Patents Assigned to The University of Texas Southwestern Medical Center
-
Publication number: 20190275014Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.Type: ApplicationFiled: July 18, 2017Publication date: September 12, 2019Applicants: Case Western Reserve University, University of Texas Southwestern Medical Center, University of Iowa Research FoundationInventors: Sanford MARKOWITZ, Joseph READY, Andrew PIEPER
-
Publication number: 20050112696Abstract: Compositions and methods for determining modulators of beta-secretase activity and specificity of protease activity relative to the APP family of proteins are disclosed.Type: ApplicationFiled: November 25, 2003Publication date: May 26, 2005Applicant: The University of Texas Southwestern Medical CenterInventors: Thomas Sudhof, Qiming Li
-
Patent number: 6723717Abstract: The present disclosure describes novel compounds of formula (A), wherein R1-R12, X and Y have the meanings given in the specification and compositions containing them which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds described herein are cardiac-sparing.Type: GrantFiled: November 30, 2001Date of Patent: April 20, 2004Assignee: The University of Texas Southwestern Medical CenterInventors: Robert Scott Youngquist, John McMillan McIver
-
Patent number: 6680344Abstract: The present invention relates to a method of treating hair loss comprising administering a composition having a cardiac-sparing compound characterized by the structure: and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof. In this compound, n may be an integer from 1 to 3; R1 and R2 may each, independently, be a hydrogen or lower alkyl; R4 may be hydrogen, lower alkyl or cycloalkyl; R6 and R9 may each, independently, be hydrogen or lower alkyl; R7 and R8 may each, independently, be hydrogen, lower alkyl, substituted phenyl, or substituted benzyl; R10 may be hydrogen, lower alkyl, cycloalkyl, or acyl; and R11 may be hydrogen, lower alkyl, or cycloalkyl.Type: GrantFiled: March 29, 2002Date of Patent: January 20, 2004Assignee: The University of Texas Southwestern Medical CenterInventors: Lixin Lilly Zhang, Robert Scott Youngquist
-
Patent number: 6646005Abstract: Methods for treating hair loss using a composition including a compound having the following structure and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof are provided. R1 is —(CH2)n(CHNR7R8)mC(O)R9, wherein n is an integer from 1 to 3, and m is an integer from 0 to 1. R3 and R5each, independently, is chlorine, bromine, iodine and —CH3. R7 and R8 each, independently, is hydrogen or C1 to C4 alkyl. R9 is hydroxy, C1 to C4 alkoxy and —NR7R8. R31 is a hydrogen, chlorine, bromine, iodine, C1 to C4 alkyl, C4 to C6 cycloalklyl, C1 to C4 haloalkyl, C4 to C6 halocycloalkyl, or CH(R10)Ar. Ar is 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methioxypyridazin-3-yl N-oxide or 6-hydroxypyridazin-3-yl N-oxide. R10 is hydrogen or C1 to C4 alkyl. R41 is hydroxy or C1 to C4 alkoxy.Type: GrantFiled: February 21, 2002Date of Patent: November 11, 2003Assignee: The University of Texas Southwestern Medical CenterInventors: Lixin Lilly Zhang, Robert Scott Youngquist
-
Publication number: 20030166731Abstract: The present disclosure describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing compound having a structure of formula (I) as described herein and a pharmaceutically-acceptable carrier.Type: ApplicationFiled: February 24, 2003Publication date: September 4, 2003Applicant: The University of Texas Southwestern Medical CenterInventors: Lixin Lilly Zhang, Robert Scott Youngquist
-
Publication number: 20030139471Abstract: The present invention relates to compositions containing i) from about 0.0001% to about 99.9% of certain compounds selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof, and ii) a vehicle.Type: ApplicationFiled: November 18, 2002Publication date: July 24, 2003Applicant: The University of Texas Southwestern Medical CenterInventors: Barton James Bradbury, Shari Joy Soper, Joseph Robert Kaczvinsky, Dorothy Limerick Bailey, Celeste Dawn Gale
-
Publication number: 20030114526Abstract: A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof.Type: ApplicationFiled: July 30, 2002Publication date: June 19, 2003Applicant: Procter & Gamble to the University of Texas Southwestern Medical CenterInventors: Barton James Bradbury, Shari Joy Soper, Joseph Robert Kaczvinsky, Dorothy Limerick Bailey, Celeste Dawn Gale
-
Patent number: 6525094Abstract: The present invention describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing compound which is a derivative of diphenylether and pharmaceutically-acceptable carrier.Type: GrantFiled: December 8, 2000Date of Patent: February 25, 2003Assignee: The University of Texas Southwestern Medical CenterInventors: Lixin Lilly Zhang, Robert Scott Youngquist
-
Publication number: 20030022171Abstract: The present invention provides methods of identifying agents that affect the cleavage of amyloid-&bgr; precursor protein (APP) and related vectors, cells and kits, as well as agents identified by the method.Type: ApplicationFiled: March 30, 2001Publication date: January 30, 2003Applicant: THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLASInventors: Thomas C. Sudhof, Xinwei Cao
-
Patent number: 6482857Abstract: The present invention relates to compositions containg i) from about 0.0001% to about 99.9% of certain compounds selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof, and ii) a vehicle.Type: GrantFiled: July 15, 1999Date of Patent: November 19, 2002Assignee: The University of Texas Southwestern Medical CenterInventors: Barton James Bradbury, Shari Joy Soper, Joseph Robert Kaczvinsky, Jr., Dorothy Limerick Bailey, Celeste Dawn Gale
-
Patent number: 6451777Abstract: A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof.Type: GrantFiled: May 10, 2000Date of Patent: September 17, 2002Assignee: The University of Texas Southwestern Medical CenterInventors: Barton James Bradbury, Shari Joy Soper, Joseph Robert Kaczvinsky, Jr., Dorothy Limerick Bailey, Celeste Dawn Gale
-
Patent number: 6001963Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.Type: GrantFiled: September 26, 1997Date of Patent: December 14, 1999Assignees: SmithKline Beecham Corporation, University of Texas Southwestern Medical Center at DallasInventors: Derk J. Bergsma, Masashi Yanagisawa
-
Patent number: RE40988Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.Type: GrantFiled: May 29, 2007Date of Patent: November 17, 2009Assignees: SmithKline Beecham Corporation, University of Texas Southwestern Medical Center at DallasInventors: Derk J. Bergsma, Masahi Yanigasawa