Patents Assigned to The University of Otago
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Publication number: 20040106579Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: November 28, 2003Publication date: June 3, 2004Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20040029851Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: ApplicationFiled: August 12, 2002Publication date: February 12, 2004Applicants: Medical Research Council, University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20030069208Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR·Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: October 18, 2002Publication date: April 10, 2003Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Patent number: 6541008Abstract: The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.Type: GrantFiled: November 2, 1999Date of Patent: April 1, 2003Assignees: University of Otago, Ludwig Institute for Cancer ResearchInventors: Lyn M. Wise, Andrew A. Mercer, Loreen J. Savory, Stephen B. Fleming, Steven A. Stacker
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Publication number: 20030013076Abstract: The invention is directed to parapoxvirus vectors. Specifically provided are orf virus vectors containing exogenous DNA. The exogenous DNA may encode a heterologous peptide or polypeptide of which expression is desired, or may encode an antigen capable of inducing an immune response. The capacity to express antigens make these vectors suitable for use in vaccines.Type: ApplicationFiled: March 2, 2001Publication date: January 16, 2003Applicant: University of OtagoInventors: Anthony J. Robinson, David J. Lyttle
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Patent number: 6403130Abstract: A polymer is provided which comprises acid casein or a non-toxic soluble salt thereof and high-methoxyl pectin cross-linked into a three-dimensional network. A process for preparing the polymer and edible films and food products comprising the polymer are also provided.Type: GrantFiled: September 1, 1999Date of Patent: June 11, 2002Assignees: Kiwitech Limited, University of OtagoInventor: Richard Beyer
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Publication number: 20020058097Abstract: The invention relates to modified casein gelling agents, gels and processes for preparing them. The modified casein gelling agent is casein in which the native structure has been disrupted.Type: ApplicationFiled: November 14, 2001Publication date: May 16, 2002Applicant: University of OtagoInventors: Richard Beyer, Patrick J. Silcock
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Publication number: 20020052342Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: October 3, 2001Publication date: May 2, 2002Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Patent number: 6379709Abstract: A process for obtaining an angiogenesis inhibitor and an angiogenesis activator from shark cartilage comprising, as the key step, the aqueous extraction of dried shark cartilage. The angiogenesis inhibitor obtained is more potent than shark cartilage not subjected to the extraction step. The angiogenesis inhibitor is particularly useful for the prevention or treatment of cancer. The angiogenesis activator is particularly useful for stimulating wound healing.Type: GrantFiled: December 10, 1999Date of Patent: April 30, 2002Assignees: Industrial Research Limited, University of OtagoInventors: George Charles Slim, Paul Frank Davis, Yi He, Bei Xu
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Patent number: 6331532Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR•Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: GrantFiled: May 25, 2000Date of Patent: December 18, 2001Assignee: University of OtagoInventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 5108292Abstract: The present invention is a dental oral simulator designed to teach the skills an operator will require in practice when dealing with a supine patient in the ergonomically preferred work zone in the midsagittal plane at heart level and in myocentric relationship.Training jaws of the dental simulator are supported to simulate the movement of the jaws in a skull about the occipito-atlantal joint. A concave dish supported on the end or a mounting arm provides bearing support for a semi spherical bowl with the attachment between the bowl and the concave dish operating to allow controlled movement of the bowl through the range of useful dental treatment anatomical movements by a human skull about its occipito-atlantal joint with the mounting for the training jaws located on the mandible plane.Type: GrantFiled: September 5, 1990Date of Patent: April 28, 1992Assignees: The University of Otago, Medic Corporation LimitedInventors: Ewen E. J. Kirk, Tony Pemberton
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Patent number: 4886655Abstract: The invention provides a method of detecting infection and/or immunity in ruminants. The method includes the steps of conducting an assay of mononuclear cell function and measuring a parameter of inflammation of a sample of blood from a ruminant, and comparing the results obtained with a predetermined database. The method of the invention is particularly suitable for detecting tuberculosis in deer.Type: GrantFiled: November 28, 1986Date of Patent: December 12, 1989Assignee: The University of OtagoInventor: John F. T. Griffin