Patents Assigned to The University of Tennessee
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Patent number: 11320893Abstract: An apparatus includes a photovoltaic module and a computation module that is coupled to the photovoltaic module and is configured to receive power therefrom, the computation module being configured to communicate an active message to a controller in response to the computation module transitioning to a power on state and configured to receive a task command from the controller in response to communicating the active message to the controller.Type: GrantFiled: June 25, 2020Date of Patent: May 3, 2022Assignees: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, DOMINION ENERGY INC.Inventors: Yilu Liu, Robert Gardner, Yuru Wu
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Patent number: 11279805Abstract: A plasticized terephthalate-based polyester blend comprising a terephthalate-based polyester (e.g., polyethylene terephthalate, i.e., PET) homogeneously blended with a fatty acid or ester thereof, wherein said fatty acid or ester thereof is present in said polyester blend in an amount of 1-50 wt %. Also described herein is a method for producing a plasticized terephthalate-based polyester blend, the method comprising melt mixing a terephthalate-based polyester with a fatty acid or ester thereof at a temperature in a range of 230-250° C. to produce said polyester blend, wherein said fatty acid or ester thereof is present in said polyester blend in an amount of 1-50 wt % and is homogeneously blended with said terephthalate-based polyester.Type: GrantFiled: July 23, 2019Date of Patent: March 22, 2022Assignees: UT-Battelle, LLC, University of Tennessee Research FoundationInventors: Amit K. Naskar, Kokouvi Akato, Ngoc A. Nguyen, David P. Harper
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Patent number: 11273147Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: GrantFiled: August 30, 2019Date of Patent: March 15, 2022Assignee: University of Tennessee Research FoundationInventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He, Jayaprakash Pagadala, Christopher C. Coss, James T. Dalton, Charles B. Duke
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Patent number: 11268254Abstract: Methods of preparing cast-in-place geopolymer piles using electrical heating wire (130) to provide heat to cure the piles are described. The heating wire (130) can be associated with a reinforcement cage (120) inserted in the pile shaft. Rod-shaped heating units comprising electrical heating wire (130) can be inserted into a pile shaft and can be reusable. Geopolymer piles with high compressive strength can be prepared from mixtures of class F fly ash and aqueous sodium hydroxide by heating the piles with the heating wire to a stable curing temperature for at least about 24 hours.Type: GrantFiled: June 1, 2017Date of Patent: March 8, 2022Assignees: University of Tennessee Research Foundation, Hebei Research Institute of Construction and Geotechnical Investigation Co., Ltd.Inventors: Baoshan Huang, Wei Hu, Xiang Shu, Qiang He, Qingke Nie
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Patent number: 11271398Abstract: A multi-dimensional holomorphic embedding method for voltage control of an AC power system includes embedding multiple independent symbolic variables representing multiple control elements of the AC power system into AC power flow equations that describe the AC power system, analytically solving voltages for targeted buses of the AC power system in a form of multivariate power series or multivariable Padé approximants about the multiple independent symbolic variables such that coefficients of the multivariate power series or multivariable Padé approximants are obtained non-iteratively, and jointly adjusting the multiple control elements according to the multivariate power series or multivariable Padé approximants to control voltages of the targeted buses.Type: GrantFiled: August 31, 2018Date of Patent: March 8, 2022Assignee: University of Tennessee Research FoundationInventors: Chengxi Liu, Kai Sun, Bin Wang, Xin Xu
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Patent number: 11266127Abstract: An apparatus and method is described for a supplemental feeder system that provides a spring loaded supplemental feeder mounted on and spaced along a feed line. The spring loaded supplemental feeder acts as control that controls one or more follower supplemental feeders that is attached to control the one or more distally space apart supplemental feeders to dispense feed. The apparatus includes a pair of left and right annular collar clamps spaced apart and a tubular collar coaxial with respect to the left and right annular collar clamps and rotationally attached to the left and right annular collars. An extension tube having an interior extension channel is communicably attached to an interior channel of the tubular collar.Type: GrantFiled: March 17, 2020Date of Patent: March 8, 2022Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventor: Mark Andrew Lister
