Patents Assigned to The University of Queensland
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Patent number: 11628449Abstract: The invention provides an integrated separator system for the preconcentration of a material comprising one or more grizzly bars and one or more electrodes which provide a high voltage pulse (HVP) discharge to the material.Type: GrantFiled: June 21, 2018Date of Patent: April 18, 2023Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Fengnian Shi, Emmanuel Manlapig
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Patent number: 11572390Abstract: Chimeric proteins that comprise one or more amino acid sequences of an insect-specific flavivirus and one or more other immunogenic proteins are provided. The chimeric proteins are suitably capable of forming virus particles. The chimeric protein and/or virus particle may be suitable for delivery to a subject to elicit an immune response to a pathogen and/or for diagnosis or detection of a pathogen. Also provided are nucleic acids and vectors encoding the chimeric proteins, and isolated chimeric insect-specific flaviviruses comprising the chimeric proteins and/or nucleic acids.Type: GrantFiled: September 7, 2017Date of Patent: February 7, 2023Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Roy Hall, Jody Hobson-Peters, Alexander Khromykh, Daniel Watterson, Mn Setoh, Thisun Piyasena, Agathe Colmant, Jessica Harrison, N Ata Lee Newton, Laura Vet, Helle Bielefeldt-Ohmann
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Publication number: 20230030950Abstract: The present invention relates to antigen binding sites, compositions and uses thereof in the treatment of conditions associated with pathogenic proteins. In one example the condition is Alzheimer's disease.Type: ApplicationFiled: December 3, 2020Publication date: February 2, 2023Applicant: THE UNIVERSITY OF QUEENSLANDInventors: Juergen GOETZ, Gerhard LEINENGA
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Patent number: 11566044Abstract: There is provided a range of novel disulfide bond containing compounds. These disulfide bond containing compounds can be used in a variety of applications such as solid phase peptide synthesis, solid phase organic synthesis, formation of dendrimers, formation of macromolecules and formation cyclic peptides; and as a component of a delivery vehicle with a bioactive molecule.Type: GrantFiled: July 26, 2018Date of Patent: January 31, 2023Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Harendra Parekh, Karnaker Reddy Tupally
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Publication number: 20220342022Abstract: A training method for training neural networks to determine a magnetic susceptibility distribution of a sample may include: storing a simulated magnetic susceptibility map of the sample, generating a modified magnetic susceptibility map by combining an influence of one or more external magnetic susceptibility sources with the simulated magnetic susceptibility map and storing the modified magnetic susceptibility maps. The method may include generating a first training image by applying a quantitative susceptibility mapping model the modified magnetic susceptibility map and storing the first training image, applying the first neural network to the first image and a second neural network to an output of the first neural network and changing network parameters of the first and the second neural network depending on a deviation of an output of the second artificial neural network from the simulated magnetic susceptibility map.Type: ApplicationFiled: April 21, 2022Publication date: October 27, 2022Applicants: Siemens Healthcare GmbH, The University of QueenslandInventors: Kieran O'Brien, Jin Jin, Steffen Bollmann, Markus Barth, Francesco Cognolato
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Patent number: 11434190Abstract: Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.Type: GrantFiled: December 21, 2017Date of Patent: September 6, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Mathias Francois, Johannes Zuegg, Jeroen Overman, Sreeman Kumar Mamidyala, Angela Aguslyarti Salim, Frank Roger Fontaine, Matthew Allister Cooper, Robert John Capon, Avril Alexis Barbara Robertson
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Patent number: 11369809Abstract: The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.Type: GrantFiled: June 19, 2015Date of Patent: June 28, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Juergen Goetz, Gerhard Leinenga
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Patent number: 11345717Abstract: An optical sensing element for use in the detection of hydrogen peroxide includes a sensing compound provided as a coating on a substrate. The sensing compound, on exposure to hydrogen peroxide, forms a luminescent reporter compound when excited with stimulating radiation at a predetermined wavelength that the sensing compound does not absorb.Type: GrantFiled: August 2, 2018Date of Patent: May 31, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Paul Leslie Burn, Paul Edward Shaw, Shengqiang Fan
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Patent number: 11345599Abstract: Particulate material comprising rough mesoporous hollow nanoparticles. The rough mesoporous hollow nanoparticles may comprise a mesoporous shell, the external surface of which has projections thereon, the projections having smaller sizes than the particle size. The particulate material may be used to deliver active agents, such as insecticides and pesticides. The active agents can enter into the hollow core of the particles and be protected from degradation by sunlight. The rough surface of the particles retains the particles on plant leaves or animal hair. Methods for forming the particles are also described. Carbon particles and methods for forming carbon particles are also described.Type: GrantFiled: April 18, 2016Date of Patent: May 31, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Chengzhong Yu, Meihua Yu, Hongwei Zhang, Yusilawati Ahmad Nor, Hao Song
