Patents Assigned to The University of Puerto Rico
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Patent number: 10883762Abstract: The invention provides an efficient equipment that can be easily implemented to dry materials in a continuous manufacturing line of pharmaceutical products without the need of external air or HEPA exhaust filter cartridges. A continuous granulo-dryer for the manufacturing of pharmaceutical products via wet granulation includes a recirculation system that allows to continuously recirculate the air used to dry the materials back into the granulo-dryer. Control systems and sensors are provided to promote a high percentage (up to 98%) of product monitored, an efficient heat and mass transfer between the air and the product avoiding the segregation of the materials and preserving the homogeneity of the Active Principal Ingredient (API).Type: GrantFiled: January 17, 2019Date of Patent: January 5, 2021Assignee: University of Puerto RicoInventors: Carlos Velazquez-Figueroa, Leonel Quinones-Fontalvo
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Patent number: 10744119Abstract: A compound to inhibit a glutathione S-transferase (GST) enzyme activity having formula (I). The compound having formula (I) is an antimalarial compound that inhibits the growth of the Plasmodium spp parasites. The compound of the present invention inhibits the growth of a malarial parasite by 50%.Type: GrantFiled: December 15, 2015Date of Patent: August 18, 2020Assignee: University of Puerto RicoInventors: Adelfa E. Serrano-Brizuela, Emilee E. Colón-Lorenzo, Jürgen Bosh, Daisy Colón-López
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Patent number: 10736684Abstract: An induction heating coil is positioned inside a tube-like instrument having dimensions similar to current laparoscopic instruments. Magnetic field intensities of up to 15 kA/m at a frequency of 289 kHz are achieved while the instrument is operated at safe temperatures. A cooling agent system maintains a desired temperature inside the instrument and temperatures sensors monitor the temperature of the cooling agent as well as the temperature of the induction heating coil to safely operate the instrument within operating temperatures.Type: GrantFiled: February 23, 2018Date of Patent: August 11, 2020Assignee: University of Puerto RicoInventors: Eduardo J. Juan, Madeline Torres-Lugo, Jorge L. Castro-Torres
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Patent number: 10729689Abstract: A series of novel EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable “U-shaped” conformation that appears to be critical for inhibitory activity against Rac. Based on modeling studies on EHop-016, compounds with a more rigid structural conformation can mimic this “U-shaped” conformation would improve the anti-migration activity against metastatic cells. Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases, for instance compounds of formula (I) Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.Type: GrantFiled: October 23, 2018Date of Patent: August 4, 2020Assignee: UNIVERSITY OF PUERTO RICOInventors: Eliud Hernandez-O'Farrill, Cornelis P. Vlaar, Suranganie Dharmawardhane Flanagan, Linette Castillo-Pichardo
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Patent number: 10676518Abstract: The ?4?2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction. The invention studied the effect of subunit phosphorylation on ?4?2 nAChR function and expression, and eleven residues located in the M3-M4 cytoplasmic loop were mutated to alanine and aspartic acid. When nicotine was used as an agonist, four mutations exhibited a statistically significant hypersensitivity to nicotine (S438D, S469A, Y576A, and S589A). Additionally, two mutations (S516D and T536A) that displayed normal activation with ACh displayed remarkable reductions in sensitivity to nicotine. The invention provides a knock-in mutant construct for the development of a transgenic mouse line with reduced nicotine sensitivity to be used in future studies.Type: GrantFiled: April 28, 2016Date of Patent: June 9, 2020Assignee: University of Puerto RicoInventors: Jose A Lasalde-Dominicci, Nilza M Biaggi-Labiosa, Emir Aviles-Pagan, Daniel Caballero-Rivera
