Patents Assigned to The University of Kansas
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Patent number: 12281333Abstract: A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish.Type: GrantFiled: November 3, 2021Date of Patent: April 22, 2025Assignee: UNIVERSITY OF KANSASInventors: Andras Czirok, Pamela Tran
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Patent number: 12280374Abstract: Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules.Type: GrantFiled: July 15, 2019Date of Patent: April 22, 2025Assignees: University of Kansas, Univ. of N Carolina at Chapel Hill, Board of Supervisors of LSU and A&M College, Northeastern University, Clarkson UniversityInventors: Steven A. Soper, Collin J. McKinney, Elizabeth Podlaha-Murphy, Sunggook Park
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Patent number: 12269798Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.Type: GrantFiled: June 7, 2021Date of Patent: April 8, 2025Assignee: University of KansasInventors: Brian S. J. Blagg, Vincent Matthew Crowley
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Patent number: 12263156Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.Type: GrantFiled: October 15, 2021Date of Patent: April 1, 2025Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Board of Regents for Oklahoma State University, University of KansasInventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell, Anabel Soldano
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Patent number: 12265237Abstract: Plasmonic substrates are provided which may be used in a variety of optoelectronic devices, e.g., biosensors and photodetectors. The plasmonic substrate may comprise a layer of graphene and a plurality of discrete, individual transition metal chalcogenide nanodomes distributed on a surface of the layer of graphene, each nanodome surrounded by bare graphene. Methods for making and using the plasmonic substrates are also provided.Type: GrantFiled: October 30, 2019Date of Patent: April 1, 2025Assignee: University of KansasInventor: Judy Z. Wu
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Patent number: 12251370Abstract: The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.Type: GrantFiled: December 3, 2019Date of Patent: March 18, 2025Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, The Board of Regents for Oklahoma State UniversityInventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell
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Patent number: 12234329Abstract: Methods of forming lignin prepolymers are provided. In an embodiment, such a method comprises adding an acid to an ozonized reaction mixture, the ozonized reaction mixture comprising ozonized lignin having a backbone, and aromatic monomers cleaved from a lignin, under conditions to react the cleaved aromatic monomers with the backbone of the ozonized lignin to form a lignin prepolymer. The methods may further comprise using the lignin prepolymer to form a lignin resin.Type: GrantFiled: December 17, 2021Date of Patent: February 25, 2025Assignee: University of KansasInventors: Bala Subramaniam, Julian R. Silverman, Andrew M. Danby, Thomas Binder, Steffan Green
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Patent number: 12230154Abstract: The present disclosure relates to systems, methods, and computer readable media implemented in connection with an unmanned aerial vehicle (UAV) to navigate a UAV along a desired path. For example, systems disclosed herein identify an anticipatory flight path and identify a plurality of reference points on the flight path relative to a current position of the UAV. The systems described herein may further determine reference angles between a current trajectory of the UAV and the reference points to determine an updated trajectory that the UAV should take to stay close to the identified flight path. The systems described herein may further cause the UAV to accelerate in a lateral direction based on the updated trajectory. The features and functionality of systems disclosed herein enable the UAV to accurately follow a complex path having sharp turns with little or no advanced knowledge of the flight path prior to departure.Type: GrantFiled: July 10, 2020Date of Patent: February 18, 2025Assignee: University of KansasInventors: Shawn Keshmiri, Jeffrey Xu, Thomas Brendan Le Pichon
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Patent number: 12228464Abstract: Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include an elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these.Type: GrantFiled: March 11, 2024Date of Patent: February 18, 2025Assignee: University of KansasInventors: Cory Berkland, Jonathan Whitlow, Jean Salash
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Patent number: 12224154Abstract: Disclosed are compositions and methods for the conductive fixation of organic material, including biological samples. The compositions and methods described herein can address the problems of charging and sample damage caused by electron beam-sample interactions within an electron microscope.Type: GrantFiled: January 10, 2019Date of Patent: February 11, 2025Assignee: University of KansasInventor: Eduardo Rosa-Molinar
