Patents Assigned to The University of Kansas
  • Patent number: 12281333
    Abstract: A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: April 22, 2025
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Andras Czirok, Pamela Tran
  • Patent number: 12280374
    Abstract: Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: April 22, 2025
    Assignees: University of Kansas, Univ. of N Carolina at Chapel Hill, Board of Supervisors of LSU and A&M College, Northeastern University, Clarkson University
    Inventors: Steven A. Soper, Collin J. McKinney, Elizabeth Podlaha-Murphy, Sunggook Park
  • Patent number: 12269798
    Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: April 8, 2025
    Assignee: University of Kansas
    Inventors: Brian S. J. Blagg, Vincent Matthew Crowley
  • Patent number: 12263156
    Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: April 1, 2025
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Board of Regents for Oklahoma State University, University of Kansas
    Inventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell, Anabel Soldano
  • Patent number: 12265237
    Abstract: Plasmonic substrates are provided which may be used in a variety of optoelectronic devices, e.g., biosensors and photodetectors. The plasmonic substrate may comprise a layer of graphene and a plurality of discrete, individual transition metal chalcogenide nanodomes distributed on a surface of the layer of graphene, each nanodome surrounded by bare graphene. Methods for making and using the plasmonic substrates are also provided.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: April 1, 2025
    Assignee: University of Kansas
    Inventor: Judy Z. Wu
  • Patent number: 12251370
    Abstract: The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: March 18, 2025
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, The Board of Regents for Oklahoma State University
    Inventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell
  • Patent number: 12234329
    Abstract: Methods of forming lignin prepolymers are provided. In an embodiment, such a method comprises adding an acid to an ozonized reaction mixture, the ozonized reaction mixture comprising ozonized lignin having a backbone, and aromatic monomers cleaved from a lignin, under conditions to react the cleaved aromatic monomers with the backbone of the ozonized lignin to form a lignin prepolymer. The methods may further comprise using the lignin prepolymer to form a lignin resin.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: February 25, 2025
    Assignee: University of Kansas
    Inventors: Bala Subramaniam, Julian R. Silverman, Andrew M. Danby, Thomas Binder, Steffan Green
  • Patent number: 12230154
    Abstract: The present disclosure relates to systems, methods, and computer readable media implemented in connection with an unmanned aerial vehicle (UAV) to navigate a UAV along a desired path. For example, systems disclosed herein identify an anticipatory flight path and identify a plurality of reference points on the flight path relative to a current position of the UAV. The systems described herein may further determine reference angles between a current trajectory of the UAV and the reference points to determine an updated trajectory that the UAV should take to stay close to the identified flight path. The systems described herein may further cause the UAV to accelerate in a lateral direction based on the updated trajectory. The features and functionality of systems disclosed herein enable the UAV to accurately follow a complex path having sharp turns with little or no advanced knowledge of the flight path prior to departure.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: February 18, 2025
    Assignee: University of Kansas
    Inventors: Shawn Keshmiri, Jeffrey Xu, Thomas Brendan Le Pichon
  • Patent number: 12228464
    Abstract: Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include an elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these.
    Type: Grant
    Filed: March 11, 2024
    Date of Patent: February 18, 2025
    Assignee: University of Kansas
    Inventors: Cory Berkland, Jonathan Whitlow, Jean Salash
  • Patent number: 12224154
    Abstract: Disclosed are compositions and methods for the conductive fixation of organic material, including biological samples. The compositions and methods described herein can address the problems of charging and sample damage caused by electron beam-sample interactions within an electron microscope.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 11, 2025
    Assignee: University of Kansas
    Inventor: Eduardo Rosa-Molinar
  • Publication number: 20250040907
    Abstract: A system for evaluating cerebrovascular function in a patient includes a respiratory monitoring device, a vascular monitoring device, an ultrasound transducer device configured to send and receive ultrasound pulses for measuring fluid velocity and fluid flow direction in a head of a patient, and a computing device in data communication with the respiratory monitoring device, vascular monitoring device, and the ultrasound transducer device.
