Patents Assigned to The University of Memphis
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Publication number: 20240310367Abstract: The present disclosure features compositions and methods related to the detection and molecular profiling of extracellular vesicles using fluorescent probes. These compositions and methods leverage the unique optoelectrical properties of quantum dots and fluorescently labeled nanoparticles, which allows reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules.Type: ApplicationFiled: May 8, 2024Publication date: September 19, 2024Applicant: The University of Memphis Research FoundationInventors: Xiaohua HUANG, Thang Ba HOANG
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Patent number: 11988663Abstract: The present disclosure features compositions and methods related to the detection and molecular profiling of extracellular vesicles using fluorescent probes. These compositions and methods leverage the unique optoelectrical properties of quantum dots and fluorescently labeled nanoparticles, which allows reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules.Type: GrantFiled: December 18, 2019Date of Patent: May 21, 2024Assignee: The University of Memphis Research FoundationInventors: Xiaohua Huang, Thang Ba Hoang
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Patent number: 11878088Abstract: The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.Type: GrantFiled: December 1, 2021Date of Patent: January 23, 2024Assignee: The University of Memphis Research FoundationInventors: Joel D. Bumgardner, Hengjie Su, Tomoko Fujiwara, Daniel G. Abebe, Kwei-Yu Liu
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Publication number: 20230324376Abstract: The present disclosure featured compositions and methods related to the detection and molecular profiling of extracellular vesicles using optical probes, dual imaging approaches, and computationally programing-based image analysis methods. These compositions and methods leverage the unique optoelectrical properties of quantum dots, fluorescently labeled nanoparticles, and gold nanoparticles, which allow reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules at single vesicle level.Type: ApplicationFiled: April 10, 2023Publication date: October 12, 2023Applicant: The University of Memphis Research FoundationInventors: Xiaohua HUANG, Thang Ba HOANG, Yongmei WANG, Caleb Edward GALLOPS
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Publication number: 20230226190Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).Type: ApplicationFiled: January 27, 2023Publication date: July 20, 2023Applicant: The University of Memphis Research FoundationInventors: Warren O. HAGGARD, Scott P. NOEL, Joel D. BUMGARDNER
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Publication number: 20220370191Abstract: Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), to form a polymer-containing solution. The method comprises electrically charging the polymer-containing solution. The method comprises writing the polymer-containing solution on a counter electrode or a ground in a grid pattern to form semi-stable fibers comprised of the polymer, the semi-stable fibers vary between bent and straight and forming the hybrid fibrous scaffold. The writing may be performed by a 3D printer. The resulting scaffolds and methods of using the same are also disclosed herein.Type: ApplicationFiled: May 18, 2022Publication date: November 24, 2022Applicant: The University of Memphis Research FoundationInventors: Gary Lee Bowlin, William Elbert King, III
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Publication number: 20220218636Abstract: Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface. Typically, the cyclopropanated structural analog has the structure according to formula (I): wherein R1 is a C1-C24 linear or branched alkyl group; or an acid halide or acid anhydride thereof.Type: ApplicationFiled: March 23, 2022Publication date: July 14, 2022Applicant: The University of Memphis Research FoundationInventors: Jessica Amber JENNINGS, Daniel Lee BAKER, Rukhsana AWAIS, Zoe HARRISON, Babatunde RAJI
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Publication number: 20220160935Abstract: The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.Type: ApplicationFiled: December 1, 2021Publication date: May 26, 2022Applicant: The University of Memphis Research FoundationInventors: Joel D. Bumgardner, Hengjie Su, Tomoko Fujiwara, Daniel G. Abebe, Kwei-Yu Liu
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Patent number: 11202850Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).Type: GrantFiled: March 11, 2019Date of Patent: December 21, 2021Assignees: The University of Memphis Research Foundation, The University of Tennessee Research FoundationInventors: Gary L. Bowlin, Allison E. Fetz, Marko Z. Radic
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Publication number: 20210190774Abstract: The invention features compositions and methods related to the detection and molecular profiling of membrane bound vesicles using the Raman Extracellular Vesicle Assay (REVA). The method makes use of highly sensitive and specific surface enhanced Raman scattering technology to label and detect membrane bound vesicles that are captured on a miniaturized device based on the protein expression on the surface of the membrane bound vesicle.Type: ApplicationFiled: December 18, 2018Publication date: June 24, 2021Applicant: The University of Memphis Research FoundationInventors: Xiaohua Huang, Allie Elyahb Kwizera, Vojtech Vinduska, Thang Ba Hoang
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Publication number: 20210154264Abstract: Compositions of chitosan and one or more polyalcohols, such as mannitol and polyethylene glycol, and methods of use thereof, are provided. The disclosed compositions can deliver high concentrations of localized antimicrobials and metabolites to make infections more susceptible to antimicrobials. The disclosed compositions may be used to deliver biologically active agents to an infection at a site of trauma or surrounding an indwelling medical device, to treat an infection caused by persister bacterial cells, and to treat and/or prevent the formation of biofilm bacteria on an indwelling medical device or surrounding tissue.Type: ApplicationFiled: November 23, 2020Publication date: May 27, 2021Applicant: The University of Memphis Research FoundationInventors: J. Amber Jennings, Leslie Pace, Madison N. Brown