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Patent number: 10662063Abstract: The invention proposes the photosensitized generation of nitric oxide (NO) from alanosine (3-(hydroxynitrosoamino)-D,L-alanine) by aluminum phthalocyanine tetrasulfonate (AlPcS4). While NO is obtained in nitrogen-saturated solutions, the invention proposes that both NO and peroxynitrite are produced in air-saturated solutions. Enhancement of NO production occurs in the presence of ubiquinone-0. The invention evidence that NO is produced by the photosensitized oxidation of alanosine. Both NO and peroxynitrite are detected during photoirradiation of AlPcS4 in the presence of 2-methyl-2-nitrosopropane (MNP) and hypoxanthine, but not in the absence of hypoxanthine, in air-saturated solutions, where HX is acting as sacrificial electron donor, thus promoting superoxide formation.Type: GrantFiled: June 6, 2017Date of Patent: May 26, 2020Assignee: University of Puerto RicoInventors: Antonio E. Alegria, Pedro Sanchez Cruz
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Patent number: 10597462Abstract: A monoclonal antibody against human (a69) and mouse clones Triggering Receptor and (Clones Expressed in Myeloid TREM) cells-like transcript-1 or TLT-1 is provided. This antibody also identifies TLT-1 on platelets by flow cytometry, in western blots, by immunofluorescence, ELISA and immunoprecipitation giving it immediate use as a diagnostic tool for research and blood marker and/or treatment for diseases such as disseminated intravascular coagulation. The Antibody can also be used as intervention for any diseases that has or may have a TLT-1 component such as Disseminated Intravascular Coagulation (DIC), Cardiovascular disease (CVD) and cancers and should overcome the problem of blocking platelet function that leads to a bleeding diathesis.Type: GrantFiled: January 8, 2019Date of Patent: March 24, 2020Assignee: University of Puerto RicoInventors: Anthony Valance-Washington, Yancy Ferrer-Acosta, Jessica Morales, Fiorella Reyes-Baez
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Patent number: 10569253Abstract: The invention provides biocomposites alginate/chitosan beads integrated with magnetite nanoparticles and modified-surface magnetite derivate created and designed to remove from environmental waters and aquatic systems different types of organic persistent compounds such as benzophenone-3 (oxybenzone).Type: GrantFiled: October 22, 2018Date of Patent: February 25, 2020Assignee: University of Puerto RicoInventors: Felix Roman Velazquez, Victor Fernandez Alos, Oscar Perales Perez
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Patent number: 10520400Abstract: A device for obtaining samples from a flowing powder stream and performing their immediate analysis using a spectroscopic method is provided. Systematic sample size reduction is achieved to provide representative samples and their immediate (real-time) analysis. The powder blends may come from pharmaceutical, vitamin and nutraceutical products, which must fulfill blend homogeneity requirements. All parts of the batch will have the same probability of being selected as a sample. Samples are obtained without disturbing or changing the composition of the powder blend during the sampling process. Unlike the sample thief commonly used in the pharmaceutical industry, the device of the invention does not disturb the powder blend and does not change the properties of the powder blend during the sampling.Type: GrantFiled: September 19, 2018Date of Patent: December 31, 2019Assignee: University of Puerto RicoInventors: Rodolfo J. Romanach, Rafael Mendez
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Patent number: 10479808Abstract: The hydrothermal reaction between bioactive metals (Ca2+, Zn2+, and Mg2+) salts and clinically utilized bisphosphonate (BP) alendronic acid (ALEN) were performed to prepare several bisphosphonate-based biocompatible coordination complexes (pBioCCs). The invention describes the effect of three variables M2+/BP molar ratio, reaction temperature, and pH on the reaction outcomes yields an unprecedented number of crystalline materials of enough crystal quality for structural elucidation. The crystal structure was unveiled by single crystal X-ray diffraction at 100 K and their solid-state properties revealed in tandem with other characterization techniques: thermogravimetry, vibrational spectroscopy, and elemental analysis. The invention provides materials with high structural stability and dissolution properties paving the way for better formulation strategies for alendronic acid (ALEN) through the design of pBioCCs for the treatment of bone-related diseases.Type: GrantFiled: February 8, 2019Date of Patent: November 19, 2019Assignee: University of Puerto RicoInventors: Vilmali Lopez-Mejias, Gabriel Quinonez-Velez, Waldemar Amaury Rodriguez-Silva
