Patents Assigned to The University of Minnesota
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Publication number: 20240189365Abstract: Provided herein are genetically modified porcine cells comprising a reduced or eliminated level of ?1,3-N-acetylglucosaminyltransferase 5 (B3gnt5) activity as compared to a normal porcine cell, and methods of improving a rejection related symptom by transplanting porcine cells, tissues or organs to a subject in need thereof.Type: ApplicationFiled: April 14, 2022Publication date: June 13, 2024Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventor: Christopher BURLAK
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Patent number: 12006294Abstract: The invention provides methods for producing analgesia in an animal comprising administering to the animal a compound of the formula Ia?, Ib?, Ic?, and Id?: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein.Type: GrantFiled: June 3, 2019Date of Patent: June 11, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Swati S. More, Robert Vince
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Patent number: 12007385Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.Type: GrantFiled: September 9, 2022Date of Patent: June 11, 2024Assignee: Regents of the University of MinnesotaInventors: Gregory Kermit Peterson, Justin Theodore Nelson, Gregory J. Sherwood
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Patent number: 11993874Abstract: Advances in actuating fabrics could enable a paradigm shift in the field of smart wearables by dynamically fitting themselves to the unique topography of the human body. Active fabrics and fitting mechanisms are described herein that enable garments to conform around surface concavities without requiring high elasticity or a multiplicity of closure devices. Advanced materials and systems innovations (1) enable novel garment manufacturing and application strategies, (2) facilitate topographical fitting (spatial actuation) through garment architectural design, and (3) provide tunable NiTi-based SMA actuation temperatures to enable actuation on the surface of human skin. Such fabrics and garments are usable in a variety of fields including medical compression, technical sportswear, exosuits, space suits and components thereof, or non-garment applications.Type: GrantFiled: September 11, 2020Date of Patent: May 28, 2024Assignee: Regents of the University of MinnesotaInventors: Kevin Eschen, Julianna Abel, Bradley Thomas Holschuh, Rachael Margaret Granberry
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Patent number: 11996232Abstract: Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an applied magnetic field to form a workpiece including at least one iron-based phase domain including uniaxial magnetic anisotropy, wherein the applied magnetic field has a strength of at least about 0.01 Tesla (T). Also disclosed are workpieces made by such methods, apparatus for making such workpieces and bulk materials made by such methods.Type: GrantFiled: April 30, 2021Date of Patent: May 28, 2024Assignee: Regents of the University of MinnesotaInventors: Jian-Ping Wang, YanFeng Jiang
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Patent number: 11994392Abstract: A vision-aided inertial navigation system (VINS) implements a square-root multi-state constraint Kalman filter (SR-MSCKF) for navigation. In one example, a processor of a VINS receives image data and motion data for a plurality of poses of a frame of reference along a trajectory. The processor executes an Extended Kalman Filter (EKF)-based estimator to compute estimates for a position and orientation for each of the plurality of poses of the frame of reference along the trajectory. For features observed from multiple poses along the trajectory, the estimator computes constraints that geometrically relate the multiple poses of the respective feature. Using the motion data and the computed constraints, the estimator computes state estimates for the position and orientation of the frame of reference. Further, the estimator determines uncertainty data for the state estimates and maintains the uncertainty data as a square root factor of a covariance matrix.Type: GrantFiled: October 10, 2022Date of Patent: May 28, 2024Assignee: Regents of the University of MinnesotaInventors: Stergios I. Roumeliotis, Kejian J. Wu
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Patent number: 11993789Abstract: Provided herein are genetically engineered Pichinde viruses that include three ambisense genomic segments. The first genomic segment includes a coding region encoding a Z protein and a coding region encoding a L RdRp protein. The second genomic segment includes a coding region encoding a nucleoprotein (NP) and the third genomic segment includes a coding region encoding a glycoprotein. Each of the second and third genomic segments optionally include an additional coding region that may encode an antigen or a detectable marker. Also provided herein is a reverse genetics system for making a genetically engineered Pichinde virus, and a collection of vectors that can be used to produce a genetically engineered Pichinde virus. Further provided are methods for using a reverse genetics system, and methods for producing an immune response in a subject.Type: GrantFiled: December 10, 2019Date of Patent: May 28, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Hình Ly, Yuying Liang
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Patent number: 11985969Abstract: This disclosure describes a cryopreservative composition and methods for storing cells. Generally, the cryopreservative composition includes a sugar component and a sugar alcohol component, and is effective for storing and recovering cells without requiring dimethyl sulfoxide (DMSO).Type: GrantFiled: July 9, 2021Date of Patent: May 21, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Allison Hubel, Kathryn Lindsay Pollock