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Patent number: 11333728Abstract: A pre-polarisation magnet arrangement for generating a pre-polarisation field for use in a low field magnetic resonance imaging process, the pre-polarisation magnet arrangement including a pre-polarisation field array including a plurality of permanent pre-polarisation magnets mounted in a support and provided in a circumferentially spaced arrangement surrounding an field of view, a number of the pre-polarisation magnets being movable between respective first and second positions, wherein in the first position the pre-polarisation magnets are configured as a cylindrical Halbach array to generate a pre-polarisation field in the field of view and in the second position the pre-polarisation magnets are configured to minimize the pre-polarisation field in the field of view.Type: GrantFiled: April 13, 2017Date of Patent: May 17, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Michael Werner Vogel, David Charles Reutens, Andrea Giorni, Ruben Pellicer-Guridi, Viktor Vegh
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Publication number: 20220143428Abstract: The present invention relates to methods of restoring cognitive function in aged individuals that do not exhibit a clinically detectable neurodegenerative disease. In one aspect, the present invention provides a method of improving cognitive function in an aged individual that does not have a neurodegenerative disease characterized by aggregation of a pathological protein, the method comprising or consisting of: applying a clinically safe level of acoustic energy to sites within a region of the brain, thereby saturating or substantially saturating the region with acoustic energy, thereby improving cognitive function in the aged individual.Type: ApplicationFiled: February 27, 2020Publication date: May 12, 2022Applicant: THE UNIVERSITY OF QUEENSLANDInventors: Juergen GOETZ, Fabrice TURPIN, Daniel BLACKMORE
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Publication number: 20220127309Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.Type: ApplicationFiled: January 11, 2022Publication date: April 28, 2022Applicant: The University of QueenslandInventors: Keith Joseph CHAPPELL, Daniel WATTERSON, Paul Robert YOUNG
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Publication number: 20220120745Abstract: The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.Type: ApplicationFiled: August 27, 2021Publication date: April 21, 2022Applicants: The University of Queensland, Seattle Children's Hospital dba Seattle Children's Research InstituteInventors: Yadveer Grewal, Gerard A. Cangelosi, Muhammad J.A. Shiddiky, Matt Trau
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Patent number: 11279733Abstract: There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.Type: GrantFiled: November 2, 2018Date of Patent: March 22, 2022Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Matthew Cooper, Mark Blaskovich, Alejandra Gallardo-Godoy, Karl Hansford, Alysha Elliott, Craig Muldoon, Bernd Becker
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Patent number: 11266968Abstract: The present invention relates to emulsion-templated silica micro and nano-capsules- and methods for making them. In particular, the template emulsion is stabilized by a biosurfactant that also assists in nucleating the silica shell Mineralizing biosurfactants and stabilized micro- and nano-emulsions useful in forming the emulsion-templated micro- and nano-capsules, and methods for the use of the silica micro- and nano-capsules are also described.Type: GrantFiled: September 16, 2014Date of Patent: March 8, 2022Assignee: The University of QueenslandInventors: Anton Peter Jacob Middelberg, Chun-Xia Zhao, David Wibowo, Brenton Charles Peters
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Patent number: 11254712Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.Type: GrantFiled: March 29, 2018Date of Patent: February 22, 2022Assignee: The University of QueenslandInventors: Keith Joseph Chappell, Daniel Watterson, Paul Robert Young
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Patent number: 11204404Abstract: A pre-polarisation magnet arrangement for generating a pre-polarisation field for use in a low field magnetic resonance imaging process, the pre-polarisation magnet arrangement including a pre-polarisation field array including a plurality of permanent pre-polarisation magnets mounted in a support and provided in a circumferentially spaced arrangement surrounding a field of view, a number of the pre-polarisation magnets being movable between respective first and second positions, wherein in the first position the pre-polarisation magnets are configured as a cylindrical Halbach array to generate a pre-polarisation field in the field of view and in the second position the pre-polarisation magnets are configured to minimize the pre-polarisation field in the field of view.Type: GrantFiled: April 13, 2017Date of Patent: December 21, 2021Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Michael Werner Vogel, David Charles Reutens, Andrea Giorni, Ruben Pellicer-Guridi, Viktor Vegh
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Patent number: 11198632Abstract: A method for treating a sludge derived from sewage or wastewater, the method comprising subjecting the sludge to a treatment step at a pH of 8.9 or greater and a free ammonia (FA) content of 100 mg NH3—N/L or greater. The treated sludge may be fed to a bioreactor to produce methane.Type: GrantFiled: March 29, 2018Date of Patent: December 14, 2021Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Qilin Wang, Zhiguo Yuan, Haoran Duan, Wei Wei
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Publication number: 20210347869Abstract: The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.Type: ApplicationFiled: October 17, 2018Publication date: November 11, 2021Applicant: THE UNIVERSITY OF QUEENSLANDInventors: Juergen GOETZ, Rebecca NISBET, Phillip JANOWICZ, Gerhard LEINENGA
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Patent number: 11136351Abstract: The invention relates to alpha conotoxin (?-conotoxin) peptides and methods for their preparation. Also described are pharmaceutical compositions comprising alpha conotoxin (?-conotoxin) peptides and their use in the treatment or prevention of indications 5 associated with nicotinic acetylcholine receptors and/or voltage gated calcium channels.Type: GrantFiled: February 16, 2017Date of Patent: October 5, 2021Assignee: The University of QueenslandInventors: Richard James Clark, James Travis Daniel