Patents Assigned to The University of Rochester
  • Polymer microparticle-based method for probe deposition in label-free biosensors
    Patent number: 11280782
    Abstract: Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface at two or more locations on the surface, wherein the hydrogel particles at a first location comprise a plurality of first probe molecules bound to the particles and the hydrogel particles at a second location comprise a plurality of second probe molecules bound to the particles. Systems that include the sensor chip, as well as methods of preparing and using the sensor chip, are also disclosed.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: March 22, 2022
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Benjamin L. Miller, Mark A. Lifson, Jared A. Carter
  • METHODS AND KITS FOR RAPID SCREENING FOR HYPOSMIA AND ANOSMIA
    Publication number: 20220054074
    Abstract: The invention provides methods and kits for rapid and inexpensive detection of hyposmia or anosmia, diminishment or loss of the sense of smell. Sudden onset of diminishment or loss of the sense of smell is an early sign of infection with SARS-CoV-2, the causative agent of COVID-19; detecting the sudden onset of diminishment or loss of the sense of smell can therefore be used to rapidly screen a population for persons who should undergo diagnostic testing for a SARS-CoV-2 infection, and more generally to screen persons for olfactory disorders.
    Type: Application
    Filed: August 24, 2021
    Publication date: February 24, 2022
    Applicant: University of Rochester
    Inventors: Christopher J STODGELL, Ronald W. WOOD
  • Methods and systems for quantitative ocular surface diagnostics
    Patent number: 11246481
    Abstract: The present disclosure provides systems and methods for characterizing thin films, such as, for example, diagnosis of dry eye syndrome, thin-film optical metrology testing, etc. The present disclosure may be embodied as a tearscope, which is sometimes referred to herein as a Macroscopic Imaging Ellipsometer (MIE) because it may be considered to be an imaging ellipsometer with, for example, a field-of-view on the order of tens of millimeters or more (i.e., macroscopic), compared with conventional imaging ellipsometers, which usually employ microscope objectives and have fields-of-view of up to several hundred microns.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: February 15, 2022
    Assignee: University of Rochester
    Inventors: James M. Zavislan, Aizhong Zhang
  • Small molecule inhibitors for transcription factors
    Patent number: 11247996
    Abstract: The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. Related pharmaceutical compositions are disclosed. Methods of treatment with the disclosed compounds and compositions are also disclosed. Related kits are further disclosed.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: February 15, 2022
    Assignees: University of Massachusetts, University of Rochester
    Inventors: Wei Zhang, Jian Zhu
  • Electro-optic silicon nitride via electric poling
    Patent number: 11243419
    Abstract: A deposition method for manufacturing an active electro-optic layer includes providing a substrate or a base layer; and applying an electric field across a silicon nitride layer as it is being deposited on the substrate or the base layer to cause a poling of a deposited layer. Alternative methods for poling an active electro-optic layer and an electro-optical device are also described.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 8, 2022
    Assignee: University of Rochester
    Inventors: Jaime Cardenas, Yi Zhang
  • MEASUREMENT APPARATUS OF WAVEFRONT AND POLARIZATION PROFILE OF VECTORIAL OPTICAL FIELDS
    Publication number: 20220011163
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Application
    Filed: July 19, 2021
    Publication date: January 13, 2022
    Applicants: The University of Rochester, University of South Florida
    Inventors: Zhimin Shi, Darrick Hay, Ziyi Zhu, Yiyu Zhou, Robert W. Boyd
  • Label-free contrast enhancement for translucent cell imaging by purposefully displacing the detector
    Patent number: 11185222
    Abstract: A method for imaging vertebrate translucent retinal structures includes: imaging a translucent retinal structure at a first imaging plane in the retina with a light source focused at such first imaging plane, and detecting reflected light with a non-confocal off-axis detector, wherein the detector is axially displaced from a plane conjugate to the first imaging plane to a plane conjugate to a reflective layer deeper in the retina along a path of illumination from the light source.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 30, 2021
    Assignee: University of Rochester
    Inventors: Raul Andres Guevara-Torres, Jesse Schallek
  • Anti-HIV peptides
    Patent number: 11186614
    Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 30, 2021
    Assignees: Colorado State University Research Foundation, University of Rochester
    Inventors: Brian R. McNaughton, David W. Crawford, Joseph E. Wedekind, Ivan A. Belashov
  • Energy efficient write scheme for non-volatile resistive crossbar arrays with selectors
    Patent number: 11189344
