Abstract: The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them.
Type:
Application
Filed:
April 14, 2008
Publication date:
February 23, 2012
Applicant:
THE UNIVERSITY OF MELBOURNE of ROYAL PARADE PARKVILLE
Inventors:
Alastair Stewart, Martin Banwell, Brenda Leung, Anu Augustine, Jacki Kitching, Tomasz Bilski
Abstract: The present invention provides cytotoxic Epstein-Barr virus (EBV) T-cell epitopes derived from EBV structural antigens. Preferred epitopes include YLLEMLWRL (SEQ ID NO:1), YFLEILWGL (SEQ ID NO:32), YLLEILWRL (SEQ ID NO:33), YLQQNWWTL (SEQ ID NO:6), LLLALLFWL (SEQ ID NO:2), LLVDLLWLL (SEQ ID NO:3), LLLIALWNL (SEQ ID NO:4), WLLLFLAIL (SEQ ID NO:5), TLLVDLLWL (SEQ ID NO:7), LLWLLLFLA (SEQ ID NO:8), ILLIIALYL (SEQ ID NO:9), VLFIFGCLL (SEQ ID NO:10), RLGATIWQL (SEQ ID NO:11), ILYFIAFAL (SEQ ID NO:15), SLVIVTTFV (SEQ ID NO:17), LMIIPLINV (SEQ ID NO:20), TLFIGSHVV (SEQ ID NO:24), LIPETVPYI (SEQ ID NO:26), VLQWASLAV (SEQ ID NO:27) and QLTPHTKAV (SEQ ID NO:29). The present invention also provides methods of treating or preventing EBV infection in subjects which involve administration of EBV cytotoxic T-cell epitopes.
Type:
Grant
Filed:
May 30, 2000
Date of Patent:
April 20, 2004
Assignees:
Council of the Queensland Institute of Medical
Research, Commonwealth Scientific and Industrial Research Organisation
of Limestone Avenue, The University of Melbourne of Royal Parade, Walter and Elisa Hall Institute of Medical Research of Royal
Melbourne Hospital, CSL Limited
Inventors:
Scott Renton Burrows, Rajiv Khanna, Martina Alison Sherritt