Patents Assigned to The University of Sheffield
  • Patent number: 11344606
    Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 31, 2022
    Assignee: University of Sheffield
    Inventors: Ian Wilkinson, Richard Ross
  • Patent number: 11345064
    Abstract: A method for removing a hollow support element (17) from within a moulded part (15) to form a cavity (25) within the moulded part, the hollow support element being disposed within the moulded part and composed of material having a softening temperature, the method comprising: heating a liquid (20) to a temperature at least equal to the softening temperature of the material; injecting the heated liquid into an opening (24) in the moulded part to deform the material; and removing deformed material and liquid from the cavity.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: May 31, 2022
    Assignees: McLaren Automotive Limited, The University of Sheffield
    Inventors: Claudio Santoni, Elaine Arnold, Timothy Swait, Mark Laycock
  • Patent number: 11345945
    Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: May 31, 2022
    Assignee: The University Of Sheffield
    Inventors: Bazbek Davletov, Andrew Alexander Peden, Aleksander Mikael Rudolf Rust, Ciara Louise Doran
  • Publication number: 20210244848
    Abstract: A solid suspension for use in bone regeneration and/or the repair of bone defects, comprising a source of at least one group II metal cation and a source of zinc cations, wherein the source of zinc cations comprises zinc oxide and wherein where there is only one group II metal cation this is strontium. A bone graft comprising a solid suspension, a method of preparation of a solid suspension and a use of a solid suspension in bone regeneration and/or in the repair of bone defects.
    Type: Application
    Filed: August 27, 2019
    Publication date: August 12, 2021
    Applicant: THE UNIVERSITY OF SHEFFIELD
    Inventors: Caroline Joanne Harrison, Paul Vincent Hatton, Rebecca Louise Hutchinson, Cheryl Ann Miller
  • Patent number: 11067545
    Abstract: A continuous wave ultrasound analysis device for analysing a surface of a component includes an input to receive ultrasound data relating to continuous wave, swept frequency ultrasound propagated through the component; a processing section to derive a standing wave amplitude spectrum from the received ultrasound data, and determine a property of an unconstrained layer on the surface based on the standing wave amplitude spectrum; and an output to output the determined property of the layer. A method of continuous wave ultrasound for analysing a surface is also provided.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 20, 2021
    Assignee: THE UNIVERSITY OF SHEFFIELD
    Inventors: Robin Mills, Robert S. Dwyer-Joyce, Matthew Marshall
  • Publication number: 20210108173
    Abstract: This invention relates to an improved method for generating otic progenitor cells. The invention also relates to uses of such otic progenitor cells, for example as a medicament (e.g. in the treatment of hearing loss, deafness or other auditory disorder associated with loss of inner ear function) and/or in drug screening methods.
    Type: Application
    Filed: October 21, 2020
    Publication date: April 15, 2021
    Applicant: THE UNIVERSITY OF SHEFFIELD
    Inventors: Carlos Marcelo Nicolas RIVOLTA, Darrell Michael BARROTT
  • Publication number: 20210013357
    Abstract: In an example, an avalanche photodiode comprises a substrate and a structure comprising a first layer and a second layer, the first and second layers over and parallel to the substrate, wherein the first layer is between the substrate and the second layer. The first layer is an Aluminium Arsenide Antimonide multiplication layer, and wherein the cross-sectional area parallel to the substrate of the first layer is smaller than that of the second layer, thereby forming a recess in a sidewall of the structure.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 14, 2021
    Applicants: University College Cardiff Consultants Limited, The Regents of The University of California, University of Sheffield
    Inventors: Baolai Liang, Shiyu Xie, Diana Lynne Huffaker, John Paul Raj DAVID, Chee Hing Tan
  • Patent number: 10844351
    Abstract: This invention relates to an improved method for generating otic progenitor cells. The invention also relates to uses of such otic progenitor cells, for example as a medicament (e.g. in the treatment of hearing loss, deafness or other auditory disorder associated with loss of inner ear function) and/or in drug screening methods.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: November 24, 2020
    Assignee: The University of Sheffield
    Inventors: Carlos Marcelo Nicolas Rivolta, Darrell Michael Barrott
  • Patent number: 10801027
    Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: October 13, 2020
    Assignee: University of Sheffield
    Inventors: Guillaume Hautbergue, Mimoun Azzouz, Alexander Whitworth, Pamela Shaw
  • Patent number: 10782238
