Patents Assigned to The University of Texas System
  • Method and apparatus for defending against laser or other electromagnetic wave-based audio injection attacks on voice-controllable devices and systems
    Patent number: 11948596
    Abstract: Embodiments may provide techniques that protect voice-controllable devices and systems such that the microphone can be shielded from attacking modulated laser beams. Embodiments may provide a physical device that may include two or more layers of integrated material that sits on top of the microphones of the voice-controllable devices and/or systems. The device may act as a physical barrier against the injected malicious laser beams while allowing sound waves reach the microphone for normal operation. For example, in an embodiment, an apparatus may comprise a first layer including at least one opening and a second layer including at least one opening, wherein the at least one opening in the first layer and the at least one opening in the second layer are arranged so as to block the passage of light, but to allow the passage of sound.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: April 2, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eugene Britto John, Ram Narayan Krishnan
  • Toggle spin-orbit torque MRAM with perpendicular magnetic anisotropy
    Patent number: 11942129
    Abstract: A magnetic tunnel junction is provided. The magnetic tunnel junction comprises an insulating tunnel barrier and a fixed ferromagnet layer adjacent the tunnel barrier. The fixed ferromagnet comprises a fixed magnetization along an easy axis approximately normal to an interface between the fixed ferromagnet and the tunnel barrier. A free ferromagnet layer is adjacent the tunnel barrier on the side opposite the fixed ferromagnet. The free ferromagnet layer comprises a bistable magnetization along the easy axis that can switch between a parallel state and an anti-parallel state with the fixed ferromagnet. A heavy metal layer is adjacent the free ferromagnet on the side opposite the tunnel barrier. A unidirectional electric current pulse through the heavy metal layer switches the bistable magnetization of the free ferromagnet, thereby switching an electrical resistance state of the magnetic tunnel junction.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: March 26, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joseph S. Friedman, Naimul Hassan
  • SOLUBLE INTERLEUKIN-7 RECEPTOR (SIL7R) MODULATING THERAPY TO TREAT AUTOIMMUNE DISEASES AND CANCER
    Publication number: 20240093204
    Abstract: The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO).
    Type: Application
    Filed: November 6, 2023
    Publication date: March 21, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Mariano A. Garcia-Blanco, Gaddiel Galarza-Munoz, Shelton S. Bradrick
  • Method and apparatus for assisting a heart
    Patent number: 11931563
    Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: March 19, 2024
    Assignees: Board of Regents, The University of Texas System, CardioVol, LLC
    Inventors: John Porterfield, Jonathan W. Valvano, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
  • LIPOCATIONIC DENDRIMERS AND USES THEREOF
    Publication number: 20240083842
    Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
    Type: Application
    Filed: November 13, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Daniel J. SIEGWART, Kejin ZHOU
  • TARGETING ALPHA2DELTA-1-BOUND GLUTAMATE RECEPTORS FOR TREATING DISEASES AND DISORDERS
    Publication number: 20240083951
    Abstract: The present disclosure provides ?2?-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an ?2?-1 C-terminal domain peptide which blocks binding of ?2?-1 to the glutamate receptors NMDAR and AMPAR.
    Type: Application
    Filed: September 11, 2023
    Publication date: March 14, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventor: Hui-lin PAN
  • miRNA biogenesis in exosomes for diagnosis and therapy
    Patent number: 11926824
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: March 12, 2024
    Assignees: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu Kalluri, Sónia Melo
  • Esters of 2-deoxy-monosaccharides with anti proliferative activity
    Patent number: 11925654
    Abstract: Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: March 12, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Marcin Cybulski, Izabela Fokt, Stanislaw Skora, Charles Conrad, Timothy Madden
  • PREDICTION AND TREATMENT OF IMMUNOTHERAPEUTIC TOXICITY
    Publication number: 20240077496
    Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.
