Abstract: Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.
Type:
Grant
Filed:
February 27, 2014
Date of Patent:
September 15, 2015
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventors:
David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang
Abstract: A method, system, and kit are provided for diagnosing L. intracellularis infection or exposure in a subject. The method includes purifying whole L. intracellularis from host cells and host debris produced in or on a suitable medium and adhering the purified whole L. intracellularis on a suitable material to form an antigen substrate for determining whether a subject produces L. intracellularis-specific antibodies against the antigen to thereby indicate L. intracellularis exposure or infection in the subject. The kit includes purified whole L. intracellularis produced from host cells and host debris adhered to a suitable material to form an antigen substrate adapted for screening serum from a subject. A method for diagnosing L. intracellularis exposure or infection in a subject includes acquiring a serum sample from a subject, introducing the serum sample to an antigen substrate followed by detecting a presence of L. intracellularis-specific antibodies in the serum.
Type:
Grant
Filed:
November 14, 2012
Date of Patent:
September 1, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Harold F. Stills, Jr., David W. Horohov, Allen E. Page
Abstract: A biometrics system captures and processes a handprint image using a structured light illumination to create a 2D representation equivalent of a rolled inked handprint. A processing unit calculates 3D coordinates of the hand from the plurality of images and maps the 3D coordinates to a 2D flat surface to create a 2D representation equivalent of a rolled inked handprint.
Type:
Application
Filed:
November 17, 2014
Publication date:
July 23, 2015
Applicant:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventors:
Laurence G. Hassebrook, Daniel L. Lau, Henry G. Dietz
Abstract: Disclosed is a nanostructure including a first set of nanowires formed from filling a plurality of voids of a template. The nanostructure also includes a second set of nanowires formed from filling a plurality of spaces created when the template is removed, such that the second set of nanowires encases the first set of nanowires. Several methods are also disclosed. In one embodiment, a method of fabricating a nanostructure including nanowires is disclosed. The method may include forming a first set of nanowires in a template, removing a first portion of the template, thereby creating spaces between the first set of nanowires, forming a second set of nanowires in the spaces between the first set of nanowires, and removing a second portion of the template.
Type:
Grant
Filed:
January 14, 2010
Date of Patent:
July 21, 2015
Assignee:
THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventors:
Charles Elijah May, Vijay Pal Singh, Suresh K S Rajaputra
Abstract: This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by binding to the substrate binding domain.
Type:
Grant
Filed:
April 1, 2011
Date of Patent:
July 14, 2015
Assignee:
The University of Kentucky Research Foundation
Inventors:
Chang-Guo Zhan, Xiaoqin Huang, Adel Hamza
Abstract: The presently-disclosed subject matter includes methods for treating Alzheimer's disease in a subject. The subject can have Alzheimer's diseases, can be identified has being at risk for developing Alzheimer's disease, or both. The method can comprise administering a composition that includes a CD33 inhibitor, which may include a CD33 antibody. In some embodiments the composition can further comprise at least one additional component useful for treating Alzheimer's disease. The presently-disclosed subject matter also includes compositions and kits for treating Alzheimer's disease in a subject.
Type:
Grant
Filed:
December 4, 2013
Date of Patent:
June 30, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Steven Estus, Manasi Malik, James Simpson
Abstract: Pharmaceutical compositions including D-tagatose along with a stilbene or stilbenoid component, or a salt or derivative thereof. Methods of prophylaxis and therapy by administering to a mammal a pharmaceutically effective amount of D-tagatose, optionally in combination with a stilbene or stilbenoid component, or a salt or derivative thereof to prevent or treat atherosclerosis, the metabolic syndrome, obesity, or diabetes.
Type:
Grant
Filed:
May 3, 2011
Date of Patent:
June 23, 2015
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Abstract: A capacitive deionization system includes a first deionization cell, a second deionization cell and an integrated DC/DC converter/power source. The first deionization cell includes a first reservoir and a first set of electrode pairs. The second deionization cell includes a second reservoir and a second set of electrode pairs.
Type:
Application
Filed:
May 1, 2014
Publication date:
June 18, 2015
Applicant:
University of Kentucky Research Foundation
Inventors:
James Landon, Aaron Cramer, Kunlei Liu, Zhiao Li
Abstract: An electrode is provided which includes a xerogel sheet coated with a silica film. A method for producing the electrode includes steps of infiltrating a carbon cloth with a solution containing resorcinol and formaldehyde, polymerizing the solution infiltrated carbon cloth, subjecting the infiltrated and polymerized carbon cloth to a solvent-exchange process, carbonizing the carbon cloth and coating the carbonized carbon cloth with a silica film.