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Publication number: 20220042718Abstract: Methods and apparatus are disclosed for high-efficiency thermal storage with a fluid-filled “battery” tank positioned within a fluid-filled “reservoir” tank. Fluid loops couple the tanks to a heat pump and a building. The heat pump can charge the battery tank or deliver thermal energy (cold or heat) to a building, using the reservoir tank or ambient air as a thermal energy source. The battery tank can discharge energy to the building jointly with the heat pump or, at periods of peak electricity usage, with the heat pump switched off. Operating modes allow significant savings in electricity usage and mitigate the “duck curve.” Low duty cycle usage of the reservoir enables efficient underground thermal storage with less digging than conventional geothermal technologies. Additional efficiency is achieved with phase change materials installed inside a tank or in a tank wall, providing temperature regulation. Control methods are disclosed.Type: ApplicationFiled: March 13, 2020Publication date: February 10, 2022Applicants: UT-Battelle, LLC, University of Tennessee Research Foundation (UTRF)Inventors: Xiaobing Liu, Ming Qu, Joseph K. Warner, Liang Shi
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Patent number: 11235193Abstract: A resistance system is disclosed. The resistance system has a line reel system for deploying a tension line and a power system for drawing in the slack line. The resistance value can be set by a subject using the device by using a resistance controller and indicator located on an outer surface of the system. The system can be self-contained with an internal power supply. The system is particularly useful for swim training or rehabilitation. It can be simply operated by a user without removing the device.Type: GrantFiled: May 8, 2019Date of Patent: February 1, 2022Assignee: University of Tennessee Research FoundationInventors: Kelsey Ann McConachie, Isaac Robert Nolan, Thao Nguyen Strong, Ryan Joseph Tinker
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Publication number: 20220024912Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.Type: ApplicationFiled: July 8, 2021Publication date: January 27, 2022Applicants: ONCTERNAL THERAPEUTICS, INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Wei LI, Min XIAO, James DALTON, Sunjoo AHN, Duane D. MILLER, Jin WANG
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Patent number: 11230531Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: GrantFiled: February 5, 2020Date of Patent: January 25, 2022Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He
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Patent number: 11230667Abstract: Codoped rare earth garnet-type oxide scintillators are described. More particularly, the scintillators include lutetium yttrium aluminum garnet (LuYAG)-type materials that are doped with an activator, such as praseodymium, and codoped with a monovalent cation, such as lithium. Radiation detectors comprising the scintillators, methods of detecting higher energy radiation using the scintillators, and methods of preparing the scintillators and altering scintillator properties are also described.Type: GrantFiled: February 7, 2019Date of Patent: January 25, 2022Assignee: University of Tennessee Research FoundationInventors: Camera Janelle Foster, Yuntao Wu, Merry A. Koschan, Charles L. Melcher
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Patent number: 11230523Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including cyclic and heterocyclic anilide rings and their synthetic precursors, and mono-, di-, or multi-substituted N-heterocyclic rings, R-isomers, non-hydroxylated and/or non-chiral propanamides in treating androgen receptor dependent diseases and conditions such as hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamType: GrantFiled: May 29, 2019Date of Patent: January 25, 2022Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He
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Publication number: 20220000830Abstract: The present invention relates to solid forms of (S)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.Type: ApplicationFiled: July 12, 2021Publication date: January 6, 2022Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: James T. Dalton, Thomas G. BIRD, Tai AHN, David A. DICKASON, Seoung-Soo HONG
