Patents Assigned to The University of Melbourne
  • Publication number: 20220142881
    Abstract: The present invention relates to compositions for uses including mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by various means including dental caries, dental corrosion and fluorosis are also provided. In one aspect, the present invention provides a method of mineralizing a dental surface or sub-surface comprising contacting the dental surface or subsurface with stabilized amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP), and simultaneously or subsequently, heating the dental surface or subsurface to which the stabilized ACP and/or ACFP has been, or is being, applied to a temperature greater than 37° C.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Applicant: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Patent number: 11297785
    Abstract: A method of spatially deriving soil moisture at a selected location within an irrigation district to be irrigated. The method includes using system identification techniques to produce an algorithm for evapotranspiration based on a predetermined selection from the following measured parameters: solar radiation spectrum, wind speed, temperature, humidity, crop factor, soil type, barometric pressure, irrigation historical data, and energy measurement from solar panels at each of a plurality of representative locations; calibrating the algorithm by direct measurement of the moisture in the soil at each of the representative locations by respective soil moisture sensors; and using measured parameters of rainfall, soil type, irrigation historical data and crop factor with the algorithm to derive or interpolate soil moisture at the selected location within the irrigation district.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: April 12, 2022
    Assignees: RUBICON RESEARCH PTY LTD, THE UNIVERSITY OF MELBOURNE
    Inventors: David John Aughton, Sumith Choy, Iven Michiel Yvonne Mareels, Dongryeol Ryu, Andrew Western
  • Patent number: 11269026
    Abstract: This disclosure relates to a magnetometer for measuring a magnetic field. The magnetometer comprises a solid state quantum system with at least two quantum spin states. A control signal generator sets the quantum system into a quantum state that accumulates a phase over time depending on the magnetic field. A detector measures a signal from the quantum system indicative of the accumulated phase at a measurement time after the setting of the quantum state. A processor determines a magnetic field measurement based on the signal measured by the detector. Importantly, the quantum system is mounted on a rotator that is configured to rotate the quantum system about a rotation axis that defines an angle with the direction of the magnetic field and at a rotation rate that modulates the magnetic field over the measurement time.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 8, 2022
    Assignee: The University of Melbourne
    Inventors: Alexander Wood, Andrew Martin, Alastair Stacey, Lloyd Hollenberg
  • Patent number: 11211167
    Abstract: Heterogeneity for biomarkers in a tissue sample can be calculated. A heterogeneity score can be combined with an immunohistochemistry combination score to provide breast cancer recurrence prognosis. Heterogeneity can be based on percent positivity determinations for a plurality of biomarkers according to how many cells in the sample stain positive. An immunohistochemistry combination score can be calculated. An imaging tool can support a digital pathologist workflow that includes designating fields of view in an image of the tissue sample. Based on the fields of view, a heterogeneity metric can be calculated and combined with an immunohistochemistry combination score to generate a breast cancer recurrence prognosis score.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: December 28, 2021
    Assignees: VENTANA MEDICAL SYSTEMS, INC., THE CLEVELAND CLINIC FOUNDATION, THE UNIVERSITY OF MELBOURNE
    Inventors: Srinivas Chukka, Olcay Sertel, Anindya Sarkar, Nikolaus Wick, Shalini Singh, Crystal Schemp, Paul Waring, Raymond Tubbs
  • Publication number: 20210393948
    Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 23, 2021
    Applicant: The University of Melbourne
    Inventors: Nicholas Lachlan Opie, Thomas James Oxley, Gil Simon Rind, Stephen Michael Ronayne, Sam Emmanuel John, Clive N. May, David B. Grayden
  • Patent number: 11154589
    Abstract: This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti-bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: October 26, 2021
    Assignee: The University of Melbourne
    Inventors: Greg GuangHua Qiao, Neil Martin O'Brien-Simpson, Shu Jie Lam, Eric Charles Reynolds
  • Patent number: 11123350
    Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: September 21, 2021
    Assignee: The University of Melbourne
    Inventors: Paul Donnelly, James Hilton, Peter Crouch
  • Patent number: 11123316
    Abstract: The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: September 21, 2021
    Assignee: The University of Melbourne
    Inventors: Paul Stephen Donnelly, Stacey Erin Rudd, Spencer John Williams
  • Patent number: 11123349
    Abstract: The present invention relates to the treatment of equine animals presenting with an inflammatory condition and/or symptoms associated with inflammation and/or which have a condition which could lead to an inflammatory disorder. Formulations and therapeutic protocols useful for the treatment of inflammation and amelioration of symptoms associated with inflammation also form part of the present invention.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: September 21, 2021
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Simon R. Bailey
  • Patent number: 11111254
    Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: September 7, 2021
    Assignee: The University of Melbourne
    Inventors: Paul Stephen Donnelly, Michelle Therese Ma, Denis Bernard Scanlon
  • Publication number: 20210213113
    Abstract: The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.
