Patents Assigned to The University of Nottingham
  • Patent number: 12242019
    Abstract: A method of measuring an acceleration using one or more trapped BECs and at least two atomic field modes within those BECs is described. A density distribution of at least one of the one or more BECs is modified by the acceleration, which leads to a change of the field modes' time evolution. The method comprises: selecting two modes that are differently affected by the acceleration; and measuring the acceleration-induced difference; and using the measured acceleration-induced difference to infer the acceleration. Also described is a method of measuring a field gradient using one or more trapped BECs. Each of the trapped BECs has a density distribution, and at least two atomic modes within those BECs, wherein the density distributions of the one or more BECs are modified by the field, which leads to a change of the atomic modes' time evolution.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 4, 2025
    Assignees: The University of Nottingham, University of Vienna
    Inventors: Ivette Fuentes Guridi, Dennis Rätzel, Tupac Bravo Ibarra, David Edward Bruschi
  • Patent number: 12186548
    Abstract: The present invention relates to an electrical nerve stimulator configured to deliver an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations. The electrical nerve stimulator may be used in the treatment of neurological conditions associated with desynchronization of neural oscillations, such as Tourette's syndrome. The electrical nerve stimulator may be wearable on a wrist of a user, and may be configured to deliver rhythmic stimulation at a frequency falling within the same frequency range of Mu-band or Beta-band neural oscillations. The invention provides a convenient means of treating conditions such as Tourette's syndrome without the need for specialist medical equipment or facilities. Also disclosed is a method of delivering an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: January 7, 2025
    Assignee: The University of Nottingham
    Inventors: Stephen Jackson, Georgina Jackson
  • Patent number: 11909367
    Abstract: The present disclosure relates to a broadband filter for confining or attenuating electromagnetic interference noise from one or more electrical signal sources, In an embodiment, the broadband filter comprises one or more filter stages electrically coupled by galvanic or by electromagnetic means to the one or more electrical signal sources for confining or attenuating conducted electromagnetic interference noise; one or more conductive shields electrically coupled by galvanic or by electromagnetic means to the electrical signal sources wherein the shields encapsulate the filter stages for confining or attenuating conducted and/or radiated electromagnetic interference noise; and one or more conductive partition layers to encapsulate the one or more filter stages such that the partition layers electromagnetically couple adjacent filter stages for a selected frequency range of the electromagnetic interference noise. The thickness of the conductive partition layers is chosen to control the degree of coupling.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: February 20, 2024
    Assignees: The Thinking Pod Innovations Ltd, The University of Nottingham
    Inventors: Zhe Zhang, Jordi Espina, Mark Johnson
  • Patent number: 11538602
    Abstract: A method of designing at least one coil for producing a magnetic field is disclosed. The method comprises: i) setting a performance target comprising: a target magnetic field, and at least two of a target power, a target resistance, a target size and/or weight, a target supply voltage or current, and a target inductance; ii) determining initial design parameters for the at least one coil; iii) modelling performance with the current design parameters to determine a simulated performance against each of the performance targets; iv) calculating a penalty function based on the difference between the simulated performance and the performance targets; v) modifying the design parameters in order to reduce the penalty function; vi) iterating steps iii) to v) until the penalty function or simulated performance has met an acceptance condition.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: December 27, 2022
    Assignee: The University of Nottingham
    Inventors: Mark Fromhold, Nathan Welch, Dominic Sims, Jorge Ferreras, Ian Taylor
  • Publication number: 20220213178
    Abstract: The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 7, 2022
    Applicant: The University of Nottingham
    Inventor: James Dixon
  • Patent number: 11242490
    Abstract: The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: February 8, 2022
    Assignees: The University of Nottingham, Tata Steel Limited
    Inventors: Bidyut Das, Sanjay Chandra, Atanu Ranjan Pal, Pratik Swarup Dash, Munish Sudan, Eleanor Binner, Christopher Dodds, Edward Henry Lester, Orla Williams, Samuel Kingman
  • Patent number: 11220610
    Abstract: Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also disclosed.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: January 11, 2022
    Assignees: PPG Industries Ohio, Inc., The University of Nottingham
    Inventors: David R. Fenn, Kurt G. Olson, Reza M. Rock, Richard J. M. Hague, Christopher John Tuck, Le Ma, Ricky Darren Wildman, Yinfeng He
  • Patent number: 11192888
    Abstract: Novel compounds having antimicrobial activity, in particular against Pseudomonas aeruginosa, Burkholderia cepacia and/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: December 7, 2021
    Assignee: The University of Nottingham
    Inventors: Weng Choon Chan, Sivaneswary Genapathy, Lei Yang
  • Patent number: 11179887
    Abstract: A method (300) of fabricating an object by additive manufacturing comprises providing (310) a layer of polymeric material (100), said polymeric material (100) being in particulate form, and comprising linear polymer chains, selectively depositing (320) a reactive liquid (200) onto the layer of particulate polymeric material (100), said reactive liquid (200) comprising reactive units (210a) which are monomeric units, linear oligomeric units, linear polymeric units, or combinations thereof, wherein said reactive units (210a) have two or fewer reactive groups, and allowing (330) linear polymeric chains in said layer of polymeric material (100) to react with reactive units in said reactive liquid (200) so as to form extended polymeric chains that are linear, so as to provide a shaped layer of linear polymer. These steps (310, 320, 330) are repeated as required to form the object from successive shaped layers of linear polymer.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: November 23, 2021
    Assignee: The University of Nottingham
    Inventors: Christopher John Tuck, Belén Begines Ruiz, Yinfeng He, Ricky Darren Wildman, Richard James Mackenzie Hague
  • Patent number: 10736991
    Abstract: Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 11, 2020
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of Nottingham
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, Jr., Lisa Jane White
  • Publication number: 20200247824
    Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.