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Patent number: 11986533Abstract: A composition includes a macromolecular polyacrylamide copolymer excipient with an ?-end including a ROMP-active norbornene end-group and a ?-end including a terminal monomer with an end group chosen from: a hydrogen atom (H); or a functionalized acrylate with functionality chosen from alkyl, hydroxyl (OH), methyl-polyethylene glycol ((PEG)-CH3), hydroxy-PEG (PEG-OH), carboxylic acid (COOH), and combinations thereof. A biological compound chosen from active pharmaceutical ingredients, proteins, polynucleotides, and mixtures and combinations thereof is non-covalently bound with the macromolecular excipient.Type: GrantFiled: January 21, 2022Date of Patent: May 21, 2024Assignee: Regents of the University of MinnesotaInventors: Theresa Reineke, Frank S. Bates, Monica Ohnsorg
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Patent number: 11987572Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.Type: GrantFiled: June 3, 2020Date of Patent: May 21, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Joseph J. Topczewski, William C. K. Pomerantz, Angela S. Carlson, Huarui Cui, Anand Divakaran
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Publication number: 20240158722Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: ApplicationFiled: November 21, 2023Publication date: May 16, 2024Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of MinnesotaInventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
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Publication number: 20240156342Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.Type: ApplicationFiled: September 25, 2023Publication date: May 16, 2024Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Robert Vince, Swati Sudhakar More
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Patent number: 11982725Abstract: Magnetic resonance images with improved image quality consistent with those obtained using parallel radio frequency (“RF”) transmission (“pTx”) techniques are generated from data acquired using single transmission hardware (e.g., single channel RF transmission). A deep-learning framework is used to train a deep neural network to convert images obtained with single transmission into pTx-like images. The pTx-like images have reduced signal variations and dropouts that may otherwise be attributable to B1+ inhomogeneities.Type: GrantFiled: May 2, 2022Date of Patent: May 14, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xiaoping Wu, Xiaodong Ma, Kamil Ugurbil
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Patent number: 11980410Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.Type: GrantFiled: October 5, 2018Date of Patent: May 14, 2024Assignee: Regents of the University of MinnesotaInventors: Samira M. Azarin, Francisco Pelaez, Navid Manuchehrabadi, John C. Bischof
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Patent number: 11981933Abstract: Devices, systems, and techniques are described for printing pre-aligned microtissues into larger tissue constructs. For example, a method of printing a tissue construct includes aligning cells in a first direction to create pre-aligned microtissues, suspending the pre-aligned microtissues in a liquid to create a bioink, and depositing the pre-aligned microtissues in a second direction to create the tissue construct.Type: GrantFiled: August 31, 2021Date of Patent: May 14, 2024Assignee: Regents of the University of MinnesotaInventors: Caleb Darwin Vogt, Angela Panoskaltsis-Mortari
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Patent number: 11979290Abstract: Systems and methods are disclosed for parallelizing service function chains.Type: GrantFiled: November 14, 2022Date of Patent: May 7, 2024Assignees: AT&T Intellectual Property I, L.P., Regents of the University of MinnesotaInventors: Bo Han, Vijay Gopalakrishnan, Muhammad Bilal Anwer, Zhi-Li Zhang, Yang Zhang
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Patent number: 11969470Abstract: The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.Type: GrantFiled: July 23, 2021Date of Patent: April 30, 2024Assignee: Regents of the University of MinnesotaInventor: James C. Cloyd
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Patent number: 11968975Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 ?m to 2.5 ?m. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.Type: GrantFiled: April 28, 2020Date of Patent: April 30, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Bryan Jones, Alptekin Aksan, Advitiya Mahajan
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Patent number: PP35830Abstract: A new cultivar of apple tree ‘MN33’ that is characterized by its fruit with a texture that is very crisp and juicy, its fruit with a flavor that is sweet/tart, well balanced, and slightly reminiscent of tropical fruits, its fruit with a storage life of 132 to 154 days without using CA or 1-MCP, its fruit skin that is 85% to 95% red in color, its fruit that is medium to large in size, and its moderate resistance to apple scab.Type: GrantFiled: July 4, 2023Date of Patent: May 28, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: David S. Bedford, James J. Luby
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Patent number: PP35845Abstract: A new cultivar of Ceanothus plant named ‘UMNCNS01’ that is characterized by its inflorescences that are light pink in color, its coral red fruit capsules, and its crown cold hardiness to U.S.D.A Zone 4a.Type: GrantFiled: August 18, 2023Date of Patent: May 28, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Steven Thomas McNamara, Peter Christian Moe