Type:
Application
Filed:
March 31, 2014
Publication date:
June 18, 2015
Applicant:
University of Kentucky Research Foundation
Inventors:
Xin Gao, James Landon, Kunlei Liu, Ayokunle Omosebi
Abstract: Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.
Type:
Grant
Filed:
August 26, 2005
Date of Patent:
June 2, 2015
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R? or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells. These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.
Type:
Application
Filed:
September 5, 2014
Publication date:
May 14, 2015
Applicant:
University of Kentucky Research Foundation
Abstract: A power plant includes a boiler, a stream turbine generator, a post combustion processing system, a feed water regeneration processing system and a heat exchanger. Heat from the heat exchanger is used to regenerate (a) a reagent that absorbs carbon dioxide from flue gas and (b) a water-lean desiccant used to increase plant operating efficiency.
Type:
Grant
Filed:
January 15, 2013
Date of Patent:
May 5, 2015
Assignee:
The University of Kentucky Research Foundation
Abstract: This invention relates to the use of microcystins as agents for treatment of cancer. Also provided are methods of screening for microcystins with improved cytotoxicity.
Type:
Grant
Filed:
May 10, 2007
Date of Patent:
April 14, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Noel R. Monks, Shuqian Liu, Jeffrey A. Moscow
Abstract: A hybrid cement clinker incorporates specific ranges of clinker phases and falls within specific modulus values as set forth and described in this document.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
March 24, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Thomas Robl, Tristana Duvallet, Robert Rathbone, Yongmin Zhou
Abstract: Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of stimulators of the TLR3 and TLR7 receptors, Trif or of IL-10 and IL-12 inhibits ocular angiogenesis. Furthermore, all siRNAs (both targeted and non-targeted) can inhibit ocular angiogenesis.
Type:
Grant
Filed:
May 15, 2007
Date of Patent:
February 17, 2015
Assignee:
University of Kentucky Research Foundation
Abstract: Embodiments of the presently-disclosed subject matter provide an isolated polypeptide comprising the sequence of SEQ ID NO: 1, fragments thereof, and/or epitopes thereof. Embodiments of the presently-disclosed subject matter also provide methods for diagnosing a Strongylus vulgaris infection in a subject that comprises providing a biological sample from the subject and contacting the sample with the present isolated polypeptide, fragment thereof, and/or epitope thereof. In some embodiments the Strongylus vulgaris infection can be detected during a prepatent period. In further embodiments the subject is a horse.
Type:
Grant
Filed:
October 29, 2013
Date of Patent:
February 10, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Martin Nielsen, Ulla Anderson, Daniel Howe
Abstract: A method of manufacturing a semiconductor structure includes the steps of depositing a layer of semiconductor oxide on a base semiconductor layer, scavenging oxygen from the layer of semiconductor oxide and recrystallizing the oxygen scavenged layer of semiconductor oxide as a semiconductor heteroepitaxy layer.
Type:
Application
Filed:
August 2, 2013
Publication date:
February 5, 2015
Applicant:
The University of Kentucky Research Foundation
Abstract: A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal multiport brain catheters connected to one or more implantable pumps wherein the flow rate is pulsed.
Type:
Grant
Filed:
October 13, 2004
Date of Patent:
February 3, 2015
Assignees:
Northern Bristol N.H.S. Trust Frenchay Hospital, University of Kentucky Research Foundation, Amgen Inc.
Inventors:
Steven S. Gill, Don M. Gash, Greg A. Gerhardt
Abstract: Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (?)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (?)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Type:
Grant
Filed:
October 23, 2013
Date of Patent:
February 3, 2015
Assignee:
University of Kentucky Research Foundation
Abstract: A computer-implemented process, system, and computer-readable storage medium having stored thereon, program code and instructions for 3-D triangulation-based image acquisition of a contoured surface/object-of-interest under observation by at least one camera, by projecting onto the surface-of-interest a multi-frequency pattern comprising a plurality of pixels representing at least a first and second superimposed sinusoid projected simultaneously, each of the sinusoids represented by the pixels having a unique temporal frequency and each of the pixels projected to satisfy I n p = A p + ? k = 1 K ? B k p ? cos ? ( 2 ? ? ? ? f k ? y p + 2 ? ? ? ? kn N ) Eq . ? ( 1.1 ) where Inp is the intensity of a pixel in the projector for nth projected image in a particular instant in time; K is an integer representing the number of component sinusoids (e.g.
Type:
Grant
Filed:
August 8, 2011
Date of Patent:
February 3, 2015
Assignee:
University of Kentucky Research Foundation
Inventors:
Kai Liu, Yongchang Wang, Daniel L. Lau, Laurence G. Hassebrook