    Type: Application
    Filed: October 25, 2024
    Publication date: February 6, 2025
    Applicant: University of Kansas
    Inventors: Sandra A. Billinger, Eric D. Vidoni
  • Patent number: 12217931
    Abstract: Disclosed are articles comprising substrate and graphene coating that are configured to support a sample for electron or optical microscopy. Also disclosed are methods of making the same and methods of using the same in imaging technology.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 4, 2025
    Assignees: University of Kansas, Kansas State University Research Foundation
    Inventors: Eduardo Rosa-Molinar, Noraida Martinez-Rivera, Prem Singh Thapa-Chetri, WenJun Xiang, Suprem Ranjan Das
  • Patent number: 12211664
    Abstract: The disclosure describes assemblies and systems for use in reel-to-reel imaging of ultrathin samples. The assemblies and the systems disclosed herein are adapted for use with a plurality of detectors and are configured for use in a variety of electron microscopes. Also, methods of using such assemblies and systems are disclosed.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: January 28, 2025
    Assignee: University of Kansas
    Inventor: Eduardo Rosa-Molinar
  • Patent number: 12194451
    Abstract: Bimetal-incorporated mesoporous silicate catalysts are provided. In embodiments, such a catalyst comprises a silicate lattice, a first transition metal M, and a second transition metal M?, wherein M and M? are selected from Zr, Nb, and W and are directly incorporated into the silicate lattice such that M and M? replace Si atoms. Methods of using the catalysts are also provided, including in methods for dehydrating alcohols. Methods of making the catalysts are also provided.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: January 14, 2025
    Assignee: University of Kansas
    Inventors: Bala Subramaniam, Anand Ramanathan, Hongda Zhu
  • Patent number: 12195167
    Abstract: A general mounting method for ducted fan propulsors is disclosed. This mounting method uses extremely slender stators that connect the duct ring to the propulsor which is mounted in the middle and drives the rotor, fan or propeller. The slender stators take the form of spokes and as such are so slender that the midspan stresses within the spokes are dominated by axial tension loads rather than the shear loads experienced by conventional stators. The spokes may have an aerodynamic shape and damping methods may be used to retard spoke vibrations and transmission of engine vibrations to the duct and force. The duct itself is also stiffened by the spoke arrangement, thereby reducing low frequency vibration modes.
    Type: Grant
    Filed: August 17, 2023
    Date of Patent: January 14, 2025
    Assignee: University of Kansas
    Inventors: Ronald Martin Barrett, Lauren Nicole Schumacher, Patrick Ian McNamee, John Austin Haug, Joshua Donald Mudd, Dalton Bastiaan Prins, Nicholas Donald Werner
  • Patent number: 12186332
    Abstract: The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: January 7, 2025
    Assignees: Stowers Institute for Medical Research, The Children's Mercy Hospital, University of Kansas
    Inventors: Linheng Li, John M. Perry, Fang Tao, Xi C. He, Anuradha Roy, Scott J. Weir, Tara Lin
  • Patent number: 12180165
    Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: December 31, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Sunil A. David, Mallesh Beesu, Giuseppe Caruso, Alex Salyer
  • Patent number: 12178831
    Abstract: The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of the present technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: December 31, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Brandon Dekosky, Cheng-Yu Chung
  • Patent number: 12173305
    Abstract: A recombinant mutant BoV genome is provided, as well as methods of using the vector, e.g., to prepare helper-free virus.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: December 24, 2024
    Assignees: University of Iowa Research Foundation, University of Kansas
    Inventors: John F. Engelhardt, Ziying Yan, Jianming Qiu
  • Publication number: 20240421989
    Abstract: Described herein is a method. The method may include receiving, by a first device, data of a first layer of the first device, the data for transmission over a network to a second device. The method may include encrypting, by the first device, the data at the first layer, to generate first encrypted data. The method may include encrypting, by the first device, the first encrypted data at a second layer, to generate second encrypted data. The method may include transmitting, by the first device, the second encrypted data via the network to the second device.
    Type: Application
    Filed: June 18, 2024
    Publication date: December 19, 2024
    Applicants: University of Kansas, Wichita State University
    Inventors: Hyuck M. Kwon, Rémi A. Chou, Richard Lahman, Taejoon Kim