Abstract: A tidal current energy converter including an infinitely variable transmission (IVT) control system and a hybrid vertical axis wind (or water) turbine (VAWTs) apparatus. The hybrid VAWT apparatus includes a modified-Savonius (MS) rotor in the central region and a straight bladed H-type Darrieus rotor in the surrounding annular region. The IVT control system includes a nonlinear closed-loop control combined with an integral time-delay feedback control to adjust a speed ratio of the IVT. A speed ratio control for an IVT system involves a forward speed controller and/or a crank length controller for different speed ranges. The time-delay control is designed to reduce speed fluctuations of the output speed of an IVT with an accurate speed ratio. The speed ratio of an IVT with the disclosed control strategy can achieve an excellent tracking response for the desired constant output speed and reduce speed fluctuations of the output speed of an IVT by the time-delay feedback control.
Type:
Grant
Filed:
April 19, 2022
Date of Patent:
January 2, 2024
Assignee:
University of Maryland, Baltimore County
Inventors:
Weidong Zhu, Gang Li, Meilin Yu, Xuefeng Wang
Abstract: The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
January 2, 2024
Assignee:
University of Maryland, Baltimore
Inventors:
James Lyons, Christopher Ward, Joseph Stains
Abstract: The present disclosure relates to electrochemical biosensing systems and methods that can be adapted to accurately and rapidly detect a target gene in clinical samples, using anti-sense oligonucleotides for selective detection of biological pathogens.
Type:
Application
Filed:
October 5, 2021
Publication date:
December 28, 2023
Applicants:
University of Maryland, Baltimore, University of Maryland, Baltimore County
Inventors:
Dipanjan PAN, Maha Mohammad Shehadeh ALAFEEF, Ketan DIGHE, Parikshit MOITRA
Abstract: Disclosed is an electromagnetic coil system for use during transcranial or transdermal stimulation procedures, in which an electrically conductive coil wraps around a magnetic core at an oblique wrapping angle to provide a more directed focal spot size at a given depth inside of, for example, a patient's body. In certain configurations, the electrically conductive coil may be adjustable with respect to the magnetic core, such that the wrapping angle of the electrically conductive coil may be modified to, in turn, adjust the focal spot size of the induced electric field generated by the system as may desired to concentrate the field at a particularly desired location.
Type:
Grant
Filed:
January 10, 2020
Date of Patent:
December 26, 2023
Assignees:
University of Maryland, Baltimore, University of Maryland, Baltimore County
Inventors:
L. Elliot Hong, Fow-Sen Choa, Qinglei Meng
Abstract: Seroprotection analysis systems, kits, and techniques are described for testing oral fluid for the presence of protective levels of antibodies of interest. In one aspect, the presence of protective levels of target antibodies indicates a test subject has achieved a target seroprotection level, such as but not limited to a target seroprotection level following vaccination. A collection kit can include a swab that enables collection of oral fluid containing antibodies from both dentulous and edentulous individuals, a container that can be pre-filled with an extraction solution, and a nozzle that can be coupled to the container to form a fluid-tight device. A user can use the nozzle to seal the swab in the container and to compress the swab within the container.
Type:
Grant
Filed:
December 23, 2019
Date of Patent:
December 19, 2023
Assignees:
Becton, Dickinson and Company, University of Maryland, Baltimore
Inventors:
Michael D. Fiechtner, Francis R. Go, Myron Levine, Scott Castanon
Abstract: The present invention relates to compositions and methods for identifying and treating signature MP-associated diseases and conditions in subjects. In particular, treatment methods of the invention include administering a gelsolin agent to produce a therapeutic effect against a signature MP-associated disease or condition in a subject.
Type:
Application
Filed:
September 23, 2021
Publication date:
December 14, 2023
Applicants:
BioAegis Therapeutics Inc., University of Maryland, Baltimore
Inventors:
Susan L. Levinson, Stephen R. Thom, Mark J. DiNubile, Thomas P. Stossel
Abstract: The invention relates to compositions and methods as part of a pharmacotherapeutic strategy that targets the endochondral ossification process in a pharmacologically selective and site-specific manner. A variety of orthopedic pathologies are caused by or associated with generalized or local dysregulation of endochondral ossification, for example trauma to the bone growth plate or diaphysis can cause a serious imbalance in bone growth, leading to progressive deformity that today can only be treated surgically. Dysregulated endochondral ossification is also behind heterotopic ossification, which arises in soft tissues and causes pain, decrease in mobility and other clinical problems. The invention therefore provides RARy agonist and antagonist nanoparticle compositions for treating abnormal endochondral ossification and bone growth that can deliver robust local therapeutic control over a particular long bone's growth with a long-lasting effect.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
December 5, 2023
Assignees:
University of Maryland, Baltimore, The Children's Hospital of Philadelphia
Abstract: A process of simply, cheaply, and reproducibly creating complex tissue models using screen printing and the tissue model prepared using the screen printing process. These models are amenable to high throughput screening. They will allow the study of components of disease progression and can be used for screening therapies.
