Patents Assigned to The University of Texas Systems
  • Patent number: 11581402
    Abstract: A method and apparatus include an n-doped layer having a first applied charge, and a p?-doped layer having a second applied charge. The p?-doped layer may be positioned below the n-doped layer. A p+-doped buffer layer may have a third applied charge and be positioned below the p?-doped layer. The respective charges at each layer may be determined based on a dopant level and a physical dimension of the layer. In one example, the n-doped layer, the p?-doped layer, and the p+-doped buffer layer comprise a lateral semiconductor manufactured from silicon carbide (SiC).
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: February 14, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventor: Qin Huang
  • Patent number: 11577074
    Abstract: In one aspect, an apparatus for stimulating and/or monitoring a nerve is described herein. In some embodiments, the apparatus comprises a top substrate layer, a bottom substrate layer in facing opposition to the top substrate layer, and a channel disposed between the top substrate layer and the bottom substrate layer. The apparatus further comprises a plurality of electrodes disposed on one or more interior surfaces of the channel. Additionally, the channel is defined by the top substrate layer, the bottom substrate layer, and a retaining wall extending at least partially between the top substrate layer and the bottom substrate layer. The retaining wall retains the nerve within the channel.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: February 14, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Muthu B. J. Wijesundara, Ryan Andrew Landrith, Caleb P. Nothnagle, Young-tae Kim
  • Patent number: 11576883
    Abstract: The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and/or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: February 14, 2023
    Assignees: Iowa State University Research Foundation, Inc., Board of Regents, The University of Texas System
    Inventors: Anumantha G. Kanthasamy, Ahmed Abdalla, Gregory Phillips, Nicholas Backes, Andrew D. Ellington, Ross Thyer
  • Patent number: 11579111
    Abstract: A biosensor pixel for measuring current that flows through the electrode surface in response to electrochemical interactions and a biosensor array architecture that includes such biosensor pixels. The biosensor pixel includes an electrode transducer configured to measure a current generated by electrochemical interactions occurring at a recognition layer placed directly on top of it in response to an electrical voltage placed across an electrode transducer-electrolyte interface. The biosensor pixel further includes a trans-impedance amplifier connected to the electrode transducer, where the trans-impedance amplifier is configured to convert the current into a voltage signal as the electrochemical interactions occur.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: February 14, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arjang Hassibi, Arun Manickam, Rituraj Singh
  • Publication number: 20230038471
    Abstract: An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.
    Type: Application
    Filed: October 7, 2022
    Publication date: February 9, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jonathan W. Valvano, John A. Pearce, Marc D. Feldman, Kaarthik Rajendran, John Porterfield, Anil Kottam, Wes Johnson
  • Publication number: 20230039515
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Application
    Filed: August 8, 2022
    Publication date: February 9, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey
  • Patent number: 11575544
    Abstract: Various embodiments provide for deep learning-based architectures and design methodologies for an orthogonal frequency division multiplexing (OFDM) receiver under the constraint of one-bit complex quantization. Single bit quantization greatly reduces complexity and power consumption in the receivers, but makes accurate channel estimation and data detection difficult. This is particularly true for OFDM waveforms, which have high peak-to average (signal power) ratio in the time domain and fragile subcarrier orthogonality in the frequency domain. The severe distortion for one-bit quantization typically results in an error floor even at moderately low signal-to-noise-ratio (SNR) such as 5 dB. For channel estimation (using pilots), various embodiments use novel generative supervised deep neural networks (DNNs) that can be trained with a reasonable number of pilots. After channel estimation, a neural network-based receiver specifically, an autoencoder jointly learns a precoder and decoder for data symbol detection.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 7, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jeffrey Andrews, Eren Balevi
  • Patent number: 11573181
    Abstract: A method of imaging described herein comprises (a) disposing ultrasound-switchable fluorophores within an environment; (b) exposing the environment to ultrasound to create a first activation region within the environment; (c) disposing the fluorophores within the first activation region to switch the fluorophores from an off state to an on state; (d) irradiating the environment to excite the fluorophores within the first activation region; (e) detecting photoluminescence from the excited fluorophores at a first optical spot on an exterior surface of the environment; (f) subsequently creating a second activation region within the environment; (g) switching fluorophores within the second activation region to an on state; (h) exciting the fluorophores in the on state within the second activation region; and (i) detecting photoluminescence from the excited fluorophores within the second activation region at a second optical spot on the exterior surface, wherein the first and second optical spots are optically res
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: February 7, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Baohong Yuan, Tingfeng Yao
  • Publication number: 20230034192
    Abstract: Systems and methods for simulating subterranean regions having multi-scale, complex fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied in conjunction with commercial or in-house simulators to efficiently and accurately model subsurface characteristics including temperature profiles in regions having complex hydraulic fractures, complex natural fractures, or a combination of both.
    Type: Application
    Filed: July 14, 2021
    Publication date: February 2, 2023
    Applicants: Sim Tech LLC, Board of Regents, The University of Texas System
    Inventors: Kamy Sepehrnoori, He Sun, Wei Yu, Jijun Miao
  • Publication number: 20230026843
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: September 4, 2022
    Publication date: January 26, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Publication number: 20230022045
    Abstract: Combination therapies for the treatment of cancers are provided. In some embodiments, a flagellin derivative such as CBLB502 is administered in combination with an immune checkpoint therapy (e.g., an anti-PD 1 antibody and an anti-CTLA4 antibody) to treat a cancer in a mammalian subject. In some embodiments, the combination therapy is administered intratumorally or peritumorally.
