Patents Assigned to The University of Maryland at Baltimore
  • Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products
    Patent number: 11346908
    Abstract: The present invention generally relates to a method of using the transverse relaxation rates (R2) of solvent NMR signal to noninvasively assess particle-containing products formulated as suspension or emulsion in solvent(s). Anomaly in released products and differences between innovator and follow-on products can be distinguished by this technology nondestructively without the vial or container being opened or protective seal compromised (i.e., broken).
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 31, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yihua Yu, Marc Taraban
  • DETECTION OF PHARMACEUTICAL PRODUCT FREEZING HISTORY USING WATER PROTON NMR
    Publication number: 20220163468
    Abstract: A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to invasively or noninvasively assess whether vaccines and other aqueous-based pharmaceutical products have been frozen during transport and/or storage.
    Type: Application
    Filed: March 11, 2020
    Publication date: May 26, 2022
    Applicant: University of Maryland, Baltimore
    Inventors: Yihua Bruce YU, Marc B. TARABAN, Katharine T. BRIGGS
  • Method and apparatus for providing economical, portable deficit-adjusted adaptive assistance during movement phases of an impaired ankle
    Patent number: 11337622
    Abstract: A method is described for providing deficit-adjusted adaptive assistance during movement phases of an impaired ankle. The method includes determining, on the processor, a value for a deficit parameter for each movement phase of a compound ankle function based on a difference between a parameter trace for a normal subject and the parameter trace for an impaired subject. The method further includes determining, on the processor, an adaptive magnitude for the robot-applied torque based on the value for the deficit parameter. The method further includes applying, to the robot joint, the adaptive magnitude for the robot-applied torque in only a first plane for the current movement phase, based on an adaptive timing. An apparatus is also described for providing deficit-adjusted adaptive assistance during movement phases of the impaired ankle.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: May 24, 2022
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Richard F. Macko, Anindo Roy
  • Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (SCAP) inhibitors
    Patent number: 11331332
    Abstract: The present disclosure provides methods of treating subjects having increased lipid levels and/or increased triglyceride levels, methods of identifying subjects having an increased risk of developing an increased lipid level and/or increased triglyceride level, methods of detecting human Sterol Regulatory Element Binding Protein Cleavage-Activating Protein (SCAP) variant nucleic acid molecules and variant polypeptides, and SCAP variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: May 17, 2022
    Assignees: Regeneron Pharmaceuticals, Inc., University of Maryland, Baltimore
    Inventors: Da-Wei Gong, James A. Perry, Alan Shuldiner, Nehal Gosalia, Cristopher Van Hout
  • Self-assembled particles for targeted delivery of immunomodulators to treat autoimmunity and cancer
    Patent number: 11311485
    Abstract: The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and/or interacts through shape-based targeting with a targeted cell type.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: April 26, 2022
    Assignees: University of Maryland, Baltimore County, University of Maryland, Baltimore, Northwestern University
    Inventors: Marilyn Allen, Evan Scott, Amit Golding, Gregory Szeto, Nicholas B. Karabin
  • Hybrid vertical axis turbine apparatus
    Patent number: 11313348
    Abstract: A multi-stage hybrid Darrieus-modified-Savonius (HDMS) vertical axis wind or water turbine (VAWT) for aero-hydro energy harvesting. The HDMS VAWT can continuously harvest fluid energy, including wind and water energy, provides excellent self-starting capability, has enhanced structural stability, and a high energy harvesting efficiency.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 26, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Meilin Yu, Weidong Zhu
  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 11306288
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: April 19, 2022
    Assignees: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • Method and apparatus for monitoring collection of physiological patient data
    Patent number: 11291369
    Abstract: A method and apparatus for monitoring collection of subject condition data is provided. The method includes receiving a value of a parameter of subject condition data and a value of a sample time, for each of a plurality of sample times. The method also includes storing the subject condition data in a data structure including a first field for holding data indicating a current sample time and a second field for holding data indicating the value of the parameter. The method also includes determining a time gap defined by a duration between the current sample time and a most recent sample time and determining whether the time gap exceeds a time gap threshold and causing an apparatus to perform remedial action. A method for presenting the subject condition data on a display is also provided.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: April 5, 2022
    Assignee: University Of Maryland, Baltimore
    Inventors: Fu-Ming Hu, Lynn G. Stansbury, Colin F. Mackenzie, Thomas M. Scalea, Deborah M. Stein, Shiming Yang
  • Ultraviolet sterilizing drainage catheter
    Patent number: 11285293
    Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: March 29, 2022
    Assignees: University Of Maryland, Baltimore, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, Jr., Mark E. Shirtliff
  • Synthesis and functionalization of highly monodispersed iron and Core/Iron oxide shell magnetic particles with broadly tunable diameter
    Patent number: 11285539
    Abstract: Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 29, 2022
    Assignees: University of Maryland, College Park, University of Maryland, Baltimore
    Inventors: Zhihong Nie, Radi Masri
  • Closed-loop control of an infinitely variable transmission
    Patent number: 11268615
