Patents Assigned to The University of Sheffield
  • Patent number: 10520446
    Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilized therein, or modified by the immobilization therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilization, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereof.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: December 31, 2019
    Assignees: Smith & Nephew PLC, University of Sheffield
    Inventors: John Kenneth Hicks, Stephen Rimmer, Dorothy McCulloch, Richard Hoskins
  • Publication number: 20190344293
    Abstract: An end effector for a robot comprising: a threaded shaft; a motor coupled to the shaft and configured to rotate the shaft about its axis; a nut threaded onto the shaft; means for preventing the nut from rotating about the axis of the shaft; and an elongate member fixed at one end to the nut and extending from the nut in a direction parallel to the axis of the shaft. The end effector may further comprise a container for containing a fluid comprising: an elongate body portion comprising an opening at one end; and a reciprocable plunger extending into an opposite end of the body portion. A second end of the elongate member may be coupled to the plunger.
    Type: Application
    Filed: February 2, 2017
    Publication date: November 14, 2019
    Applicants: BAE SYSTEMS PLC, THE UNIVERSITY OF SHEFFIELD
    Inventors: Martin Knott, Ryan Wesley Diver
  • Publication number: 20190204159
    Abstract: A thermal imaging device is provided, comprising: a detector for receiving radiation and outputting a detector signal corresponding thereto; a steerable mirror device arranged in relation to the detector; wherein the steerable mirror device is steerable to scan an entrance pupil over a plurality of locations such that the detector outputs respective detector signals indicative of temperatures of respective portions of the object corresponding to the locations of the entrance pupil, and wherein the thermal imaging device is configured to provide a substantially constant etendue for all of the entrance pupil locations of the plurality of entrance pupil locations.
    Type: Application
    Filed: March 7, 2019
    Publication date: July 4, 2019
    Applicant: The University of Sheffield
    Inventor: Jonathan Raffe Willmott
  • Publication number: 20190194660
    Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.
    Type: Application
    Filed: May 30, 2017
    Publication date: June 27, 2019
    Applicant: University of Sheffield
    Inventors: Guillaume Hautbergue, Mimoun Azzouz, Alexander Whitworth, Pamela Shaw
  • Publication number: 20190185813
    Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/ kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.
    Type: Application
    Filed: September 14, 2017
    Publication date: June 20, 2019
    Applicant: THE UNIVERSITY OF SHEFFIELD
    Inventors: Carlos Marcelo Nicolas Rivolta, Sarah Louise Boddy
  • Patent number: 10280197
    Abstract: A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting ?-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: May 7, 2019
    Assignees: The Regents of the University of California, The Texas A & M University System, The University of Queensland, The University of Sheffield
    Inventors: Dimitrios Monikis, Christodoulos Floudas, Trent Woodruff, Matthew A. Cooper, Daniel E. Croker, Peter N. Monk
  • Patent number: 10227680
    Abstract: A first multi phase niobium silicide alloy composition consists essentially of: from 15 to 24 at % of Si; from 0 to 25 at % of one or more sp outer electron configuration element which is not Si; from 1 to 26 at % of one or more sd outer electron configuration element which is not Nb; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance of an article, for example a gas turbine engine blade. A second multi phase niobium silicide alloy composition consists essentially of: from 1 to 24 at % of Si; from 0 to 34 at % of one or more sp outer electron configuration element which is not Si; from 19.5 to 48.5 at % of one or more sd outer electron configuration element which is not Nb or Cr; from 0.5 to 9 at % Cr; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance and/or to increase the oxidation resistance of an article, for example a gas turbine engine blade.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: March 12, 2019
    Assignee: The University of Sheffield
    Inventor: Panos Tsakiropoulos
  • Publication number: 20180372695
    Abstract: A continuous wave ultrasound analysis device for analysing a surface of a component includes an input to receive ultrasound data relating to continuous wave, swept frequency ultrasound propagated through the component; a processing section to derive a standing wave amplitude spectrum from the received ultrasound data, and determine a property of an unconstrained layer on the surface based on the standing wave amplitude spectrum; and an output to output the determined property of the layer. A method of continuous wave ultrasound for analysing a surface is also provided.