    Type: Application
    Filed: May 10, 2019
    Publication date: July 15, 2021
    Applicants: The Walter and Eliza Hall Instiitute of Medical Research, The University of Melbourne
    Inventors: Chris TONKIN, Alessandro UBOLDI, Malcolm MCCONVILLE, Martin BLUME
  • Publication number: 20210213053
    Abstract: A method of enhancing embryo implantation in a subject is disclosed which comprises administering to the uterine cavity of the subject a formulation comprising copper and/or zinc in an amount effective to stimulate endometrial production of leukaemia inhibitory factor (LIF) and/or vascular endothelial growth factor (VEGF). Alternatively, a device may be inserted into the uterine cavity of the subject, wherein the device comprises copper and/or zinc, for a period of time that is effective to stimulate endometrial production of LIF and/or VEGF. The method is suitable for use with women undergoing treatment by any of the assisted reproductive technologies, such as those involving the transfer of embryos such as in vitro fertilisation (IVF) and variants including IVF-ICSI (intracytoplasmic sperm injection) and in vitro maturation (IVM) treatments, as well as intrauterine-insemination (IUI) therapy.
    Type: Application
    Filed: May 29, 2019
    Publication date: July 15, 2021
    Applicants: The Flinders University of South Australia, The University of Melbourne
    Inventors: Kelton Paul Tremellen, David K. Gardner, Alexandra J. Harvey
  • Publication number: 20210161778
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 3, 2021
    Applicant: The University of Melbourne
    Inventor: Eric Charles REYNOLDS
  • Patent number: 10932041
    Abstract: A method of outputting a warning indicative of potential migraine onset includes controlling a display of an electronic device to display, to a user, test stimuli of at least one spatial visual contextual test that is a perceptual analogue of centre-surround neuronal responses in human vision, and receiving, via an input device of the electronic device, at least one response of the user to the test stimuli. The method also includes processing the at least one response of the user to obtain test outcome data, and outputting a warning indication of potential migraine onset to the user if the test outcome data is outside an expected range for daily fluctuation in test outcome data.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: February 23, 2021
    Assignees: The University of Melbourne, The University of Western Australia
    Inventors: Allison McKendrick, David Badcock
  • Patent number: 10912722
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: February 9, 2021
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 10870664
    Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: December 22, 2020
    Assignee: The University of Melbourne
    Inventors: Paul Stephen Donnelly, Michelle Therese Ma, Denis Bernard Scanlon
  • Patent number: 10830717
    Abstract: This disclosure relates to determining a spatial configuration of multiple nuclei. An electron dipole generates a spatially varying magnetic field such that each of the multiple nuclei is resonant at a respective resonance frequency defined by the magnetic field at a location of that nucleus. A first signal generator generates a first signal at a first signal frequency such that, as a result of dipole-dipole interaction between the electron dipole and a subset of the multiple nuclei that are resonant at the first signal frequency, a phase of the electron dipole is indicative of a number of nuclei that are resonant at the first signal frequency. A readout module determines the phase of the electron dipole, and determines the spatial configuration of the multiple nuclei based on the phase of the electron dipole. As a result of the high spatial resolution of the sensing the nuclear structure of molecules can be determined with low noise.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: November 10, 2020
    Assignee: The University of Melbourne
    Inventors: Lloyd Hollenberg, Viktor Perunicic
  • Patent number: 10809333
    Abstract: An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients can also be included in the pulse sequence.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: October 20, 2020
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Roger John Ordidge
  • Publication number: 20200247895
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: March 31, 2020
    Publication date: August 6, 2020
    Applicant: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Publication number: 20200246378
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds