Patents Assigned to The University of Newcastle upon Tyne
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Patent number: 10054339Abstract: This invention relates to a chemisorption based energy storage device, able to provide electricity, heating or cooling depending on the desired energy output. The device typically comprises sorbent materials which have an affinity for a refrigerant gas at different temperatures.Type: GrantFiled: February 6, 2015Date of Patent: August 21, 2018Assignee: UNIVERSITY OF NEWCASTLE UPON TYNEInventors: Huashan Bao, Anthony Paul Roskilly
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Publication number: 20180207599Abstract: This invention relates to a method of chemical looping using non-stoichiometric materials with a variable degree of non-stoichiometry. One application of these methods is in the water gas shift reaction for H2 production. The methods of the invention can overcome limitations, e.g. those associated with chemical equilibria, which prevent chemical processes from proceeding with complete conversion of starting materials to products.Type: ApplicationFiled: July 7, 2016Publication date: July 26, 2018Applicant: University of Newcastle upon TyneInventor: Ian Metcalfe
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Patent number: 9999632Abstract: The present invention provides the use of an alginate Io inhibit pancreatic lipase. The use may be directed to the control of weight in animals including human beings. Preferably the fraction of guluronate dimers in the alginate is at least 0.5.Type: GrantFiled: July 27, 2016Date of Patent: June 19, 2018Assignees: RD Biomed Limited, University of Newcastle upon TyneInventors: Johnathan Craig Richardson, Peter William Dettmar, Matthew David Wilcox, Iain Andrew Brownlee, Jeffrey Peter Pearson
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Publication number: 20180155401Abstract: The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention has applications in use as a natural food colouring, as antioxidants in the food supplement industries, in the nutraceutical, pharmaceutical, and cosmeceutical industries, and a non-toxic ink. The method results in pigment that is relatively easy to separate from the microorganism culture.Type: ApplicationFiled: February 6, 2018Publication date: June 7, 2018Applicant: University of Newcastle upon TyneInventors: Chelsea Marie Brain, Gary Stephen Caldwell
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Publication number: 20180067122Abstract: The invention relates to a Model Gut System (MGS) comprising a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, preferably about 7.9 to about 8.2, and porcine bile.Type: ApplicationFiled: November 21, 2014Publication date: March 8, 2018Applicant: University of Newcastle Upon TyneInventors: Jeff Pearson, Iain Brownlee, Matt Wilcox, Peter Chater
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Publication number: 20180029893Abstract: This invention relates to methods of producing aerogels and composites thereof. In particular, the invention relates to methods of producing silica aerogels and composites thereof. The invention also relates to doped aerogels and doped silica aerogels. The method involves the use of alkaline solutions, and particularly aqueous alkaline solutions, during the aerogel drying process. The method is more energy efficient and cheaper than prior art methods.Type: ApplicationFiled: February 16, 2016Publication date: February 1, 2018Applicant: UNIVERSITY OF NEWCASTLE UPON TYNEInventors: LIDIJA SILLER, XIAO HAN
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Patent number: 9879255Abstract: The present invention provides oligonucleotides that inhibit the binding of miR-27a to VE-cadherin mRNA, particularly in the form of blockmirs. The invention also provides compositions comprising such oligonucleotides and methods of use of such oligonucleotides to modulate the activity of VE-cadherin, inhibit or reduce vascular permeability, treat or prevent a vascular permeability-associated disease or condition, inhibit tumor growth, treat ischaemic injury, enhance recovery from ischaemic injury, treat surgical wounds and/or promotes post-operative recovery, and promote or induce angiogenesis.Type: GrantFiled: October 2, 2013Date of Patent: January 30, 2018Assignee: University of Newcastle Upon TyneInventors: Jennifer Gamble, Mathew Vadas, Thorleif Moller
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Patent number: 9862750Abstract: The invention provides a chaperone/usher family polymer comprising at least one chaperone/usher family polypeptide monomer, wherein said at least one chaperone/usher family polypeptide monomer comprises an exogenous bioactive sequence.Type: GrantFiled: June 11, 2013Date of Patent: January 9, 2018Assignee: University of Newcastle Upon TyneInventor: Jeremy Lakey
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Patent number: 9789439Abstract: The present invention relates to the use of solid metal materials for catalyzing the hydration of carbon dioxide. It also relates to methods of and apparatus for hydrating carbon dioxide and capturing carbon. The solid metal materials may be nickel nanoparticles. The invention finds particular application in the sequestration of carbon dioxide either at the point of release or from the atmosphere.Type: GrantFiled: May 14, 2013Date of Patent: October 17, 2017Assignee: University of Newcastle upon TyneInventors: Lidija Siller, Gaurav Ashok Bhaduri
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Patent number: 9791456Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.Type: GrantFiled: February 27, 2015Date of Patent: October 17, 2017Assignees: Vertex Pharmaceuticals Incorporated, University of Newcastle Upon TyneInventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
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Publication number: 20170285770Abstract: A method, for a device, for enhancing user interaction with the device is provided. The method comprises the steps of: receiving a user input; receiving a signal comprising information indicating a motion and/or orientation of a sensor during a period of time occurring before, during, and/or after occurrence of the user input; performing an operation depending on the user input and the motion and/or orientation of the sensor.Type: ApplicationFiled: December 19, 2014Publication date: October 5, 2017Applicant: University of Newcastle Upon TyneInventors: Jonathan Hook, Patrick Olivier