    Abstract: A device for sensing and/or detecting species or stimulus at a locus, preferably at a fluid or moist locus by means of fluid communication therewith, comprising a surface configured to contact the locus, wherein the surface comprises a polyurethane material which material comprises a polyurethane polymer network having a hydrophilic polymer immobilised therein wherein the hydrophilic polymer comprises immobilised therein a ligand or moiety for detecting or sensing species or stimulus and an indicator for indicating detection or sensing prior to contact with the locus and change in indication as a function of species or stimulus present at the locus wherein species or stimulus are selected from chemical and biological species or stimulus; the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; and a Kit.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: September 22, 2020
    Assignees: Smith & Nephew PLC, University of Sheffield
    Inventors: John Kenneth Hicks, Stephen Rimmer, Richard Hoskins, Dorothy McCulloch
  • Publication number: 20200289590
    Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
    Type: Application
    Filed: February 13, 2020
    Publication date: September 17, 2020
    Applicants: Virttu Biologics Limited, The University of Sheffield
    Inventors: Joe Conner, Munitta Muthana, Claire Elizabeth Lewis
  • Patent number: 10765779
    Abstract: The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: September 8, 2020
    Assignee: THE UNIVERSITY OF SHEFFIELD
    Inventors: Aileen Crawford-Corrie, David John Buttle, John William Haycock
  • Publication number: 20200268851
    Abstract: The disclosure relates to a composition comprising adrenocorticotropic hormone (ACTH) or a synthetic ACTH analogue for use in a diagnostic test for adrenal insufficiency. A method to conduct said diagnostic test; a combined diagnostic and method of treatment; and kits comprising the components for said test are also disclosed.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 27, 2020
    Applicants: Sheffield Children's NHS Foundation Trust, University of Sheffield
    Inventors: Neil Peter Wright, Charlotte Jane Elder
  • Patent number: 10717095
    Abstract: An end effector for a robot having a threaded shaft; a motor coupled to the shaft and configured to rotate the shaft about its axis; a nut threaded onto the shaft; a feature for preventing the nut from rotating about the axis of the shaft; and an elongate member fixed at one end to the nut and extending from the nut in a direction parallel to the axis of the shaft. The end effector may further include a container for containing a fluid having an elongate body portion having an opening at one end; and a reciprocable plunger extending into an opposite end of the body portion. A second end of the elongate member may be coupled to the plunger.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: July 21, 2020
    Assignees: BAE Systems plc, The University of Sheffield
    Inventors: Martin Knott, Ryan Wesley Diver
  • Publication number: 20200164033
    Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 28, 2020
    Applicant: University of Sheffield
    Inventors: Ian Wilkinson, Richard Ross
  • Publication number: 20200160706
    Abstract: Examples relate to detectors for determining motion from visual cues, said determining being invariant to changes in at least one of temporal and spatial frequencies of said visual cues.
    Type: Application
    Filed: May 8, 2018
    Publication date: May 21, 2020
    Applicant: The University of Sheffield
    Inventor: Alex COPE
  • Patent number: 10617553
    Abstract: A neck orthosis, head support system and method of use for supporting a head of a patient having a medical condition are described. The neck orthosis can comprise a body made of a material which is flexible and stretchy and a releasable fastener. The neck orthosis is shaped to cause the neck orthosis snuggly to conform to the anatomy of the patient adjacent the neck of the patient when the neck support is secured in use about the neck of the patient by the releasable fastener to support the head of the patient. A head support system can include a plurality of different support members which can be releasably attached to the neck orthosis to provide different types of support to the head of the patient.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: April 14, 2020
    Assignee: THE UNIVERSITY OF SHEFFIELD
    Inventors: Alexander Heathcliff Reed, Joseph Langley, Andrew Stanton, Nicola Heron, Christopher McDermott
  • Patent number: 10596210
    Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 24, 2020
    Assignees: Virttu Biologics, The university of Sheffield
    Inventors: Joe Conner, Munitta Muthana, Claire Elizabeth Lewis
  • Publication number: 20200024639
    Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.
    Type: Application
    Filed: February 14, 2018
    Publication date: January 23, 2020
    Applicant: THE UNIVERSITY OF SHEFFIELD
    Inventors: Bazbek Davletov, Andrew Alexander Peden, Aleksander Mikael Rudolf Rust, Ciara Louise Doran
  • Patent number: 10520446
    Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilized therein, or modified by the immobilization therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilization, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereof.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: December 31, 2019
    Assignees: Smith & Nephew PLC, University of Sheffield
    Inventors: John Kenneth Hicks, Stephen Rimmer, Dorothy McCulloch, Richard Hoskins