Abstract: The present disclosure provides compositions of matter comprising a polymer or peptide bound to an oxidized amino acid or an analog thereof. The present disclosure also provides packaging materials, consumer products, and cosmetic products comprising the compositions of matter disclosed herein.
Type:
Application
Filed:
March 16, 2022
Publication date:
September 19, 2024
Applicants:
The Trustees of Princeton University, THE UNIVERSITY OF UTAH
Inventors:
Micah T. NELP, Anthon P. YOUNG, John T. GROVES
Abstract: An exoskeleton device that includes an artificial joint and a frame member extending from the artificial joint. The frame member is configured for extension over a limb of a user. The exoskeleton device also includes a self-aligning mechanism connected to the frame member. The self-aligning mechanism includes three passive degrees of freedom (pDOF) provided in a prismatic-revolute-revolute (PRR) configuration. The self-aligning mechanism also includes a limb attachment member configured for mechanically coupling to a portion of the limb of the user.
Type:
Grant
Filed:
March 19, 2021
Date of Patent:
July 30, 2024
Assignee:
The University of Utah Research Foundation
Inventors:
Sergei V. Sarkisian, Tommaso Lenzi, Dante Amico Bennett Archangeli
Abstract: Ultra-compact inductor devices for use in integrated circuits (e.g., RF ICs) that use 3-dimensional Dirac materials for providing the inductor. Whereas inductors currently require significant real estate on an integrated circuit, because they require use of an electrically conductive winding around an insulative core, or such metal deposited in a spiral geometry, the present devices can be far more compact, occupying significantly less space on an integrated circuit. For example, an ultra-compact inductor that could be included in an integrated circuit may include a 3-dimensional Dirac material formed into a geometric shape capable of inductance (e.g., as simple as a stripe or series of stripes of such material), deposited on a substantially non-conductive (i.e., insulative) substrate, on which the Dirac material in the selected geometric shape is positioned. Low temperature manufacturing methods compatible with CMOS manufacturing are also provided.
Type:
Grant
Filed:
March 12, 2020
Date of Patent:
January 24, 2023
Assignee:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors:
Berardi Sensale Rodriguez, Ashish Chanana, Steven M Blair, Vikram Deshpande, Michael A Scarpulla, Hugo Orlando Condori, Jeffrey Walling
Abstract: The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
Type:
Grant
Filed:
September 27, 2019
Date of Patent:
May 24, 2022
Assignees:
Curza Global, LLC, The University of Utah
Inventors:
Ryan E. Looper, Justin M. Salvant, Emily K. Kirkeby, Wenxing Guo, Katrin P. Guillen, Bryan E. Welm
Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
Type:
Grant
Filed:
May 27, 2015
Date of Patent:
December 1, 2020
Assignees:
Navigen, Inc., The University of Utah Research Foundation
Inventors:
Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.
Type:
Grant
Filed:
May 29, 2018
Date of Patent:
July 14, 2020
Assignee:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
Type:
Grant
Filed:
July 27, 2018
Date of Patent:
June 23, 2020
Assignees:
Stingray Therapeutics, Inc., The University of Utah
Abstract: Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician.
Type:
Grant
Filed:
February 1, 2013
Date of Patent:
March 24, 2020
Assignee:
The University of Utah Research Foundation
Inventors:
Erik N. Kubiak, Kylee North, Tomasz Petelenz, Robert W. Hitchcock
Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.
Type:
Application
Filed:
November 18, 2019
Publication date:
March 19, 2020
Applicant:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors:
Julie Ruth Korenberg, Karen Sue Wilcox, Peter Jeffrey West, Raymond Pierre Kesner
Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
Type:
Grant
Filed:
June 20, 2019
Date of Patent:
February 25, 2020
Assignee:
The University of Utah Research Foundation
Abstract: Methods and kits for performing polymerase chain reaction (PCR) and melting analyses to determine copy number variation and/or gene expression are disclosed herein. Related uses of such methods and analyses are also disclosed herein.
Type:
Grant
Filed:
December 23, 2015
Date of Patent:
December 3, 2019
Assignees:
The University of Utah Research Foundation, Utah Valley University
Inventors:
Carl Wittwer, Luming Zhou, Robert Palais
Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.
Type:
Grant
Filed:
April 8, 2015
Date of Patent:
November 19, 2019
Assignee:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors:
Julie Ruth Korenberg, Karen Sue Wilcox, Peter Jeffrey West, Raymond Pierre Kesner
Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
Type:
Grant
Filed:
April 20, 2017
Date of Patent:
August 6, 2019
Assignee:
The University of Utah Research Foundation
Abstract: Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.
Type:
Grant
Filed:
June 15, 2016
Date of Patent:
January 8, 2019
Assignee:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors:
H. Steve White, Brian Donald Klein, Cameron Spencer Metcalf, Daniel Ryan McDougle, Erika Adkins Scholl, Misty Danielle Smith, Grzegorz Bulaj, Liuyin Zhang
Abstract: Systems, methods and devices are provided for fitting kinetic models to measurements of dynamic curves where the kinetic models give rise to nonlinear fitting equations in two or more unknowns that can be formulated so that they are linear in one or more of the unknown parameters and nonlinear in one or more of the unknown parameters. Such systems, methods and devices may be utilized to monitor and characterize the attributes of a given tracer such as a radioactive substance within a body, a drug within the body, a concentration of a substance within a particular medium, and the like.
Type:
Grant
Filed:
June 5, 2012
Date of Patent:
January 8, 2019
Assignee:
The University of Utah Research Foundation
Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.
Type:
Grant
Filed:
October 23, 2015
Date of Patent:
July 3, 2018
Assignee:
The University of Utah Research Foundation
Abstract: Methods are provided of treating and preventing stroke diseases, such as cerebral cavernous malformation, by the administration of tempol and/or cholecalciferol.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
April 10, 2018
Assignee:
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
Abstract: Embodiments of the present disclosure relate devices, systems, methods, and for displaying information about the direction and magnitude of position, movement, and/or resistive force experienced for an object. The present disclosure also provides a shear display device that can generate skin shear with one or more tactors. The movement of the tactors can represent to a user various information about an object.
Type:
Grant
Filed:
February 12, 2016
Date of Patent:
September 19, 2017
Assignee:
The University of Utah Research Foundation
Inventors:
William R. Provancher, Markus N. Montandon, Andrew J. Doxon, Nathan A. Caswell, Landon T. Gwilliam