Abstract: The present disclosure provides methods for re-programming effector T cells to a central memory phenotype comprising culturing the effector T cells with a histone deacetylase inhibitor (HDACi) and IL-21. Further provided are methods of treating cancer comprising administering the central memory T cells.

Abstract: A global navigation satellite system (GNSS) spoofing detection and classification technique is provided. An optimization problem is formulated at the baseband correlator domain by using an optimization algorithm such as the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm, for example. A model of correlator tap outputs of the intended received signal is created to form a dictionary of pre-computed waveform functions (e.g., triangle-like-shaped functions). Sparse signal processing can be leveraged to choose a decomposition of pre-computed waveform functions from the dictionary. The optimal solution of this minimization problem can discriminate the presence of a potential spoofing attack peak by observing the decomposition of two different code-phase values (authentic and spoofed) in a sparse vector output. A threshold can be used to mitigate false alarms. Furthermore, a variation of the minimization problem can be provided that enhances the dictionary to a higher resolution.

Abstract: Certain embodiments are directed to mechanical devices for augmenting dexterous reach and sensing of a user. The devices can include a proximal portion configured to receive an appendage of a user; a distal portion configured to detect sensory information; an articulation positioned between the proximal and distal portion to provide for motion of the distal portion via manipulation of the proximal portion; wherein the distal portion comprising a sensing element and the proximal portion comprises a feedback element, the feedback element being connected to the sensing element providing for physical extension of sensory capabilities of the appendage.

Abstract: The present disclosure addresses the problem of UAVs pursuing a swarm of target UAVs. The target UAVs are flying together as a flock that are initially modeled as a circle having a time-varying radius or an arbitrarily-shaped swarm that may change in size. Guidance of the pursuing UAVs is developed based on a collision cone framework, wherein the pursuing UAVs cooperatively steer the velocity vector of any point in their convex hull, to intercept the target. Also, the problem of capturing a swarm of intruder UAVs using a net manipulated by a team of defense UAVs is disclosed. The intruder UAV swarm may be stationary, in motion, and even maneuver. Collision cones in 3-dimensional space are used to determine the strategy used by the net carrying UAVs to maneuver or manipulate the net in space in order to capture the intruders.

Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. The apparatus has a first cardiac assist device and a second cardiac assist device tuned to maximize blood flow to the body of the patient, while resting the heart so the heart may recover function. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

Abstract: Disclosed are methods for direct electrodeposition of a metal from the liquid medium. The methods include electro-reduction of lithium anions on cathode electrodes in the presence of various metal deposition selectivity enhancements. The selectivity enhancement disclosed herein comprises the presence of a magnet, a solvent that is immiscible with an original liquid medium comprising the desired metal ions or various separators. Also disclosed are systems for electrodeposition of the desired metals from the liquid medium.

Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.

Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.

Abstract: A system for measuring surface deflection of a road includes a first stereo line-scan camera pair on a sensor rig and for capturing a first set of 3D images of a road surface; a second stereo line-scan camera pair on the sensor rig and for capturing a second set of 3D images of the road surface; at least one digital electro-optical (EO) camera rigidly attached to the sensor rig; an inertial measurement unit (IMU) detecting inertial forces acting upon the sensor rig; and a processor compensating for acceleration and vibration effects upon the sensor rig; and calculating the surface deflection of the road based on the first and second sets of 3D images. The processor utilizes imagery from the EO camera and inertial measurements from the IMU to produce 2D mosaics and 3D reconstructions of the road surface from the first and second sets of 3D images.

Abstract: Wood template-supported phase change material (PCM) composite having thermal energy storage applications. A wood template-supported PCM may include a wood template that has had at least a portion of its xylan and/or lignin removed and saturated with a PCM. The PCM may be stabilized with a cross linkable network for improved infiltration into the wood template. The wood template-supported PCM composite may be formed by extracting xylan and/or lignin from the wood to create a wood template, densifying at least a portion of the wood template, and inserting a PCM into the wood template.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Systems, methods, and devices disclosed herein include three-dimensional bioprinting technologies which produce cell scaffolds with a high degree of complexity and precision. A bioprinting ink mixture can be formed with coated gold nanoparticles in an alginate-gelatin solution. Upon bioprinting a 3D scaffold microstructure from the bioink mixture, an imaging procedure is performed on the 3D scaffold microstructure using the coated gold nanoparticles as a contrasting agent. A microstructure characterization is determined from the imaging procedure, and a virtual 3D reconstruction of the microstructure characterization can be generated for presentation on a graphical user interface (GUI) of a computing device.

Abstract: A crowdsourced energy system includes a plurality of distributed energy resources managed by crowdsourcees of the system, a power network to which the distributed energy resources are connected, and a system operator that manages energy trading transactions and energy delivery within the system, the system operator operating at least one computing device configured to: obtain day-ahead peer-to-peer energy trading transaction requests from crowdsourcees for energy to be delivered from the distributed energy resources, estimate day-ahead energy load and solar forecasts, determine optimal power flow for the delivery of energy, and schedule delivery of energy from the distributed energy resources across the power network based upon the energy trading transaction requests, the estimated forecasts, and the determined optimal power flow.

Abstract: The present disclosure presents arrhythmia analysis systems and methods. One such method comprises processing an acquired ECG waveform signal to remove noise artifacts and form a denoised ECG waveform signal; processing the denoised ECG waveform signal to remove low quality segments and form a high quality ECG waveform signal; analyzing the high quality ECG waveform to detect a presence of a beat-independent ventricular arrhythmia; processing the denoised ECG signal to extract beat (R-peak) locations corresponding to QRS complexes from the denoised ECG signal; analyzing the denoised ECG signal to detect a presence of a beat-dependent ventricular arrhythmia based on the extracted beat (R-peak) locations; analyzing the denoised ECG signal to detect a presence of one or more supraventricular arrhythmias based on the extracted beat locations of the ECG signal; and outputting a report containing one or more arrhythmias detected by the analyzing steps. Other methods/systems are also provided.

Abstract: Provided, in one aspect, is a battery pack. The battery pack, in accordance with this aspect, includes an enclosure. The battery pack, in accordance with this aspect, further includes an intake port attached to a first section of the enclosure, the intake port coupleable to a source of cooling fluid, a first exhaust port attached to a third section of the enclosure and a second exhaust port coupled to a fourth section of the enclosure. The battery pack of this aspect further includes a first set of battery cells located within the enclosure in the first and third sections, the first set of battery cells separated by one or more first fluid passageways and a second set of battery cells located within the enclosure in a second and the fourth sections, the second set of battery cells separated by one or more second fluid passageways.

Abstract: The present disclosure comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. In other embodiments, the method provides for directed to a method of determining the level of circulating tumor cells (CTCs) in a sample having blood cells from a patient by contacting a sample having blood cells from a patient.

Abstract: Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.

Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.

Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.