Patents Assigned to The University of Texas Health Science Center at Houston
  • COMPOSITIONS AND METHODS FOR IDENTIFYING AND INHIBITING A PAN-CANCER CELLULAR TRANSITION OF ADIPOSE-DERIVED STROMAL CELLS
    Publication number: 20220235357
    Abstract: The present subject matter relates to the use of one or more inhibitors to treat a disease, e.g., cancer, in a subject. The presently disclosed subject matter provides for compositions and methods for treating a subject using a cancer transition inhibitor, an inhibitor that reduces the expression level of a marker of the transition of adipose-derived stromal cells (ASCs) to COL11A1-expressing cancer-associated fibroblasts (CAFs).
    Type: Application
    Filed: December 28, 2021
    Publication date: July 28, 2022
    Applicants: The Trustees of Columbia University in the City of New York, The University of Texas Health Science Center at Houston
    Inventors: Dimitris Anastassiou, Lingyi Cai, Kaiyi Zhu, Mikhail Kolonin
  • Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
    Patent number: 6900036
    Abstract: Prion peptides exhibiting structural isomerism to wild-type prion peptide are disclosed. The invention further discloses methods of making prion isomers, compositions comprising prion isomers, and compositions and products comprising antibody to a prion isomer. Methods for screening a patient for a neuro-degenerative disease, and methods for treating a patient afflicted with a neuro-degenerative disease are also disclosed.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: May 31, 2005
    Assignee: University of Texas Health Science Center Houston
    Inventors: Jui-Yoa Chang, Bao-Yuan Lu
  • Method of treating a non-penetrating head wound with hypothermia
    Patent number: 5486204
    Abstract: A method of treating severe brain trauma with hypothermia includes the introduction of specified medication to reduce the risk of cardiac arrhythmia and other malfunctions that may result from the brain trauma or the hypothermia. The method further includes a protocol for the treatment which defines time, temperature, rate of change of temperature, and the timing of the introduction of medications. Finally, rigidly controlled rewarming reduces the incidence of rewarming shock in recovering patients.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: January 23, 1996
    Assignee: University of Texas Health Science Center Houston
    Inventor: Guy L. Clifton