    Type: Application
    Filed: December 3, 2020
    Publication date: January 26, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: David PIWNICA-WORMS, Caleb GONZALEZ, Seth GAMMON
  • Publication number: 20230024822
    Abstract: Aspects of self-powered weigh-in-motion systems and methods that utilize piezoelectric components for sensing load as well as powering data acquisition and analysis components. In one example, the weigh-in-motion system includes a number of piezoelectric stacks, each stack including a number of piezoelectric elements. Each stack includes one or more top or upper piezoelectric element that provides vehicle sensing data. Each stack also includes a set of piezoelectric elements used for energy harvesting. The sensing piezoelectric elements are connected to a data input of a microcontroller for vehicle classification, while the energy harvesting piezoelectric elements are connected to a power input of the microcontroller.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 26, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Sara Ahmed, Mohamadreza Khalili, Athanassios Thomas Pagagiannakis, Gopal Vishwakarma, Samer Dessouky
  • Publication number: 20230023987
    Abstract: The present disclosure provides methods of treating cancer in a patient comprising administering a combination of a low dose radiotherapy and an immune checkpoint inhibitor therapy. The patient may be further administered a cell therapy, such as chimeric antigen receptor T-cell therapy or chimeric antigen receptor NK-cell therapy. The low dose radiation modulates the tumor microenvironment of solid tumors to allow better efficacy, activation, and infiltration of the anti-tumor effector immune cells.
    Type: Application
    Filed: December 18, 2020
    Publication date: January 26, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: James W. WELSH, Hampartsoum B. BARSOUMIAN, Maria Angelica CORTEZ
  • Patent number: 11563573
    Abstract: Systems and methods for quantum clock synchronization are provided. Various embodiments can use time-energy and polarization entangled photons to securely extract the absolute time difference between two remote clocks. In some embodiments, two parties can each have a source of entangled photons. Each party can detect one member of the pair locally and time stamp the detection time, while the other photon gets sent over a common channel (single optical mode) to the other party where the transmitted photon is detected and time stamped. The time stamp values can be shared over an open authenticated channel and each receiver can run a cross-correlation of the detection times. The authenticity and non-spoofability of the timing signal are ensured if each party does not just perform a simple time of arrival measurement but also incorporate polarization measurements whose joint values constitute a Bell test.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: January 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Antia Lamas-Linares, James Troupe
  • Patent number: 11561421
    Abstract: Various embodiments of the present technology enable growth of a-axis oriented barium titanate (BTO) films by inserting a relaxed strain control layer having a larger lattice constant than the c-axis of BTO and a similar thermal expansion mismatch. As a result, in-plane tensile stress causes BTO to grow with its ferroelectric polarization in-plane. Some embodiments allow for BTO films to immediately be grown on silicon with a-axis orientation, and without the need to create thick layers for relaxation. Using various embodiments of the present technology, the BTO can be grown in-plane with minimal dislocation density that is confined to the interface region.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: January 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Alexander A. Demkov, Marc Reynaud, Agham Posadas
  • Patent number: 11560366
    Abstract: Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g. Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, progressive supranuclear palsy, Lewy body disease, Kennedy's disease, and other related conditions), from neuropathies resulting from neurological damage (chemotherapy-induced peripheral neuropathy, diabetic neuropathy, and related conditions) and from cognitive disorders caused by pharmacological intervention (e.g. chemotherapy induced cognitive disorder, also known as chemobrain).
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: January 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael J. Soth, Kang Le, Philip Jones, Jason Cross
  • Patent number: 11562666
    Abstract: Various implementations include a Human Thermoregulation Simulator (HTRS) that simulates the natural and primary thermoregulatory functions of a patient that are relevant during therapeutic hypothermia procedures. For example, in various implementations, a HTRS includes a core container configured to be at least partially filled with water, and the core container includes a heat generator configured to heat the water inside the core container. A middle container is disposed concentrically around the core container, and the middle container includes a foam layer configured to be saturated by water. An outer container is disposed concentrically around the middle container, and the outer container includes a network of tubing disposed on at least a portion of an inner surface of the outer container. The HTRS also includes a pump configured to circulate water from the core container through the network of tubing.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: January 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kenneth R. Diller, Priya Chacko, Ali Seifi
  • Publication number: 20230014398
    Abstract: Provided herein are agents, such as antibodies, antibody-drug conjugates, or chimeric antigen receptors, that target B7-H3. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an B7-H3-targeting agent. The patient may be selected for treatment if the cancer expresses an increased level of B7-H3.
    Type: Application
    Filed: November 18, 2020
    Publication date: January 19, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: David PIWNICA-WORMS, Seth GAMMON, Federica PISANESCHI
  • Patent number: 11555056
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for using a BiPE that can include (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell), (b) an optional linker component, and (c) one or more molecules having the ability to bind to an antigen presenting cell (e.g., a human macrophage) to treat cancer are provided.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: January 17, 2023
    Assignees: Mayo Foundation for Medical Education and Research and Board of Regents, The University of Texas System
    Inventors: Yon Son Betty Kim, Wen Jiang, Christina Von Roemeling
  • Patent number: 11555200
    Abstract: The present invention includes compositions and methods of modulating the length of one or more cotton fibers in a plant by contacting the plant or tissue derived therefrom with at least one of: a nucleotide; a modulator of ectoapyrase gene transcription; or an anti-ectoapyrase antibody or fragments thereof, at a concentration that modulates growth of one or more cotton fibers.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 17, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Stanley J. Roux, Greg Clark, Jonathan Torres, Zengjian Jeffrey Chen