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Patent number: 10392396Abstract: Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.Type: GrantFiled: May 3, 2018Date of Patent: August 27, 2019Assignee: University of Puerto RicoInventors: Cornelis P. Vlaar, Suranganie Dharmawardhane Flanagan, Eliud Hernandez-O'Farrill, Linette Castillo-Pichardo
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Patent number: 10385327Abstract: The invention analyzed a protein sequence using the Udwary-Merski algorithm and identified a tetradomain fragment (DH1-DH2-UMA) which consists of two predicted DH-like domains and two pseudodomains N-terminal to them. This arrangement of domains and pseudodomains is fundamentally the opposite of what is typically observed in the DH cassettes of actinobacterial polyketide synthases or mammalian fatty acid synthases, both of which feature C-terminal pseudodomains. The invention modified E. coli by over expressing DH1-DH2-UMA in E. coli resulting in an increase in the overall production of all the fatty acids normally present in the E. coli fatty acid profile.Type: GrantFiled: January 5, 2012Date of Patent: August 20, 2019Assignee: University of Puerto RicoInventors: Abel Baerga-Ortiz, Delise Oyola-Robles
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Patent number: 10379033Abstract: The invention provides the use of instrumentation and methods for the rapid separation, detection, and identification of chemical compounds by coupling a well-established chromatographic separation science technique, TLC, with mid-infrared (MIR) QCLS for the analysis of explosives, pollutants, and other threat chemicals. The stationary phases were silica gel adhered to metallic aluminum supports. The mobile phases consisted of organic solvents and their mixes. The position and spot diameter of the TNT samples on the plate containing the adsorbent silica film were measured and compared before and after the chromatographic runs. The MIR vibrational identification of TNT was performed through reflectance measurements using a widely tunable three-diode source. The symmetric stretching vibration of the nitro group [?s(NO2)] centered at approximately 1350 cm?1 and the asymmetric stretching vibration of the nitro group [?as(NO2)] at approximately 1530 cm?1 were clearly observed.Type: GrantFiled: June 6, 2017Date of Patent: August 13, 2019Assignee: University of Puerto RicoInventors: Samuel P. Hernandez Rivera, John R. Castro Suarez
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Patent number: 10376244Abstract: Decompression sickness (DCS) occurs when divers rise to the surface exposing the body to sudden changes in pressure, generating nitrogen bubbles in tissues, causing serious bodily injury and even death. Therefore, the present invention allows prevention of DCS with a method that detects the presence of bubbles in real time. The invention proposes a new method for bubble detection with a piezoelectric ring (PZT) and pill microphones (PM) placed around a divers thigh. The electrical signals from the piezoelectric ring (PZT) and microphones (PM) are the inputs to a pattern recognition algorithm used for determining the presence, amount and size of bubbles.Type: GrantFiled: September 22, 2015Date of Patent: August 13, 2019Assignee: University of Puerto RicoInventors: Silvina Cancelos, Carlos Javier Marin, Andrés Saavedra
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Patent number: 10377645Abstract: The invention presents a urea bio-electrochemical (UBE) system to achieve resource recovery from water recycling systems. A GAC-urease bioreactor was used to recover urea from wastewater stream, and converted to ammonia. Then, the ammonia produced was used to feed an electrochemical cell to gather electrical energy. The invention shows the feasibility of using the UBE system in combination with a forward osmosis subsystem for water reclamation.Type: GrantFiled: August 31, 2012Date of Patent: August 13, 2019Assignee: University of Puerto RicoInventors: Carlos R. Cabrera, Eduardo Nicolau, Michael Flynn, Kai Griebenow
