Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steriod, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: The invention relates to a method of producing a preform for a holey optical fiber, and more particularly, to a method of producing polymer holey optical fiber using novel capillary and cane designs that allow a construction of complex holey structures. The capillaries may have a complex internal structure including multiple holes, holes of non-circular shape, off-center holes, holes of different sizes, or any combination of these. The canes may have a complex external shape to define interstitial holes when the canes arc combined in a stack (see FIG. 1). The capillaries and canes may be made of different materials and combined within the same structure.

Abstract: A control system for controlled exercise controls a functional electrical stimulation (FES) system which applies electrical signals to muscle groups of a user such as a user having a disability; the user exercises on a motor driven exercise machine such that substantially isokinetic exercise during a movement is obtained as the user's body part moves with a motor driven displaceable element of the machine. This element provides resistance to applied displacement load from the user's stimulated muscles. A feedback control system receives signals indicative of the user's performance and a control arrangement controls electrical stimulation to the user's muscles to achieve a desired exercise regime.