Patents Assigned to The University of Queensland
  • Modulators of protease activated receptors
    Patent number: 9868763
    Abstract: The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: January 16, 2018
    Assignee: The University of Queensland
    Inventors: David Fairlie, Ligong Liu, Mei-Kwan Yau, Jacky Yung Suen, Robert Reid, Rink-Jan Lohman, Abishek Venkatasubramanian Iyer, Junxian Lim, Lindsay Charles Brown
  • Anti-CD83 antibodies and use thereof
    Patent number: 9840559
    Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: December 12, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNIVERSITY OF QUEENSLAND, DENDROCYTE BIOTECH PTY LTD
    Inventors: Therese Ann Seldon, David John Munster, Derek Nigel John Hart, Martina Louise Jones, Trent Phillip Munro, Stephen Michael Mahler, Eunice Yu Zhou, James D. Marks
  • Neurodegenerative disorders and methods of treatment and diagnosis thereof
    Patent number: 9833430
    Abstract: This invention relates to compositions and methods for the therapy and diagnosis of neurodegenerative or neuromuscular disorders. More particularly, this invention relates to use of anaplerotic agents for treating, preventing, or delaying the onset of a neurodegenerative or neuromuscular disorder.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: December 5, 2017
    Assignee: The University of Queensland
    Inventors: Karin Borges, Shyuan T. Ngo
  • Block copolymer and associated photoresist composition and method of forming an electronic device
    Patent number: 9815930
    Abstract: A block copolymer useful in electron beam and extreme ultraviolet photolithography includes a first block with units derived from a base-solubility-enhancing monomer and an out-of-band absorbing monomer, and a second block having a low surface energy. Repeat units derived from the out-of-ban absorbing monomer allow the copolymer to absorb significantly in the wavelength range 150 to 400 nanometers. When incorporated into a photoresist composition with a photoresist random polymer, the block copolymer self-segregates to form a top layer that effectively screens out-of-band radiation.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: November 14, 2017
    Assignees: ROHM AND HAAS ELECTRONIC MATERIALS LLC, THE UNIVERSITY OF QUEENSLAND
    Inventors: James W. Thackeray, Ke Du, Peter Trefonas, III, Idriss Blakey, Andrew Keith Whittaker
  • Cyclotide genes in the fabaceae plant family
    Patent number: 9796764
    Abstract: The present invention relates to cyclotides and cyclotide-encoding genes from the Fabaceae plant family, and to the expression of cyclotides in Fabaceae. The present invention further relates to isolated nucleic acids configured to express cyclotides comprising heterologous peptide grafts in plants of the Fabaceae family.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 24, 2017
    Assignees: The University of Queensland, Commonwealth Scientific and Industrial Research Organisation
    Inventors: Aaron G. Poth, Michelle Colgrave, Russell Lyons, David Craik
  • Protease-based biosensor
    Patent number: 9791436
    Abstract: A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: October 17, 2017
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Kirill Alexandrov, Viktor Stein, Matt Trau
  • Bimolecular protease-based biosensor
    Patent number: 9772328
    Abstract: A biosensor comprises first and second molecular components and is capable of displaying protease activity in response to a binding event mediated by first and second binding partners of the biosensor. The first and second binding partners may bind each other directly or may both bind a target molecule. At least the first molecular component comprises an autoinhibited protease, whereby the binding event switches the protease frora an autoinhibited inactive state to a protease active state. The second molecular component may activate the protease of the first molecular component by binding a cross-binder which releases the autoinhibitor or by cleaving a linker which releases the autoinhibitor. The first and second molecular components may both have autoinhibited proteases which reciprocally activate each other.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 26, 2017
    Assignee: The University of Queensland
    Inventors: Viktor Stein, Kirill Alexandrov
  • Auto thermal reforming (ATR) catalytic structures
    Patent number: 9745191
    Abstract: An autothermal reforming catalytic structure for generating hydrogen gas from liquid hydrocarbons, steam and an oxygen source. The autothermal reforming catalytic structure includes a support structure and nanosized mixed metal oxide particles dispersed homogenously throughout the support structure.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: August 29, 2017