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Patent number: 11213419Abstract: The present subject matter relates to orthotic devices, systems, and methods configured to support a lumbar spine. In some embodiments, a lumbar spinal orthosis system includes a torso belt configured to be secured about a torso of a user, a pelvic belt configured to be secured about a pelvis of the user, and a distractive force mechanism connected between the torso belt and the pelvic belt. The distractive force mechanism is configured to generate a force between the torso belt and the pelvic belt acting bi-directionally across a lumbar spine of the user to substantially offload bodyweight of the user passing through the lumbar spine.Type: GrantFiled: April 5, 2018Date of Patent: January 4, 2022Assignee: University of Tennessee Research FoundationInventors: Denis J. DiAngelo, Daniel Clay Hillyard, Chloe Chung, Daniel Hoyer
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Patent number: 11209469Abstract: A method includes performing by a processor: receiving a plurality of synchrophasor measurements of a power system signal associated with a time interval from a phasor measurement unit (PMU), each of the plurality of synchrophasor measurements including a phase angle, frequency value, and a timestamp associated with the synchrophasor measurement, determining a plurality of relative phase angles based on the plurality of phase angles, determining a correlation coefficient between the plurality of relative phase angles and a plurality of corresponding frequency values of the power system signal, and detecting an error in the plurality of timestamps based on the correlation coefficient; estimating the error in the plurality of timestamps based on the plurality of relative phase angles and the plurality of corresponding frequency values.Type: GrantFiled: May 21, 2019Date of Patent: December 28, 2021Assignees: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, UT-BATTELLE, LLCInventors: Yilu Liu, Wenpeng Yu, Wenxuan Yao
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Patent number: 11202850Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).Type: GrantFiled: March 11, 2019Date of Patent: December 21, 2021Assignees: The University of Memphis Research Foundation, The University of Tennessee Research FoundationInventors: Gary L. Bowlin, Allison E. Fetz, Marko Z. Radic
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Patent number: 11195644Abstract: The disclosure describes techniques for forming nanoparticles including Fe16N2 phase. In some examples, the nanoparticles may be formed by first forming nanoparticles including iron, nitrogen, and at least one of carbon or boron. The carbon or boron may be incorporated into the nanoparticles such that the iron, nitrogen, and at least one of carbon or boron are mixed. Alternatively, the at least one of carbon or boron may be coated on a surface of a nanoparticle including iron and nitrogen. The nano particle including iron, nitrogen, and at least one of carbon or boron then may be annealed to form at least one phase domain including at least one of Fe16N2, Fe16(NB)2, Fe16(NC)2, or Fe16(NCB)2.Type: GrantFiled: March 26, 2015Date of Patent: December 7, 2021Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, UT-BATTELLE, LLC, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Jian-Ping Wang, Yanfeng Jiang, Craig A. Bridges, Michael Brady, Orlando Rios, Roberta A. Meisner, Lawrence F. Allard, Edgar Lara-Curzio, Shihai He
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Publication number: 20210344299Abstract: A solar powered robotic mower power shed and related methods of use are disclosed. One example robotic mower power shed comprises a housing structure containing one or more compartments. The charging station further includes a roof structure equipped with one or more photovoltaic (PV) cell elements, wherein the one or more PV cell elements are configured to generate electrical energy from captured solar energy. The charging station also includes a charge control unit configured to receive electrical energy via a connection to the one or more PV cell elements and to provide the electrical energy to at least a robotic mower device docked in the housing structure.Type: ApplicationFiled: April 30, 2021Publication date: November 4, 2021Applicants: University of Tennessee Research Foundation, Solar AllianceInventors: Matthew Edward Layne, Harvey Abouelata, Jonathan B. Hamilton
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Publication number: 20210340122Abstract: This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedys disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: ApplicationFiled: September 5, 2019Publication date: November 4, 2021Applicant: University of Tennessee Research FoundationInventors: Ramesh NARAYANAN, Duane D. MILLER, Yali HE, Dong-Jin HWANG, Thamarai PONNUSAMY
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Patent number: D934507Type: GrantFiled: June 29, 2020Date of Patent: October 26, 2021Assignee: University of Tennessee Research FoundationInventor: Maged Samir Guerguis