Abstract: A device for machining a work piece creates an electrical potential between an electrode and the work piece or another conducting body proximate to the work piece. The electrical potential establishes an electrical field within the work piece that is expected to repel electrons and create a region of positively charged ions which repel one another. This region is expected to be weakened and material is expected to be removable from this region of the work piece using less force and energy than when machined by traditional machining techniques.

Abstract: Disclosed herein are embodiments of methods that utilize dry adhesion tuning of a composite structure to adhere substrates. In some embodiments, the disclosed methods utilize dry adhesion between a composite structure and a substrate and further dynamically control the resulting dry adhesion strength through a heating step, which facilitates rigidity tuning of a core component of the composite structure and/or facilitates thermal control of the interface between the substrate and the composite structure. Also disclosed herein are array devices and other products comprising the disclosed composite structures.

Abstract: Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: One aspect of the invention provides an automotive electronic control unit (ECU) including: an application processor; and one or more co-processors communicatively coupled to the application processor. The one or more co-processors are configured to: receive data from the application processor; encrypt the data received from the application processor; process the encrypted data to detect faults and generate secure data that is encrypted and free from faults; and communicate the secure data to the application processor.

Abstract: Disclosed herein are methods of altering tissue succulence in plants. In some examples, a disclosed method includes overexpressing a modified helix-loop-helix transcription factor CEB1 in a plant cell, thereby altering plant succulence. The disclosed methods can be used to improve the drought and salinity tolerance of plants, such as in plants in arid or saline environments, and also enhance the ability of plants to perform. Also disclosed are CEB1 nucleic acids and transgenic plants containing such nucleic acids.

Abstract: Disclosed herein, are compositions and methods for the treatment of human immunodeficiency virus infection. The compositions comprise engineered transcription activator like effector nucleases (TALENs) comprising a TALE DNA binding domain flanked by two spacer sequences, and a Fokl nuclease catalytic domain. Also, described herein, are methods of using TALENs to cleave nucleic acids; and methods of administering the TALENs to subjects at risk for or having an HIV infection.

Abstract: Disclosed are conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand. Disclosed are methods of clearing amyloid beta aggregates from a subject comprising administering a therapeutically effective amount of the conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand. Disclosed are methods of treating Alzheimer's Disease comprising administering to a subject in need thereof a therapeutically effective amount of conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand.

Abstract: Methods and systems are disclosed for performing Transmission Control Protocol (TCP) communications. A TCP packet may be received. An artificial error may be added to the TCP packet to prevent the occurrence of a TCP meltdown.

Abstract: Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro. The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation. The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof. Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites.

Abstract: Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Disclosed herein are embodiments of engineered geothermal systems (EGS). Also disclosed are methods and devices for the construction and use of planar artificial fractures in EGS wells, including wells that contain both an injection and extraction points.

Abstract: A video gaming machine provides partial symbols that match other partial symbols across adjacent horizontal frames. Matches of two melding frames provides absolute payouts, multipliers, bonus events and the like.

Abstract: Compositions including one or more polymers are provided. Exemplary polymers include polymeric carbon monoxides. The compositions can be prepared by subjecting a source material to x-rays, optionally at increased pressures. The compositions can be used in a variety of applications, such as fuels, optics, and electronics.

Abstract: Disclosed herein are embodiments of polycyclic aromatic compounds and methods of making and using the same. Various different types of polycyclic ring systems are disclosed, including, but not limited to, polymeric aromatic compounds (e.g., nanographene compounds), pentacene-like compounds, chiral aromatic compounds, asymmetric arene compounds formed from naphthalene-, anthracene-, phenanthrene-, and pyrene-based starting compounds, and dimerized aromatic compounds. Also disclosed herein are novel benzannulation-based methods for making the disclosed polycyclic aromatic compounds.

Abstract: Disclosed herein are embodiments of a molybdate-based composition and a conversion coating obtained therefrom that can replace conventional and toxic chromate-based conversion coatings in a variety of applications and industries. The molybdate-based composition provides conversion coatings that exhibit anodic inhibition and rapid repassivation when applied to objects, such as metal-based objects, and do not contain hexavalent chromium. The molybdate-based composition and conversion coating can be used to reduce corrosion. Embodiments of methods of protecting objects, such as metal surfaces, with the molybdate-based conversion coating also are disclosed.

Abstract: Disclosed herein are method of altering CAM pathways in plants. In some examples, a disclosed method includes overexpressing one or more genes encoding one or more enzymes that carry out the basic biochemical sequence of nocturnal CO2 fixation (carboxylation) into C4 acids (malate), store C4 acids in the vacuole of the plant, and/or then decarboxylate and refix the released CO2 by C3 photosynthesis during the subsequent day in a plant cell, thereby altering CAM in the plant cell. Also disclosed herein are isolated polynucleotide sequences, transformation vectors, transgenic plant cells, plant part, and plants. The disclosed methods and compositions can be used to improve the water-use efficiency and drought tolerance and durability of plants, such as in plants in arid environments, and also enhance the ability of plants to perform.

Abstract: An automated rumble strip assembly includes a frame having a top surface configured to support a vehicle tire moving along the frame. The automated rumble strip assembly also includes a plurality of elongate members, each elongate member having a top surface. The automated rumble strip assembly also includes an actuator assembly configured to move the elongate members from a first position where each of the top surfaces of the elongate members is flush with the top surface of the frame, to a second position where each of the top surfaces of the elongate members is recessed relative to the top surface of the frame.

Abstract: Disclosed are capsular polysaccharide (CPS)-protein immunogenic conjugates useful for providing protection against any condition or disease associated with Burkholderia pseudomallei or Burkholderia mallei, such as melioidosis or glanders, respectively. For example, a disclosed CPS-protein immunogenic conjugate includes purified 6-deoxyheptan capsular polysaccharide (CPS) from B. pseudomallei chemically activated and covalently linked to recombinant CRM 197 diphtheria toxin mutant (CRM197) to produce CPS-CRM197. Methods of inducing an immune response are disclosed. The methods include the use of a CPS-protein immunogenic conjugate, alone or in conjunction with other agents, such as Hcp1 and TssM, to prevent infection with B. pseudomallei or B. mallei. Also disclosed are methods for treating a subject having melioidosis or glanders.