    Assignees: Saudi Arabian Oil Company, The University of Queensland
    Inventors: Thang V. Pham, Sai P. Katikaneni, Jorge N. Beltramini, Moses O. Adebajo, Joao Carlos Diniz Da Costa, Gao Qing Lu
  • Modulators of protease activated receptors
    Patent number: 9701711
    Abstract: The present application provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: July 11, 2017
    Assignee: The University of Queensland
    Inventors: David Paul Fairlie, Ligong Liu, Mei Kwan Yau, Jacky Yung Suen, Robert Reid
  • Nanoparticle-polymer resists
    Patent number: 9696624
    Abstract: A composite, which is a blend comprising: a nanoparticle comprising a core and a coating surrounding the core; and a polymer, wherein the coating of the nanoparticle comprises a ligand, wherein the ligand is a substituted or unsubstituted C1-C16 carboxylic acid or a salt thereof, a substituted or unsubstituted C1-C16 amino acid or a salt thereof, a substituted or unsubstituted C1-C16 dialkyl phosphonate, or a combination thereof; and wherein the polymer is a polymerization product of a photoacid generator comprising a polymerizable group; at least one unsaturated monomer, which is different from the photoacid generator comprising a polymerizable group; and a chain transfer agent of formula (I); wherein: Z is a y valent C1-20 organic group, x is 0 or 1, and Rd is a substituted or unsubstituted C1-20 alkyl, C3-20 cycloalkyl, C6-20 aryl, or C7-20 aralkyl.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: July 4, 2017
    Assignees: ROHM AND HAAS ELECTRONIC MATERIALS LLC, THE UNIVERSITY OF QUEENSLAND
    Inventors: James W. Thackeray, Meiliana Siauw, Peter Trefonas, III, Idriss Blakey, Andrew Keith Whittaker
  • Method and apparatus for forming the profile of deformable materials and deformable tubular sections
    Patent number: 9676018
    Abstract: An apparatus for forming the profile of deformable materials including tubular sections. The apparatus (1) includes at least two sets (4, 5) of die elements (6), each set (4,5) including a plurality of die elements (6) respectively arranged to travel along corresponding endless path. The paths each include a forming portion (9,10) in which die elements (6) of each set (4. 5) are opposed to define a forming space (11) therebetween. The forming portion (9, 10) of each path is configured so that one or more dimensions of the forming space (11) reduce along the length of the forming portion (9,10) to simultaneously apply lateral forces to material progressing through the forming portion.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: June 13, 2017
    Assignee: The University of Queensland
    Inventor: Shichao Ding
  • Microbiopsy device
    Patent number: 9662095
    Abstract: A microbiopsy device for taking biological samples, comprising a body including two or more cutting elements for cutting tissue to form a biological sample; and a chamber inside the body for receiving and retaining the biological sample, the chamber having an opening between the cutting elements, wherein the cutting elements are arranged to cut a section of tissue having a width of less than 1 mm.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: May 30, 2017
    Assignee: The University of Queensland
    Inventors: Tarl W. Prow, H. Peter Soyers, Alexander Bernard Ansaldo
  • Lithographically produced features
    Patent number: 9606440
    Abstract: The present invention relates to a method for modifying line edge roughness on a lithographically-produced feature in a material, the method comprising applying a block copolymer to an area on the feature having line edge roughness, the block copolymer comprising a charged hydrophilic polymer block and a non-charged hydrophilic polymer block.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: March 28, 2017
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Idriss Blakey, Ya-Mi Chuang, Andrew Keith Whittaker, Kevin Stanley Jack
  • Release media
    Patent number: 9587104
    Abstract: The present invention relates to a composition comprising polymer particles and functionalized stimulus responsive polymer; the polymer particles (i) comprising block co-polymer, and (ii) having a core-shell structure, said block co-polymer comprising (a) a non-stimulus responsive polymer block that forms at least part of the core structure, and (b) a stimulus responsive polymer block that forms at least part of the shell structure; wherein the stimulus responsive polymer of both the polymer particles and the functionalized stimulus responsive polymer are responsive to at least one common stimulus.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 7, 2017
