Abstract: The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.
Type:
Application
Filed:
July 14, 2010
Publication date:
July 5, 2012
Applicants:
THE UNIVERSITY OF MASSACHUSETTS FOUNDATION, INC., TRUSTEES OF TUFTS COLLEGE
Inventors:
Xiaohui Zhang, David L. Kaplan, Scott E. Wharram, Stephen McCarthy