    Abstract: A nonlinear closed-loop control combined with an integral time-delay feedback control is disclosed to adjust a speed ratio of an infinitely variable transmission (IVT) system. A speed ratio control for an IVT system involves a forward speed controller and a crank length controller for different speed ranges. The time-delay control is designed to reduce speed fluctuations of the output speed of an IVT with an accurate speed ratio. The speed ratio of an IVT with the disclosed control strategy can achieve an excellent tracking response for the desired constant output speed and reduce speed fluctuations of the output speed of an IVT by the time-delay feedback control.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 8, 2022
    Assignee: University of Maryland, Baltimore County
    Inventors: Weidong Zhu, Xuefeng Wang, Gang Li
  • Valve translocation device and method for the treatment of functional valve regurgitation
    Patent number: 11259925
    Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: March 1, 2022
    Assignees: University of Maryland, Baltimore, University of Maryland Medical System LLC
    Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
  • Method and apparatus for coaptive ultrasound gastrostomy
    Patent number: 11259838
    Abstract: Disclosed is a system and method for the placement of elongate medical members within a patients body using coaptive ultrasound. In a particularly preferred embodiment, a flexible tube includes a first balloon at a distal end of the tube, and a second balloon at the distal end of the tube and positioned within the first balloon. The first and second balloons are inflatable to form one or more echogenic windows between them, which echogenic window may be detected from within a patient's body by an ultrasound probe that is external to the patient's body. Detection of such echogenic window is used to identify an acceptable location on the patient's body at which to insert a guidewire configured to receive an elongate medical member without damage to surrounding patient tissues or organs.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: March 1, 2022
    Assignee: University of Maryland, Baltimore
    Inventor: Steven Tropello
  • ASPARAGINASE-INDUCED GLUTAMINE DEPLETION COMBINED WITH BCL-2 INHIBITION FOR TREATMENT OF HEMATOLOGIC AND SOLID CANCERS
    Publication number: 20220054606
    Abstract: Methods of treating cancer and prolonging survival of a subject having cancer, such as acute myeloid leukemia, via administration of therapeutically effective amounts of agents that depletes plasma glutamine and agents that inhibit BCL-2 activity are detailed herein. Suitable agents that depletes plasma glutamine include asparaginase Suitable agents that inhibit BCL-2 activity include Venetoclax.
    Type: Application
    Filed: December 19, 2019
    Publication date: February 24, 2022
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Ashkan EMADI, Rena G. LAPIDUS
  • Methods for detecting and/or predicting age-related macular degeneration and/or Alzheimer's disease
    Patent number: 11253614
    Abstract: The present invention provides for the use of hydroxyapatite-selective fluorescent dyes in combination with fluorescence lifetime imaging to detect any hydroxyapatite spherules or hydroxyapatite deposits in the retina tissue of a subject, including the peripheral or macula tissue, wherein the hydroxyapatite spherules or hydroxyapatite deposits initiate or support the growth of sub-RPE deposits and correlates with age-related macular degeneration and/or Alzheimer's disease.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Richard Thompson, Huihui Zeng, Henryk Szmacinski, Imre Lengyel
  • Flex-nucleoside analogues, novel therapeutics against filoviruses and flaviviruses
    Patent number: 11253529
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Katherine L. Radtke
  • Methods of treating resistant cancers
    Patent number: 11246856
    Abstract: Provided herein is a method for reducing resistance in an individual having a drug resistant cancer, for example, a BRAF inhibitor resistant cancer. A Hippo signaling pathway inhibitor such as a Yes-associated protein 1 (YAP1) inhibitor, a Transcriptional Coactivator with PDZ-binding motif (TAZ) inhibitor, a Transcription enhancer domain (TEAD) inhibitor or a combination of these is administered. Also provided is a method of treating BRAF inhibitor resistance in an individual with a BRAF inhibitor resistant cancer, for example, malignant melanoma, with a Hippo signaling pathway inhibitor, such as Verteporfin, and a BRAF inhibitor.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: February 15, 2022
    Assignee: University of Maryland, Baltimore
    Inventors: Richard L. Eckert, Matthew Fisher, Daniel Grun, Gautam Adhikary, Wen Xu
  • Methods for Preparing Therapeutically Active Cells Using Microfluidics
    Publication number: 20220041985
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Application
    Filed: September 6, 2021
    Publication date: February 10, 2022
    Applicants: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony WARD, Roberto CAMPOS-GONZALEZ, Alison SKELLEY, Khushroo GANDHI, Curt CIVIN, James C. STURM, Michael GRISHAM
  • Cloward-style cervical mesh cage with lateral stabilizers
    Patent number: 11234831
    Abstract: A Cloward-style cage device for anterior cervical fusion and fixation includes a body and a lateral stabilizer. The device uses the historical Cloward-style approach, and, as such, decompresses the interbody disc. The device can be used with a cylindrical drill bit to drill through the interbody disc to remove a portion of the interbody endplates to decompress a remaining portion of the interbody disc. The lateral portions of the endplates are generally preserved. The device has a cylindrical body formed of a mesh-like material, with lateral stabilizers.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: February 1, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventor: Charles Sansur
  • METHODS FOR DECREASING INFLUENZA-INDUCED LETHALITY USING GASTRIN-RELEASING PEPTIDE (GRP) INHIBITORS OR GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR) ANTAGONISTS
    Publication number: 20220002399
    Abstract: Gastrin-releasing peptide (GRP) is a neuroendocrine peptide that acts as a novel contributor to the inflammatory response to influenza infection. Thus, inhibition of GRP or antagonizing the GRP receptor (GRPR) during influenza infection represents a novel therapeutic approach to mitigating lung damage. The present invention encompasses methods of treatment based on these novel findings and observations.
    Type: Application
    Filed: September 10, 2019
    Publication date: January 6, 2022
    Applicants: University of Maryland, Baltimore, The United Stated of America, as represented by the Secretary, Departmnet of Health and Human Servic
    Inventors: Stefanie N VOGEL, Kari Ann SHIREY, Frank CUTTITTA