    Assignee: The University of Queensland
    Inventors: Peter Gray, Michael John Monteiro, Trent Phillip Munro, Andrew Benjamin James Prowse
  • Modulators of C3a receptors
    Patent number: 9586914
    Abstract: Heterocyclic compounds that modulate C3a receptors and their use in the treatment or prevention of inflammatory diseases, infectious diseases, cancers, metabolic disorders, obesity, type 2 diabetes, metabolic syndrome and associated cardiovascular diseases are described. The use of the compounds in stimulating or suppressing an immune response is also described together with pharmaceutical compositions comprising the compounds or their pharmaceutically acceptable salts.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: March 7, 2017
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: David Fairlie, Robert C. Reid
  • Real-time object analysis with occlusion handling
    Patent number: 9582895
    Abstract: A method includes the following steps. A video sequence including detection results from one or more detectors is received, the detection results identifying one or more objects. A clustering framework is applied to the detection results to identify one or more clusters associated with the one or more objects. The clustering framework is applied to the video sequence on a frame-by-frame basis. Spatial and temporal information for each of the one or more clusters are determined. The one or more clusters are associated to the detection results based on the spatial and temporal information in consecutive frames of the video sequence to generate tracking information. One or more target tracks are generated based on the tracking information for the one or more clusters. The one or more target tracks are consolidated to generate refined tracks for the one or more objects.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 28, 2017
    Assignees: International Business Machines Corporation, The University of Queensland
    Inventors: Lisa M. Brown, Sayed Ali Emami, Mehrtash Harandi, Sharathchandra U. Pankanti
  • Immunogenic compositions and methods therefor
    Patent number: 9580481
    Abstract: The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunize an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: February 28, 2017
    Assignee: University of Queensland
    Inventors: Anton Peter Jacob Middelberg, Linda Hwee-Lin Lua
  • Delivery device
    Patent number: 9572969
    Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: February 21, 2017
    Assignee: The University of Queensland
    Inventor: Mark Anthony Fernance Kendall
  • Compositions and methods for modulating immune responses
    Patent number: 9561272
    Abstract: This invention discloses methods and compositions for modulating immune responses, which involve particulate delivery of agents to immune cells, wherein the agents comprise an inhibitor of the NF-?B signaling pathway and an antigen that corresponds to a target antigen. The methods and compositions of the present invention are particularly useful in the treatment or prophylaxis of an undesirable immune response associated with the target antigen, including autoimmune diseases, allergies and transplantation associated diseases.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: February 7, 2017
    Assignee: The University of Queensland
    Inventors: Ranjeny Thomas, Nigel Meredith Davies, Brendan John O'Sullivan
  • Nanoemulsions
    Patent number: 9554995
    Abstract: The invention relates to nanoemulsions useful for analytical techniques and delivery of cargoes such as pharmaceutically active agents. In particular, the invention relates to nanoemulsions comprising an oil phase dispersed in an aqueous phase and at least two peptide surfactants adsorbed at the liquid-liquid interface, one peptide surfactant comprising a short peptide sequence having ?-helical propensity and at least one second polypeptide surfactant comprising at least two peptide sequences having ?-helical propensity linked by a linking sequence of 3 to 11 amino acid residues. Optionally the at least one second polypeptide surfactant comprises at least one pharmacokinetic modifying agent and/or a targeting agent. Furthermore, the nanoemulsion may further comprise a cargo such as a pharmaceutically active agent.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: January 31, 2017
    Assignee: The University of Queensland
    Inventors: Anton Peter Jacob Middelberg, Bijun Zeng