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Publication number: 20210047653Abstract: The invention features compositions and methods for the inducible regulation of one or more target genes using a CRISPR-based synthetic gene regulatory network that responds to spatiotemporally-controlled agents present, for example, on a substrate (e.g., an electrospun template).Type: ApplicationFiled: January 29, 2019Publication date: February 18, 2021Applicant: The University of Memphis Research FoundationInventors: Gary L. Bowlin, Diego Augusto Velasquez Pulgarin, Alexander Espinosa
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Patent number: 10405746Abstract: In one embodiment, a method is disclosed in which an analog sensor receives an electromagnetic (EM) wave (e.g., a radio frequency signal) from an interrogation device. The sensor converts a biological measurement of a subject into an electrical resistance and modulates a response to reflect the incident signal based on the electrical resistance. The sensor then provides the response to the interrogation device that corresponds to the biological measurement.Type: GrantFiled: April 14, 2015Date of Patent: September 10, 2019Assignee: The University of Memphis Research FoundationInventors: Bashir I. Morshed, Sergi Consul-Pacareu
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Patent number: 10182499Abstract: A multilayer printed circuit as well as printed passive and active electronic components using additive printing technology is provided. The fabrication process includes a substrate and a first conductive layer that is printed with conductive ink on the substrate. An insulation layer that has uniform thickness is printed on the first conductive layer and the substrate, less via cavities, test point cavities, and a surface mount component contact point and mounting cavities. The insulation layer is replaceable with resistive layer or semi-conductive layer to fabricate electronic components. The vias are printed with conductive ink inside of the via cavities. Additionally, a second conductive layer is printed on the vias and over the insulation layer. The insulation, resistive, or semi-conducting layer, the vias, and the conductive layers are repeatedly printed in sequence to thus form the multilayer printed circuit.Type: GrantFiled: November 9, 2016Date of Patent: January 15, 2019Assignee: The University of Memphis Research FoundationInventor: Bashir I. Morshed
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Patent number: 9962468Abstract: This invention describes a cell growth apparatus, particularly neuronal printed circuit board apparatus comprising an aerogel base and a pre-printed cellular growth pattern. The cellular growth pattern is comprised of combinations of layers of cellular adhesion promoting materials, cellular adhesion inhibiting materials, and/or cellular signal promoting materials. The invention further describes methods of promoting cell growth using the neuronal printed circuit board apparatus of the invention. The invention is useful for regeneration and precise guidance of cells, particularly nerve cells, when used as an implant.Type: GrantFiled: April 15, 2010Date of Patent: May 8, 2018Assignee: The University of Memphis Research FoundationInventor: Firouzeh Sabri
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Patent number: 9952209Abstract: Magnetic-optical iron oxide-gold core-shell nanoparticles are disclosed. Methods for making and using the nanoparticles are also disclosed.Type: GrantFiled: July 1, 2014Date of Patent: April 24, 2018Assignee: The University of Memphis Research FoundationInventors: Xiaohua Huang, Saheel Bhana
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Patent number: 9733351Abstract: A system for detecting object movement including a sensory network having at least one sensory device using modulated radar for detecting an object in proximity to the sensory network. The sensory network including wireless transmission means and a base station having computer processing means located remote from the sensory network and including wireless transmission means to communicate with the sensory network. The base station having computer readable program code means for causing the computer processing means to analyze data received from the sensory network to determine motion characteristics of the object in proximity to the sensory network.Type: GrantFiled: December 6, 2011Date of Patent: August 15, 2017Assignee: The University of Memphis Research FoundationInventors: Robert Kozma, Khan M. Iftekharuddin, Lan Wang, Ross Deming
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Patent number: 9662400Abstract: The invention provides improved methods for generating biodegradable chitosan compositions, and therapeutic methods of using such compositions to deliver therapeutic agents.Type: GrantFiled: March 14, 2013Date of Patent: May 30, 2017Assignee: The University of Memphis Research FoundationInventors: James Keaton Smith, Ashley C. Parker, Jessica A. Jennings, Benjamin T. Reves, Warren O. Haggard
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Patent number: 9642948Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).Type: GrantFiled: February 10, 2015Date of Patent: May 9, 2017Assignee: The University of Memphis Research FoundationInventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
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Patent number: 9603522Abstract: This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.Type: GrantFiled: August 26, 2010Date of Patent: March 28, 2017Assignees: Mayo Foundation for Medical Education and Research, The University of Memphis Research FoundationInventors: Kendall H. Lee, Kevin E. Bennet, Charles D. Blaha