    Type: Application
    Filed: September 21, 2018
    Publication date: August 6, 2020
    Applicant: The University of Nottingham
    Inventors: David Brook, Chris Hayes, Nicholas Bennett, Matthew Palframan, Sue Cramp, Richard Bull, Michael Bodnarchuk
  • Patent number: 10722860
    Abstract: A mixing reactor for precipitating nanoparticles by mixing a precursor fluid with a second fluid at a higher temperature than the precursor fluid. The reactor comprises: a first fluid conduit with an inlet region configured to receive a flow of the precursor fluid, and an outlet region configured to output a mixed flow; and a second fluid conduit configured to receive a flow of the second fluid. The second fluid conduit extends into the first fluid conduit in a direction substantially perpendicular to the flow within the first fluid conduit, and has an opening for introducing the second fluid into the first fluid conduit. Related processes for producing nanoparticles are disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: July 28, 2020
    Assignee: The University of Nottingham
    Inventors: Edward Lester, Thomas Huddle
  • Patent number: 10406499
    Abstract: A mixing reactor (1), the reactor comprising a body (2) having a first inlet (3), a second inlet (5) and an outlet (4), in which there is an inner passage (6) through the body (2) from the first inlet (3) at a first end (12) of the body (2) to the outlet (4) at a second end of the body (2) along a length of the body (2), the inner passage (6) having a side wall (17) along the length, and an outer passage (7) closer to a surface (14) of the body (2) than the inner passage (6), the outer passage (7) running from the second inlet (5) at the second end, travelling through the body (2) along the length and meeting the inner passage (6) at a junction (11) at the first end, the outer passage (7) joining the inner passage (6) through the side wall (17) at the junction (11). Such a mixing reactor can be used for producing particles such as nanoparticles or Metal-Organic frameworks.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 10, 2019
    Assignee: The University of Nottingham
    Inventors: Edward Lester, Thomas Huddle
  • Patent number: 10352984
    Abstract: A method of locating a fault on an electricity transmission line is disclosed. The transmission line has a known line impedance and is operable to transport electricity at one or more system frequencies. The method comprises using measurements of the current and voltage made on the line at one or more frequencies which are different to the system frequency and the known line impedance (Z) to determine a distance to the fault. The method may include monitoring the voltage and the current on the transmission line at the one or more non-system frequencies, and determining from the presence of signals at a non-system frequency on the transmission line that a fault has occurred.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 16, 2019
    Assignee: The University of Nottingham
    Inventors: David Thomas, Mark Sumner, Jia Ke
  • Patent number: 10301264
    Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 28, 2019
    Assignee: The University of Nottingham
    Inventors: Steven James Harper, David Owen Bates, Melissa Gammons, Jonathan Morris
  • Patent number: 10226537
    Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 12, 2019
    Assignee: The University of Nottingham
    Inventors: James Dixon, Kevin Shakesheff, Chris Denning
  • Patent number: 10139406
    Abstract: A method of determining the P. aeruginosa or related species infection status of a subject comprising: (i) providing a sample of material obtained from the subject; (ii) determining the level of one or more alkyl quinolones or metabolites thereof produced by P.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 27, 2018
    Assignee: The University of Nottingham
    Inventors: Miguel Camara, Paul Williams, David Barrett, Nigel Halliday, Alan Knox, Alan Smyth, Andrew Fogarty, Helen Barr, Doug Forrester
  • Patent number: 10125739
    Abstract: A system suitable for extracting power directly from the main shafts of slow-moving mechanical systems. The system has a closed gas circuit having a lower-pressure (LP) side and a higher-pressure (HP) side. The LP side is at a pressure substantially greater than atmospheric pressure. The system includes primary compressors coupled to the wind turbines, thermal stores coupled to heat-exchangers on both the LP and HP sides of the closed gas circuit, a secondary motor-compressor set and an expander-generator set. The system allows some degree of independence between the input power resource and the output power. When substantial wind power is present and the demand for electrical power is weak, this system can export a fraction of the energy captured and store the rest. When the wind resource is low, the system can export more power than is being collected by drawing energy from the thermal stores.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: November 13, 2018
    Assignee: The University of Nottingham
    Inventor: Seamus Dominic Garvey
  • Publication number: 20180296733
    Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(=0)-0-]n, R (I) [H2C?CR?—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
    Type: Application
    Filed: May 24, 2018
    Publication date: October 18, 2018
    Applicants: The University of Nottingham, Massachusetts Institute of Technology
    Inventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
  • Publication number: 20180271987
    Abstract: The invention relates to apH mediated cell delivery vehicle comprising: a cargo or a cargo-binding molecule for binding to a cargo; a protein transduction domain; and a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell, wherein the GAG binding element is a peptide which is modified to comprise one or more histidine residues which are capable of being protonated in an acidic environment. The invention further relates to the use of such a delivery vehicle including methods of treatment, such as treatment for cancer.
    Type: Application
    Filed: June 23, 2016
    Publication date: September 27, 2018
    Applicant: The University of Nottingham
    Inventor: James Dixon