Abstract: A fiber ring resonator having a relatively long loop of standard single-mode fiber with a short nanofiber segment. The evanescent mode of the nanofiber segment allows the cavity-enhanced field to interact with atoms in close proximity to the nanofiber surface.

Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.

Abstract: The present invention relates to an air deflector configuration that can be fabricated into the construction of a new truck or trailer container or secured to the rear face of a flat rear box-like end of trucks and trailers as an attachment, with the aim of reducing aerodynamic resistance and correspondingly the fuel consumption of land vehicles used for the transportation of such containers.

Abstract: Described herein are methods for activating or differentiating a T cell comprising contacting a T cell with a pharmaceutically effective amount of an agent that inhibits Yap and culturing the T cells for a time, and under conditions sufficient to induce activation or differentiation. Compositions comprising the activated or differentiated T cells, and methods for treating a disease or disorder caused by or associated with T cell dysfunction comprising administering the same are described herein. In one embodiment, the disease or disorder is cancer, an autoimmune disease or a microbial infectious disease.

Abstract: An oral vaccine composition for fish, and related oral vaccine delivery system and methods for making and using such oral vaccine composition and delivery system are described. The oral vaccine composition includes virus-like particles effective to mediate an immunoprotective response in a target fish species, wherein the virus-like particles are contained in biomass of an organism or cell culture in which the virus-like particles have been expressed, optionally further including (i) adjuvant effective to enhance the immunoprotective response of the virus-like particles in the target fish species; (ii) encapsulant protectively associated with the virus-like particles for selective locus bioavailability in the target fish species; and/or (iii) binding agent aggregating the ingredients of the composition with one another.

Abstract: Methods and systems to control magnetic fields and magnetic field induced currents, and to provide stimulations within a patient's body, e.g.: deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. An array of magnetic coils is provided and positionable about a portion of a patient's body, and are configured to create a small region of a magnetic hole, or configured to create a small region of concentrated magnetic field strength, or their combination, and at depths within the patient's body in a focused region and sparing the surrounding tissues of the focused region, that have previously not been receptive to non-invasive TMS methods, which are either focused but can affect only the surface and shadow areas, or that can reach certain depths but by doing so only through affecting large surface areas and deep tissue areas.

Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.

Abstract: Disclosed are systems, devices and methods for detecting and measuring TMS-induced electrical fields. In accordance with certain aspects of an embodiment of the invention, a TMS sensor probe is provided having a field detector, a first electrical connection connecting the field detector to either a power source or a processor, and a second electrical connection connecting the field detector to a processor. The field detector is configured to measure a characteristic of a TMS-induced electrical field at the location of the field detector, and the processor is configured to receive the measured characteristic of the induced electrical fields and display a human-readable depiction of a calculated induced electrical field. A system using such a sensor probe to calibrate a TMS-induced electrical field is also provided, including the foregoing sensor probe, and a magnetic field generator.

Abstract: Methods are provided for delivery of at least one agent into egg(s) from an egg-producing aquatic animal including contacting fertilized or unfertilized egg(s) from said egg-producing aquatic animal with the at least one agent in the presence of a guanidine-containing compound capable of enhancing the permeability of the chorion of the egg(s). Methods are provided for the drug screening and compound toxicity assays. Methods are also provided for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of agents that lead to the failure of fertile gonadal development. Agents may be delivered to the eggs directly before the fertilization or post fertilization by contacting eggs in an immersion medium including the agent of interest.

Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

Abstract: A vibrating platform for the deploying of passive sampling devices in sediments and other media to be sampled. The vibrating platform can greatly enhance the rate of mass transfer of analytes, such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls, into passive sampler material by disrupting the formation of a depletion layer in proximity of the passive sampler material.

Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.

Abstract: The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain.

Abstract: Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.

Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.

Abstract: Methods employed for the discovery, enrichment, and characterization of a marine consortium of fermentative and methanogenic microorganisms developed from the solid waste digestor of a fully contained, land-based, marine recirculating aquaculture system are described. The methanogenic microbial consortium discovered is capable of reducing over 90% of marine fish waste in an aquaculture system to biomethane and carbon dioxide at saline concentrations found in marine aquaculture. Systems and methods for the treatment of marine fish waste utilizing the methanogenic marine consortium are also disclosed.

Abstract: The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune suppression and restoring T cell activation.

Abstract: The present invention provides for excitable molecules positioned near metallic structures, wherein the metallic structures have a particles size from about 1 nm to 1000 nm and wherein the excitable molecules have fluorescence, phosphorescence or alpha-fluorescence emissions that are altered due to positioning near the metal structures. The emission spectra are distorted on either the blue or red edges in a range from 1 to 10 nm thereby changing the color of emissions. Further, the width of the emission spectrum is modified either by narrowing or broadening depending on the material of the metallic structures and type of excitable molecule.

Abstract: A turbulence-free CCD camera system with nonclassical imaging resolution, for applications in long-distance imaging, such as satellite and aircraft-to-ground based distant imaging, utilizing an intensity-fluctuation correlation measurement of thermal light. The proposed camera system has the following advantages over classic imaging technology: (1) it is turbulence-free; (2) its spatial resolution is mainly determined by the angular diameter of the light source. For example, using sun as the light source, this camera may achieve a spatial resolution of 200 micrometer for any object on Earth. 200-micrometer resolution is insignificant for short distance imaging, however, taking a picture of a target at 10-kilometer, a classic camera must have a lens of 90-meter diameter in order to achieve 200-micrometer resolution.