    Type: Application
    Filed: June 21, 2023
    Publication date: March 7, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: David E. Gerber, Edward Wakeland, Quan Li, Saad Khan, Jason Y. Park, Xin Luo, Yang Xie
  • Method and apparatus for assisting a heart
    Patent number: 11918799
    Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: March 5, 2024
    Assignees: Board of Regents, The University of Texas System, Cardio Vol, LLC
    Inventors: John Porterfield, Jonathan W. Valvano, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
  • Prefusion-stabilized hMPV F proteins
    Patent number: 11919927
    Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jason McLellan, Ching-Lin Hsieh, Scott Rush, Nianshuang Wang
  • T cell receptors for immunotherapy
    Patent number: 11919937
    Abstract: Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind the T-cell leukemia/lymphoma 1 (TCL1) oncoprotein. The TCR may be utilized in various therapies, such as autologous TCL1-TCR adoptive T cell therapy, to treat a cancer, such as a B-cell malignancy or a solid tumor expressing TCL1. Methods for expanding a population of T cells that target TCL1 are also provided.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jinsheng Weng, Kelsey Moriarty, Sattva S. Neelapu
  • Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration
    Patent number: 11918646
    Abstract: Described herein are dry immunogenic compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry composition can be readily administered without loss of activity. Also described are methods of intranasal administering dry immunogenic compositions comprising antigens and aluminum adjuvants.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Zhengrong Cui, Sachin G. Thakkar
  • COMPOSITIONS AND METHODS FOR TREATMENT OF CHRONIC LUNG DISEASES
    Publication number: 20240067713
    Abstract: Methods for treating, reducing, ameliorating or inhibiting symptoms idiopathic pulmonary fibrosis (IPF) or interstitial pneumonia, comprising administering to a subject in need of an effective amount of a) multiple EGF-like-domains-9 (MEGF9) or a biologically active fragment thereof; b) uncoordinated receptor 5A (UNC5A) or a biologically active fragment thereof; c) dolichyl-phosphate beta-glucosyltransferase (ALG5) or a biologically active fragment thereof; d) a combination of two or three of a)-c); e) an antibody specifically binding to a); f) an antibody specifically binding to b); g) an antibody specifically binding to c); h) a combination of two or three of e)-g); or i) a combination of at least one of a)-c) and at least one of e)-g). Pharmaceutical compositions and processes for making and using the compositions are also disclosed.
    Type: Application
    Filed: October 5, 2023
    Publication date: February 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventor: Sreerama SHETTY
  • USE OF SDHA AS A PROGNOSTIC MARKER AND THERAPEUTIC TARGET IN UVEAL MELANOMA
    Publication number: 20240068047
    Abstract: Provided herein are methods for identifying expression of SDHA, MIF, and or monosomy 3 or disomy 3 status in sample to identify the sample as high-risk melanoma and/or the sensitivity to oxidative phosphorylation inhibitors. Also provided herein are methods for treating monosomy 3 uveal melanoma by administering a SDHA inhibitor in combination with an oxidative phosphorylation inhibitor.
    Type: Application
    Filed: September 7, 2023
    Publication date: February 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Chandrani CHATTOPADHYAY, Janos ROSZIK
  • Upper-body robotic exoskeleton
    Patent number: 11911330
    Abstract: A robotic exoskeleton including a back portion providing at least two degrees of freedom, two shoulder portions, each shoulder portion providing at least five degrees of freedom, two elbow portions, each elbow portion providing at least one degree of freedom, and two forearm portions, each forearm portion providing at least one degree of freedom.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: February 27, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ashish Warren Deshpande, Bongsu Kim
  • Method and apparatus for assisting a heart
    Patent number: 11911602
    Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: February 27, 2024
    Assignees: Board of Regents, The University of Texas System, Cardio Vol, I.LC
    Inventors: Jonathan W. Valvano, John Porterfield, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
  • Control of Lost Circulation Through a Thermally Activated Metallic Additive
    Publication number: 20240059957
    Abstract: Compositions for treating a wellbore include an exothermic additive capable of initiating an exothermic event following contact with a carrier fluid. The exothermic additive can have a coating that delays the exothermic event after contact with the carrier fluid. Methods disclosed herein include emplacing a fluid loss treatment composition in an interval of a wellbore, the fluid loss treatment including: a metallic fluid loss additive; an exothermic additive; and a carrier fluid; and reacting the exothermic additive to initiate an increase in temperature in the interval of the wellbore above a melting point of the metallic fluid loss additive; and converting the metallic fluid loss additive to a molten fluid loss additive; and treating the interval of the wellbore with the molten fluid loss additive.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 22, 2024
    Applicants: Newpark Drilling Fluids LLC, Board of Regents, The University of Texas System
    Inventors: Ahmed Said Amer, Eric van Oort
  • OX2R compounds
    Patent number: 11905297
    Abstract: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: February 20, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Daniel Rosenbaum, Qiren Liang, Wentian Wang
  • Rotor configuration for switched reluctance motor with minimized torque ripple
    Patent number: 11909264
    Abstract: A hybrid switched reluctance motor is provided that reduces torque ripple. A novel rotor design includes flux barriers. The flux barriers are positioned and shaped to create implicit saliency and reluctance torque for the motor. A gradual change in the motor reluctance results which avoids rapid increases in flux density. The rotor also increases efficiency by reducing acoustical and vibrational responses and associated energy loses.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: February 20, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Babak Fahimi, Seyed Ehsan Movahed Mohammadi, Mehdi Moallem