Abstract: Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.

Abstract: The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition.

Abstract: The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytized or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: The present invention relates to a MUC1 cytoplasmic tail peptide or portion thereof. These peptides are useful for inducing an immune response to MUC1-expressing tumor cells and thus for preventing or treating cancer.

Abstract: The present invention is concerned with a method of preparing and delivering small particles of a pharmaceutically active material to a mammalian subject for treating diseases or disorders.

Abstract: The present invention relates to a method for inhibiting reperfusion injury in the brain. The method involve injecting via the carotid artery or jugular vein an antioxidant-loaded nanoparticle. A nanoparticle formulation containing an inert plasticizer is also provided for sustained release of an active agent.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition.

Abstract: The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography. Advantageously, the method can be performed in a relatively short period of time, involves inexpensive reagents, and requires little sample preparation before and during the purification process. Protein fusions between cystine-knot proteins and proteins of interest are further provided for the isolation of said protein of interest or complexes containing said protein of interest using the two-step method disclosed.

Abstract: A fabricated wall system employs a plurality of modular wall sections that may be coupled to laboratory benches, cabinets or the like, within the laboratory environment. Each modular wall section comprises a frame including an upper frame portion having one or more slots formed therein for receiving demising panels. The demising panels provide a wall surface within the upper frame portion for demising or separating the laboratory environment into distinct areas. The lower frame portion includes a slot for receiving demising panels removed from the upper frame portions, thereby providing for self-storage of the panels behind the laboratory bench.

Abstract: The present invention provides an apparatus for advancing an endotracheal tube through and along the length a patient's larynx with a laryngeal mask airway in place and without interrupting ventilation.

Abstract: A method, system, and article of manufacture for detecting, recording, quantifying, and classifying gait data. In one embodiment, the method of the invention includes a step of detecting foot contact events using a portable sensor device. Stride data is collected by processing the detected foot contact events to obtain and record gait pattern data. At least one gait stability value is determined from the gait pattern data using a specified gait stability metric. The gait stability value is preferably a mathematical chaos value which is processed utilizing clustering correlation to classify the gait pattern data in association with a neuromuscular status. In a preferred embodiment, fuzzy logic is utilized to correlate the determined gait stability value with a plurality of gait stability values each associated with a distinct neuromuscular status.

Abstract: A two-piece wrist-hand-finger orthosis of the present invention includes a rigid forearm section secured to the patient's arm, and a rigid hand section with a proximally projecting extension lever. The hand section is donned on the patient with the patient's hand in flexion. The hand section is then leveraged into a position of predetermined flexion or extension by pivoting the extension lever downwardly into contact with the forearm section. The extension lever is then secured to the forearm section.

Abstract: The present invention provides methods and systems to facilitate pattern recognition in complex biological data using component plane presentations of clustered data.