Patents Assigned to The University of Rochester Medical Center
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Publication number: 20130288976Abstract: In one aspect, the invention provides a method of screening a human subject to determine if said subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD), said method comprising: (a) providing a biological sample comprising genomic DNA from the subject; and (b) analyzing the portion of the genomic DNA in the sample corresponding to the distal D4Z4-pLAM region on chromosome 4 and determining the presence or absence of a polymorphism resulting in a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene, wherein a determination of the absence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject does not have a genetic predisposition to develop, and is not suffering from FSHD, and/or wherein a determination of the presence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject has a genetic predisposition to develType: ApplicationFiled: August 18, 2011Publication date: October 31, 2013Applicants: Fred Hutchinson Cancer Research Center, University of Rochester Medical Center, Leiden University Medical CenterInventors: Silvere M. van der Maarel, Stephen J. Tapscott, Rabi Tawil, Richard J.L.F. Lemmers, Linda Geng, Lauren Snider
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Patent number: 8198323Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: GrantFiled: April 12, 2010Date of Patent: June 12, 2012Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20100197784Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: ApplicationFiled: April 12, 2010Publication date: August 5, 2010Applicants: The University of North Carlina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20100160174Abstract: Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.Type: ApplicationFiled: July 27, 2009Publication date: June 24, 2010Applicant: University of Rochester Medical CenterInventors: Harold C. Smith, Mark P. Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind
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Patent number: 7709535Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: GrantFiled: February 13, 2008Date of Patent: May 4, 2010Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Patent number: 7645140Abstract: A method for assessing the navigational capacity in human subjects, and its use in diagnosing spatial disorientation in neurodegenerative diseases, such as, for example Alzheimer's disease. The method for assessing the navigational capacity includes conducting a spatial orientation test, recording the results of the test, analyzing the test results and making a determination of the navigational capacity of a human subject. In its most simple sense, navigational capacity includes the capacity not to get lost. The spatial orientation test includes various naturalistic navigation tasks that are each designed to assess specific areas of the navigational capacity of a subject.Type: GrantFiled: November 5, 2003Date of Patent: January 12, 2010Assignee: University of Rochester Medical CenterInventors: Charles J. Duffy, Laura Cushman, Mark Mapstone
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Publication number: 20090325235Abstract: Methods and kits performing reverse transcription and RT-PCR reactions having high fidelity, processivity and DNA polymerase activity are described. The methods involve performance of reverse transcription at an increased temperature with a reverse transcriptase from Simian Immunodeficiency Virus-agm.sab or a variation thereof. The kits of the present invention include a reverse transcriptase from Simian Immunodeficiency Virus-agm.sab or a variation thereof, a DNA polymerase capable of amplifying cDNA under conditions suitable for polymerase chain reaction, and the reagents necessary to carry out both processes.Type: ApplicationFiled: June 25, 2008Publication date: December 31, 2009Applicant: University of Rochester Medical CenterInventor: Baek KIM
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Publication number: 20090290766Abstract: A method for analyzing the placenta and histology slides of placental tissue comprising: selecting a placental sample to be analyzed; obtaining a digital image of the placental sample; and performing an analysis on the digital image, wherein a mathematical algorithm is applied to the digital image. The results of the analysis are correlated with data on health outcomes in infants, children, or adults and are used to assess future physiological risks to a patient.Type: ApplicationFiled: May 23, 2008Publication date: November 26, 2009Applicants: Placental Analytics, LLC., University of Rochester Medical CenterInventors: Carolyn M. Salafia, Richard K. Miller
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Publication number: 20090282496Abstract: Disclosed are compositions and methods for treating bladder cancer.Type: ApplicationFiled: April 3, 2009Publication date: November 12, 2009Applicant: University of Rochester Medical CenterInventor: Chawnshang Chang
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Patent number: 7595346Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: GrantFiled: February 13, 2008Date of Patent: September 29, 2009Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Patent number: 7546156Abstract: A system and method for managing imaging data related to a biological trait, including generating a three-dimensional representation of the external surface of the body a patient; obtaining the imaging data; associating the imaging data with a coordinate location of the three-dimensional representation, to generate an associated imaging data; and managing the associated imaging data using the surface representation. The association includes uniquely associating numerical values (e.g., Cartesian coordinates) to particular surface features. The three-dimensional model includes the ability to adjust the pose of the 3D models made from data taken at different times so that the coordinate systems closely correspond.Type: GrantFiled: May 7, 2004Date of Patent: June 9, 2009Assignee: University of Rochester Medical CenterInventors: Brian C. Madden, Craig C. Miller, Alice P. Pentland
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Publication number: 20080249400Abstract: The invention provides methods for visualizing hepatobiliary structures, or lesions in a liver, intraoperatively by use of fluorescent dyes.Type: ApplicationFiled: October 5, 2007Publication date: October 9, 2008Applicant: University of Rochester Medical CenterInventors: Dragan Golijanin, Ronald Wood, Jay E. Reeder
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Publication number: 20080161662Abstract: The invention provides methods for visualizing renal tumors and for staging cysts during an operation by use of a fluorescent dye.Type: ApplicationFiled: August 9, 2007Publication date: July 3, 2008Applicant: University of Rochester Medical CenterInventors: Dragan Golijanin, Edward M. Messing
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Publication number: 20080161391Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: ApplicationFiled: February 13, 2008Publication date: July 3, 2008Applicants: The University of North Carolina, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20080161744Abstract: The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.Type: ApplicationFiled: September 6, 2007Publication date: July 3, 2008Applicants: University of Rochester Medical Center, Novadaq Technologies Inc.Inventors: Dragan Golijanin, Lukasz Brzozowski, Ronald Wood
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Publication number: 20080146660Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: ApplicationFiled: February 13, 2008Publication date: June 19, 2008Applicants: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20080125650Abstract: The invention provides methods for visualizing and distinguishing sentinel lymph nodes and involved nodes from other lymph nodes in the vicinity of the bladder in patients undergoing cystectomy or other operations to remove bladder tumors.Type: ApplicationFiled: July 9, 2007Publication date: May 29, 2008Applicant: University of Rochester Medical CenterInventors: Dragan Golijanin, Edward M. Messing, Jay E. Reeder, Ronald Wood, Aimee Johnson
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Publication number: 20080125663Abstract: The invention provides methods for visualizing perfusion or lack thereof in the spermatic cord and testicle, as well as for detecting testicular trauma. A surgical forceps adapted to facilitate such visualization is also provided.Type: ApplicationFiled: July 19, 2007Publication date: May 29, 2008Applicant: University of Rochester Medical CenterInventor: Drajan Golijanin
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Patent number: 7355081Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: GrantFiled: October 15, 2004Date of Patent: April 8, 2008Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20070173697Abstract: A combined flexible and rigid intubating video laryngoscope. The laryngoscope has a handle, and a rigid blade, having a proximal end connectible to the handle and a distal end projecting therefrom. The laryngoscope also has a flexible video endoscope having a distal end connectible near the distal end of the blade, the distal end of the endoscope being movable relative to the distal end of the blade, so as to enable the endoscope to obtain a variable view including a more anterior anatomical view of a patient's vocal cords during direct laryngoscopy.Type: ApplicationFiled: August 16, 2006Publication date: July 26, 2007Applicant: University of Rochester Medical CenterInventors: Paul Dutcher, Farhan Taghizadeh