Patents Assigned to The University of Utah
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Patent number: 12048668Abstract: An exoskeleton device that includes an artificial joint and a frame member extending from the artificial joint. The frame member is configured for extension over a limb of a user. The exoskeleton device also includes a self-aligning mechanism connected to the frame member. The self-aligning mechanism includes three passive degrees of freedom (pDOF) provided in a prismatic-revolute-revolute (PRR) configuration. The self-aligning mechanism also includes a limb attachment member configured for mechanically coupling to a portion of the limb of the user.Type: GrantFiled: March 19, 2021Date of Patent: July 30, 2024Assignee: The University of Utah Research FoundationInventors: Sergei V. Sarkisian, Tommaso Lenzi, Dante Amico Bennett Archangeli
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Patent number: 11339140Abstract: The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.Type: GrantFiled: September 27, 2019Date of Patent: May 24, 2022Assignees: Curza Global, LLC, The University of UtahInventors: Ryan E. Looper, Justin M. Salvant, Emily K. Kirkeby, Wenxing Guo, Katrin P. Guillen, Bryan E. Welm
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Patent number: 10849901Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.Type: GrantFiled: May 27, 2015Date of Patent: December 1, 2020Assignees: Navigen, Inc., The University of Utah Research FoundationInventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
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Patent number: 10689376Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.Type: GrantFiled: July 27, 2018Date of Patent: June 23, 2020Assignees: Stingray Therapeutics, Inc., The University of UtahInventors: Hariprasad Vankayalapati, Xiaohui Liu, Gurusankar Ramamoorthy, Sunil Sharma, Mohan Rao Kaadige, Alexis Weston, Trason Thode
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Patent number: 10595748Abstract: Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician.Type: GrantFiled: February 1, 2013Date of Patent: March 24, 2020Assignee: The University of Utah Research FoundationInventors: Erik N. Kubiak, Kylee North, Tomasz Petelenz, Robert W. Hitchcock
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Patent number: 10568857Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.Type: GrantFiled: June 20, 2019Date of Patent: February 25, 2020Assignee: The University of Utah Research FoundationInventor: Tianxin Yang
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Patent number: 10494682Abstract: Methods and kits for performing polymerase chain reaction (PCR) and melting analyses to determine copy number variation and/or gene expression are disclosed herein. Related uses of such methods and analyses are also disclosed herein.Type: GrantFiled: December 23, 2015Date of Patent: December 3, 2019Assignees: The University of Utah Research Foundation, Utah Valley UniversityInventors: Carl Wittwer, Luming Zhou, Robert Palais
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Patent number: 10369125Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.Type: GrantFiled: April 20, 2017Date of Patent: August 6, 2019Assignee: The University of Utah Research FoundationInventor: Tianxin Yang
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Patent number: 10175216Abstract: Systems, methods and devices are provided for fitting kinetic models to measurements of dynamic curves where the kinetic models give rise to nonlinear fitting equations in two or more unknowns that can be formulated so that they are linear in one or more of the unknown parameters and nonlinear in one or more of the unknown parameters. Such systems, methods and devices may be utilized to monitor and characterize the attributes of a given tracer such as a radioactive substance within a body, a drug within the body, a concentration of a substance within a particular medium, and the like.Type: GrantFiled: June 5, 2012Date of Patent: January 8, 2019Assignee: The University of Utah Research FoundationInventors: Dan J. Kadrmas, Mehmet Bugrahan Oktay
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Patent number: 10010532Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.Type: GrantFiled: October 23, 2015Date of Patent: July 3, 2018Assignee: The University of Utah Research FoundationInventor: Tianxin Yang
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Patent number: 9901624Abstract: Disclosed are compositions and methods for treating nephrogenic diabetes insipidus and for induction of diuretic effect.Type: GrantFiled: June 16, 2014Date of Patent: February 27, 2018Assignees: The United States of America as represented by the Department of Veterans Affairs, The University of UtahInventors: Bellamkonda K. Kishore, Noel G. Carlson, Donald E. Kohan, Raoul D. Nelson
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Patent number: 9767659Abstract: Embodiments of the present disclosure relate devices, systems, methods, and for displaying information about the direction and magnitude of position, movement, and/or resistive force experienced for an object. The present disclosure also provides a shear display device that can generate skin shear with one or more tactors. The movement of the tactors can represent to a user various information about an object.Type: GrantFiled: February 12, 2016Date of Patent: September 19, 2017Assignee: The University of Utah Research FoundationInventors: William R. Provancher, Markus N. Montandon, Andrew J. Doxon, Nathan A. Caswell, Landon T. Gwilliam
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Publication number: 20170189405Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.Type: ApplicationFiled: May 27, 2015Publication date: July 6, 2017Applicants: Navigen, Inc., The University of Utah Research FoundationInventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