    Abstract: A method to adaptively and dynamically set a bias scheme of a crossbar array for a write operation includes: performing a read-before-write operation to determine a number of cells n to be written during a write operation; comparing n to a predetermined threshold value to determine an efficient bias scheme; setting at least one voltage regulator to provide a bias voltage according to the efficient bias scheme; and performing the write operation. A method to determine threshold value to determine an efficient bias scheme of a crossbar array and an energy efficient crossbar array device are also described.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: November 30, 2021
    Assignee: University of Rochester
    Inventors: Albert Ciprut, Eby G. Friedman
  • Optical Tweezer Phonon Laser
    Publication number: 20210358651
    Abstract: An optical tweezer phonon laser system and method for modulating mechanical vibrations of an optically levitated mechanical oscillator to produce coherence is disclosed. A feedback loop is configured to simultaneously supply an electro-optic modulator with an amplification signal and a cooling signal representing an amplification force linear in the mechanical oscillator momentum and a cooling force nonlinear in the mechanical oscillator variable position and linear in the momentum, respectively controlling the intensity of a trap beam levitating the mechanical oscillator.
    Type: Application
    Filed: May 14, 2021
    Publication date: November 18, 2021
    Applicants: Rochester Institute of Technology, University of Rochester
    Inventors: Mishkatul Bhattacharya, Anthony Nickolas Vamivakas
  • Device and Method for Isolating Extracellular Vesicles From Biofluids
    Publication number: 20210356366
    Abstract: A device and method for isolating extracellular vesicles from biofluids is disclosed. A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid. A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.
    Type: Application
    Filed: January 8, 2017
    Publication date: November 18, 2021
    Applicant: University of Rochester
    Inventors: James Lionel McGrath, Kilean Scott Lucas, Henry Hung Li Chung
  • Broadly neutralizing anti-influenza human monoclonal antibody and uses thereof
    Patent number: 11168129
    Abstract: The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: November 9, 2021
    Assignee: University of Rochester
    Inventors: James J. Kobie, Michael Piepenbrink, Michael Keefer, Luis Martinez-Sobrido, Aitor Nogales
  • Compact freeform echelle spectrometer
    Patent number: 11169024
    Abstract: An echelle spectrometer includes a slit opening for incoming light, a collimator which collimates a diverging beam of light generated through the slit, a reflective echelle grating which disperses the collimated light along a first dimension; a cross-disperser which disperses at least a portion of the collimated light in a second dimension orthogonal to the first dimension to create a two-dimensional spectral field-of-view; and an imaging system which images the two-dimensional spectral field-of-view onto a detector; wherein the imaging system comprises primary, secondary, and tertiary tilted mirrors, where each of the tilted mirrors comprises a freeform, rotationally non-symmetric surface shape.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: November 9, 2021
    Assignees: University of Rochester, PerkinElmer Health Sciences Canada, Inc.
    Inventors: Jannick Rolland-Thompson, Aaron Bauer, Dennis Yates, Mahsa Farsad
  • Single-shot, adaptive metrology of rotationally variant optical surfaces using a spatial light modulator
    Patent number: 11168979
    Abstract: Single-shot, adaptive metrology of rotationally variant optical surfaces, such as toroids, off-axis conies and freeform surfaces. An adaptive interferometric null test uses a high definition liquid crystal phase-only spatial light modulator (SLM) as the reconfigurable null element, on which a simulated nulling phase function is encoded, based on the specifications of the surface under test to generate a null interferogram. The power component of the surface sag is nulled by system design, not the SLM, enabling the SLM to fully compensate the residual departure without the need to tilt the optic or use a custom Offner-null. By wrapping the phase function at multiples of 2*pi radian, the upper limit in sag of the optic under test is theoretically removed.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: November 9, 2021
    Assignee: University of Rochester
    Inventors: Romita Chaudhuri, Jannick Rolland-Thompson
  • FAIL SAFE BEAM SHUTTER DEVICES AND SYSTEMS
    Publication number: 20210333446
    Abstract: The invention provides apparatuses and systems for cutting off electromagnetic radiation (ER) beams, such as laser beams. The apparatuses and systems employ gravitational force on a shutter to close off the path of the ER beam if power is cut to an electromagnet holding the shutter out of the beam path. Power to the electromagnet is typically connected to a safety interlock connected to a door or other entry point to an enclosure in which the ER beam is being used. Additionally, the invention provides add-on devices that allow the ER beam to be blocked to change lenses or targets.
