Patents Assigned to The University of Reading
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Patent number: 10451784Abstract: A narrow bandpass filter that may be used in a mid-infrared sensor for monitoring a species, which may be a component of a fluid or a solid material. The filter comprises a cavity comprising a low refractive index material. By providing a high ratio of low refractive index material in the filter with respective to high refractive index material, the filter is configured so that wavelength transmission remains constant with varying temperature. Materials used for the low and/or high refractive index provide a temperature invariant filter that transmits mid-infrared spectra without serious degradation.Type: GrantFiled: September 9, 2015Date of Patent: October 22, 2019Assignees: SCHLUMBERGER TECHNOLOGY CORPORATION, UNIVERSITY OF READINGInventors: Timothy Jones, Nathan Lawrence, Gary Hawkins, Richard Sherwood, Karim Djotni
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Publication number: 20130267681Abstract: The invention discloses processes for preparing compounds comprising an ?-amino acid motif. The compounds are useful in e.g. the chemical ligation of peptides.Type: ApplicationFiled: August 12, 2011Publication date: October 10, 2013Applicant: THE UNIVERSITY OF READINGInventors: Laurence Marius Harwood, Donald A. Wellings, David John Moody
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Patent number: 8399612Abstract: A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemization, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerization.Type: GrantFiled: July 20, 2011Date of Patent: March 19, 2013Assignee: University of ReadingInventors: Laurence M. Harwood, Ran Yan
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Publication number: 20130018110Abstract: The invention provides a method for preparing a hydrogel from a hydrophilic polymer having one or more functional groups which are capable of co-reacting in a condensation reaction which method comprises the steps of: (i) preparing a solution of the polymer; (ii) heating the solution to a temperature sufficient for the condensation reaction to take place for a period of time sufficient for the hydrogel to cross-link wherein where the hydrophilic polymer comprises a first and a second hydrophilic polymer, step (i) comprises a step of mixing the hydrophilic polymers to prepare a homogeneous intimate mixture of the polymers; and wherein the heating step (ii) is carried out at a pressure greater than atmospheric pressure. The method of the invention is advantageous because it is relatively low cost, it is a safer procedure with less health & safety concerns, it is carried out in a liquid state and is not limited by film thickness.Type: ApplicationFiled: January 20, 2011Publication date: January 17, 2013Applicant: The University of ReadingInventors: Vitaliy Khutoryanskiy, Olga Khutoryanskaya, Joseph Peter Cook, Glenn William Goodall
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Publication number: 20120264935Abstract: The invention discloses an improved process for the preparation of 2,2,5,5-tetrasubstituted hexane-1,6-dicarbonyl compounds, and in particular diethyl 2,2,5,5-tetramethylhexanedioate and dimethyl 2,2,5,5-tetramethylhexanedioate, by the alkylation of 1,2-difunctional ethane compounds with enolates of carbonyl compounds. The process provides higher yields and greater synthetic brevity than existing processes.Type: ApplicationFiled: December 21, 2010Publication date: October 18, 2012Applicant: THE UNIVERSITY OF READINGInventors: Francis William Lewis, Laurence Marius Harwood, Michael James Hudson
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Patent number: 8044173Abstract: A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.Type: GrantFiled: March 20, 2008Date of Patent: October 25, 2011Assignee: University of ReadingInventors: Laurence M. Harwood, Ran Yan
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Publication number: 20110109464Abstract: A system and method are described for detecting toxic gas releases in an urban environment. The system includes a series of repositionable remote sensor nodes that are located in an environment containing a toxic gas, the sensor nodes including a chemical sensor and/or a meteorological sensor. The sensor nodes gather data relating to the type of gas released and the surrounding atmospheric conditions and relay the information back to a data processing hub where the data is collated and analysed to produce an indication of the likely spread of the gas plume, the likely danger to the surrounding population and an indication of the release point of the gas.Type: ApplicationFiled: January 21, 2011Publication date: May 12, 2011Applicants: Selex Galileo Limited, University of Reading, University of SurreyInventors: Jason LEPLEY, Graham Bourdon, Douglas Friedrich, Alison C. Rudd, Stephen Belcher, Alan G. Robins
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Publication number: 20100047658Abstract: An ion-conducting membrane comprising a polymer component and a macrocyclic compound, wherein the macro-cyclic compound is functionalised with one or more ion-conducting groups is disclosed. The membrane is suitable for use in a fuel cell.Type: ApplicationFiled: June 14, 2007Publication date: February 25, 2010Applicants: Johnson Matthey Public Limited Company, University of ReadingInventors: Howard Matthew Colquhoun, Zhixue Zhu, David Thompsett, Nadia Michele Walsby
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Publication number: 20090304094Abstract: An Orthogonal Frequency Division Multiplexing (OFDM) communication system with a transmitter and a receiver. The transmitter is arranged to transmit channel estimation sequences on each of a plurality of band groups, or bands, and to transmit data on each of the band groups or bands. The receiver is arranged to receive the channel estimation sequences for each band group or band to calculate channel state information from each of the channel estimation sequences transmitted on that band group or band and to form an average channel state information. The receiver receives the transmitted data, transforms the received data into the frequency domain, equalizes the received data using the channel state information, demaps the equalized data to re-construct the received data as soft bits and modifies the soft bits using the averaged channel state information.Type: ApplicationFiled: June 4, 2008Publication date: December 10, 2009Applicant: THE UNIVERSITY OF READING WHITEKNIGHTSInventors: R. Simon Sherratt, Runfeng Yang, Oswaldo Cadenas
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Patent number: 7456260Abstract: The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.Type: GrantFiled: June 17, 2003Date of Patent: November 25, 2008Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The University of ReadingInventors: Susanna M. Rybak, Juergen Krauss, Michaela Arndt, Andrew C. R. Martin
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Patent number: 7125708Abstract: A novel probiotic strain termed Lactobacillus pentosus NCIMB 41114 is capable of preventing growth of pathogenic microorganisms in the GI tract. In particular, this bacterium inhibits Candida overgrowth, and can be employed to prevent and treat associated diseases, including IBS and thrush.Type: GrantFiled: October 11, 2002Date of Patent: October 24, 2006Assignee: University of Reading, School of Food BiosciencesInventors: Anthony G. Wynne, Glenn R. Gibson, Jonathan Brostoff
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Publication number: 20060194276Abstract: The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.Type: ApplicationFiled: June 17, 2003Publication date: August 31, 2006Applicants: THE GOVERMMENT of the USA as Represented by the Secretary of the Dept, of Health and Human Service, University of ReadingInventors: Jurgen Krauss, Michaela Arndt, Andrew Martin, Susanna Rybak
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Patent number: 7038821Abstract: A scanning apparatus comprises two rotatable bodies (1, 10 or 40) arranged to rotate in opposite directions. The first body being a polarizer (10) and the second being a mirror (1) or a second polarizer (40). The apparatus is arranged to define an optical path for a polarized beam, wherein the optical path passes through the first body (10), is reflected at the second body (1 or 40), and is reflected by the first body (10) back to the second body (1 or 40) from where it is transmitted or reflected to produce a linear scan. There is also disclosed a scanning system comprising a reflector (1) and an optical wedge (42) containing refractive materials, arranged to counter rotate and arranged so that a beam passing through the optical wedge (42), is reflected by the reflector (1) and passes back through the optical wedge (42) to produce a linear scan.Type: GrantFiled: July 22, 2002Date of Patent: May 2, 2006Assignee: The University of ReadingInventor: Alan Lettington
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Publication number: 20040142016Abstract: Materials and methods for reacting polysaccharides are set forth. Examples include reacting polysaccharides with a surface, and reacting polysaccharides with other polysaccharides or polymers to form a polysaccharide polymer. Layers of polysaccharides and/or polysaccharide polymers may be formed on surfaces, for example, medical device surfaces that contact bodily fluids.Type: ApplicationFiled: January 5, 2004Publication date: July 22, 2004Applicant: Biointeractions, Ltd., University of ReadingInventors: Ajay K. Luthra, Shivpal S. Sandhu, John O. Hudson