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Patent number: 9656061Abstract: The present embodiments are directed to implantable electrode arrays having virtual electrodes. The virtual electrodes may improve the resolution of the implantable electrode array without the burden of corresponding complexity of electronic circuitry and wiring. In a particular embodiment, a virtual electrode may include one or more passive elements to help steer current to a specific location between the active electrodes. For example, a passive element may be a metalized layer on a substrate that is adjacent to, but not directly connected to an active electrode. In certain embodiments, an active electrode may be directly coupled to a power source via a conductive connection. Beneficially, the passive elements may help to increase the overall resolution of the implantable array by providing additional stimulation points without requiring additional wiring or driver circuitry for the passive elements.Type: GrantFiled: September 11, 2015Date of Patent: May 23, 2017Assignee: The University of Utah Research FoundationInventors: Carlos Jose Cela, Gianluca Lazzi
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Patent number: 9642795Abstract: The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. The lubricant may be an aqueous lubricant. The present technology further provides an intravaginal device including a solid first segment that includes a hydrophilic semi-permeable elastomer, an outer surface and an aqueous lubricant, wherein the first segment is configured to deliver the aqueous lubricant to the outer surface.Type: GrantFiled: January 4, 2016Date of Patent: May 9, 2017Assignee: The University of Utah Research FoundationInventors: Patrick F. Kiser, R. Tyler McCabe, Margaret N. Kiser, Theodore Henry Albright
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Patent number: 9642623Abstract: Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device.Type: GrantFiled: April 15, 2011Date of Patent: May 9, 2017Assignee: The University of Utah Research FoundationInventors: Jayant P. Agarwal, Bruce K. Gale, Lam Nguyen, Cory Shorr, Brian Stauffer, Cody Lee Gehrke
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Patent number: 9616540Abstract: Devices, systems, and methods are provided for controlling a quantity of cutting fluid dispensed for a cutting tool within a CNC or other machining system. The devices, systems, and methods may include controlling multiple fluids such that coolant, lubricant, or other fluids can be delivered at different locations, at different flow rates, have their flow rates changed independently, and/or have their flow rates changed dynamically during a machining operation. In some embodiments, a feedback loop or input may be provided to obtain and/or provide information regarding the machining operation—such as cutting force, cutting temperature, cutting friction, machining operation, tool in use, work piece geometry, and/or material—and automatically and/or independently modify the fluid flow rates. The fluid may be atomized with air or other gases to minimize the quantities of fluid used. Components in the system may be modular to allow the system to be used with existing and new machining technologies.Type: GrantFiled: February 8, 2012Date of Patent: April 11, 2017Assignee: The University of Utah Research FoundationInventors: Alagar Krishnan Balaji, Venugopal Raghavendra Ghatikar
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Patent number: 9585855Abstract: The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.Type: GrantFiled: March 11, 2014Date of Patent: March 7, 2017Assignee: The University of Utah Research FoundationInventor: Tianxin Yang
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Patent number: 9569562Abstract: A video game in possession of and/or in the proximity of a patient. The patient computing system receives an indication that it is to begin a game, and executes the game using identified game parameters that are associated with the patient by a clinician as part of a disease therapy program. As the game executes, game state progresses in response to physical activity of the patient, causing the patient to exercise. The physical activity is received as input into the patient computing system. Such input causes game state to be progressed dependent on the identified game parameters that are associated with the game. Thus, the game is tailored for the patient by a clinician in order to motivate physical activity that is medically beneficial to the patient in order to advance through the disease therapy program.Type: GrantFiled: May 18, 2012Date of Patent: February 14, 2017Assignee: The University of Utah Research FoundationInventors: Grzegorz Wlodzimierz Bulaj, Carol S. Bruggers, Roger Alan Altizer, Jr., Robert R. Kessler, Craig Bernreuter Caldwell, Wade Ray Patterson, Kurt Joseph Coppersmith, Laura Mae Warner, Brandon H. Davies
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Patent number: 9548736Abstract: Technology is described for a relative timed clock gated cell. In one example, the relative timed clock gated cell includes a trigger latch and a data clock latch. The trigger latch includes a clock input coupled to a trigger line for transmitting a trigger signal. The trigger latch is configured to generate a data clock signal on an output. The trigger signal is based on a clock signal. The data clock latch includes a clock input coupled to the output of the trigger latch that latches a data input of the data clock latch based on the data clock signal. Various other computing circuitries and methods are also disclosed.Type: GrantFiled: June 15, 2015Date of Patent: January 17, 2017Assignee: The University of Utah Research FoundationInventors: Kenneth S. Stevens, William Lee