    Type: Application
    Filed: April 26, 2021
    Publication date: October 28, 2021
    Applicant: University of Rochester
    Inventors: Astrid M. MUELLER, Jeffery W. LEFLER
  • Microfluidic Devices and Methods for Rapid Detection of Pathogens and Other Analytes
    Publication number: 20210325386
    Abstract: The invention provides devices and methods for detecting viruses, bacteria, and other analytes of interest in a fluid sample. The fluid sample flows through a first microfluidic channel to a nanoporous or microporous membrane on which are disposed ligands, such as antibodies, specific for the analyte. If the analyte of interest is captured by the ligand, it clogs the pores of the membrane, preventing the fluid sample from passing through the membrane and diverting the fluid into a second channel. Detecting movement of the fluid sample in the second channel signals the presence of the analyte in the fluid sample, while failure of the fluid sample to move in the second channel signals absence of the analyte in the fluid sample.
    Type: Application
    Filed: February 15, 2021
    Publication date: October 21, 2021
    Applicant: University of Rochester
    Inventor: James L. McGrath
  • SWITCHING OF PERPENDICULARLY MAGNETIZED NANOMAGNETS WITH SPIN-ORBIT TORQUES IN THE ABSENCE OF EXTERNAL MAGNETIC FIELDS
    Publication number: 20210319939
    Abstract: A method of controlling a trajectory of a perpendicular magnetization switching of a ferromagnetic layer using spin-orbit torques in the absence of any external magnetic field includes: injecting a charge current Je through a heavy-metal thin film disposed adjacent to a ferromagnetic layer to produce spin torques which drive a magnetization M out of an equilibrium state towards an in-plane of a nanomagnet; turning the charge current Je off after te seconds, where an effective field experienced by the magnetization of the ferromagnetic layer Heff is significantly dominated by and in-plane anisotropy Hkx, and where M passes a hard axis by precessing around the Heff; and passing the hard axis, where Heff is dominated by a perpendicular-to-the-plane anisotropy Hkz, and where M is pulled towards the new equilibrium state by precessing and damping around Heff, completing a magnetization switching.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 14, 2021
    Applicant: University of Rochester
    Inventors: Mohammad Kazemi, Eby G. Friedman, Engin Ipek
  • Delivery of biomolecules into cells through carbon nanotube arrays
    Patent number: 11142776
    Abstract: Disclosed herein are carbon nanotube arrays as well as transfer systems comprising said carbon nanotube arrays and an administration platform. The disclosed carbon nanotube arrays can also be provided in kits further comprising a culture platform. Also disclosed herein is the use of said carbon nanotube arrays and transfer systems in administering agents to a cell.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 12, 2021
    Assignees: UNIVERSITY OF ROCHESTER, ROCHESTER INSTITUTE OF TECHNOLOGY
    Inventors: Ian Dickerson, Michael Schrlau, Masoud Golshadi
  • Gabor Domain Optical Coherence Elastography
    Publication number: 20210307611
    Abstract: a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.
    Type: Application
    Filed: April 2, 2020
    Publication date: October 7, 2021
    Applicant: University of Rochester
    Inventors: Jose Fernando ZVIETCOVICH ZEGARRA, Jannick P. Rolland, Cristina Canavesi, Kevin J. Parker
  • METABOLIC BIOMARKERS FOR MEMORY LOSS
    Publication number: 20210285973
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Application
    Filed: January 25, 2021
    Publication date: September 16, 2021
    Applicants: Georgetown University, University of Rochester
    Inventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone