Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.

Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.

Abstract: An ultrasound generator having a signal generator; and to generate a pulsed drive signal from a modulating signal, the pulsed drive signal having at least a zero output level, a positive output level and a negative output level. The position and width of pulses are defined by at least first and second switching angles per half cycle of the modulating signal. In part of the range of the modulating signal one switching angle increases while the other switching angle decreases simultaneously such that the fundamental frequency of the pulsed drive signal increases or decreases with the modulating signal and such that a selected harmonic component of the generated pulsed drive signal is maintained below a first threshold. A transducer is arranged to generate ultrasound in response to the pulsed drive signal.

Abstract: A method for allowing a first party and a second party to obtain shared secret information is provided. The method comprises the steps of: obtaining, by the first party, a sequence of values A=X+NA where X is a sequence of values and NA is a random sequence associated with the first party; obtaining, by the second party, a sequence of values B=X+NB where NB is a random sequence associated with the second party; performing, by the first and second parties, a data matching procedure to identify corresponding pairs of values, a, b, in respective sequences A and B that match, wherein sequences A and B are discrete-valued sequences equal to, derived from, or derived using, sequences A and B; wherein the shared secret information is equal to, or derived from, or derived using, the matching values in sequences A and B.

Abstract: This invention relates to bubble generation, in particular to microbubble generation in a microfluidic device, which bubbles may be useful as contrasting agents or drug delivery vehicles. The invention further relates to apparatuses, systems and methods for manufacturing said microbubbles, microbubbles produced by such methods and to their uses, e.g. in medical, diagnostic and other such applications. The microbubbles are preferentially formed using a microspray regime.

Abstract: There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a ?-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.

Abstract: Electrical tomography apparatus comprises: a first electrode; a second electrode; and current driving means for driving an electrical current between the first electrode and the second electrode through a medium, wherein the current driving means comprises: a first transformer having a first winding and a second winding, the second winding having a first terminal and a second terminal; and means for generating an alternating current through the first winding so as to generate an alternating voltage between said first terminal and said second terminal. The apparatus further comprises connecting means arranged to connect the first terminal to the first electrode and the second terminal to the second electrode. Generation of the alternating current in the first winding results in generation of an alternating voltage between the first and second electrodes. In certain embodiments, a current sensing transformer provides an indication of current driven through the medium.

Abstract: The present invention relates to a zero-waste process for extraction of alumina from different types of bauxite ores and red mud residues and of titanium dioxide from ilmenite. Iron oxide is first reduced to metallic iron above the melting point of C-saturated cast iron alloy which yields a high-C iron alloy and an Al and Ti metal oxide rich slag which is then treated with alkali carbonate to form alkali aluminates and titanates. The alkali aluminates are separated by water leaching from which the hydroxide of alumina is precipitated by bubbling C02. The residue from water leaching is treated with sulphuric acid and Ti02 is precipitated via a hydrolysis route. The process recovers most of the metal values and generates only small quantities of silicious residues at pH 4-5 which can be used for soil conditioning.

Abstract: A method and apparatus is disclosed for ejecting material. The ejected material is ejected as liquid and liquid vapour via an explosive process which can provide a very fast ejection as well as an ejection which has a large throw.

Abstract: There is provided a bacteriophage capable of lysing a P. acnes bacterium and incapable of lysing a bacterium which is not P. acnes, and which is incapable of sustaining lysogeny in a bacterium. There is also provided a pharmaceutical composition comprising such a bacteriophage.

Abstract: The present invention seeks to improve beneficiation of a titanium oxide-containing composition (such as a low-grade or highly radioactive TiO2 ore) by combining a roasting and selective leaching steps.

Abstract: The present invention provides a method of, and apparatus for, utilizing ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularized in continuous form. The present invention also provides for the production of tissue matrices with improved recellularization properties, cell stratification or patterning.

Abstract: The invention provides a process for synthesising functionalised chain transfer polymers of Formula (1) or Formula (2) using thiocarbonyl thio compounds as chain transfer agents. Why R1 is a moiety comprising a functional group; Q is obtained from an olefinically unsaturated monomer; R? is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, an aromatic saturated or unsaturated carbocyclic or heterocyclic ring, optionally substituted with one or more substituents, amino alkyl, cyanoalkyl, hydroxylalkyl, saturated and unsaturated amido; an organometallic species, a polymer chain and any of the foregoing substituted with one or more CN or OH groups; q=an integer of at least 2; p=an integer of at least 1. Chain transfer agents and polymers produced by the method are also provided.

Abstract: A nucleic acid which encodes a peroxisomal fatty acid transporter, uses thereof and a method of genetic manipulation of peroxisomal fatty acid transport and/or Metabolism. The nucleic acid and its products are especially for use in regulation of peroxisomal fatty acid transport in plant and in controlling the spectrum of fatty acids which can be utilised by the plant.

Abstract: The invention provides a process for synthesising functionalised chain transfer polymers of Formula (1) or Formula (2) using thiocarbonyl thio compounds as chain transfer agents. Why R1 is a moiety comprising a functional group; Q is obtained from an olefinically unsaturated monomer; R? is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, an aromatic saturated or unsaturated carbocyclic or heterocyclic ring, optionally substituted with one or more substituents, amino alkyl, cyanoalkyl, hydroxylalkyl, saturated and unsaturated amido; an organometallic species, a polymer chain and any of the foregoing substituted with one or more CN or OH groups; q=an integer of at least 2; p=an integer of at least 1. Chain transfer agents and polymers produced by the method are also provided.

Abstract: There is provided a bacteriophage capable of lysing a P. acnes bacterium and incapable of lysing a bacterium which is not P. acnes, and which is incapable of sustaining lysogeny in a bacterium. There is also provided a pharmaceutical composition comprising such a bacteriophage.

Abstract: There is provided a bacteriophage capable of lysing a P. acnes bacterium and incapable of lysing a bacterium which is not P. acnes, and which is incapable of sustaining lysogeny in a bacterium. There is also provided a pharmaceutical composition comprising such a bacteriophage.

Abstract: A nucleic acid encoding a promoter and comprising a nucleic acid sequence of SEQ ID NO:1, fragments and/or variants thereof, for use in gene therapy derived from the Herpesvirus saimiri (HVS) ORF73 (ECLFI) gene. The invention also includes a gene therapy system and an HVS vector system including the promoter.