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Patent number: 10376561Abstract: Toll-like receptor 4 (TLR4), the innate immunity receptor for bacterial endotoxins, plays a pivotal role in the induction of inflammatory responses. There is a need to develop molecules that block either activation through TLR4 or the downstream signaling pathways to inhibit the storm of inflammation typically elicited by bacterial lipopolysaccharide (LPS), which is a major cause of the high mortality associated with bacterial sepsis. The present invention provides that a single intraperitoneal injection of 15 ?g Fasciola hepatica fatty acid binding protein (Fh12) 1 hour before exposure to LPS suppressed significantly the expression of serum inflammatory cytokines in a model of septic shock using C57BL/6 mice. Whereas Fh12 alone did not induce cytokine expression, it significantly suppressed the expression of IL12, TNF?, IL6 and IL1? cytokines as well as iNOS2 in bmM?s, and also impaired the phagocytic capacity of bmM?s.Type: GrantFiled: May 16, 2016Date of Patent: August 13, 2019Assignee: University of Puerto RicoInventors: Ana M. Espino, Ivelisse Martin
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Patent number: 10369544Abstract: The invention employs tetrapropylammonium (TPA+) and tetrabutylammonium (TBA+) as structure directing agents (SDAs), respectively for the preparation of the flexible titanium silicate UPRM-5. Both UPRM-5 variants are detemplated and modified to include extraframework Sr2+ and produce materials for carbon dioxide adsorption.Type: GrantFiled: May 13, 2013Date of Patent: August 6, 2019Assignee: University of Puerto RicoInventors: Arturo J. Hernandez-Maldonado, Marietta E. Marcano-Gonzalez, Jose N. Primera-Pedrozo
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Patent number: 10357521Abstract: The invention relates to methods and compositions for restoring normal microbiota in pre-term newborns or newborns delivered by Cesarean section and methods for preventing or ameliorating diseases associated with delivery by Cesarean section or pre-term birth comprising administering to said newborns at the time of birth or shortly thereafter an effective amount of a vaginal microbiota inoculum obtained from the newborn's mother or a donor or an effective amount of a probiotic composition.Type: GrantFiled: May 16, 2016Date of Patent: July 23, 2019Assignees: University of Puerto Rico, New York UniversityInventor: Maria Gloria Dominguez-Bello
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Patent number: 10358475Abstract: The invention is a high-throughput voltage screening crystallographic device and methodology that uses multiple micro wells and electric circuits capable of assaying different crystallization condition for the same or different proteins of interest at the same of different voltages under a humidity and temperature controlled environment. The protein is solubilized in a lipid matrix similar to the lipid composition of the protein in the native environment to ensure stability of the protein during crystallization. The invention provides a system and method where the protein is transferred to a lipid matrix that holds a resting membrane potential, which reduces the degree of conformational freedom of the protein. The invention overcomes the majority of the difficulties associated with vapor diffusion techniques and essentially reconstitutes the protein in its native lipid environment under “cuasi” physiological conditions.Type: GrantFiled: June 5, 2018Date of Patent: July 23, 2019Assignee: University of Puerto RicoInventors: Jose A. Lasalde-Dominicci, Orestes Quesada-Gonzalez, Josue Rodriguez-Cordero, Carlos Baez-Pagan
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Patent number: 10272414Abstract: Na+-SAPO-34 sorbents were ion-exchanged with several individual metal cations for CO2 absorption at different temperatures (273-348 K) and pressures (<1 atm). In general, the overall adsorption performance of the exchanged materials increased as follows: Ce3+<Ti3+<Mg2+<Ca2+<Ag+<Na+<Sr2+. The strontium exchanged materials excelled at low-pressure ranges, exhibiting very sharp isotherms slopes at all temperatures. The Sr2+ species were responsible for the surface strong interaction and the cations were occupying exposed sites (SII?) in the materials Chabazite cages. All the sorbent materials exhibited higher affinity for CO2 over the other gases tested (i.e., CH4, H2, N2 and O2) due to strong ion-quadrupole interactions. Sr2+-SAPO-34 sorbents are by far the best option for CO2 removal from CH4 mixtures, especially at low concentrations.Type: GrantFiled: August 24, 2016Date of Patent: April 30, 2019Assignee: University of Puerto RicoInventors: Arturo J Hernandez-Maldonado, Milton E Rivera-Ramos, Ana G Arevalo-Hidalgo