Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.

Abstract: A film and heated plastic blank are sized to fit over a mold cavity and a combination of said film and blank formed. The combination is positioned over the mold cavity and formed in said mold cavity into the shape of said mold cavity.

Abstract: A film is placed over a mold cavity and molten plastic deposited thereon to form a combination of a film with molten plastic thereon. The film-molten plastic combination is then formed in said mold cavity into a molded article in the shape of the mold cavity.

Abstract: A molded plastic article having improved electromagnetic interference (EMI) shielding properties. The article includes a plastic layer and an outer film layer over the plastic layer. The outer film layer has an inner surface adjacent to and bonded to the plastic layer and an outer surface opposed to the inner surface. The plastic layer and outer layer are electrically conductive. Preferably the outer layer has higher conductivity than the plastic layer.

Abstract: A paint film particularly for servicing an automobile body part including: a clear coat layer of a sheet of polymer, said sheet having chemical resistance, weatherability and optical clarity, said sheet having an outer surface and an opposed bonding surface; a color layer adhered to said bonding surface, said color layer, said color layer including an adhesive and at least one color pigment; and a support layer of an extruded film adhered to said color layer.

Abstract: A template is placed over a mold cavity, with the template including a series of orifices which extend over substantially the entire surface of the mold cavity. Molten plastic is passed through the orifices in a pattern corresponding to the shape of the article to be molded, and the molten plastic is formed into a molded article having the shape of the mold cavity.

Abstract: In situ hybridization methods for assessing, determining or observing the RNA produced by transcriptionally active genes. In one embodiment, the methods allow simultaneous observation of the gene and its transcripts in a spatially correlated manner. As the in situ hybridization methods have established their ability to maintain the targeted mRNA at the site of its transcription, it can be determined which genes are being expressed and the level of expression can be quantitated.

Abstract: A method for fabricating x-ray-detecting structured screens using laser-based micro-machining techniques results in devices having improved spatial resolution. In one case, each pixel of the screen contains an optically active scintillating material surrounded with a optically inactive material having a relatively lower refractive index; following absorption of light, each pixel channels x-ray-induced phosphorescence to a small region of a detector. Alternatively, the optically active material can be a photoconducting material, such as selenium, and the surrounding optically inactive material is chosen to have a relatively high resistivity.

Abstract: A unique method and apparatus for therapeutically treating immunological disorders and disease states which are characterized by the present of immunologically abnormal leukocytes in the body of the afflicted subject is provided. The apparatus and methodology utilized a sealed diffusion chamber which may be surgically implanted in-vivo or may be extracorporeally joined to the circulatory system of the afflicted subject. In either mode of use, the diffusion chamber utilizes immunologically normal leukocytes of various types and concentration which are able to provide cell functions and cellular secretory products which therapeutically counterbalance the effects of the immunological abnormality within the afflicted subject.