Abstract: A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.
Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.
Type:
Application
Filed:
August 2, 2021
Publication date:
March 3, 2022
Applicants:
University of Maryland, College Park, The United States of America, as represented by the Secretary, Department of Health and Human Servic
Inventors:
Scott Durum, Julie Hixon, Wen Qing Li, Scott Walsh, Lila Kashi
Abstract: A microfluidic cell system to measure proton concentration in a fluid sample. The microfluidic cell system includes: a first microchip and a second microchip dimensioned to permit electron beam scanning of a fluid sample; a first membrane attached to the first microchip; a second membrane attached to the second microchip, the first membrane and the second membrane being disposed adjacent to one another with a space for the fluid sample therebetween, and the first membrane and the second membrane including a region of the fluid sample in which an electron beam is scanned; a first electrode patterned onto the first membrane and positioned a first distance from the region; a second electrode patterned onto the first microchip and positioned a second distance from the region, the first distance being less than the second distance; and a potentiostat in communication with the first electrode and the second electrode.
Abstract: The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state.
Type:
Grant
Filed:
January 3, 2019
Date of Patent:
March 1, 2022
Assignee:
University of Maryland, College Park
Inventors:
Christopher Monroe, Jiehang Zhang, David Wong-Campos, Antonios Kyprianidis, Patrick Michael Becker
Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.
Type:
Grant
Filed:
November 18, 2020
Date of Patent:
February 15, 2022
Assignee:
University of Maryland, College Park
Inventors:
Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
Abstract: A method and apparatus for monitoring arterial properties, including systolic and diastolic pressure levels, of a subject is provided, in which a hardware processor receives and analyzes ballistocardiogram (BCG) data of the subject. A non-transient computer readable medium, accessible by the hardware processor, contains instructions that, when executed by the hardware processor, identify features of the BCG waveform and determine the arterial properties therefrom. For example, a diastolic pressure level may be determined from a time interval between the ‘I’ and ‘J’ peaks of the waveform and a systolic pressure level determined from the amplitude difference between the ‘J’ and ‘K’ peaks of the waveform in combination with the ‘I-J’ time interval or amplitude difference. A physical mechanism for the BCG data is disclosed that enables other arterial properties of the subject to be determined from the BCG data alone or from the BCG data in combination with other measurements.
Type:
Grant
Filed:
April 6, 2018
Date of Patent:
February 8, 2022
Assignees:
University of Maryland, College Park, Board of Trustees of Michigan State University, Georgia Tech Research Corporation
Inventors:
Chang-Sei Kim, Stephanie Lind-Ober Martin, Jin-Oh Hahn, Ramakrishna Mukkamala, Omer T. Inan
Abstract: The disclosure relates to solid oxide fuel cell (SOFC) anode materials that comprise various compositions of chromate based oxide materials. These materials offer high conductivity achievable at intermediate and low temperatures and can be used to prepare the anode layer of a SOFC. A method of making a low- or intermediate-temperature SOFC having an anode layer comprising a chromate based oxide material is also provided.
Type:
Grant
Filed:
September 25, 2018
Date of Patent:
January 18, 2022
Assignee:
University of Maryland, College Park
Inventors:
Mohammed Hussain Abdul Jabbar, Eric D. Wachsman, Ke-Ji Pan
Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.
Type:
Application
Filed:
November 12, 2019
Publication date:
January 6, 2022
Applicants:
University of Maryland, College Park, The Regents of the University of California
Inventors:
Anne Elizabeth Simon, Jingyuan Liu, Georgios Vidalakis, Sohrab Bodaghi
Abstract: A method termed “superacid-surfactant exchange” (S2E) for the dispersion of carbon nanomaterials in aqueous solutions. This S2E method enables nondestructive dispersion of carbon nanomaterials (including single-walled carbon nanotubes, double-walled carbon nanotubes, multi-wall carbon nanotubes, and graphene) at rapidly and at large scale in aqueous solution without a requirement for expensive or complicated equipment. Dispersed carbon nanotubes obtained from this method feature long length, low defect density, high electrical conductivity, and in the case of semiconducting single-walled carbon nanotubes, bright photoluminescence in the near-infrared.
