Patents Assigned to The University of Texas Systems
  • Method for extraction and purification of 68GA
    Patent number: 11723992
    Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: August 15, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mai Lin, Carlos E. Gonzalez-Lepera
  • Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
    Patent number: 11725008
    Abstract: The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: August 15, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Timothy Joseph McAfoos
  • Library of pH responsive polymers and nanoprobes thereof
    Patent number: 11723990
    Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: August 15, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jinming Gao, Gang Huang, Tian Zhao, Xinpeng Ma, Yiguang Wang, Yang Li, Baran D. Sumer
  • METHODS AND COMPOSITIONS FOR TREATMENT OF APC-DEFICIENT CANCER
    Publication number: 20230250433
    Abstract: The disclosure provides methods and compositions for treating subject having cancers with abnormal WNT signaling, such as APC-deficient cancers. Accordingly, aspects of the disclosure relate to methods for treating APC-deficient cancers comprising administering an inhibitor of TDO2 or of a cytokine activated by TDO2. Additional aspects relate to methods for identifying a cancer as being sensitive to TDO2 inhibition comprising detecting a deficiency in an APC gene and/or measuring an expression level of TDO2.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 10, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Rumi LEE, Ronald A DEPINHO
  • Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Patent number: 11718612
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: August 8, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Hamilton, William J. Ray, Fernando Alvarez, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • ADENO-ASSOCIATED VIRUS VECTOR FOR DWARF OPEN READING FRAME
    Publication number: 20230241249
    Abstract: Disclosed are methods of treating a subject, such as those having or at risk of cardiomyopathies, with an effective amount of a recombinant adeno-associated virus (rAAV) virion, the rAAV virion comprising an AAV capsid and an expression cassette comprising a polynucleotide encoding a DWORF polypeptide operatively linked to a promoter. Compositions and kits relating to the same are also disclosed.
    Type: Application
    Filed: July 6, 2021
    Publication date: August 3, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Eric N. OLSON, Rhonda S. BASSEL-DUBY, Benjamin R. NELSON, Catherine A. MAKAREWICH
  • GLS1 inhibitors for treating disease
    Patent number: 11713313
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: August 1, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard Thomas Lewis, Philip Jones, Alessia Petrocchi, Naphtali Reyna, Matthew Hamilton, Michael J. Soth, Timothy Heffernan, Michelle Han, Jason P. Burke
  • Collaborative distributed agent-based traffic light system and method of use
    Patent number: 11715371
    Abstract: In this disclosure, collaborative multi-agent-based TST is presented with dedicated intersection controllers that include software agents which read local and remote detection systems and then collaboratively optimize signal timing phases by considering the feedback of all controller agents that may be affected by a change. The disclosure also presents an augmented system which considers network input from handheld remote devices to update certain traffic light phase information and adapt to emerging emergency situations.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: August 1, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Rym Zalila-Wenkstern, Behnam Torabi
  • Zinc sensors for in vivo imaging of beta-cell function by MRI
    Patent number: 11713305
    Abstract: In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: August 1, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Andre F. Martins, Sara Chirayil, Maria Veronica Clavijo Jordan, A. Dean Sherry
  • Cellular array electrostatic actuator
    Patent number: 11713240
    Abstract: Illustrative embodiments provide an electrostatic actuator and methods of making and operating an electrostatic actuator. The electrostatic actuator comprises a framework and a plurality of electrodes. The framework comprises walls defining a plurality of cells forming an array of cells. The plurality of electrodes comprise an electrode in each cell in the plurality of cells. A gap separates the electrode in each cell from the walls of the cell. The framework is configured to contract in response to an electrical signal applied between the framework and the plurality of electrodes.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: August 1, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Siavash Pourkamali, Amin Abbasalipour, Prithviraj Palit
  • Permeative amine or acid introduction for very weak acid detection in ion chromatography
    Patent number: 11714070
    Abstract: A permeative amine/acid introduction device (PAID) is placed after a conventional KOH eluent suppressed conductometric anion chromatography (SCAC) system. The PAID converts the suppressed eluites from the acid form to the corresponding salt. For example, when the analytes are acids, they are converted to the corresponding ammonium salt (NR2H+HX?NR2H2++X?) and allows very weak acids HX (pKa?7.0) that cannot normally be detected by SCAC to be measured by a second conductivity detector following the PAID. Permeative reagent introduction is dilutionless, can be operated without pumps and provides good mixing with low band dispersion (as small as 30 ?L). An exemplary amine is diethylamine (DEA), which was chosen as the amine source due to its low pKb value (pKb 3.0), high vapor pressure, and low toxicity and low odor.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: August 1, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Purnendu K. Dasgupta, Charles Philip Shelor, Hongzhu Liao