    Type: Application
    Filed: December 21, 2016
    Publication date: December 27, 2018
    Applicant: THE UNIVERSITY OF SHEFFIELD
    Inventors: Robin MILLS, Robert S. DWYER-JOYCE, Matthew MARSHALL
  • Patent number: 10150946
    Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 11, 2018
    Assignee: The University of Sheffield
    Inventors: Irene Canton, Steven Peter Armes, Nicholas John Warren, Harry Moore, Giuseppe Battaglia, Denis Cecchin
  • Patent number: 10128709
    Abstract: An electric machine comprising: a) a first means for providing a first magneto motive force comprising a first set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic in said first set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant undesirable harmonic; and b) a second means for providing a second magneto motive force comprising a second set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said second set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or e
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: November 13, 2018
    Assignee: The University of Sheffield
    Inventor: Jiabin Wang
  • Patent number: 10053476
    Abstract: The invention relates to phosphohistidine analogs. The invention also relates to antibodies that specifically bind to the analogs and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analog of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: August 21, 2018
    Assignee: UNIVERSITY OF SHEFFIELD
    Inventors: Richard Jackson, Richmond Muimo, Matthew Lilley
  • Publication number: 20180071348
    Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
    Type: Application
    Filed: March 11, 2016
    Publication date: March 15, 2018
    Applicants: VIRTTU BIOLOGICS LIMITED, THE UNIVERSITY OF SHEFFIELD
    Inventors: Joe CONNER, Munitta MUTHANA, Claire Elizabeth LEWIS
  • Patent number: 9865771
    Abstract: A semiconductor light-emitting element includes: a lower clad layer 12 that is provided on a substrate 10; an active layer 20 that is provided on the lower clad layer 12 and includes a quantum well layer 24 and a plurality of quantum dots 28 sandwiching a second barrier layer 22b together with the quantum well layer 24; and an upper clad layer 14 that is provided on the active layer 20, wherein a distance D between the quantum well layer 24 and the plurality of quantum dots 28 is smaller than an average of distances X between centers of the plurality of quantum dots 28.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: January 9, 2018
    Assignees: QD LASER, INC., UNIVERSITY OF SHEFFIELD
    Inventors: Kenichi Nishi, Takeo Kageyama, Keizo Takemasa, Mitsuru Sugawara, Richard Hogg, Siming Chen
  • Publication number: 20170271846
    Abstract: A laser structure comprising a first photonic crystal surface emitting laser (PCSEL), a second PCSEL, and a coupling region that extends between the first PCSEL and the second PCSEL along a longitudinal axis and that is electrically controllable so as to be capable of coherently coupling the first PCSEL to the second PCSEL. Each PCSEL include an active layer, a photonic crystal, and a two-dimensional periodic array distributed in an array plane parallel to the longitudinal axis within the photonic crystal where the two-dimensional periodic array is formed of regions having a refractive index that is different to the surrounding photonic crystal.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 21, 2017
    Applicant: The University of Sheffield
    Inventors: Richard James Edward Taylor, David T. D. Childs, Richard Hogg
  • Patent number: 9611335
    Abstract: A method of preparing a block copolymer of Formula (B) wherein P1 represents a substantially aqueously soluble polymeric component and P2 represents a substantially aqueously insoluble polymeric component, comprises admixing an aqueously soluble polymer macro-chain transfer agent comprising P1 with a monomer (M2) and initiating an aqueous dispersion-type radical addition fragmentation chain transfer (RAFT) polymerization. (P1) is derived from a monomer (M1) selected from monomers of the Formulae (M1A), (M1B) and/or (M1C) where R1, R10 and R11 represent a substituent of (M1A) or (M1C) which allows P1 to be at least partially aqueously soluble, R2 represents H, CH3 or CN, RS represents one or more substituents of the aromatic ring effective to allow P1 to be at least partially aqueously soluble, and monomer M2 is selected from: where R3 is a substituent of (M2) which allows P2 to be substantially aqueously insoluble, and R4 and R6 independently represent H or methyl.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: April 4, 2017
    Assignee: University of Sheffield
    Inventors: Steven P. Armes, Yuting Li
  • Patent number: 9520230
    Abstract: A rare earth magnet, which is represented by a neodymium magnet (Nd2Fe14B) and neodymium magnet films with applications in micro-systems. A method for producing a rare earth magnet, comprising: (a) quenching a molten metal having a rare earth magnet composition to form quenched flakes of nanocrystalline structure; sintering the quenched flakes; subjecting the sintered body obtained to an orientation treatment; and applying a heat treatment with pressurization at a temperature sufficiently high to enable diffusion or fluidization of a grain boundary phase and at the same time, low enough to prevent coarsening of the crystal grains, (b) thick films deposited on a substrate, applying an annealing to crystallize with pressurization at a temperature sufficiently high to enable diffusion or fluidization of a grain boundary phase and, at the same time, low enough to prevent coarsening of the crystal grains.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 13, 2016
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, LEIBNIZ INSTITUTE FOR SOLID STATE AND MATERIALS RESEARCH DRESDEN, UNIVERSITY OF SHEFFIELD
    Inventors: Noritsugu Sakuma, Hidefumi Kishimoto, Akira Kato, Tetsuya Shoji, Dominique Givord, Nora Dempsey, Thomas George Woodcock, Oliver Gutfleisch, Gino Hrkac, Thomas Schrefl
  • Publication number: 20160336480
    Abstract: A semiconductor light-emitting element includes: a lower clad layer 12 that is provided on a substrate 10; an active layer 20 that is provided on the lower clad layer 12 and includes a quantum well layer 24 and a plurality of quantum dots 28 sandwiching a second barrier layer 22b together with the quantum well layer 24; and an upper clad layer 14 that is provided on the active layer 20, wherein a distance D between the quantum well layer 24 and the plurality of quantum dots 28 is smaller than an average of distances X between centers of the plurality of quantum dots 28.
    Type: Application
    Filed: January 7, 2015
    Publication date: November 17, 2016
    Applicants: QD LASER, INC., UNIVERSITY OF SHEFFIELD
    Inventors: Kenichi NISHI, Takeo KAGEYAMA, Keizo TAKEMASA, Mitsuru SUGAWARA, Richard HOGG, Siming CHEN
  • Publication number: 20160207948
    Abstract: The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analogue of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.
    Type: Application
    Filed: September 2, 2014
    Publication date: July 21, 2016
    Applicant: University of Sheffield
    Inventors: Richard Jackson, Richard Muimo, Matthew Lilley
  • Patent number: 9354113
    Abstract: Apparatus, systems, and methods relate to use of a time-varying bias for application to an avalanche photodiode. Embodiments include systems and methods of determining an appropriate time-varying bias for application to an avalanche photodiode in linear mode. Avalanche photodiode having appropriate parameters may also be determined. Additional apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: May 31, 2016
    Assignees: STC.UNM, The University of Sheffield
    Inventors: Majeed M. Hayat, John P. David, Sanjay Krishna, Luke F. Lester, David A. Ramirez, Payman Zarkesh-Ha
  • Patent number: 9334327
    Abstract: The disclosure relates to agents that inhibit the activity of osteoprotegerin and their use in the treatment of pulmonary hypertension.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: May 10, 2016
    Assignee: University of Sheffield
    Inventor: Allan Lawrie