Type:
Grant
Filed:
August 8, 2019
Date of Patent:
December 28, 2021
Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
YuHuang Wang, Peng Wang, Mijin Kim, Chiyu Zhang
Abstract: Solid-state lithium ion electrolytes of metal lithium chloride derivative compounds having a crystal morphology in the P21/c space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.15 to 0.40 eV and conductivities are from 0.01 to 3 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
Type:
Application
Filed:
June 23, 2020
Publication date:
December 23, 2021
Applicants:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Abstract: An apparatus for generating a blood pressure estimation model includes: a signal acquirer configured to receive input a first signal and a second signal from a user; and a processor configured to obtain a pulse transit time (PTT) as a first predictor variable value based on the first signal and the second signal, to extract at least one feature from the second signal, to obtain a second predictor variable value based on the extracted at least one feature, and to generate a blood pressure estimation model based on the first predictor variable value and the second predictor variable value.
Type:
Application
Filed:
May 17, 2021
Publication date:
December 23, 2021
Applicants:
SAMSUNG ELECTRONICS CO., LTD., University of Maryland, College Park
Inventors:
Dae Geun JANG, Peyman Yousefian, Jin-Oh Hahn, Ui Kun Kwon, Youn Ho Ho Kim, Sungtae Shin
Abstract: Solid-state lithium ion electrolytes of lithium zinc chloride derivative compounds having a crystal morphology in the Pmn21 space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.15 to 0.40 eV and conductivities are from 0.01 to 15 mS/cm at 300 K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
Type:
Application
Filed:
June 23, 2020
Publication date:
December 23, 2021
Applicants:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Abstract: Solid-state lithium ion electrolytes of lithium aluminum chloride derivative compounds having a crystal morphology in the Pnma space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.2 to 0.45 eV and conductivities are from 0.01 to 10 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
Type:
Application
Filed:
June 23, 2020
Publication date:
December 23, 2021
Applicants:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Abstract: A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.
Abstract: In various embodiments, a solid oxide fuel cell features a functional layer for reducing interfacial resistance between the cathode and the solid electrolyte.
Type:
Grant
Filed:
September 17, 2019
Date of Patent:
December 7, 2021
Assignees:
REDOX POWER SYSTEMS, LLC, UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Ke-Ji Pan, Mohammed Hussain Abdul Jabbar, Dong Ding, Eric Wachsman
Abstract: The present invention provides for novel fucosidase mutants that server as fuco-ligases for core fucosylation of a range of biological glycopeptides and glycoproteins including intact therapeutic antibodies. Several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei ?1,6-fucosidase, including E274A, E274S, and E274G, were able to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. The site specific mutants enable the transfer of fucose to a core GlcNAc-Asn residue and useful for drug delivery and vaccine development.
Abstract: This disclosure provides a method for preventing, treating, or managing an ebolavirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least one pan-ebolavirus internal fusion loop antibody or antigen-binding fragment thereof, wherein the binding domain specifically binds to the epitope on two or more ebolavirus species or strains.
Type:
Grant
Filed:
October 9, 2017
Date of Patent:
November 30, 2021
Assignees:
INTEGRATED BIOTHERAPEUTICS, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Mohammad Javad Aman, Katie A. Howell, Frederick Wayne Holtsberg, Xuelian Zhao, Yuxing Li
Abstract: Most automatic cuff blood pressure (BP) measurement devices are based on oscillometry. These devices estimate BP from the envelopes of the cuff pressure oscillations using fixed ratios. The values of the fixed ratios represent population averages, so the devices may be accurate only in subjects with normal BP levels. A patient-specific oscillometric BP measurement method was developed. The idea was to represent the cuff pressure oscillation envelopes with a physiologic model and then estimate the patient-specific parameters of the model, which includes BP levels, by optimally fitting it to the envelopes.
Type:
Grant
Filed:
September 9, 2016
Date of Patent:
November 23, 2021
Assignees:
Board of Trustees of Michigan State University, University of Maryland, College Park
Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.
Abstract: The present invention relates to a method for concentrating a biological sample containing nucleic acids by using magnetic chitosan microparticles and subsequently performing a PCR reaction on the nucleic acids captured on the microparticles. The chitosan microparticles added to the biological sample at a PCR compatible pH are mechanically agitated to provide for cell lysis and simultaneous DNA capture, and then serve as a solid support for the nucleic acid template during the PCR reaction. As the chitosan microparticles are utilized for lysis and the nucleic acids do not need to be removed from the microparticles before PCR, the ease of the sample preparation procedure is dramatically improved.
Type:
Grant
Filed:
May 20, 2016
Date of Patent:
November 16, 2021
Assignees:
University of Maryland, College Park, Canon U.S.A., Inc.
Inventors:
Ian M. White, Srinivasa Raghavan, Kunal R. Pandit, Imaly Nanayakkara, Weidong Cao