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Publication number: 20250040907Abstract: A system for evaluating cerebrovascular function in a patient includes a respiratory monitoring device, a vascular monitoring device, an ultrasound transducer device configured to send and receive ultrasound pulses for measuring fluid velocity and fluid flow direction in a head of a patient, and a computing device in data communication with the respiratory monitoring device, vascular monitoring device, and the ultrasound transducer device.Type: ApplicationFiled: October 25, 2024Publication date: February 6, 2025Applicant: University of KansasInventors: Sandra A. Billinger, Eric D. Vidoni
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Patent number: 12217931Abstract: Disclosed are articles comprising substrate and graphene coating that are configured to support a sample for electron or optical microscopy. Also disclosed are methods of making the same and methods of using the same in imaging technology.Type: GrantFiled: December 11, 2019Date of Patent: February 4, 2025Assignees: University of Kansas, Kansas State University Research FoundationInventors: Eduardo Rosa-Molinar, Noraida Martinez-Rivera, Prem Singh Thapa-Chetri, WenJun Xiang, Suprem Ranjan Das
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Patent number: 12211664Abstract: The disclosure describes assemblies and systems for use in reel-to-reel imaging of ultrathin samples. The assemblies and the systems disclosed herein are adapted for use with a plurality of detectors and are configured for use in a variety of electron microscopes. Also, methods of using such assemblies and systems are disclosed.Type: GrantFiled: August 6, 2020Date of Patent: January 28, 2025Assignee: University of KansasInventor: Eduardo Rosa-Molinar
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Patent number: 12194451Abstract: Bimetal-incorporated mesoporous silicate catalysts are provided. In embodiments, such a catalyst comprises a silicate lattice, a first transition metal M, and a second transition metal M?, wherein M and M? are selected from Zr, Nb, and W and are directly incorporated into the silicate lattice such that M and M? replace Si atoms. Methods of using the catalysts are also provided, including in methods for dehydrating alcohols. Methods of making the catalysts are also provided.Type: GrantFiled: January 24, 2019Date of Patent: January 14, 2025Assignee: University of KansasInventors: Bala Subramaniam, Anand Ramanathan, Hongda Zhu
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Patent number: 12195167Abstract: A general mounting method for ducted fan propulsors is disclosed. This mounting method uses extremely slender stators that connect the duct ring to the propulsor which is mounted in the middle and drives the rotor, fan or propeller. The slender stators take the form of spokes and as such are so slender that the midspan stresses within the spokes are dominated by axial tension loads rather than the shear loads experienced by conventional stators. The spokes may have an aerodynamic shape and damping methods may be used to retard spoke vibrations and transmission of engine vibrations to the duct and force. The duct itself is also stiffened by the spoke arrangement, thereby reducing low frequency vibration modes.Type: GrantFiled: August 17, 2023Date of Patent: January 14, 2025Assignee: University of KansasInventors: Ronald Martin Barrett, Lauren Nicole Schumacher, Patrick Ian McNamee, John Austin Haug, Joshua Donald Mudd, Dalton Bastiaan Prins, Nicholas Donald Werner
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Patent number: 12186332Abstract: The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.Type: GrantFiled: June 26, 2020Date of Patent: January 7, 2025Assignees: Stowers Institute for Medical Research, The Children's Mercy Hospital, University of KansasInventors: Linheng Li, John M. Perry, Fang Tao, Xi C. He, Anuradha Roy, Scott J. Weir, Tara Lin
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Patent number: 12180165Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.Type: GrantFiled: September 10, 2021Date of Patent: December 31, 2024Assignee: UNIVERSITY OF KANSASInventors: Sunil A. David, Mallesh Beesu, Giuseppe Caruso, Alex Salyer
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Patent number: 12178831Abstract: The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of the present technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection.Type: GrantFiled: February 27, 2019Date of Patent: December 31, 2024Assignee: UNIVERSITY OF KANSASInventors: Brandon Dekosky, Cheng-Yu Chung
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Patent number: 12173305Abstract: A recombinant mutant BoV genome is provided, as well as methods of using the vector, e.g., to prepare helper-free virus.Type: GrantFiled: May 26, 2017Date of Patent: December 24, 2024Assignees: University of Iowa Research Foundation, University of KansasInventors: John F. Engelhardt, Ziying Yan, Jianming Qiu
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Publication number: 20240421989Abstract: Described herein is a method. The method may include receiving, by a first device, data of a first layer of the first device, the data for transmission over a network to a second device. The method may include encrypting, by the first device, the data at the first layer, to generate first encrypted data. The method may include encrypting, by the first device, the first encrypted data at a second layer, to generate second encrypted data. The method may include transmitting, by the first device, the second encrypted data via the network to the second device.Type: ApplicationFiled: June 18, 2024Publication date: December 19, 2024Applicants: University of Kansas, Wichita State UniversityInventors: Hyuck M. Kwon, Rémi A. Chou, Richard Lahman, Taejoon Kim