalent modification of assay elements, such that they are preserved, destroyed, created, or immobilized. Methods for detecting an analyte in a biological sample. The method includes providing a mixture of a biological sample potentially containing the analyte, and a molecular recognition element physically coupled to a covalent modification agent, wherein the molecular recognition element is capable of specific recognition of the analyte, and exposing the mixture to a first set of reaction conditions, wherein the analyte and molecular recognition element can associate to form a recognition complex. Upon formation of the recognition complex, the method further includes generating by use of the covalent modification agent, a template complex; and exposing the template complex to a second set of reaction conditions, wherein the template complex is amplified to generate a detectable product indicative of the presence of the analyte.Type: ApplicationFiled: October 26, 2018Publication date: November 19, 2020Applicant: The University of Houston SystemInventors: Hui CHEN, Mary CRUM, Dimple CHAVAN, Ekaterini KOURENTZI, Binh V. VU, Richard C. WILLSON
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Patent number: 10832843Abstract: A superconductor tape may be fabricated via Metal Organic Chemical Vapor Deposition (MOCVD) to achieve peel strengths greater than approximately 4.5 N/cm. The superconductor tape may be fabricated via MOCVD with a REBCO composition that includes the elements Samarium (Sm)-Barium(Ba)-Copper(Cu)-Oxygen(O). Varying levels of Copper (Cu) content can achieve peel strengths ranging between approximately 4.5 N/cm to approximately 8.0 N/cm.Type: GrantFiled: March 17, 2016Date of Patent: November 10, 2020Assignee: The University of Houston SystemInventor: Venkat Selvamanickam
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Patent number: 10818416Abstract: A REBCO superconductor tape that can achieve a lift factor greater than or equal to approximately 3.0 or 4.0 in an approximately 3 T magnetic field applied perpendicular to a REBCO tape at approximately 30 K. In an embodiment, the REBCO superconductor tape can include a critical current density less than or equal to approximately 4.2 MA/cm2 at 77 K in the absence of an external magnetic field. In another embodiment, the REBCO superconductor tape can include a critical current density greater than or equal to approximately 12 MA/cm2 at approximately 30 K in a magnetic field of approximately 3 T having an orientation parallel to a c-axis.Type: GrantFiled: April 1, 2014Date of Patent: October 27, 2020Assignee: The University of Houston SystemInventor: Venkat Selvamanickam
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Publication number: 20180269509Abstract: Electrochemical devices including solid oxide fuel cells (SOFCs) or thin film solid oxide fuel cells (TFSOFCs) having a porous metallic anode with nanoporous surface structure enabling the deposition of a dense, impermeable thin film electrolyte layer on the porous anode. Fabricating methods include forming a mixture of nanopowder metallic agents and nanopowder proppant that are sintered, smoothed and etched to form the nanoporous surface structure.Type: ApplicationFiled: January 29, 2016Publication date: September 20, 2018Applicant: The University of Houston SystemInventors: Rabi Ebrahim, Mukhtar Yeleuov, Alex Ignatiev
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Patent number: 10039796Abstract: The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.Type: GrantFiled: February 13, 2015Date of Patent: August 7, 2018Assignee: The University of Houston SystemInventors: Xiaoliu Zhang, Xinping Fu
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Publication number: 20180061542Abstract: A superconductor tape may be fabricated via Metal Organic Chemical Vapor Deposition (MOCVD) to achieve peel strengths greater than approximately 4.5 N/cm. The superconductor tape may be fabricated via MOCVD with a REBCO composition that includes the elements Samarium (Sm)-Barium(Ba)-Copper(Cu)-Oxygen(O). Varying levels of Copper (Cu) content can achieve peel strengths ranging between approximately 4.5 N/cm to approximately 8.0 N/cm.Type: ApplicationFiled: March 17, 2016Publication date: March 1, 2018Applicant: The University of Houston SystemInventor: Venkat Selvamanickam
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Publication number: 20170337343Abstract: A new cardiac risk factors are disclosed along with method for deriving the components of the factors, for developing the factors and for using the factors. Methods for computing pericardial fat and abdominal fat are also disclosed as well as methods for motion compensation.Type: ApplicationFiled: July 28, 2014Publication date: November 23, 2017Applicant: The University of Houston SystemInventors: Ioannis A. Kakadiaris, Morteza Naghavi
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Patent number: 9770482Abstract: A compound can destabilize an epidermal growth factor receptor (EGFR) protein and a sodium/glucose co-transporter 1 (SGLT 1) protein. In one embodiment, the compound is a peptide derived from the interacting domain of EGFR. In another embodiment, the peptide is administered to a patient to treat cancer.Type: GrantFiled: April 26, 2016Date of Patent: September 26, 2017Assignee: The University of Houston SystemInventor: Zhang Weihua
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Patent number: 9555135Abstract: Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.Type: GrantFiled: January 27, 2016Date of Patent: January 31, 2017Assignees: Board of Regents, The University of Texas System, The University of Houston SystemInventors: Steven J. Frank, Karen Martirosyan