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Publication number: 20170222523Abstract: A method of manufacturing a compressed coil and a system for holding a wire during the manufacture of a compressed coil are disclosed. The method includes providing a wire including a first lead section, a central section and a second lead section. The central section of the wire is wound around a bobbin to form a coil. A punch top is located over an end of the bobbin such that the end of the bobbin is located at least partially within a through-hole of the punch top. A second lead section of the wire is located within a groove in an outer surface of the punch top or bobbin and pressure is applied to the bobbin and/or punch top to compress the coil.Type: ApplicationFiled: September 30, 2015Publication date: August 3, 2017Applicant: University of Newcastle Upon TyneInventors: Christopher David Manning, James Widmer, Richard Martin
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Patent number: 9675736Abstract: The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.Type: GrantFiled: February 11, 2011Date of Patent: June 13, 2017Assignee: UNIVERSITY OF NEWCASTLE UPON TYNEInventors: James Grant Burgess, Michael John Hall, Reindert Nijland
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Publication number: 20170143985Abstract: An optrode arrangement for delivering optical stimulation to target tissue in a patient, the optrode arrangement comprising an implantable optrode comprising at least one electrically powered light emitter and an electrical circuit and control lines for controlling the light emitter, whereby an associated controller has two modes of operation: a stimulation mode in which it is configured to control the light emitter to deliver optical stimulation to the target tissue and a diagnostic mode in which it is configured to determine a condition of the light emitter and/or the optrode.Type: ApplicationFiled: June 18, 2015Publication date: May 25, 2017Applicant: University of Newcastle Upon TyneInventors: Patrick DEGENAAR, Hubin ZHAO
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Publication number: 20170010028Abstract: This invention relates to a chemisorption based energy storage device, able to provide electricity, heating or cooling depending on the desired energy output. The device typically comprises sorbent materials which have an affinity for a refrigerant gas at different temperatures.Type: ApplicationFiled: February 6, 2015Publication date: January 12, 2017Applicant: UNIVERSITY OF NEWCASTLE UPON TYNEInventors: Huashan Bao, Anthony Paul Roskilly
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Publication number: 20160320419Abstract: A three dimensional (3-D) model comprising a scaffold and autologous skin cells, the invention also provides methods of predicting immunogenicity and hypersensitivity or allergic or adverse immune reactions to potential therapeutic compounds, biologies, cosmetics and chemical sensitizers using the 3-D model of skin cells. The methods provide an in vitro assay employing autologous blood derived cells in the 3-D skin equivalent model and is of particular utility in the identification and prediction of skin sensitizers and in particular agents that may cause allergic contact dermatitis. The assay of the present invention provides inter alia methods of screening library compounds for sensitizing activity, identifying optimal therapeutics, especially but not exclusively, monoclonal antibodies and kits therefor.Type: ApplicationFiled: February 27, 2014Publication date: November 3, 2016Applicants: Alcyomics Ltd, University of Newcastle Upon TyneInventors: Penny Lovat, David Hill, Anne Dickinson, Shaheda Ahmed
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Publication number: 20160291704Abstract: A method for processing an input applied by an input object is provided. The method comprises the steps of receiving, from a motion unit, motion data comprising information indicating motion of the motion unit, wherein the motion unit is arranged to co-move with the input object; receiving, from the motion unit, identification information for identifying the motion unit; receiving input data, wherein the input data comprises information indicating characteristics of one or more inputs applied to an input unit; comparing the motion data with the input data; and outputting a signal for controlling processing of the inputs depending on a result of the comparison, and according to the identification information.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Applicant: University of Newcastle Upon TyneInventors: Dan Jackson, Patrick Oliver, Ahmed Kharrufa, Nils Hammerla
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Patent number: 9416019Abstract: An ammonia production process is disclosed. The process uses gasification of biomass waste and the like to produce syngas which, using an integrated system including using nitrogen enriched air and a porous coated catalyst, produces ammonia in a plasma reactor. The ammonia is finally recovered using sulphonated PolyHIPE Polymer which can be used as a fertilizer after neutralization.Type: GrantFiled: August 30, 2011Date of Patent: August 16, 2016Assignee: University of Newcastle upon TyneInventor: Galip Akay
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Patent number: 9402858Abstract: The present invention provides the use of an alginate Io inhibit pancreatic lipase. The use may be directed to the control of weight in animals including human beings. Preferably the fraction of guluronate dimers in the alginate is at least 0.5.Type: GrantFiled: November 25, 2010Date of Patent: August 2, 2016Assignees: RD Biomed Limited, University of Newcastle Upon TyneInventors: Johnathan Craig Richardson, Peter William Dettmar, Matthew David Wilcox, Iain Andrew Brownlee, Jeffrey Peter Pearson
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Patent number: 9171374Abstract: An image processing system is described which is arranged to highlight information in image displays by selectively blurring less important areas of an image. By generating such displays comprising areas which are in focus and areas which are out of focus, a viewer's attention is preferentially drawn towards those areas of an image which appear sharp. By having a display system which is arranged to generate such images a means is provided to direct a viewer's attention towards considering the sharp areas of the image display first. Further the selective blurring portions of an image reduces rather than increases the amount of information presented to a viewer and hence reduces the likelihood that a viewer will become overloaded with information. Display systems of this type are therefore especially applicable to complex control environments as means of directing viewer's attention.Type: GrantFiled: January 15, 2014Date of Patent: October 27, 2015Assignee: University of Newcastle Upon TyneInventor: Yoav Tadmor