Type:
Grant
Filed:
February 23, 2021
Date of Patent:
November 21, 2023
Assignees:
University of Maryland, Baltimore County, University of Maryland, Baltimore
Inventors:
Erin Lavik, Steve Bernstein, Adam Day, Bryan Ibarra
Abstract: The present invention relates to, in part, artificial antigen presenting cells that are useful in treating disease (including cancers) and have uses, for example, directly in vivo and/or in the expansion of a patients cells for re-introduction ex vivo.
Abstract: Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
Type:
Application
Filed:
September 29, 2022
Publication date:
October 26, 2023
Applicant:
University of Maryland, Baltimore
Inventors:
Hanping Feng, James Eugene GALEN, Kevin CHEN, Yixuan ZHU
Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
Type:
Grant
Filed:
January 25, 2021
Date of Patent:
October 17, 2023
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Inventors:
Govind Rao, Yordan Kostov, Mustafa Al-Adhami, Chandrasekhar Gurramkonda
Abstract: Compositions and methods for improved delivery of mRNA into eukaryotic cells using histidine-lysine (HK) peptide polymers are disclosed. The branched polymers comprising four short peptide branches linked to a three-lysine amino acid core. The peptide branches consist of histidine and lysine amino acids, in different configurations, and they can vary in their location on the lysine core.
Abstract: The present invention relates in part to compositions for targeted delivery of an agent and agent delivery systems comprising a novel tissue-targeting peptide ligand (CKPFDRALC) (SEQ ID NO: 1) named ART-2. In certain aspects, the ART-2-coated liposomes encapsulating an agent, such as a therapeutic agent, diagnostic agent, imaging agent, or any combination thereof, were more effective in inhibiting, diagnosing, or imaging a disease or disorder, such as an arthritis progression, than control, despite a comparable safety profile.
Type:
Grant
Filed:
March 20, 2020
Date of Patent:
September 26, 2023
Assignees:
University of Maryland, Baltimore, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Kamal D. Moudgil, Rakeshchandra R. Meka
Abstract: Mcl-1 selective inhibitors, Bcl-2 selective inhibitors, and Mcl-1/Bcl-2 dual inhibitors and methods of using the same for the treatment of disease are disclosed.
Abstract: A method and apparatus is provided for automatic emergency airway detection. The apparatus includes a frame with a carriage guide configured to be secured around a neck of a subject. A carriage including a sensor is configured to move along the carriage guide. The sensor is configured to measure a value of a parameter indicating a topography of the neck of the subject. A processor includes a memory with instructions to receive first data from the sensor of the value of the parameter as the carriage is moved along the carriage guide and to determine, with the first data, second data indicating a position along the carriage guide corresponding to the cricothyroid region of the neck. The processor subsequently transmits a first signal indicating the second data. A method of using the apparatus is also provided.
Type:
Grant
Filed:
December 9, 2019
Date of Patent:
September 12, 2023
Assignee:
University Of Maryland, Baltimore
Inventors:
Rajabrata Sarkar, Jeffrey S. Wolf, Aldo T. Iacono, Stephen Restaino, Riddhi Gopal
Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
Type:
Grant
Filed:
May 15, 2018
Date of Patent:
September 5, 2023
Assignees:
UNIVERSITY OF MARYLAND, BALTIMORE, NATIONAL RESEARCH COUNCIL OF CANADA
Inventors:
James E. Galen, Thanh Pham, Dacie R. Bridge, Jin Yuan Wang, Wangxue Chen
Abstract: Energy harvesters (EH) which can effectively harvest wasted vibrational/kinematic energy and convert it into electrical energy for battery-free sensor operation are described herein. The energy harvesters can be integrated with a power management circuit and a wireless sensor for monitoring wind turbine blades. The target application of the energy harvesters includes powering the wireless sensors used for wind turbine blade structural monitoring.
Type:
Grant
Filed:
August 22, 2018
Date of Patent:
August 15, 2023
Assignee:
University of Maryland, Baltimore County
Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
Type:
Grant
Filed:
June 16, 2021
Date of Patent:
August 8, 2023
Assignee:
University of Maryland, Baltimore
Inventors:
Paul S. Shapiro, Alexander D. Mackerell, Jr., Jeffrey D. Hasday, Steven Fletcher
Abstract: The present disclosure provides methods of treating patients having decreased bone mineral density, methods of identifying subjects having increased risk of developing decreased bone mineral density, methods of detecting human Zinc And Ring Finger 3 (ZNRF3) variant nucleic acid molecules and variant polypeptides, and ZNRF3 variant nucleic acid molecules and variant polypeptides.
Type:
Grant
Filed:
June 22, 2020
Date of Patent:
August 1, 2023
Assignees:
Regeneran Pharmaceuticals, Inc., University of Maryland, Baltimore
Inventors:
Da-Wei Gong, Nehal Gosalia, Alan Shuldiner, Cristopher Van Hout, James Perry