Abstract: A potent complement regulator is disclosed. The complement regulator comprises a complement regulatory region connected by a flexible linker to a multifunctional binding region that enables binding to C3b activation/inactivation products and/or oxidation end products, as well as to polyanionic surface markers on host cells. An embodiment of the invention utilizes factor H SCRs 1-4 as the complement regulatory region and factor H SCRs 19 and 20 as the multi-functional binding region, linked together by a poly-Gly linker at least 12 residues in length. Pharmaceutical compositions comprising the complement regulator and methods of using the complement regulator are also disclosed.
Type:
Application
Filed:
March 15, 2013
Publication date:
April 23, 2015
Applicant:
UNIVERSITY ULM
Inventors:
John D. Lambris, Christoph Schmidt, Daniel Ricklin
Abstract: The invention relates to novel polyaromatic and polyheteroaromatic compounds and derivatives thereof. The compounds display high solubility in organic solvents. A further aspect of the invention relates to the use of the novel compounds in the fabrication of organic film based heterojunction devices. In one form the devices display high conversion efficiencies in solar cell applications.
Type:
Application
Filed:
November 27, 2009
Publication date:
February 2, 2012
Applicants:
THE UNIVERSITY OF ULM, THE UNIVERSITY OF MELBOURNE
Inventors:
Andrew Holmes, David Jones, Wing Ho Wallace Wong, Chang Qi Ma, Peter Baeuerle