  • COMPOUNDS WITH ANTI-TUMOR ACTIVITY AGAINST CANCER CELLS BEARING EGFR OR HER2 EXON 20 MUTATIONS
    Publication number: 20230233563
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Application
    Filed: August 24, 2022
    Publication date: July 27, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • Powered prosthesis with torque dense, low ratio actuation
    Patent number: 11707366
    Abstract: Disclosed herein are embodiments of a powered prosthesis. In one embodiment, the powered prosthesis may include a first joint actuator; a second joint actuator; a connector to connect the first joint actuator with the second joint actuator; and a power source connected with both the first and second joint actuator; wherein the first joint actuator and the second joint actuator are both at least backdrivable and configured such that when one of the first or second joint actuator is drawing power from the power source, the other of the first or second joint actuator may be generating power for the power source. In some embodiments, the first motor is at least a high output torque motor. In other embodiments, the second motor is at least a high output torque motor.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: July 25, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert D. Gregg, Toby B. Elery, Christopher R. Nesler, Siavash Rezazadeh
  • Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
    Patent number: 11708602
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: July 25, 2023
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • Systems and methods for determining a natural frequency of a structure
    Patent number: 11704452
    Abstract: In one embodiment, a system and method for determining a natural frequency of a structure involve modeling the structure, creating a synthesized excitation comprising a plurality of waves having various frequencies within a defined range of frequencies, applying the synthesized excitation to a base of the modeled structure, and generating response data indicative of a natural frequency of the modeled structure that is based upon the application of the synthesized excitation.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: July 18, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sayantan Chakraborty, Jasaswee T. Das, Aritra Banerjee, Anand J. Puppala
  • Sealed isocyanates
    Patent number: 11697706
    Abstract: The present disclosure relates to sealed isocyanate resin compositions. The resin compositions may be used for additive manufacturing. One embodiment of the invention includes a photopolymerizable resin for additive manufacturing, the resin comprising: a blocked isocyanate; at least one monomer or oligomer; and a multifunctional nucleophile.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: July 11, 2023
    Assignees: Adaptive 3D Technologies, Board of Regents, The University of Texas System
    Inventors: Benjamin R. Lund, Walter Voit
  • System and process for recycling foam
    Patent number: 11697722
    Abstract: System and methods for recycling a material comprising a polymer in an expanded state is disclosed. The system can include a shredder, a heating chamber operatively connected to the shredder, a condenser operatively connected to the heating chamber, a solvent tank operatively connected to the condenser, and a circulation unit operatively connected to the solvent tank and the heating chamber.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: July 11, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Karen Lozano, Luis Sosa, Adonica De Los Santos, Salomon Luna, Jared Solis
  • Efficient sequencing of dsDNA with extremely low level of errors
    Patent number: 11697837
    Abstract: DNA is sequenced by: (a) combining dsDNA fragments with Y-adapters and hairpin adapters comprising an affinity-label under conditions wherein the adapters ligate to fragments forming a mixture of fragment inserts flanked by two Y-adapters, a Y-adapter and a hairpin adapter, and two hairpin adapters; and (b) sequencing the selected fragment inserts with sequencing primers selecting for the Y-adapters.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: July 11, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Zbyszek Otwinowski, Dominika Borek
  • T CELL RECEPTORS WITH VGLL1 SPECIFICITY AND USES THEREOF
    Publication number: 20230212256
    Abstract: Provided herein are tumor-antigen VGLL 1 specific T cell receptors. The TCR may be utilized in various therapies, such as autologous cell transplantation, to treat a cancer. Methods for expanding a population of T cells that target VGLL 1 are also provided.
    Type: Application
    Filed: May 21, 2021
    Publication date: July 6, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Gregory LIZÉE, Cassian YEE
  • 20-HETE receptor (GPR75) antagonists and methods of use
    Patent number: 11690825
    Abstract: The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: July 4, 2023
    Assignees: Board of Regents, The University of Texas System, New York Medical College
    Inventors: John R. Falck, Michal L. Schwartzman, Victor Garcia