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Patent number: 9450123Abstract: A design of a quantum well region that allows faster and more efficient carrier collection in quantum well solar cells. It is shown that for a quantum well material system displaying a negligible valence band offset, the conduction band confinement energies and barrier thicknesses can be designed to favor a sequential thermionic promotion and resonant tunneling of electrons to the conduction band continuum resulting in faster carrier collection rates than for a conventional design. An evaluation of the proposed design in the context of devices incorporating GaAs/GaAsN quantum wells shows a collection of all photo-generated carriers within several to tenths of ps (10?12 s) from deep quantum wells rather than several ns, as it is the case for conventional designs. The incorporation of the proposed design in single and multijunction solar cells is evaluated with efficiency enhancements.Type: GrantFiled: January 14, 2013Date of Patent: September 20, 2016Assignee: The University of Houston SystemInventors: Alexandre Freundlich, Andenet Alemu
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Publication number: 20160172080Abstract: A REBCO superconductor tape that can achieve a lift factor greater than or equal to approximately 3.0 or 4.0 in an approximately 3 T magnetic field applied perpendicular to a REBCO tape at approximately 30 K. In an embodiment, the REBCO superconductor tape can include a critical current density less than or equal to approximately 4.2 MA/cm2 at 77 K in the absence of an external magnetic field. In another embodiment, the REBCO superconductor tape can include a critical current density greater than or equal to approximately 12 MA/cm2 at approximately 30 K in a magnetic field of approximately 3 T having an orientation parallel to a c-axis.Type: ApplicationFiled: April 1, 2014Publication date: June 16, 2016Applicant: The University of Houston SystemInventor: Venkat Selvamanickam
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Patent number: 9355267Abstract: Provided herein are systems and methods for an Integrated File Level Cryptographical Access Control (IFLCAC). The system comprises, on a local computer, an encryption database to store information relating to encrypted files and encryption algorithms, a user interface communicatively linked to the encryption database, an administrator interface communicatively linked to the encryption database independently of the user interface, and a file system gateway communicatively linked to the encryption database that resides above and operates independently of the file system and transparently to any calling application on the local computer. Also provided are methods of using the IFLCAC system and a computer program product comprising a memory tangibly storing computer executable instructions for the IFLCAC system and method and one or more computer readable media tangibly storing computer executable instructions for the IFLCAC system and method.Type: GrantFiled: March 26, 2010Date of Patent: May 31, 2016Assignee: The University of Houston SystemInventor: Ryan Seifert
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Patent number: 9345790Abstract: Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.Type: GrantFiled: August 25, 2014Date of Patent: May 24, 2016Assignees: Board of Regents, The University of Texas System, The University of Houston SystemInventors: Steven J. Frank, Karen Martirosyan
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Patent number: 9334307Abstract: A compound can destabilize a binding interaction between an epidermal growth factor receptor (EGFR) and a sodium/glucose co-transporter 1 (SGLT 1). In one embodiment, the compound is a peptide derived from the interacting domain of EGFR. In another embodiment, the peptide is administered to a patient to treat cancer.Type: GrantFiled: May 8, 2014Date of Patent: May 10, 2016Assignee: The University of Houston SystemInventor: Zhang Weihua
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Patent number: 9259390Abstract: Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation.Type: GrantFiled: July 24, 2008Date of Patent: February 16, 2016Assignee: The University of Houston SystemInventors: Diana Shu-Lian Chow, Pranav Gupta, Yulan Qi, Dong Liang
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Patent number: 9259391Abstract: Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation.Type: GrantFiled: June 10, 2010Date of Patent: February 16, 2016Assignee: The University of Houston SystemInventors: Diana Shu-Lian Chow, Pranav Gupta, Yulan Qi, Dong Liang
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Publication number: 20150357090Abstract: An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities.Type: ApplicationFiled: March 13, 2014Publication date: December 10, 2015Applicant: The University of Houston SystemInventors: Goran Majkic, Venkat Selvamanickam
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Patent number: 9145295Abstract: A graphene nano-sensor with a suspended graphene flake electrically connected to metal electrodes. The graphene nano-sensor is capable of detecting single molecules in an atmosphere through a change in electrical conductance through the graphene flake.Type: GrantFiled: July 12, 2012Date of Patent: September 29, 2015Assignee: The University of Houston SystemsInventor: Haibing Peng
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Patent number: 9023642Abstract: A bioreactor and method that permits continuous and simultaneous short, moderate, or long term cell culturing of one or more cell types or tissue in a laminar flow configuration is disclosed, where the bioreactor supports at least two laminar flow zones, which are isolated by laminar flow without the need for physical barriers between the zones. The bioreactors of this invention are ideally suited for studying short, moderate and long term studies of cell cultures and the response of cell cultures to one or more stressors such as pharmaceuticals, hypoxia, pathogens, or any other stressor. The bioreactors of this invention are also ideally suited for short, moderate or long term cell culturing with periodic cell harvesting and/or medium processing for secreted cellular components.Type: GrantFiled: July 6, 2007Date of Patent: May 5, 2015Assignee: The University of Houston SystemInventors: Stanley J. Kleis, Sandra K. Geffert, Steve R. Gonda