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Patent number: 6620590Abstract: A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis and can be used to predict the onset of secondary symptoms.Type: GrantFiled: April 25, 2001Date of Patent: September 16, 2003Assignees: Isis Innovation Limited, The University of Reading, Oxford Brookes UniversityInventors: Nigel Patrick Groome, Philip Gerald Knight, William Leigh Ledger, Christopher Willard George Redman, Shanthi Muttukrishna
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Patent number: 6589971Abstract: “Head-to-head” bis-benzimidazoles having the following formula wherein A1, A2, X1 and X2 are as defined in the following specification, have been found to bind to specific sequences in the minor groove of duplex DNA, and to have cytotoxic effects against a range of tumor cell lines.Type: GrantFiled: April 18, 2002Date of Patent: July 8, 2003Assignees: The Queens University of Belfast, Institute of Cancer Research, The University of ReadingInventors: Stephen Neidle, John Monn
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Patent number: 6024985Abstract: The invention provides a synthetic bone precursor material comprising amorphous calcium phosphate and a constituent that inhibits the crystallisation of calcium hydroxyapatite to amorphous calcium phosphate. The synthetic bone precursor may comprise a material of formula CaxMgyPO4 wherein Mg acts as an inhibitor for crystallisation. Other crystallisation inhibitors such as pyrophosphate may be present. The inhibitor is capable of dissolving in physiological saline. Loss of inhibitor from the precursor allows crystallisation of hydroxyapatite. The invention relates to use of a synthetic bone precursor to form bone in vivo, by a transformation of the amorphous precursor material to crystalline hydroxyapatite bone material by the leaching action on inhibitory ions body fluids. it is envisaged that the material will be useful in facilitating bone repair, inducing bone formation or assisting in the attachment of prostheses.Type: GrantFiled: April 5, 1995Date of Patent: February 15, 2000Assignee: University of ReadingInventors: Kenneth Simkiss, Marina Gloria Taylor
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Patent number: 5844080Abstract: A Corticotropin Releasing Factor-binding protein (CRF-BP) is isolated and purified sufficient to provide AA sequence data from which the DNA is obtained, which is then used to produce the protein recombinantly. The CRF-BP is useful for modulating the biological activity of CRF, such as reducing the high ACTH levels in mammals caused by excess CRF. The CRF-BP or fragments thereof and/or antibodies to the proteins may be employed in diagnostic assays to determine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. The DNA or subsequence thereof can be used as probes for genetic material in certain assays. The anti-CRF-BP antibodies are also useful to purify the CRF-BP protein and to modulate the biological effect of CRF-BPs proteins.Type: GrantFiled: June 5, 1995Date of Patent: December 1, 1998Assignees: The Salk Institute for Biological Studies, The University of ReadingInventors: Ellen Potter, Dominic P. Behan, Wolfgang H. Fischer, Elizabeth A. Linton, Philip J. Lowry, Wylie W. Vale, Jr.
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Patent number: 5750805Abstract: Epoxides containing hydroxy groups are rearranged enantioselectively using a chiral base to give allyl alcohols in high enantiomeric excess, e.g. ##STR1## If R.sup.3 .noteq.H, the reaction also has the effect of generating a chiral tetrasubstituted carbon atom.Type: GrantFiled: September 12, 1996Date of Patent: May 12, 1998Assignee: The University of ReadingInventors: David Michael Hodgson, Jason Witherington
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Patent number: 5733790Abstract: Corticotropin Releasing Factor-binding protein (CRF-BP) is produced recombinantly and is useful for modulating the biological activity of CRF. CRF-BP or fragments thereof and/or antibodies to such polypeptides are employed in diagnostic assays to determine the levels of CRF and CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. Following such an assay, pregnancy-related pathological disorders, such as increased risk of premature labor, can be treated, for example, by administering CRF-BP to lower the ratio of CRF/CRF-BP to within a normal range for pregnancy. Anti-CRF-BP antibodies are also useful to purify CRF-BP and to modulate the biological effect of CRF-BPs.Type: GrantFiled: June 7, 1995Date of Patent: March 31, 1998Assignees: The Salk Institute for Biological Studies, The University of ReadingInventors: Ellen Potter, Dominic P. Behan, Elizabeth A. Linton, Philip J. Lowry, Wylie W. Vale, Jr.